Cited by 140Gastrointestinal motility and disordersInfant Health and DevelopmentStress Responses and Cortisol

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Neonatal Maternal Separation Causes Colonic Dysfunction in Rat Pups Including Impaired Host Resistance

Gareau, Mélanie G, Jury, Jennifer, Yang, Ping Chang, MacQueen, Glenda, Perdue, Mary H·2006·Pediatric Research

DOI 10.1203/01.pdr.0000190577.62426.45

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Abstract

Previous studies have shown that early life stress in the form of intermittent maternal separation (MS) predisposes adult rats to develop stress-induced intestinal mucosal dysfunction and visceral hypersensitivity. However, the mechanism involved in the functional abnormalities is unclear. Our aim was to study immature animals during or shortly after exposure to MS to determine whether there are early pathophysiological changes in the gut. Sprague-Dawley rat pups were individually separated from the dam for 3 h/d from 4 to 21 d of age; nonseparated (NS) control pups remained in the home cage with the dam. On d 19-20, d 24-25, and d 29-30, blood was collected for corticosterone measurement, and colonic tissues were removed for functional and morphologic assessment. Corticosteroid levels were elevated in MS pups compared with NS, indicating that MS was indeed stressful. The distal colon demonstrated significantly enhanced ion secretion and macromolecular permeability at d 19-20 and d 24-25, returning to normal by d 29-30. Electron microscopy and bacterial culture studies indicated bacteria adhering to and penetrating into the colonic epithelium of the MS pups at all time points, while such events were rare in NS pups. The pathophysiological changes were inhibited by injecting pups sc with a corticotropin-releasing hormone (CRH) receptor antagonist daily during MS. Our studies indicate that early psychological trauma predisposes neonatal rats to develop persistent mucosal barrier dysfunction, including impaired host defense to luminal bacteria, by a mechanism involving peripheral CRH receptors.

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Authors: Gareau, M. G., Jury, J., Yang, P. C., MacQueen, G., & Perdue, M. H.
Affiliations: McMaster University (CA)
Corresponding author: Gareau, Mélanie G
ORCID: Gareau, Mélanie G
Jury, Jennifer
Yang, Ping Chang
MacQueen, Glenda
Venue: Pediatric Research
Publisher: Springer Science and Business Media LLC
Published: 2006-01
Volume: 59
Issue: 1
Pages: 83-88
ISSN: 0031-3998 (ISSN-L)
1530-0447
DOI: 10.1203/01.pdr.0000190577.62426.45
OpenAlex: W1970620887
Cited by: 139
References: 38
Citations by year: 2025: 3 · 2024: 3 · 2023: 8 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 8 · 2017: 4 · 2016: 7 · 2015: 14 · 2014: 13 · 2013: 9 · 2012: 9
FWCI: 4.08
Type: journal article
Language: en
Open access: closed
Locations: Pediatric Research (publishedVersion)
PubMed (publishedVersion)
Funders: AstraZeneca
Crohn's and Colitis Foundation
Crohn's and Colitis Foundation of Canada
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: maternal separation, early life stress, neonatal rats, corticosterone, macromolecule permeability, corticotropin-releasing factor receptor, CRH receptor antagonist, visceral hypersensitivity, host resistance
MeSH terms: Animals, Animals, Newborn, Bacterial Adhesion, Body Weight, Colon, Colonic Diseases, Corticosterone, Female, Intestinal Mucosa, Maternal Deprivation, Rats, Sprague-Dawley, Receptors, Corticotropin-Releasing Hormone, Rats

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Neonatal Maternal Separation Causes Colonic Dysfunction in Rat Pups Including Impaired Host Resistance

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