Cited by 1,406Advanced Drug Delivery SystemsOcular Infections and TreatmentsNanoparticle-Based Drug Delivery

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Ocular Drug Delivery

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Gaudana, Ripal, Ananthula, Hari Krishna, Parenky, Ashwin, Mitra, Ashim K.·2010·The AAPS Journal

DOI 10.1208/s12248-010-9183-3PMC PMC2895432

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Abstract

Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood-retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a significant challenge for delivery of a drug alone or in a dosage form, especially to the posterior segment. Identification of influx transporters on various ocular tissues and designing a transporter-targeted delivery of a parent drug has gathered momentum in recent years. Parallelly, colloidal dosage forms such as nanoparticles, nanomicelles, liposomes, and microemulsions have been widely explored to overcome various static and dynamic barriers. Novel drug delivery strategies such as bioadhesive gels and fibrin sealant-based approaches were developed to sustain drug levels at the target site. Designing noninvasive sustained drug delivery systems and exploring the feasibility of topical application to deliver drugs to the posterior segment may drastically improve drug delivery in the years to come. Current developments in the field of ophthalmic drug delivery promise a significant improvement in overcoming the challenges posed by various anterior and posterior segment diseases.

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Authors: Gaudana, R., Ananthula, H. K., Parenky, A., & Mitra, A. K.
Affiliations: University of Missouri–Kansas City (US)
Corresponding author: Mitra, Ashim K.
Venue: The AAPS Journal
Publisher: Springer Science and Business Media LLC
Published: 2010-05-01
Volume: 12
Issue: 3
Pages: 348-360
ISSN: 1550-7416 (ISSN-L)
DOI: 10.1208/s12248-010-9183-3
PMC: PMC2895432
OpenAlex: W2018516156
Cited by: 1,406
References: 256
Citations by year: 2026: 114 · 2025: 114 · 2024: 98 · 2023: 118 · 2022: 110 · 2021: 126 · 2020: 116 · 2019: 93 · 2018: 100 · 2017: 96 · 2016: 82 · 2015: 60 · 2014: 54 · 2013: 58 · 2012: 32
FWCI: 4.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: The AAPS Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Eye Institute (R01EY009171, R01EY10659-12, R01EY010659, R01-EY09171-14)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: ocular drug delivery, blood-aqueous barrier, blood-retinal barrier, cornea, sclera, retina, choroidal blood flow, lymphatic clearance, efflux pumps, influx transporters, nanoparticles, nanomicelles, liposomes, microemulsions, bioadhesive gel, fibrin glue, sustained drug release, topical drug delivery, posterior segment, anterior segment
MeSH terms: Administration, Topical, Colloids, Eye, Half-Life, Humans, Iontophoresis, Melanins, Pharmacokinetics, Ultrasonics, Drug Delivery Systems

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