Cited by 11Inflammatory Bowel DiseaseOcular Diseases and Behçet’s SyndromeGut microbiota and health

The influence of family pattern abnormalities in the early stages of life on the course of inflammatory bowel diseases

Włodarczyk, Marcin, Sobolewska-Włodarczyk, Aleksandra, Stec-Michalska, Krystyna, Fichna, Jakub, Wiśniewska-Jarosińska, Maria·2016·Pharmacological Reports

Abstract

Crohn's disease (CD) and ulcerative colitis (UC) belong to the group of inflammatory bowel diseases (IBD), chronic immune mediated diseases of the gastrointestinal (GI) tract with significant negative impact on patients' quality of life. CD and UC are related with the development of chronic inflammatory lesions in the GI tract, causing digestive and absorption disorders. Typical symptoms of IBD are: abdominal pain, vomiting, diarrhea, rectal bleeding, and weight loss. In addition, IBD are often associated with the extraintestinal manifestations, including arthritis and dermatoses. While the cause of IBD is still not fully understood, the psychological aspects are regarded as possible trigger factors. Moreover, most recent studies suggest that family pattern abnormalities associated with stress at the early stages of life may strongly affect health balance. In this paper, the most relevant studies focusing on the association between early life stress and IBD, found in MEDLINE, Cochrane Library and EMBASE are discussed. Possible effects of the early life stress on IBD progression and response to undertaken therapies are analyzed.

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Crossref · 10.1016/j.pharep.2016.04.008

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  • The adverse impact caused by abnormal family pattern (parental separation in childhood) contributes to the development of IBD in adulthood.

    “The adverse impact caused by this abnormal family pattern contributes to the development of IBD in adulthood (81).”

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Authors
Włodarczyk, M., Sobolewska-Włodarczyk, A., Stec-Michalska, K., Fichna, J., & Wiśniewska-Jarosińska, M.
Affiliations
Medical University of Lodz (PL)
Corresponding author
Włodarczyk, Marcin
Venue
Pharmacological Reports
Published
2016-08
Volume
68
Issue
4
Pages
852-858
ISSN
1734-1140 (ISSN-L)
OpenAlex
W2342819684
Cited by
11
References
77
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2
FWCI
0.22
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacological Reports (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Medical University of Lodz
  • National Science Centre
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
inflammatory bowel disease, Crohn's disease, ulcerative colitis, early life stress, family patterns, childhood stress, disease progression, treatment response, psychological factors, extraintestinal manifestations
MeSH terms
Animals, Humans, Quality of Life, Stress, Psychological, Inflammatory Bowel Diseases, Disease Progression, Family Conflict

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