Role of the breast cancer resistance protein (ABCG2) in drug transport

A multidrug resistance transporter from human MCF-7 breast cancer cells

Doyle, L. A., Yang, W., Abruzzo, L. V., Krogmann, T., Gao, Y., Rishi, A. K., & Ross, D. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15665 · Cited by 2,322

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

Zhou, S., Schuetz, J. D., Bunting, K. D., Colapietro, A.-M., Sampath, J., Morris, J. J., Lagutina, I., Grosveld, G. C., Osawa, M., Nakauchi, H., et al. (2001) · Nature Medicine · doi:10.1038/nm0901-1028 · Cited by 2,280

Mammalian ABC Transporters in Health and Disease

Borst, P., & Elferink, R. O. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.102301.093055 · Cited by 1,571

Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.

Maliepaard, M., Scheffer, G. L., Faneyte, I. F., van Gastelen, M. A., Pijnenborg, A. C. L. M., Schinkel, A. H., van de Vijver, M. J., Scheper, R. J., & Schellens, J. H. M. (2001) · PubMed · Cited by 1,130

P-glycoprotein: from genomics to mechanism

Ambudkar, S. V., Kimchi-Sarfaty, C., Sauna, Z. E., & Gottesman, M. M. (2003) · Oncogene · doi:10.1038/sj.onc.1206948 · Cited by 1,074

Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

Austin Doyle, L., & Ross, D. D. (2003) · Oncogene · doi:10.1038/sj.onc.1206938 · Cited by 1,051

Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.

Miyake, K., Mickley, L. A., Litman, T., Zhan, Z., Robey, R. W., Cristensen, B., Brangi, M., Greenberger, L., Dean, M. C., Fojo, T., et al. (1999) · PubMed · Cited by 823

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

Jonker, J. W., Buitelaar, M., Wagenaar, E., van der Valk, M. A., Scheffer, G. L., Scheper, R. J., Plösch, T., Kuipers, F., Elferink, R. P. J. O., Rosing, H., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202607599 · Cited by 822

A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance.

Allikmets, R., Schriml, L. M., Hutchinson, A. A., Romano-Spica, V., & Dean, M. C. (1998) · PubMed · Cited by 798

The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors

Scharenberg, C. W., Harkey, M. A., & Torok-Storb, B. (2002) · Blood · doi:10.1182/blood.v99.2.507 · Cited by 770

Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

Allen, J. D., van Loevezijn, A., Rademaker-Lakhai, J. M., van der Valk, M., van Tellingen, O., Reid, G., Schellens, J. H. M., Koomen, G., & Schinkel, A. H. (2002) · PubMed · Cited by 704

The Stem Cell Marker Bcrp/ABCG2 Enhances Hypoxic Cell Survival through Interactions with Heme

Krishnamurthy, P., Ross, D. D., Nakanishi, T., Bailey-Dell, K., Zhou, S., Mercer, K. E., Sarkadi, B., Sorrentino, B. P., & Schuetz, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313599200 · Cited by 661

Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart

Martin, C. M., Meeson, A. P., Robertson, S. M., Hawke, T. J., Richardson, J. A., Bates, S., Goetsch, S. C., Gallardo, T. D., & Garry, D. J. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2003.09.028 · Cited by 655

Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan

Jonker, J. W. (2000) · Journal of the National Cancer Institute · doi:10.1093/jnci/92.20.1651 · Cited by 638

Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

Yu, L., Li-Hawkins, J., Hammer, R. E., Berge, K. E., Horton, J. D., Cohen, J. C., & Hobbs, H. H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216001 · Cited by 596

ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport

Klucken, J., Büchler, C., Orsó, E., Kaminski, W. E., Porsch-Özcürümez, M., Liebisch, G., Kapinsky, M., Diederich, W., Drobnik, W., Dean, M., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.817 · Cited by 543

The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)

Litman, T., Brangi, M., Hudson, E., Fetsch, P., Abati, A., Ross, D. D., Miyake, K., Resau, J. H., & Bates, S. E. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.11.2011 · Cited by 538

Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo

Zhou, S., Morris, J. J., Barnes, Y., Lan, L., Schuetz, J. D., & Sorrentino, B. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192276999 · Cited by 502

Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.

Rabindran, S. K., Ross, D. D., Doyle, L. A., Yang, W., & Greenberger, L. M. (2000) · PubMed · Cited by 487

Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line.

Maliepaard, M., van Gastelen, M. A., de Jong, L. A., Pluim, D., van Waardenburg, R. C., Ruevekamp, M. C., Floot, B. G., & Schellens, J. H. M. (1999) · PubMed · Cited by 487

(Section A: Molecular, Structural, and Cellular Biology of Drug Transporters) The MRP-Related and BCRP / ABCG2 Multidrug Resistance Proteins: Biology, Substrate Specificity and Regulation

Haimeur, A., Conseil, G., Deeley, R., & Cole, S. (2004) · Current Drug Metabolism · doi:10.2174/1389200043489199 · Cited by 485

ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion

Graf, G. A., Yu, L., Li, W.-P., Gerard, R., Tuma, P. L., Cohen, J. C., & Hobbs, H. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m310223200 · Cited by 475

Increased Oral Bioavailability of Topotecan in Combination With the Breast Cancer Resistance Protein and P-Glycoprotein Inhibitor GF120918

Kruijtzer, C. M. F., Beijnen, J. H., Rosing, H., ten Bokkel Huinink, W. W., Schot, M., Jewell, R. C., Paul, E. M., & Schellens, J. H. M. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.12.116 · Cited by 464

ABC Transporters as Phenotypic Markers and Functional Regulators of Stem Cells

Bunting, K. D. (2002) · STEM CELLS · doi:10.1002/stem.200011 · Cited by 458

Correlation of Gene Expression of Ten Drug Efflux Proteins of the ATP-Binding Cassette Transporter Family in Normal Human Jejunum and in Human Intestinal Epithelial Caco-2 Cell Monolayers

Taipalensuu, J., Törnblom, H., Lindberg, G., Einarsson, C., Sjöqvist, F., Melhus, H., Garberg, P., Sjöström, B., Lundgren, B., & Artursson, P. (2001) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29314-9 · Cited by 444

C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance.

Imai, Y., Nakane, M., Kage, K., Tsukahara, S., Ishikawa, E., Tsuruo, T., Miki, Y., & Sugimoto, Y. (2002) · PubMed · Cited by 442

Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.

Honjo, Y., Hrycyna, C. A., Yan, Q. W., Medina-Pérez, W. Y., Robey, R. W., van de Laar, A., Litman, T., Dean, M. C., & Bates, S. E. (2001) · PubMed · Cited by 429

Localisation of breast cancer resistance protein in microvessel endothelium of human brain

Cooray, H. C., Blackmore, C. G., Maskell, L., & Barrand, M. A. (2002) · NeuroReport · doi:10.1097/00001756-200211150-00014 · Cited by 419

Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump

Burger, H., van Tol, H., Boersma, A. W. M., Brok, M., Wiemer, E. A. C., Stoter, G., & Nooter, K. (2004) · Blood · doi:10.1182/blood-2004-04-1398 · Cited by 417

Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome

Kartenbeck, J., Leuschner, U., Mayer, R., & Keppler, D. (1996) · Hepatology · doi:10.1002/hep.510230519 · Cited by 398

The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells.

Kim, M., Turnquist, H. R., Jackson, J. D., Sgagias, M. K., Yan, Y., Gong, M., Dean, M. C., Sharp, J. G., & Cowan, K. H. (2002) · PubMed · Cited by 397

Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity

Robey, R. W., Honjo, Y., Morisaki, K., Nadjem, T. A., Runge, S., Risbood, M., Poruchynsky, M. S., & Bates, S. E. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601370 · Cited by 368

Flavonoids Are Inhibitors of Breast Cancer Resistance Protein (ABCG2)-Mediated Transport

Zhang, S., Yang, X., & Morris, M. E. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.5.1208 · Cited by 359

The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin.

Allen, J. D., Brinkhuis, R. F., Wijnholds, J., & Schinkel, A. H. (1999) · PubMed · Cited by 353

Identification of myogenic-endothelial progenitor cells in the interstitial spaces of skeletal muscle

Tamaki, T., Akatsuka, A., Ando, K., Nakamura, Y., Matsuzawa, H., Hotta, T., R Roy, R., & Edgerton, V. R. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112106 · Cited by 350

Atypical Multidrug Resistance: Breast Cancer Resistance Protein Messenger RNA Expression in Mitoxantrone-Selected Cell Lines

Ross, D. D., Yang, W., Abruzzo, L. V., Dalton, W. S., Schneider, E., Lage, H., Dietel, M., Greenberger, L., Cole, S. P. C., & Doyle, L. A. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.5.429 · Cited by 350

Pheophorbide a Is a Specific Probe for ABCG2 Function and Inhibition

Robey, R. W., Steadman, K., Polgar, O., Morisaki, K., Blayney, M., Mistry, P., & Bates, S. E. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3298 · Cited by 350

Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells.

Robey, R. W., Medina-Pérez, W. Y., Nishiyama, K., Lahusen, T. J., Miyake, K., Litman, T., Senderowicz, A. M., Ross, D. D., & Bates, S. E. (2001) · PubMed · Cited by 341

ABCG2 Transports Sulfated Conjugates of Steroids and Xenobiotics

Suzuki, M., Suzuki, H., Sugimoto, Y., & Sugiyama, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212399200 · Cited by 341

High-Affinity Interaction of Tyrosine Kinase Inhibitors with the ABCG2 Multidrug Transporter

Özvegy-Laczka, C., Hegedűs, T., Várady, G., Ujhelly, O., Schuetz, J. D., Váradi, A., Kéri, G., Őrfi, L., Német, K., & Sarkadi, B. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.6.1485 · Cited by 340

Expression, Up-Regulation, and Transport Activity of the Multidrug-Resistance Protein Abcg2 at the Mouse Blood-Brain Barrier

Cisternino, S., Mercier, C., Bourasset, F., Roux, F., & Scherrmann, J.-M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2033 · Cited by 329

Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro

Houghton, P. J., Germain, G. S., Harwood, F. C., Schuetz, J. D., Stewart, C. F., Buchdunger, E., & Traxler, P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3344 · Cited by 323

Functional Characterization of the Human Multidrug Transporter, ABCG2, Expressed in Insect Cells

Özvegy, C., Litman, T., Szakács, G., Nagy, Z., Bates, S., Váradi, A., & Sarkadi, B. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5130 · Cited by 319

Single nucleotide polymorphisms result in impaired membrane localization and reduced atpase activity in multidrug transporter ABCG2

Mizuarai, S., Aozasa, N., & Kotani, H. (2004) · International Journal of Cancer · doi:10.1002/ijc.11669 · Cited by 318

Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport.

Chen, Z., Robey, R. W., Belinsky, M. G., Shchaveleva, I., Ren, X. Q., Sugimoto, Y., Ross, D. D., Bates, S. E., & Kruh, G. D. (2003) · PubMed · Cited by 305

Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C.

Rabindran, S. K., He, H., Singh, M. S., Brown, E., Collins, K., Annable, T., & Greenberger, L. M. (1998) · PubMed · Cited by 305

Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR

de Bruin, M., Miyake, K., Litman, T., Robey, R., & Bates, S. E. (1999) · Cancer Letters · doi:10.1016/s0304-3835(99)00182-2 · Cited by 298

RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response.

Burger, H., Foekens, J. A., Look, M. P., Gelder, M. E. M., Klijn, J. G. M., Wiemer, E. A. C., Stoter, G., & Nooter, K. (2003) · PubMed · Cited by 292

Dominant‐negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S‐S dependent homodimerization

Kage, K., Tsukahara, S., Sugiyama, T., Asada, S., Ishikawa, E., Tsuruo, T., & Sugimoto, Y. (2002) · International Journal of Cancer · doi:10.1002/ijc.10100 · Cited by 291

Complete Characterization of the Human ABC Gene Family

Dean, M., & Allikmets, R. (2001) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1012823120935 · Cited by 289

ABCG2 – a transporter for all seasons

Sarkadi, B., Özvegy-Laczka, C., Német, K., & Váradi, A. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.03.123 · Cited by 282

Phytoestrogens/Flavonoids Reverse Breast Cancer Resistance Protein/ABCG2-Mediated Multidrug Resistance

Imai, Y., Tsukahara, S., Asada, S., & Sugimoto, Y. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0078 · Cited by 280

Frequent expression of the multi‐drug resistance‐associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP‐21 monoclonal antibody in paraffin‐embedded material

Diestra, J. E., Scheffer, G. L., Català, I., Maliepaard, M., Schellens, J. H. M., Scheper, R. J., Germà‐Lluch, J. R., & Izquierdo, M. A. (2002) · The Journal of Pathology · doi:10.1002/path.1203 · Cited by 275

Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine

Zamber, C. P., Lamba, J. K., Yasuda, K., Farnum, J., Thummel, K., Schuetz, J. D., & Schuetz, E. G. (2003) · Pharmacogenetics · doi:10.1097/00008571-200301000-00004 · Cited by 272

Characterization of Oligomeric Human Half-ABC Transporter ATP-binding Cassette G2

Xu, J., Liu, Y., Yang, Y., Bates, S., & Zhang, J.-T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310785200 · Cited by 267

Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells.

Brangi, M., Litman, T., Ciotti, M., Nishiyama, K., Kohlhagen, G., Takimoto, C. H. M., Robey, R. W., Pommier, Y. G., Fojo, T., & Bates, S. E. (1999) · PubMed · Cited by 263

Expression of breast cancer resistance protein in blast cells from patients with acute leukemia

Ross, D. D., Karp, J. E., Chen, T. T., & Doyle, L. A. (2000) · Blood · doi:10.1182/blood.v96.1.365 · Cited by 250

Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance.

Volk, E. L., Farley, K. M., Wu, Y. F., Li, F., Robey, R. W., & Schneider, E. (2002) · PubMed · Cited by 248

A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2)

Robey, R. W., Honjo, Y., van de Laar, A., Miyake, K., Regis, J. T., Litman, T., & Bates, S. E. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(01)00308-x · Cited by 245

Breast Cancer Resistance Protein Directly Confers SN-38 Resistance of Lung Cancer Cells

Kawabata, S., Oka, M., Shiozawa, K., Tsukamoto, K., Nakatomi, K., Soda, H., Fukuda, M., Ikegami, Y., Sugahara, K., Yamada, Y., et al. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4267 · Cited by 242

Breast Cancer Resistance Protein Impacts Clinical Outcome in Platinum-Based Chemotherapy for Advanced Non-Small Cell Lung Cancer

Yoh, K., Ishii, G., Yokose, T., Minegishi, Y., Tsuta, K., Goto, K., Nishiwaki, Y., Kodama, T., Suga, M., & Ochiai, A. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0937-3 · Cited by 242

Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype*1

SPARREBOOM, A. (2004) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2004.03.003 · Cited by 241

The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

van Herwaarden, A. E., Jonker, J. W., Wagenaar, E., Brinkhuis, R. F., Schellens, J. H. M., Beijnen, J. H., & Schinkel, A. H. (2003) · PubMed · Cited by 235

Breast Cancer Resistance Protein Exports Sulfated Estrogens but Not Free Estrogens

Imai, Y., Asada, S., Tsukahara, S., Ishikawa, E., Tsuruo, T., & Sugimoto, Y. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.3.610 · Cited by 235

Mechanism of the Pharmacokinetic Interaction between Methotrexate and Benzimidazoles

Breedveld, P., Zelcer, N., Pluim, D., Sönmezer, O., Tibben, M. M., Beijnen, J. H., Schinkel, A. H., van Tellingen, O., Borst, P., & Schellens, J. H. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-4062 · Cited by 233

Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood–brain barrier

Eisenblätter, T., Hüwel, S., & Galla, H.-J. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02401-6 · Cited by 232

Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.

Maliepaard, M., van Gastelen, M. A., Tohgo, A., Hausheer, F. H., van Waardenburg, R. C. A. M., de Jong, L. A., Pluim, D., Beijnen, J. H., & Schellens, J. H. M. (2001) · PubMed · Cited by 231

Interaction of the breast cancer resistance protein with plant polyphenols

Cooray, H. C., Janvilisri, T., van Veen, H. W., Hladky, S. B., & Barrand, M. A. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.03.040 · Cited by 226

BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia

Steinbach, D., Sell, W., Voigt, A., Hermann, J., Zintl, F., & Sauerbrey, A. (2002) · Leukemia · doi:10.1038/sj.leu.2402541 · Cited by 226

The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux.

Erlichman, C., Boerner, S. A., Hallgren, C. G., Spieker, R. S., Wang, X., James, C. D., Scheffer, G. L., Maliepaard, M., Ross, D. D., Bible, K. C., et al. (2001) · PubMed · Cited by 224

HIV Protease Inhibitors Are Inhibitors but Not Substrates of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

Gupta, A., Zhang, Y., Unadkat, J. D., & Mao, Q. (2004) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.065342 · Cited by 216

Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter.

Volk, E. L., & Schneider, E. (2003) · PubMed · Cited by 215

Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter

Lechner, A., Leech, C. A., Abraham, E. J., Nolan, A. L., & Habener, J. F. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00275-9 · Cited by 210

Characterization of Drug Transport, ATP Hydrolysis, and Nucleotide Trapping by the Human ABCG2 Multidrug Transporter

Özvegy, C., Váradi, A., & Sarkadi, B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207857200 · Cited by 204

Expression and functional characterization of ABCG2 in brain endothelial cells and vessels

Zhang, W., Mojsilovic-Petrovic, J., Andrade, M. F., Zhang, H., Ball, M., & Stanimirovic, D. B. (2003) · The FASEB Journal · doi:10.1096/fj.02-1131fje · Cited by 204

Hepatic Oval Cells Have the Side Population Phenotype Defined by Expression of ATP-Binding Cassette Transporter ABCG2/BCRP1

Shimano, K., Satake, M., Okaya, A., Kitanaka, J., Kitanaka, N., Takemura, M., Sakagami, M., Terada, N., & Tsujimura, T. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63624-3 · Cited by 195

Multidrug resistance and pharmacological protection mediated by the breast cancer resistance protein (BCRP/ABCG2).

Allen, J. D., & Schinkel, A. H. (2002) · PubMed · Cited by 193

Subcellular Localization and Activity of Multidrug Resistance Proteins

Rajagopal, A., & Simon, S. M. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-11-0704 · Cited by 190

Transport of 7-Ethyl-10-hydroxycamptothecin (SN-38) by Breast Cancer Resistance Protein ABCG2 in Human Lung Cancer Cells

Nakatomi, K., Yoshikawa, M., Oka, M., Ikegami, Y., Hayasaka, S., Sano, K., Shiozawa, K., Kawabata, S., Soda, H., Ishikawa, T., et al. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5850 · Cited by 189

The Product of the ABC Half-Transporter Gene ABCG2 (BCRP/MXR/ABCP) Is Expressed in the Plasma Membrane

Rocchi, E., Khodjakov, A., Volk, E. L., Yang, C.-H., Litman, T., Bates, S. E., & Schneider, E. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2590 · Cited by 184

ABCG2 overexpression in colon cancer cells resistant to SN38 and in irinotecan‐treated metastases

Candeil, L., Gourdier, I., Peyron, D., Vezzio, N., Copois, V., Bibeau, F., Orsetti, B., Scheffer, G. L., Ychou, M., Khan, Q. A., et al. (2004) · International Journal of Cancer · doi:10.1002/ijc.20032 · Cited by 180

Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML)

van den Heuvel-Eibrink, M., Wiemer, E., Prins, A., Meijerink, J., Vossebeld, P., van der Holt, B., Pieters, R., & Sonneveld, P. (2002) · Leukemia · doi:10.1038/sj.leu.2402496 · Cited by 175

Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines.

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2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, a Carcinogen in High- Temperature-Cooked Meat, and Breast Cancer Risk

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