Failure of Parturition in Mice Lacking the Prostaglandin F Receptor
Abstract
Mice lacking the gene encoding the receptor for prostaglandin F 2α (FP) developed normally but were unable to deliver normal fetuses at term. Although these FP-deficient mice showed no abnormality in the estrous cycle, ovulation, fertilization, or implantation, they did not respond to exogenous oxytocin because of the lack of induction of oxytocin receptor (a proposed triggering event in parturition), and they did not show the normal decline of serum progesterone concentrations that precedes parturition. Ovariectomy at day 19 of pregnancy restored induction of the oxytocin receptor and permitted successful delivery in the FP-deficient mice. These results indicate that parturition is initiated when prostaglandin F 2α interacts with FP in ovarian luteal cells of the pregnant mice to induce luteolysis.
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Multiple factors initiate parturition, including fetal cortisol, maternal drop in progesterone, oxytocin, prostaglandin F2α and other endocrine factors.
“Multiple factors initiate parturition, including fetal cortisol, maternal drop in progesterone, oxytocin, prostaglandin F2α and other endocrine factors56–59.”
From Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse (2019) · cites this paper as [58]
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- Authors
- Sugimoto, Y., Yamasaki, A., Segi, E., Tsuboi, K., Aze, Y., Nishimura, T., Oida, H., Yoshida, N., Tanaka, T., Katsuyama, M., Hasumoto, K.-Y., Murata, T., Hirata, M., Ushikubi, F., Negishi, M., Ichikawa, A., & Narumiya, S.
- Affiliations
- Kyoto University (JP)
- Y. Sugimoto, A. Yamasaki, E. Segi, K. Tsuboi, M. Katsuyama, K. Hasumoto, M. Negishi, A. Ichikawa, Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan.
- Corresponding author
- Ichikawa, Atsushi
- ORCID
- Venue
- Science
- Published
- 1997-08
- Volume
- 277
- Issue
- 5326
- Pages
- 681-683
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2142980049
- Cited by
- 608
- References
- 16
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 11 · 2023: 10 · 2022: 12 · 2021: 12 · 2020: 24 · 2019: 19 · 2018: 18 · 2017: 12 · 2016: 17 · 2015: 17 · 2014: 21 · 2013: 15 · 2012: 11
- FWCI
- 85.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- childbirth, prostaglandin F2alpha, FP receptor, oxytocin receptor, luteolysis, progesterone, ovariectomy, luteal cells, pregnancy, knockout mice, estrous cycle
- MeSH terms
- Animals, Corpus Luteum, Female, Heterozygote, Homozygote, Labor, Obstetric, Male, Mice, Inbred C57BL, Ovariectomy, Oxytocin, Pregnancy, Progesterone, Receptors, Prostaglandin, Uterine Contraction, Uterus, Dinoprost, Receptors, Oxytocin, Gene Targeting, Mice
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