Plasma Cholesterol and Lathosterol Levels in Term Infants in the Early Neonatal Period
Abstract
Plasma cholesterol concentrations increase after birth. Whether this is due to increased cholesterol synthesis has not been reported. Additionally, it is not known if formulas, which lack cholesterol, result in higher rates of cholesterol synthesis than feeding breast milk. To address this, plasma lathosterol (quantitated by gas chromatography), a potential indicator of cholesterol synthesis, was measured in term infants at birth (cord) and 4 d of age fed either formula or breast milk (n = 6 each), normal adults (n = 6) at the expected nadir and peak of the diurnal rhythm (1700 h and 0830 h), and cholestyramine-treated hypercholesterolemic adults (n = 6). Plasma cholesterol and apo B increased, and apo AI (measured by immunoprecipitation) did not change over the first 4 d of life. The increase in plasma cholesterol was greater in the formula-fed infants compared with breast-fed infants. The plasma lathosterol concentrations (mumol/L) and the lathosterol:cholesterol ratios (10(2) x mmol lathosterol/mol cholesterol) decreased from birth to 4 d of age by 12 and 36%, respectively, in the breast-fed infants and by 20 and 46%, respectively, in formula-fed infants. The infant plasma lathosterol concentrations, however, were not different from normal adult levels [1700 h: 5.50 +/- 1.52 (SD); 0830 h: 6.18 +/- 1.80], but were lower than those of cholestyramine-treated adults (20.48 +/- 13.41). Sterol ratios of infants were higher than those of normal adults (1700 h: 112.5 +/- 26.0; 0830 h: 129.4 +/- 42.2), but not different from those of cholestyramine-treated adults (322.9 +/- 168.4).(ABSTRACT TRUNCATED AT 250 WORDS)
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Cholesterol and desmosterol play essential roles during embryogenesis, myelination, and brain development.
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- Authors
- Hamilton, J. J., Synnes, A., & Innis, S. M.
- Affiliations
- University of British Columbia (CA)
- Venue
- Pediatric Research
- Published
- 1992-04
- Volume
- 31
- Issue
- 4
- Pages
- 396-400
- ISSN
- 0031-3998 (ISSN-L)
- 1530-0447
- OpenAlex
- W2021359340
- Cited by
- 13
- References
- 35
- Citations by year
- 2023: 1 · 2021: 2 · 2018: 1 · 2014: 1
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- BC Children's Hospital
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- serum cholesterol, lathosterol, term infants, neonatal period, cholesterol biosynthesis, breastfeeding, infant formula, apolipoprotein B, apolipoprotein A-I, diurnal cycle, cholestyramine, hypercholesterolemia
- MeSH terms
- Adult, Apolipoproteins, Breast Feeding, Cholesterol, Female, Homeostasis, Humans, Infant Food, Infant, Newborn, Isomerism, Male
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