Cited by 83Preterm Birth and ChorioamnionitisMaternal and Perinatal Health InterventionsPregnancy-related medical research

Insights into parturition biology from genetically altered mice

Ratajczak, Christine K, Muglia, Louis J·2008·Pediatric Research

Abstract

With the growing frequency of preterm birth, increased effort has been made to elucidate the physiology of normal and aberrant parturition. As with many developmental processes, the study of genetically altered mice has led to an increased understanding of mechanisms controlling the maintenance and resolution of pregnancy. Studies in genetically altered mice have implicated critical roles for both prostaglandin synthesis and degradation in luteolysis and the progression of labor. The importance of local modulation of progesterone activity to cervical ripening has also been demonstrated. Although a decline in levels of serum progesterone is a part of normal labor initiation in mice but not humans, murine labor without progesterone withdrawal has been reported in some cases. These findings emphasize the importance of other components of the parturition cascade that are shared in mice and humans and highlights the importance of an increased understanding of the physiology of mouse parturition.

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Crossref · 10.1203/pdr.0b013e31818718d2

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106 of 106 references verified0 citation errors · 0 not checkable

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  • Mice studies demonstrate that during birth, oxytocin operates through a series of pathways that overlap with numerous other hormonal systems such as cortisol and corticotrophin-releasing hormone.

    “Mice studies demonstrate that during birth, oxytocin operates through a series of pathways that overlap with numerous other hormonal systems such as cortisol and corticotrophin-releasing hormone (Gross et al., 2000; Ratajczak and Muglia, 2008).”

    From The evolved nest, oxytocin functioning, and prosocial development (2023) · cites this paper as Ratajczak and Muglia, 2008

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Authors
Ratajczak, C. K., & Muglia, L. J.
Affiliations
Washington University in St. Louis (US)
Corresponding author
Muglia, Louis J
Venue
Pediatric Research
Published
2008-12
Volume
64
Issue
6
Pages
581-589
ISSN
  • 0031-3998 (ISSN-L)
  • 1530-0447
OpenAlex
W2076065642
Cited by
83
References
106
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 1 · 2018: 8 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 6 · 2013: 9 · 2012: 4
FWCI
0.50
Type
journal article
Language
en
Open access
closed
Locations
  • Pediatric Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
  • Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
Keywords
childbirth, labor initiation, preterm birth, genetically modified mice, prostaglandin synthesis, prostaglandin degradation, luteolysis, progesterone withdrawal, cervical ripening, pregnancy maintenance
MeSH terms
Animals, Circadian Rhythm, Luteolysis, Female, Humans, Hydroxyprostaglandin Dehydrogenases, Mice, Transgenic, Oxytocin, Pregnancy, Pregnancy, Animal, Progesterone, Prostaglandins, Uterine Contraction, 20-Hydroxysteroid Dehydrogenases, Connexin 43, Cervical Ripening, Potassium Channels, Calcium-Activated, Parturition, Pulmonary Surfactant-Associated Protein A, Premature Birth, Mice

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