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Cited by 53Polyamine Metabolism and ApplicationsBirth, Development, and HealthNeonatal and fetal brain pathology

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Biochemical Determinants of Growth Sparing during Neonatal Nutritional Deprivation or Enhancement: Ornithine Decarboxylase, Polyamines, and Macromolecules in Brain Regions and Heart

Bell, J M, Whitmore, W L, Queen, K L, Orband-Miller, L, Slotkin, T A·1987·Pediatric Research
DOI 10.1203/00006450-198711000-00024
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Abstract

In order to elucidate the biochemical mechanisms operating to protect the brain from growth retardation in response to nutritional deprivation, comparisons were made of markers of cellular development in brain regions (cerebellum, cerebral cortex, midbrain + brainstem) and in a tissue which is not spared (heart). Nutritional status of neonatal rats was manipulated by increasing or decreasing the litter size beginning at birth, and development of DNA, RNA, and proteins followed throughout the neonatal period. In addition, we assessed the activity and levels of ornithine decarboxylase and its metabolic products, the polyamines, which are known to coordinate macromolecule synthesis in immature tissue and to provide an early index of perturbed development. Cardiac ornithine decarboxylase and polyamines were altered within 48 h of initiating the changes in litter size, and the direction and magnitude of these biochemical effects were predictive of subsequent impairment or enhancement of organ growth and of cellular development. All three brain regions were buffered from growth alterations relative to the heart, but the cerebellum, which undergoes major phases of cell replication later than the other two regions, was somewhat less protected. The spared brain regions also showed evidence of compensatory hypertrophy in nutritional deprivation (increased protein/DNA ratio) which accounts for maintenance of growth in the presence of reduced cell numbers. Thus, brain growth sparing involves specific cellular responses which are dependent on the maturational profile of each brain region.

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Crossref · 10.1203/00006450-198711000-00024

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Metadata

Authors
Bell, J. M., Whitmore, W. L., Queen, K. L., Orband-Miller, L., & Slotkin, T. A.
Affiliations
Duke Medical Center (US)
ORCID
Venue
Pediatric Research
Publisher
Springer Science and Business Media LLC
Published
1987-11
Volume
22
Issue
5
Pages
599-604
ISSN
  • 0031-3998 (ISSN-L)
  • 1530-0447
DOI
10.1203/00006450-198711000-00024
OpenAlex
W1973996042
Cited by
53
References
15
Citations by year
2019: 1 · 2016: 1 · 2012: 2
FWCI
0.55
Type
journal article
Language
en
Open access
closed
Locations
  • Pediatric Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 09713)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Keywords
litter size, ornithine decarboxylase, polyamines, brain development, heart development, cerebellum, cerebral cortex, compensatory hypertrophy, protein/DNA ratio, macromolecular synthesis, cell replication, organ growth
MeSH terms
Animals, Brain, DNA, Litter Size, Myocardium, Ornithine Decarboxylase, Polyamines, Protein-Energy Malnutrition, Proteins, Rats, Inbred Strains, RNA, Rats

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