Prenatal Head Growth and White Matter Injury in Hypoplastic Left Heart Syndrome
Open accessAbstract
Children with hypoplastic left heart syndrome (HLHS) have an increased prevalence of central nervous system (CNS) abnormalities. The extent to which this problem is due to CNS maldevelopment, prenatal ischemia, postnatal chronic cyanosis and/or multiple exposures to cardiopulmonary bypass is unknown. To better understand the etiology of CNS abnormalities in HLHS, we evaluated 68 neonates with HLHS; in 28 cases, both fetal ultrasound and echocardiogram data were available to assess head size, head growth and aortic valve anatomy (atresia or stenosis). In addition, we evaluated neuropathology in 11 electively aborted HLHS fetuses. The mean head circumference percentile in HLHS neonates was significantly smaller than HLHS fetuses (22 +/- 2% versus 40 +/- 4%, p < 0.001). A significant decrease in head growth, defined as a 50% reduction in head circumference percentile, was observed in half (14/28) of HLHS fetuses and nearly a quarter (6/28) were already growth restricted (<or=10%) at the time of initial evaluation. Brains from HLHS fetuses demonstrated chronic diffuse white matter injury of varying severity. These patterns of prenatal head growth and brain histopathology identify a spectrum of abnormal CNS development and/or injury in HLHS fetuses.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A high prevalence of anatomic and functional neurologic abnormalities has been documented before surgery in newborns with congenital heart disease, and such abnormalities are associated with childhood developmental status.
“Reports from a number of investigators have documented a high prevalence of anatomic and functional neurologic abnormalities prior to surgery in newborns with CHD [9-17], and an association of such abnormalities with childhood developmental status [11,13,18,19].”
From Brain Volume and Metabolism in Fetuses With Congenital Heart Disease: Evaluation With Quantitative Magnetic Resonance Imaging and Spectroscopy (2010) · cites this paper as [16]
Adverse neurodevelopmental outcomes in children with complex congenital heart disease are due not only to perioperative insult but also to inborn factors.
“However, there is increasing evidence that adverse neurodevelopmental outcomes in children with complex CHD are due not only perioperative insult, but to inborn factors as well.”
From Brain Volume and Metabolism in Fetuses With Congenital Heart Disease: Evaluation With Quantitative Magnetic Resonance Imaging and Spectroscopy (2010) · cites this paper as [16]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
CDC GROWTH CHARTS FOR THE UNITED STATES: METHODS AND DEVELOPMENT 2000
Kuczmarski, R. J., Ogden, C. L., Guo, S. S., Strawn, L. G., Flegal, K. M., & Mei, Z. (2002) · Cited by 6,426 · see citing works
2000 CDC Growth Charts for the United States: methods and development.
Kuczmarski, R. J., Ogden, C. L., Guo, S. S., Grummer‐Strawn, L. M., Flegal, K. M., Mei, Z., Wei, R. X., Curtin, L. R., Roche, A. F., & Johnson, C. L. (2002) · PubMed · Cited by 3,716 · see citing works
Neonatal MRI to Predict Neurodevelopmental Outcomes in Preterm Infants
Woodward, L. J., Anderson, P. J., Austin, N. C., Howard, K., & Inder, T. E. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa053792 · Cited by 1,344 · see citing works
Abnormal brain development in newborns with congenital heart disease
Miller, S. P., McQuillen, P. S., Hamrick, S., Xu, D., Glidden, D. V., Charlton, N., Karl, T., Azakie, A., Ferriero, D. M., Barkovich, A. J., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067393 · Cited by 860 · see citing works
Bellinger, D. C., Jonas, R. A., Rappaport, L., Wypij, D., Wernovsky, G., Kuban, K., Barnes, P. D., Holmes, G. L., Hickey, P. R., Strand, R. D., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503023320901 · Cited by 803 · see citing works
Hadlock, F. P., Harrist, R. B., Carpenter, R. J., Deter, R. L., & Park, S. K. (1984) · Radiology · doi:10.1148/radiology.150.2.6691115 · Cited by 784 · see citing works
HEAD CIRCUMFERENCE FROM BIRTH TO EIGHTEEN YEARS
Nellhaus, G. (1968) · PEDIATRICS · doi:10.1542/peds.41.1.106 · Cited by 745 · see citing works
Newburger, J. W., Jonas, R. A., Wernovsky, G., Wypij, D., Hickey, P. R., Kuban, K., Farrell, D. M., Holmes, G. L., Helmers, S. L., Constantinou, J., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199310073291501 · Cited by 702 · see citing works
Improved Surgical Outcome After Fetal Diagnosis of Hypoplastic Left Heart Syndrome
Tworetzky, W., McElhinney, D. B., Reddy, V. M., Brook, M. M., Hanley, F. L., & Silverman, N. H. (2001) · Circulation · doi:10.1161/01.cir.103.9.1269 · Cited by 678 · see citing works
The development of cerebral connections during the first 20–45 weeks’ gestation
Kostović, I., & Milošević, N. J. (2006) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2006.07.001 · Cited by 568 · see citing works
Estimating fetal age: computer-assisted analysis of multiple fetal growth parameters.
Hadlock, F. P., Deter, R. L., Harrist, R. B., & Park, S. K. (1984) · Radiology · doi:10.1148/radiology.152.2.6739822 · Cited by 561 · see citing works
An MRI Study of Neurological Injury Before and After Congenital Heart Surgery
Mahle, W. T., Tavani, F., Zimmerman, R. A., Nicolson, S. C., Galli, K. K., Gaynor, J. W., Clancy, R. R., Montenegro, L. M., Spray, T. L., Chiavacci, R. M., et al. (2002) · Circulation · doi:10.1161/01.cir.0000032908.33237.b1 · Cited by 541 · see citing works
Miller, S. P., Ferriero, D. M., Leonard, C. H., Piecuch, R. E., Glidden, D. V., Partridge, J. C., Pérez, M., Mukherjee, P., Vigneron, D. B., & Barkovich, A. J. (2005) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.06.033 · Cited by 481 · see citing works
Donofrio, M. T., Bremer, Y. A., Schieken, R. M., Gennings, C., Morton, L. D., Eidem, B. W., Cetta, F., Falkensammer, C. B., Huhta, J. C., & Kleinman, C. S. (2003) · Pediatric Cardiology · doi:10.1007/s00246-002-0404-0 · Cited by 364 · see citing works
Fetal Aortic Valve Stenosis and the Evolution of Hypoplastic Left Heart Syndrome
Mäkikallio, K., McElhinney, D. B., Levine, J. C., Marx, G. R., Colan, S. D., Marshall, A. C., Lock, J. E., Marcus, E. N., & Tworetzky, W. (2006) · Circulation · doi:10.1161/circulationaha.105.588194 · Cited by 364 · see citing works
Wernovsky, G. (2006) · Cardiology in the Young · doi:10.1017/s1047951105002398 · Cited by 335 · see citing works
Cognitive Development After the Fontan Operation
Wernovsky, G., Stiles, K. M., Gauvreau, K., Gentles, T. L., duPlessis, A. J., Bellinger, D. C., Walsh, A. Z., Burnett, J. T., Jonas, R. A., Mayer, J. E., et al. (2000) · Circulation · doi:10.1161/01.cir.102.8.883 · Cited by 272 · see citing works
Congenital Brain Anomalies Associated With the Hypoplastic Left Heart Syndrome
Glauser, T. A., RORKE, L. B., Weinberg, P. M., & Clancy, R. R. (1990) · PEDIATRICS · doi:10.1542/peds.85.6.984 · Cited by 270 · see citing works
Hypoplastic Left Heart Syndrome Is Heritable
Hinton, R. B., Martin, L. J., Tabangin, M. E., Mazwi, M., Cripe, L. H., & Benson, D. W. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.07.021 · Cited by 249 · see citing works
Self-citationLeft Heart Obstructive Lesions and Left Ventricular Growth in the Midtrimester Fetus
Hornberger, L. K., Sanders, S. P., Rein, A. J. J. T., Spevak, P. J., Parness, I. A., & Colan, S. D. (1995) · Circulation · doi:10.1161/01.cir.92.6.1531 · Cited by 233 · see citing works
The natural history of the hypoplastic left heart syndrome
Allan, L. D., Sharland, G. K., & Tynan, M. J. (1989) · International Journal of Cardiology · doi:10.1016/0167-5273(89)90226-x · Cited by 200 · see citing works
Pathologic anatomy and interrelationship of hypoplasia of the aortic tract complexes.
LEV, M. (1952) · PubMed · Cited by 195 · see citing works
The nomenclature, definition and classification of hypoplastic left heart syndrome
Tchervenkov, C. I., Jacobs, J. P., Weinberg, P. M., Aiello, V. D., Béland, M. J., Colan, S. D., Elliott, M. J., Franklin, R. C. G., Gaynor, J. W., Krogmann, O. N., et al. (2006) · Cardiology in the Young · doi:10.1017/s1047951106000291 · Cited by 193 · see citing works
Neurodevelopmental outcome of infants with hypoplastic left heart syndrome
Rogers, B., Msall, M. E., Louis, G. M. B., Lyon, N., Norris, M., Roland, J.-M. A., Gingell, R. L., Cleveland, D. C., & Pieroni, D. R. (1995) · The Journal of Pediatrics · doi:10.1016/s0022-3476(95)70478-7 · Cited by 189 · see citing works
Natowicz, M. R., Chatten, J., Clancy, R. R., Conard, K. A., Glauser, T. A., Huff, D. S., Lin, A. E., Norwood, W. I., RORKE, L. B., Uri, A. K., et al. (1988) · PEDIATRICS · doi:10.1542/peds.82.5.698 · Cited by 186 · see citing works
Riddle, A., Luo, N. L., Manese, M., Beardsley, D. J., Green, L., Rorvik, D. A., Kelly, K. A., Barlow, C. H., Kelly, J. J., Hohimer, A. R., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5200-05.2006 · Cited by 186 · see citing works
Acquired Neuropathologic Lesions Associated With the Hypoplastic Left Heart Syndrome
Glauser, T. A., RORKE, L. B., Weinberg, P. M., & Clancy, R. R. (1990) · PEDIATRICS · doi:10.1542/peds.85.6.991 · Cited by 183 · see citing works
Models of congenital heart disease in fetal lambs.
Fishman, N. H., Hof, R., Rudolph, A. M., & Heymann, M. A. (1978) · Circulation · doi:10.1161/01.cir.58.2.354 · Cited by 168 · see citing works
Developmental pathology of the neonate
Larroche, J. (1977) · Medical Entomology and Zoology · Cited by 162 · see citing works
Rosenthal, G. L. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008771 · Cited by 155 · see citing works
Experimental production of hypoplastic left heart syndrome in the chick embryo
Harh, J. Y., Paul, M. H., Gallen, W. J., Friedberg, D. Z., & Kaplan, S. A. (1973) · The American Journal of Cardiology · doi:10.1016/0002-9149(73)90810-2 · Cited by 150 · see citing works
Loffredo, C. A., Chokkalingam, A. P., Sill, A. M., Boughman, J. A., Clark, E. B., Scheel, J. N., & Brenner, J. I. (2003) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.20366 · Cited by 136 · see citing works
Hypoxic-ischemic brain injury in infants with congenital heart disease dying after cardiac surgery
Kinney, H. C., Panigrahy, A., Newburger, J. W., Jonas, R. A., & Sleeper, L. A. (2005) · Acta Neuropathologica · doi:10.1007/s00401-005-1077-6 · Cited by 134 · see citing works
Aortic morphometry and microcephaly in hypoplastic left heart syndrome
Shillingford, A. J., Ittenbach, R. F., Marino, B. S., Rychik, J., Clancy, R. R., Spray, T. L., Gaynor, J. W., & Wernovsky, G. (2007) · Cardiology in the Young · doi:10.1017/s1047951107000248 · Cited by 129 · see citing works
Association Between Congenital Heart Defects and Small for Gestational Age
Malik, S., Cleves, M. A., Zhao, W., Correa, A., Hobbs, C. A., & Study, A. T. N. B. D. P. (2007) · PEDIATRICS · doi:10.1542/peds.2006-2742 · Cited by 115 · see citing works
Task Force 3: Valvular heart disease
Bonow, R. O., Cheitlin, M. D., Crawford, M. H., & Douglas, P. S. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.010 · Cited by 110 · see citing works
Fetal magnetic resonance imaging (MRI) of ischemic brain injury
de Laveaucoupet, J., Audibert, F., Guis, F., Rambaud, C., Suarez, B., Boithias-Guerot, C., & Musset, D. (2001) · Prenatal Diagnosis · doi:10.1002/pd.135 · Cited by 102 · see citing works
Cardiac Malformations in Relatives of Infants With Hypoplastic Left-Heart Syndrome
Brenner, J. I. (1989) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1989.02150240114030 · Cited by 94 · see citing works
Inborn errors of development : the molecular basis of clinical disorders of morphogenesis
Epstein, C. J., Erickson, R. P., & Wynshaw-Boris, A. J. (2004) · Cited by 90 · see citing works
The head-to-abdomen circumference ratio: a reappraisal
David, C., Gabrielli, S., Pilu, G., & Bovicelli, L. (1995) · Ultrasound in Obstetrics & Gynecology · doi:10.1046/j.1469-0705.1995.05040256.x · Cited by 90 · see citing works
Cerebral developmental disorders
Lian, G., & Sheen, V. L. (2006) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e328010542d · Cited by 51 · see citing works
Developmental changes in regional cerebral blood flow in fetal and newborn lambs
Szymonowicz, W., WALKER, A. M., Cussen, L. J., Cannata-Andía, J. B., & YU, V. Y. H. (1988) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1988.254.1.h52 · Cited by 50 · see citing works
The neuropathology of acquired pre- and perinatal brain injuries
Folkerth, R. D. (2007) · Seminars in Diagnostic Pathology · doi:10.1053/j.semdp.2007.02.006 · Cited by 39 · see citing works
Intrauterine growth retardation: predictive value of US criteria for antenatal diagnosis.
Benson, C. B., Doubilet, P. M., & Saltzman, D. H. (1986) · Radiology · doi:10.1148/radiology.160.2.3523593 · Cited by 33 · see citing works
Kleinman, C. S. (2006) · Circulation · doi:10.1161/circulationaha.106.615047 · Cited by 25 · see citing works
Ertan, A. K., He, J., Tanriverdi, H. A., Hendrik, J., Limbach, H.-G., & Schmidt, W. (2003) · Journal of Perinatal Medicine · doi:10.1515/jpm.2003.043 · Cited by 22 · see citing works
Flagged first, then by citations
1 of the 47 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Marino, B. S., Lipkin, P. H., Newburger, J. W., Peacock, G., Gerdes, M., Gaynor, J. W., Mussatto, K. A., Uzark, K., Goldberg, C. S., Johnson, W. H., et al. (2012) · Circulation · doi:10.1161/cir.0b013e318265ee8a · Cited by 1,608 · see citing works
Rychik, J. R., Atz, A. M., Celermajer, D. S., Deal, B. J., Gatzoulis, M. Α., Gewillig, M. H. M. L., Hsia, T., Hsu, D. T., Kovacs, A. H., McCrindle, B. W., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000696 · Cited by 1,036 · see citing works
Limperopoulos, C., Tworetzky, W., McElhinney, D. B., Newburger, J. W., Brown, D. W., Robertson, R. L., Guizard, N., McGrath, E., Geva, J., Annese, D., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.865568 · Cited by 663 · see citing works
Hypoplastic Left Heart Syndrome
Feinstein, J. A., Benson, D. W., Dubin, A. M., Cohen, M. S., Maxey, D. M., Mahle, W. T., Pahl, E., Villafañe, J., Bhatt, A. B., Peng, L. F., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.09.022 · Cited by 504 · see citing works
Self-citationNewburger, J. W., Sleeper, L. A., Bellinger, D. C., Goldberg, C. S., Tabbutt, S., Lu, M., Mussatto, K. A., Williams, I. A., Gustafson, K. E., Mital, S., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.064113 · Cited by 363 · see citing works
Delayed cortical development in fetuses with complex congenital heart disease
Clouchoux, C., du Plessis, A. J., Bouyssi-Kobar, M., Tworetzky, W., McElhinney, D. B., Brown, D. W., Gholipour, A., Kudelski, D., Warfield, S. K., McCarter, R. J., et al. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs281 · Cited by 309 · see citing works
Neurodevelopmental Outcomes in Children With Congenital Heart Disease—What Can We Impact?
Wernovsky, G., & Licht, D. J. (2016) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000000800 · Cited by 268 · see citing works
Neurodevelopmental Abnormalities and Congenital Heart Disease
Morton, P. D., Ishibashi, N., & Jonas, R. A. (2017) · Circulation Research · doi:10.1161/circresaha.116.309048 · Cited by 205 · see citing works
Bellinger, D. C., Watson, C. G., Rivkin, M. J., Robertson, R. L., Roberts, A. E., Stopp, C. D., Dunbar‐Masterson, C., Bernson, D., DeMaso, D. R., Wypij, D., et al. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002302 · Cited by 168 · see citing works
Congenital heart disease and brain development
McQuillen, P. S., & Miller, S. P. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05116.x · Cited by 164 · see citing works
Effects of congenital heart disease on brain development
McQuillen, P. S., Goff, D. A., & Licht, D. J. (2010) · Progress in Pediatric Cardiology · doi:10.1016/j.ppedcard.2010.06.011 · Cited by 143 · see citing works
Severe Congenital Heart Defects Are Associated with Global Reduction of Neonatal Brain Volumes
von Rhein, M., Buchmann, A., Hagmann, C., Dave, H., Bernet, V., Scheer, I., Knirsch, W., Latal, B., Bernet, V., Bürki, C., et al. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.07.006 · Cited by 128 · see citing works
Jones, H. N., Olbrych, S. K., Smith, K. L., Cnota, J. F., Habli, M. A., Ramos-Gonzales, O., Owens, K. J., Hinton, A. C., POLZIN, W. J., Muglia, L. J., et al. (2015) · Placenta · doi:10.1016/j.placenta.2015.08.003 · Cited by 121 · see citing works
Self-citationNattel, S. N., Adrianzen, L., Kessler, E. C., Andelfinger, G., Dehaes, M., Côté‐Corriveau, G., & Trelles, M. P. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.09.020 · Cited by 102 · see citing works
Self-citationEncephalopathy of Congenital Heart Disease– Destructive and Developmental Effects Intertwined
Volpe, J. J. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.01.002 · Cited by 90 · see citing works
Masoller, N., Martínez, J. M., Gómez, O., Bennasar, M., Crispi, F., Sanz‐Cortés, M., Egaña‐Ugrinovic, G., Bartrons, J., Puerto, B., & Gratacós, E. (2014) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.13373 · Cited by 89 · see citing works
‘Big issues’ in neurodevelopment for children and adults with congenital heart disease
Verrall, C. E., Blue, G. M., Loughran‐Fowlds, A., Kasparian, N. A., Gécz, J., Walker, K., Dunwoodie, S. L., Cordina, R., Sholler, G. F., Badawi, N. A., et al. (2019) · Open Heart · doi:10.1136/openhrt-2018-000998 · Cited by 89 · see citing works
Cerebral oxygen delivery is reduced in newborns with congenital heart disease
Lim, J. M., Kingdom, T., Saini, B., Chau, V., Post, M., Blaser, S., Macgowan, C., Miller, S. P., & Seed, M. (2016) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2016.05.027 · Cited by 86 · see citing works
Masoller, N., Sanz‐Cortés, M., Crispi, F., Gómez, O., Bennasar, M., Egaña‐Ugrinovic, G., Bargalló, N., Martínez, J. M., & Gratacós, E. (2016) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.14919 · Cited by 84 · see citing works
Brossard‐Racine, M., du Plessis, A. J., Vézina, G., Robertson, R. L., Bulas, D., Evangelou, I. E., Donofrio, M. T., Freeman, D., & Limperopoulos, C. (2014) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3903 · Cited by 85 · see citing works
Neurodevelopmental outcomes of children with congenital heart disease: A review
Howell, H. B., Zaccario, M. L., Kazmi, S. H., Desai, P. V., Sklamberg, F. E., & Mally, P. (2019) · Current problems in pediatric and adolescent health care · doi:10.1016/j.cppeds.2019.100685 · Cited by 84 · see citing works
Owen, M., Shevell, M. I., Majnemer, A., & Limperopoulos, C. (2011) · Journal of Child Neurology · doi:10.1177/0883073811402073 · Cited by 73 · see citing works
Ruiz, A., Cruz-Lemini, M., Masoller, N., Cortés, M. S., Ferrer, Q., Ribera, I., Martínez, J. M., Crispi, F., Arévalo, S., Gómez, O., et al. (2016) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.15970 · Cited by 66 · see citing works
Goff, D. A., Shera, D. M., Tang, S., Lavin, N. A., Durning, S. M., Nicolson, S. C., Montenegro, L. M., Rome, J. J., Gaynor, J. W., Spray, T. L., et al. (2014) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2013.06.021 · Cited by 65 · see citing works
Single-ventricle anatomy predicts delayed microstructural brain development
Sethi, V., Tabbutt, S., Dimitropoulos, A., Harris, K. C., Chau, V., Poskitt, K., Campbell, A., Azakie, A., Xu, D., Barkovich, A. J., et al. (2013) · Pediatric Research · doi:10.1038/pr.2013.29 · Cited by 64 · see citing works
Role of Copy Number Variants in Structural Birth Defects
Southard, A. E., Edelmann, L. J., & Gelb, B. D. (2012) · PEDIATRICS · doi:10.1542/peds.2011-2337 · Cited by 64 · see citing works
Arduini, M., Rosati, P., Caforio, L., Guariglia, L., Clerici, G., Renzo, G. C. D., & Scambia, G. (2011) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2010.547961 · Cited by 63 · see citing works
Zeng, S., Zhou, Q., Zhou, J., Li, M., Long, C., & Peng, Q. (2014) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.14677 · Cited by 64 · see citing works
Factors Influencing Neurodevelopment after Cardiac Surgery during Infancy
Hövels-Gürich, H. H. (2016) · Frontiers in Pediatrics · doi:10.3389/fped.2016.00137 · Cited by 64 · see citing works
Dehaes, M., Cheng, H. H., Buckley, E. M., Lin, P., Ferradal, S. L., Williams, K., Vyas, R., Hagan, K., Wigmore, D., McDavitt, E. C., et al. (2015) · Biomedical Optics Express · doi:10.1364/boe.6.004749 · Cited by 58 · see citing works
MRI characterization of hemodynamic patterns of human fetuses with cyanotic congenital heart disease
Sun, L., van Amerom, J. F. P., Marini, D., Portnoy, S., Lee, F., Saini, B. S., Lim, J. M., Aguet, J., JAEGGI, E. T., Kingdom, J. C., et al. (2021) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.23707 · Cited by 58 · see citing works
Rudolph, A. M. (2016) · Pediatric Research · doi:10.1038/pr.2016.65 · Cited by 55 · see citing works
McElhinney, D. B., Benson, C. B., Brown, D. W., Wilkins-Haug, L. E., Marshall, A. C., Zaccagnini, L., & Tworetzky, W. (2009) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2009.09.004 · Cited by 52 · see citing works
Heye, K. N., Knirsch, W., Latal, B., Scheer, I., Wetterling, K., Hahn, A., Akintürk, H., Schranz, D., Beck, I., O´Gorman Tuura, R., et al. (2018) · Pediatric Research · doi:10.1038/pr.2017.203 · Cited by 51 · see citing works
Papile, L. A. (2010) · Yearbook of Neonatal and Perinatal Medicine · doi:10.1016/s8756-5005(10)79268-4 · Cited by 50 · see citing works
Watson, C. G., Stopp, C. D., Wypij, D., Bellinger, D. C., Newburger, J. W., & Rivkin, M. J. (2018) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2018.04.022 · Cited by 50 · see citing works
Laraja, K., Sadhwani, A., Tworetzky, W., Marshall, A. C., Gauvreau, K., Freud, L. R., Hass, C. J., Dunbar‐Masterson, C., Ware, J., Lafranchi, T., et al. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.01.034 · Cited by 47 · see citing works
Neurodevelopment in Children with Hypoplastic Left Heart Syndrome
Sarajuuri, A., Jokinen, E. V., Puosi, R., Mildh, L. H., Mattila, I. P., Lano, A., & Lönnqvist, T. R. I. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.04.027 · Cited by 43 · see citing works
Soto, C. B., Olude, O., Hoffmann, R. G., Bear, L. M., Chin, A., Dasgupta, M., & Mussatto, K. A. (2011) · Congenital Heart Disease · doi:10.1111/j.1747-0803.2011.00546.x · Cited by 43 · see citing works
Antenatal and Perioperative Mechanisms of Global Neurological Injury in Congenital Heart Disease
Barkhuizen, M., Abella, R. F., Vles, J. S. H., Zimmermann, L. J. I., Gazzolo, D., & Gavilanes, A. W. D. (2020) · Pediatric Cardiology · doi:10.1007/s00246-020-02440-w · Cited by 42 · see citing works
Mulkey, S. B., Yap, V. L., Bai, S., Ramakrishnaiah, R. H., Glasier, C. M., Bornemeier, R. A., Schmitz, M. L., & Bhutta, A. T. (2015) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2015.02.026 · Cited by 40 · see citing works
Fetal brain imaging in isolated congenital heart defects – a systematic review and meta‐analysis
Jansen, F. A. R., Everwijn, S. M. P., Scheepjens, R., Stijnen, T., Peeters‐Scholte, C. M. P. C. D., Lith, J. M. M. V., & Haak, M. C. (2016) · Prenatal Diagnosis · doi:10.1002/pd.4842 · Cited by 40 · see citing works
Fetal brain issues in congenital heart disease
Lee, F., Seed, M., Sun, L., & Marini, D. (2021) · Translational Pediatrics · doi:10.21037/tp-20-224 · Cited by 37 · see citing works
Microcephaly is associated with early adverse neurologic outcomes in hypoplastic left heart syndrome
Hangge, P. T., Cnota, J. F., Woo, J. G., Hinton, A. C., Divanovic, A. A., Manning, P. B., Ittenbach, R. F., & Hinton, R. B. (2013) · Pediatric Research · doi:10.1038/pr.2013.61 · Cited by 36 · see citing works
Self-citationMulti-Tiered Analysis of Brain Injury in Neonates With Congenital Heart Disease
Mulkey, S. B., Swearingen, C. J., Melguizo, M. S., Schmitz, M. L., Ou, X., Ramakrishnaiah, R. H., Glasier, C. M., Bradley Schaefer, G., & Bhutta, A. T. (2013) · Pediatric Cardiology · doi:10.1007/s00246-013-0712-6 · Cited by 34 · see citing works
Jansen, F. A. R., van Zwet, E. W., Rijlaarsdam, M. E. B., Pajkrt, E., van Velzen, C. L., Zuurveen, H., Kragt, A., Bax, C. J., Clur, S. B., Lith, J. M. M. V., et al. (2016) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.15980 · Cited by 32 · see citing works
Szwast, A. L., Putt, M. E., Gaynor, J. W., Licht, D. J., & Rychik, J. R. (2017) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.18919 · Cited by 30 · see citing works
Disorders of the Fetal Circulation and the Fetal Brain
Limperopoulos, C. (2009) · Clinics in Perinatology · doi:10.1016/j.clp.2009.07.005 · Cited by 30 · see citing works
Volumetric Brain MRI Study in Fetuses with Congenital Heart Disease
Olshaker, H., Ber, R., Hoffman, D., Derazne, E., Achiron, R., & Katorza, E. (2018) · American Journal of Neuroradiology · doi:10.3174/ajnr.a5628 · Cited by 29 · see citing works
Congenital Heart Defects and Measures of Prenatal Brain Growth: A Systematic Review
Hansen, T., Henriksen, T. B., Bach, C. C., & Matthiesen, N. B. (2017) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2017.03.014 · Cited by 29 · see citing works
In Favor of the Hybrid Stage 1 as the Initial Palliation for Hypoplastic Left Heart Syndrome
Galantowicz, M. (2013) · Seminars in Thoracic and Cardiovascular Surgery Pediatric Cardiac Surgery Annual · doi:10.1053/j.pcsu.2013.01.005 · Cited by 27 · see citing works
Watson, C. G., Stopp, C. D., Wypij, D., Newburger, J. W., & Rivkin, M. J. (2017) · Pediatric Research · doi:10.1038/pr.2017.30 · Cited by 27 · see citing works
Somatic growth trajectory in the fetus with hypoplastic left heart syndrome
Cnota, J. F., Hangge, P. T., Wang, Y., Woo, J. G., Hinton, A. C., Divanovic, A. A., Michelfelder, E. C., & Hinton, R. B. (2013) · Pediatric Research · doi:10.1038/pr.2013.100 · Cited by 26 · see citing works
Self-citationThe neurodevelopmental implications of hypoplastic left heart syndrome in the fetus
Lloyd, D. F. A., Rutherford, M., Simpson, J. M., & Razavi, R. (2016) · Cardiology in the Young · doi:10.1017/s1047951116001645 · Cited by 23 · see citing works
Bhroin, M. N., Seada, S. A., Bonthrone, A. F., Kelly, C. J., Christiaens, D., Schuh, A., Pietsch, M., Hutter, J. M., Tournier, J., Cordero‐Grande, L., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102423 · Cited by 22 · see citing works
Martin, B., Jonker, I. D. V., Joffe, A. R., Bond, G. Y., Acton, B. V., Ross, D. B., Robertson, C. M. T., Rebeyka, I. M., & Atallah, J. (2017) · Pediatric Cardiology · doi:10.1007/s00246-017-1598-5 · Cited by 21 · see citing works
Ross, L. F., & Frader, J. E. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.03.008 · Cited by 21 · see citing works
Brain angiogenic gene expression in fetuses with congenital heart disease
Sánchez, O., Ruiz, A., Domı́nguez, C., Ferrer, Q., Ribera, I., Rodríguez‐Sureda, V., Alijotas‐Reig, J., Arévalo, S., Carreras, E., Cabero, L., et al. (2017) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.18977 · Cited by 19 · see citing works
The Neurodevelopmental Outcomes of Patients With Single Ventricles Across the Lifespan
du Plessis, K., & d’Udekem, Y. (2019) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2019.05.043 · Cited by 20 · see citing works
Alsaied, T., Tseng, S., King, E. C., Hahn, E., Divanovic, A. A., Habli, M. A., & Cnota, J. F. (2017) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.18936 · Cited by 19 · see citing works
Longitudinal analysis of head and somatic growth in fetuses with congenital heart defects
Turan, Ş., Rosenbloom, J. I., Hussein, M., Berg, C., Gembruch, U., Baschat, A., & Turan, O. M. (2016) · Journal of Clinical Ultrasound · doi:10.1002/jcu.22395 · Cited by 18 · see citing works
Impact of extracardiac pathology on head growth in fetuses with congenital heart defect
van Nisselrooij, A. E. L., Jansen, F. A. R., van Geloven, N., Linskens, I. H., Pajkrt, E., Clur, S. B., Rammeloo, L. A. J., Rozendaal, L., Lith, J. M. M. V., Blom, N. A., et al. (2019) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.20260 · Cited by 19 · see citing works
The Congenital Heart Disease Brain: Prenatal Considerations for Perioperative Neurocritical Care
Ortinau, C. M., & Shimony, J. S. (2020) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2020.01.002 · Cited by 17 · see citing works
Prenatal Diagnosis and Management of Single-Ventricle Heart Disease
Freud, L. R., & Seed, M. (2022) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2022.04.003 · Cited by 17 · see citing works
Abnormal fetal cerebral and vascular development in hypoplastic left heart syndrome
Kinnear, C., Haranal, M. Y., Shannon, P. T., JAEGGI, E. T., Chitayat, D. A., & Mital, S. R. (2018) · Prenatal Diagnosis · doi:10.1002/pd.5395 · Cited by 16 · see citing works
Glial fibrillary acidic protein as a biomarker for brain injury in neonatal CHD
McKenney, S., Mansouri, F. F., Everett, A. D., Graham, E. M., Burd, I. D., & Sekar, P. (2016) · Cardiology in the Young · doi:10.1017/s1047951115002346 · Cited by 15 · see citing works
Self-citationThe Role of Fetal Echocardiography in Fetal Intervention: A Symbiotic Relationship
Sekar, P., & Hornberger, L. K. (2009) · Clinics in Perinatology · doi:10.1016/j.clp.2009.03.013 · Cited by 13 · see citing works
Self-citation“Functionally” Univentricular Hearts: Impact of Pre-Natal Diagnosis
Corno, A. F. (2015) · Frontiers in Pediatrics · doi:10.3389/fped.2015.00015 · Cited by 12 · see citing works
Anesthetic Considerations in Infants With Hypoplastic Left Heart Syndrome
Twite, M. D., & Ing, R. J. (2013) · Seminars in Cardiothoracic and Vascular Anesthesia · doi:10.1177/1089253213476958 · Cited by 12 · see citing works
Neurocognitive profiles in adolescents and young adults with congenital heart disease
Areias, M. E., Peixoto, B., Santos, I., Cruz, L. A., Regadas, A., Pinheiro, C., Monteiro, H., Araújo, S., Carvalho, T., Miranda, J., et al. (2018) · Revista Portuguesa de Cardiologia · doi:10.1016/j.repc.2017.11.017 · Cited by 10 · see citing works
Fetal cardiovascular magnetic resonance imaging
Aguet, J., Seed, M., & Marini, D. (2020) · Pediatric Radiology · doi:10.1007/s00247-020-04902-y · Cited by 10 · see citing works
Neurodevelopmental Outcomes for Infants Born With Congenital Heart Disease
Chock, V. Y., & Lee, H. C. (2014) · NeoReviews · doi:10.1542/neo.15-8-e344 · Cited by 9 · see citing works
Graupner, O., Koch, J., Enzensberger, C., Götte, M., Wolter, A., Müller, V., Kawecki, A., Herrmann, J., & Axt-Fliedner, R. (2019) · Ultraschall in der Medizin - European Journal of Ultrasound · doi:10.1055/a-0900-4021 · Cited by 9 · see citing works
Fetal cardiac intervention—Perspectives from a single center
Guseh, S. H., Friedman, K. G., & Wilkins-Haug, L. E. (2019) · Prenatal Diagnosis · doi:10.1002/pd.5631 · Cited by 8 · see citing works
Muneuchi, J., Nagatomo, Y., Okada, S., Iida, C., Shirozu, H., Sugitani, Y., & Watanabe, M. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.09.065 · Cited by 8 · see citing works
Neurocognitive Difficulties Among Youth with POTS within an Intensive Pain Rehabilitation Program
Owens, M. T., Harbeck‐Weber, C., Kirsch, A. C., Sim, L. A., Zaccariello, M. J., Homan, K. J., & Fischer, P. R. (2018) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsy106 · Cited by 8 · see citing works
Autism spectrum disorder and congenital heart disease: a narrative review of the literature
Nayar, K., Katz, L., Heinrich, K. P., & Berger, N. I. (2023) · Cardiology in the Young · doi:10.1017/s1047951123000598 · Cited by 7 · see citing works
In Utero Brain Development in Fetuses With Congenital Heart Disease
Seed, M. (2017) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.117.007181 · Cited by 7 · see citing works
Growth patterns in fetuses with isolated cardiac defects
Haveman, I., Fleurke‐Rozema, J. H., Mulder, E. J. H., Benders, M. J. N. L., Sarvaas, G. D. M., ter Heide, H., de Heus, R., & Bilardo, C. M. (2018) · Prenatal Diagnosis · doi:10.1002/pd.5242 · Cited by 6 · see citing works
Karunakaran, K. B., Gabriel, G. C., Balakrishnan, N., Lo, C. W. Y., & Ganapathiraju, M. K. (2022) · Genes · doi:10.3390/genes13040627 · Cited by 5 · see citing works
Tseng, S. Y., Anixt, J. S., Meinzen‐Derr, J. K., Thomas, C., Cooper, D. S., & Heydarian, H. C. (2020) · Cardiology in the Young · doi:10.1017/s1047951120004394 · Cited by 6 · see citing works
Neurodevelopmental Outcomes in Children with Congenital Heart Disease
Wernovsky, G. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0134-0.10057-5 · Cited by 7 · see citing works
Gabriel, G. C., Yagi, H., Tan, T., Bais, A. S., Glennon, B. J., Stapleton, M. C., Huang, L., Reynolds, W. T., Shaffer, M. G., Ganapathiraju, M. K., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55741-6 · Cited by 5 · see citing works
In Utero Evidence of Impaired Somatic Growth in Hypoplastic Left Heart Syndrome
Triebwasser, J. E., & Treadwell, M. C. (2017) · Pediatric Cardiology · doi:10.1007/s00246-017-1676-8 · Cited by 5 · see citing works
Sánchez, O., Ribera, I., Ruiz, A., Eixarch, E., Antolin, E., Cruz-Lemini, M., Domı́nguez, C., Arévalo, S., Ferrer, Q., Rodríguez‐Sureda, V., et al. (2023) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.27441 · Cited by 5 · see citing works
Transition from Fetal to Neonatal Circulation
Cuneo, B. F. (2013) · Springer eBooks · doi:10.1007/978-1-4471-4619-3_155 · Cited by 5 · see citing works
Hövels-Gürich, H. H. (2019) · Klinische Pädiatrie · doi:10.1055/a-0942-1756 · Cited by 5 · see citing works
Szwast, A. L., & Rychik, J. R. (2012) · Future Cardiology · doi:10.2217/fca.12.2 · Cited by 4 · see citing works
Psychosocial Issues in Adult Congenital Heart Disease
Moons, P., & Luyckx, K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-7020-6929-1.00025-3 · Cited by 4 · see citing works
Jansen, F. A. R., van Zwet, E. W., Everwijn, S. M. P., Teunissen, A. K. K., Rozendaal, L., Lith, J. M. M. V., Blom, N. A., & Haak, M. C. (2019) · Fetal Diagnosis and Therapy · doi:10.1159/000488674 · Cited by 4 · see citing works
Brain pathology in patients with congenital heart disease
Alturkustani, M. A., & Szymanski, L. (2022) · Folia Neuropathologica · doi:10.5114/fn.2022.119623 · Cited by 3 · see citing works
Hemodynamic adaptation to suboptimal fetal growth in patients with single ventricle physiology
Alsaied, T., Tseng, S. Y., King, E. C., Hahn, E., Divanovic, A. A., Habli, M. A., & Cnota, J. F. (2018) · Echocardiography · doi:10.1111/echo.14047 · Cited by 3 · see citing works
Hypoplastic Left Heart Syndrome: Diagnosis, Care and Management From Fetal Life and Beyond
Moodley, S., & Tacy, T. A. (2015) · NeoReviews · doi:10.1542/neo.16-2-e109 · Cited by 3 · see citing works
Chronic hypoxemia induces mitochondrial respiratory complex gene expression in the fetal sheep brain
Moon, J. K., Lawrence, K. M., Hunt, M. L., Davey, M. G., Flake, A. W., Licht, D. J., Chen, J. M., Kilbaugh, T. J., Gaynor, J. W., & Beiting, D. P. (2022) · JTCVS Open · doi:10.1016/j.xjon.2022.04.040 · Cited by 2 · see citing works
Hypoplastic Left Heart Syndrome
Bell-Cheddar, Y. R., Devine, W. H., Castro-Medina, M., Morales, R., Xu, X., Lo, C. W. Y., & Lin, J.-H. I. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.104723 · Cited by 1 · see citing works
Dubé, M., Bigras, J., Thibeault, M., Bureau, N., Chétaille, P., Richter, A. M., Mercier, J., Bellavance, M., Rohlicek, C. V., Rozen, R. R., et al. (2011) · Cardiology in the Young · doi:10.1017/s1047951111000813 · Cited by 1 · see citing works
Self-citationGlass, T. J. A., Seed, M., & Chau, V. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-54392-7.00015-7 · Cited by 1 · see citing works
Commentary: Once again—the heart and the brain
Reitz, J. G., & Yerebakan, C. (2020) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2020.11.079 · Cited by 1 · see citing works
Hypoplastic Left Heart Syndrome
Hinton, R. B., & Benson, D. W. (2012) · doi:10.1002/9781444398786.ch38 · Cited by 1 · see citing works
Self-citationDevelopmental Physiology of the Circulation
Rudolph, A. M. (2012) · Wiley eBooks · doi:10.1002/9781444398786.ch3
- Authors
- Hinton, R. B., Andelfinger, G., Sekar, P., Hinton, A. C., Gendron, R. L., Michelfelder, E. C., Robitaille, Y., & Benson, D. W.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Good Samaritan Hospital (US)
- Université de Montréal (CA)
- Venue
- Pediatric Research
- Published
- 2008-10
- Volume
- 64
- Issue
- 4
- Pages
- 364-369
- ISSN
- 0031-3998 (ISSN-L)
- 1530-0447
- PMC
- PMC2681225
- OpenAlex
- W2004723483
- Cited by
- 118
- References
- 47
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 2 · 2020: 7 · 2019: 11 · 2018: 8 · 2017: 14 · 2016: 10 · 2015: 8 · 2014: 5 · 2013: 9 · 2012: 9
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pediatric Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service (GMHD79045)
- Canadian Institutes of Health Research
- National Heart, Lung, and Blood Institute (HL 085122, HL 069712, K23HL085122, K24HL069712)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- hypoplastic left heart syndrome, white matter injury, fetal brain development, head circumference, fetal growth restriction, aortic valve anatomy, cardiopulmonary bypass, chronic cyanosis
- MeSH terms
- Aortic Valve, Cephalometry, Echocardiography, Head, Humans, Infant, Newborn, Ohio, Hypoplastic Left Heart Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
