Is oxytocin a maternal-foetal signalling molecule at birth? Implications for development
Abstract
The neuropeptide oxytocin was first noted for its capacity to promote uterine contractions and facilitate delivery in mammals. The study of oxytocin has grown to include awareness that this peptide is a neuromodulator with broad effects throughout the body. Accumulating evidence suggests that oxytocin is a powerful signal to the foetus, helping to prepare the offspring for the extrauterine environment. Concurrently, the use of exogenous oxytocin or other drugs to manipulate labour has become common practice. The use of oxytocin to expedite labour and minimise blood loss improves both infant and maternal survival under some conditions. However, further investigations are needed to assess the developmental consequences of changes in oxytocin, such as those associated with pre-eclampsia or obstetric manipulations associated with birth. This review focuses on the role of endogenous and exogenous oxytocin as a neurochemical signal to the foetal nervous system. We also examine the possible developmental consequences, including those associated with autism spectrum disorder, that arise from exogenous oxytocin supplementation during labour.
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Some evidence indicates that oxytocin administration can curb the effects, not only of dangerous, prolonged labor but under some conditions, postpartum hemorrhage.
“However, some evidence indicates that oxytocin administration can curb the effects, not only of dangerous, prolonged labor but under some conditions, postpartum hemorrhage (Kenkel et al., 2014).”
From The evolved nest, oxytocin functioning, and prosocial development (2023) · cites this paper as Kenkel et al., 2014
Increased use of oxytocin receptor agonists such as Pitocin and antagonists such as Atosiban during human pregnancy to manage labor timing makes potential fetal oxytocin effects relevant.
“These potential effects are relevant, in part, because of the increased use of Oxtr agonists, such as Pitocin, and antagonists, such as Atosiban, during human pregnancy in order to manage labor timing (95, 96).”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [95]
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The Neurobiology of Human Attachments
Feldman, R. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2016.11.007 · Cited by 839 · see citing works
Is oxytocin “nature’s medicine”
Carter, C. S., Kenkel, W. M., MacLean, E. L., Wilson, S. R., Perkeybile, A. M., Yee, J. R., Ferris, C. F., Nazarloo, H. P., Porges, S. W., Davis, J. M., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019398 · Cited by 394 · see citing works
Self-citationFeldman, R., Monakhov, M., Pratt, M., & Ebstein, R. P. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.008 · Cited by 352 · see citing works
Oxytocin during Development: Possible Organizational Effects on Behavior
Miller, T. V., & Caldwell, H. K. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00076 · Cited by 79 · see citing works
The evolved nest, oxytocin functioning, and prosocial development
Tarsha, M. S., & Narvaez, D. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1113944 · Cited by 25 · see citing works
- Authors
- Kenkel, W. M., Yee, J. R., & Carter, C. S.
- Affiliations
- Northeastern University (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Kenkel, W. M.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2014-09-16
- Volume
- 26
- Issue
- 10
- Pages
- 739-749
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2104329940
- Cited by
- 70
- References
- 173
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 9 · 2019: 11 · 2018: 3 · 2017: 8 · 2016: 7 · 2015: 5 · 2014: 5
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Child Health and Human Development (075750)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- oxytocin, births, labor induction, exogenous oxytocin, preeclampsia, autism spectrum disorder, neonatal development, uterine contraction
- MeSH terms
- Female, Humans, Maternal-Fetal Exchange, Oxytocin, Pregnancy, Signal Transduction
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