Ocular Drug Delivery

Block copolymer micelles for drug delivery: design, characterization and biological significance

Kataoka, K., Harada, A., & Nagasaki, Y. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00124-1 · Cited by 3,506

Cyclodextrins and their uses: a review

Del Valle, E. M. M. (2004) · Process Biochemistry · doi:10.1016/s0032-9592(03)00258-9 · Cited by 3,375

Cyclodextrins and their pharmaceutical applications

Loftsson, Þ., & Duchêne, D. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.10.044 · Cited by 1,766

Prodrugs: design and clinical applications

Rautio, J., Kumpulainen, H., Heimbach, T., Oliyai, R., Oh, D.-M., Järvinen, T., & Savolainen, J. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2468 · Cited by 1,681

Birth of a new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry.

Tomalia, D. A. (2005) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2005.01.007 · Cited by 1,115

Challenges and obstacles of ocular pharmacokinetics and drug delivery

Urtti, A. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.07.027 · Cited by 1,003

Permeability of cornea, sclera, and conjunctiva: A literature analysis for drug delivery to the eye

Prausnitz, M. R., & Noonan, J. S. (1998) · Journal of Pharmaceutical Sciences · doi:10.1021/js9802594 · Cited by 630

Recent Perspectives in Ocular Drug Delivery

Gaudana, R., Jwala, J., Boddu, S., & Mitra, A. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9694-0 · Cited by 600

Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants

Sieving, P. A., Caruso, R. C., Tao, W., Coleman, H. R., Thompson, D. J. S., Fullmer, K. R., & Bush, R. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600236103 · Cited by 591

Topical Ocular Drug Delivery: Recent Developments and Future Challenges

Lee, V. H. L., & Robinson, J. R. (1986) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.1986.2.67 · Cited by 504

Viral Vectors for Gene Transfer

Walther, W., & Stein, U. (2000) · Drugs · doi:10.2165/00003495-200060020-00002 · Cited by 452

Vesicular systems in ocular drug delivery: an overview

Kaur, I. P., Garg, A. B., Singla, A. K., & Aggarwal, D. (2003) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.09.016 · Cited by 450

Current and future ophthalmic drug delivery systems

del Amo, E. M., & Urtti, A. O. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2007.11.002 · Cited by 424

Poly(amidoamine) dendrimers as ophthalmic vehicles for ocular delivery of pilocarpine nitrate and tropicamide

Vandamme, T. F., & Brobeck, L. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.09.015 · Cited by 402

Topical and systemic drug delivery to the posterior segments

HUGHES, P., OLEJNIK, O., Chang-Lin, J.-E., & WILSON, C. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.09.004 · Cited by 400

Inner limiting membrane barriers to aav-mediated retinal transduction from the vitreous

Dalkara, D., Kolstad, K. D., Caporale, N., Visel, M., Klimczak, R. R., Schaffer, D. V., & Flannery, J. G. (2009) · Molecular Therapy · doi:10.1038/mt.2009.181 · Cited by 357

Drug transport in corneal epithelium and blood–retina barrier: Emerging role of transporters in ocular pharmacokinetics

Mannermaa, E., Vellonen, K., & Urtti, A. O. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.07.024 · Cited by 356

Liposomes as an ocular delivery system for acetazolamide: In vitro and in vivo studies

Hathout, R. M., Mansour, S., Mortada, N. D., & Guinedi, A. S. (2007) · AAPS PharmSciTech · doi:10.1208/pt0801001 · Cited by 346

Ocular drug delivery

Ghate, D. A., & Edelhauser, H. F. (2006) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.3.2.275 · Cited by 336

Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation

Shaunak, S., Thomas, S., Gianasi, E., Godwin, A., Jones, E., Teo, I. A., Mireskandari, K., Luthert, P. J., Duncan, R., Patterson, S., et al. (2004) · Nature Biotechnology · doi:10.1038/nbt995 · Cited by 331

Suprachoroidal drug delivery to the back of the eye using hollow microneedles

Patel, S. R., Lin, A. S. P., Edelhauser, H. F., & Prausnitz, M. R. (2011) · Pharmaceutical Research · doi:10.1007/s11095-010-0271-y · Cited by 330

Role of Mucins in the Function of the Corneal and Conjunctival Epithelia

Gipson, I. K., & Argüeso, P. (2003) · International review of cytology · doi:10.1016/s0074-7696(03)31001-0 · Cited by 323

The targeted delivery of cancer drugs across the blood–brain barrier: chemical modifications of drugs or drug-nanoparticles?

Juillerat‐Jeanneret, L. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2008.09.005 · Cited by 318

Ocular novel drug delivery: impacts of membranes and barriers

Barar, J., Javadzadeh, A., & Omidi, Y. (2008) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.5.567 · Cited by 309

Ophthalmic Drug Delivery through Contact Lenses

Gulsen, D., & Chauhan, A. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0959 · Cited by 305

Biodegradable Implants for Sustained Drug Release in the Eye

Lee, S. S., Hughes, P. M., Ross, A. D., & Robinson, M. R. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0159-x · Cited by 288

Importance of the noncorneal absorption route in topical ophthalmic drug delivery.

Ahmed, I., & Patton, T. F. (1985) · PubMed · Cited by 287

Interaction Between Chemicals and Melanin

LARSSON, B. S. (1993) · Pigment Cell Research · doi:10.1111/j.1600-0749.1993.tb00591.x · Cited by 287

Coated Microneedles for Drug Delivery to the Eye

Jiang, J., Gill, H. S., Ghate, D. A., McCarey, B. E., Patel, S. R., Edelhauser, H. F., & Prausnitz, M. R. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0066 · Cited by 286

Transscleral drug delivery for posterior segment disease

Geroski, D. H., & Edelhauser, H. F. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00193-4 · Cited by 282

Dispersion of microemulsion drops in HEMA hydrogel: a potential ophthalmic drug delivery vehicle

Gulsen, D., & Chauhan, A. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.11.033 · Cited by 277

Longitudinal Study of Cone Photoreceptors during Retinal Degeneration and in Response to Ciliary Neurotrophic Factor Treatment

Talcott, K. E., Ratnam, K., Sundquist, S. M., Lucero, A. S., Lujan, B. J., Tao, W., Porco, T. C., Roorda, A., & Duncan, J. L. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6479 · Cited by 276

Ocular drug delivery by liposome–chitosan nanoparticle complexes (LCS-NP)

Diebold, Y., Jarrı́n, M., Sáez, V., Carvalho, E. L. S., Orea, M. J., Calonge, M., Seijo, B., & Alonso, M. J. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.11.028 · Cited by 273

Permeability of Retinal Pigment Epithelium: Effects of Permeant Molecular Weight and Lipophilicity

Pitka¨nen, L., Ranta, V.-P., Moilanen, H., & Urtti, A. (2005) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.04-1051 · Cited by 261

Subconjunctival nano- and microparticles sustain retinal delivery of budesonide, a corticosteroid capable of inhibiting VEGF expression.

Kompella, U., Bandi, N., & Ayalasomayajula, S. (2003) · Investigative Ophthalmology and Visual Science · doi:10.1167/iovs.02-0791 · Cited by 259

Periocular routes for retinal drug delivery

Raghava, S., Hammond, M., & Kompella, U. B. (2004) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.1.1.99 · Cited by 257

Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery

Li, N., Zhuang, C.-Y., Wang, M., Sun, X., Nie, S., & Pan, W. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.06.020 · Cited by 248

Intraocular implants for extended drug delivery: Therapeutic applications

Bourges, J., Bloquel, C., Thomas, A., Froussart, F., Bochot, A., Azan, F., Gurny, R., BenEzra, D., & Béhar‐Cohen, F. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.07.026 · Cited by 239

Drug delivery to the retina: challenges and opportunities

Duvvuri, S., Majumdar, S., & Mitra, A. K. (2003) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.3.1.45 · Cited by 238

Ionic Surfactant Aggregates in Saline Solutions: Sodium Dodecyl Sulfate (SDS) in the Presence of Excess Sodium Chloride (NaCl) or Calcium Chloride (CaCl2)

Sammalkorpi, M., Karttunen, M., & Haataja, M. (2009) · The Journal of Physical Chemistry B · doi:10.1021/jp901228v · Cited by 235

Intravenously administered gold nanoparticles pass through the blood–retinal barrier depending on the particle size, and induce no retinal toxicity

Kim, J. H., Kim, J. H., Kim, K., Kim, M. H., & Yu, Y. S. (2009) · Nanotechnology · doi:10.1088/0957-4484/20/50/505101 · Cited by 228

Size-dependent disposition of nanoparticles and microparticles following subconjunctival administration

Amrite, A. C., & Kompella, U. B. (2005) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.57.12.0005 · Cited by 213

Intravenous transferrin, RGD peptide and dual-targeted nanoparticles enhance anti-VEGF intraceptor gene delivery to laser-induced CNV

Singh, S. R., GROSSNIKLAUS, H. E., Kang, S. J., Edelhauser, H. F., Ambati, B. K., & Kompella, U. B. (2009) · Gene Therapy · doi:10.1038/gt.2008.185 · Cited by 211

Intrascleral Drug Delivery to the Eye Using Hollow Microneedles

Jiang, J., Moore, J. S., Edelhauser, H. F., & Prausnitz, M. R. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9756-3 · Cited by 209

Recombinant adeno-associated virus serotype 4 mediates unique and exclusive long-term transduction of retinal pigmented epithelium in rat, dog, and nonhuman primate after subretinal delivery

Weber, M., Rabinowitz, J., Provost, N., Conrath, H., Folliot, S., Briot, D., Chérel, Y., Chenuaud, P., Samulski, J., Moullier, P., et al. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(03)00098-4 · Cited by 203

Acyclovir-containing liposomes for potential ocular delivery

Law, S. L., Huang, K.-J., & Chiang, C. ‐. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00192-3 · Cited by 202

In Vivo Gene Transfer to the Mouse Eye Using an HIV-Based Lentiviral Vector; Efficient Long-Term Transduction of Corneal Endothelium and Retinal Pigment Epithelium

Bainbridge, J., Stephens, C., Parsley, K., Demaison, C., Halfyard, A., Thrasher, A., & Ali, R. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301574 · Cited by 197

Self-assembled liquid crystalline nanoparticles as a novel ophthalmic delivery system for dexamethasone: Improving preocular retention and ocular bioavailability

Gan, L., Han, S., Shen, J., Zhu, J., Zhu, C., Zhang, X., & Gan, Y. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.06.015 · Cited by 197

Acetazolamide: future perspective in topical glaucoma therapeutics

Kaur, I. P., Smitha, R., Aggarwal, D., & Kapil, M. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00438-6 · Cited by 192

AAV hybrid serotypes: improved vectors for gene delivery

Choi, V., McCarty, D., & Samulski, R. (2005) · Current Gene Therapy · doi:10.2174/1566523054064968 · Cited by 191

Vitreous: A Barrier to Nonviral Ocular Gene Therapy

Peeters, L., Sanders, N. N., Braeckmans, K., Boussery, K., Van de Voorde, J., De Smedt, S. C., & Demeester, J. (2005) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.05-0165 · Cited by 189 · cited 2×

Polyethylene glycol–polyamidoamine dendritic micelle as solubility enhancer and the effect of the length of polyethylene glycol arms on the solubility of pyrene in water

Yang, H., Morris, J. J., & Lopina, S. T. (2004) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2003.12.023 · Cited by 185

Transport processes across the rabbit corneal epithelium: a review

Klyce, S. D., & Crosson, C. E. (1985) · Current Eye Research · doi:10.3109/02713688509025145 · Cited by 185

High concentration of dexamethasone in aqueous and vitreous after subconjunctival injection

Weijtens, O., Feron, E. J., Schoemaker, R. C., Cohen, A. F., Lentjes, E. G. W. M., Romijn, F. P. H. T. M., & van Meurs, J. C. (1999) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(99)00129-4 · Cited by 184

Biodegradable Thermoresponsive Hydrogels for Aqueous Encapsulation and Controlled Release of Hydrophilic Model Drugs

Huang, X. B., & Lowe, T. L. (2005) · Biomacromolecules · doi:10.1021/bm050116t · Cited by 181

Binding of Drugs to Eye Melanin Is Not Predictive of Ocular Toxicity

Leblanc, B., Jezequel, S. G., Davies, T., Hanton, G. C., & Taradach, C. (1998) · Regulatory Toxicology and Pharmacology · doi:10.1006/rtph.1998.1243 · Cited by 179

Investigating the movement of intravitreal human serum albumin nanoparticles in the vitreous and retina

Kim, H., Robinson, S. B., & Csaky, K. G. (2009) · Pharmaceutical Research · doi:10.1007/s11095-008-9745-6 · Cited by 174

Transport Barriers in Transscleral Drug Delivery for Retinal Diseases

Kim, S. H., Lutz, R. J., Wang, N. S., & Robinson, M. R. (2007) · Ophthalmic Research · doi:10.1159/000108117 · Cited by 173

Liposomes in topical drug delivery.

Schaeffer, H. E., & Krohn, D. L. (1982) · PubMed · Cited by 170

Dendrimers as Potential Drug Carriers. Part I. Solubilization of Non-Steroidal Anti-Inflammatory Drugs in the Presence of Polyamidoamine Dendrimers

Yiyun, C., & Xu, T. (2005) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2005.06.010 · Cited by 168

Ketorolac entrapped in polymeric micelles: preparation, characterisation and ocular anti-inflammatory studies

Gupta, A. K. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00508-1 · Cited by 160

Dispersion of DMPC Liposomes in Contact Lenses for Ophthalmic Drug Delivery

Gulsen, D., Li, C., & Chauhan, A. (2005) · Current Eye Research · doi:10.1080/02713680500346633 · Cited by 159

Long-term Follow-up Results of a Pilot Trial of a Fluocinolone Acetonide Implant to Treat Posterior Uveitis

Jaffe, G. J., McCallum, R. M., Branchaud, B., Skalak, C., Butuner, Z., & Ashton, P. (2005) · Ophthalmology · doi:10.1016/j.ophtha.2005.03.013 · Cited by 158

Drug Transporter and Cytochrome P450 mRNA Expression in Human Ocular Barriers: Implications for Ocular Drug Disposition

Zhang, T., Xiang, C. D., Gale, D. C., Carreiro, S. T., Wu, E. Y., & Zhang, E. Y. (2008) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.021121 · Cited by 156

Colloidal Carriers for Ophthalmic Drug Delivery

Mainardes, R. M., Urban, M. C. C., Cinto, P. O., Khalil, N. M., Chaud, M. V., Evangelista, R. C., & Gremião, M. P. D. (2005) · Current Drug Targets · doi:10.2174/1389450053765914 · Cited by 155

Gene delivery to the eye using adeno-associated viral vectors

Martin, K. R. G., Klein, R. L., & Quigley, H. A. (2002) · Methods · doi:10.1016/s1046-2023(02)00232-3 · Cited by 149

Distribution of peptide transporter PEPT2 mRNA in the rat nervous system

Berger, U. V., & Hediger, M. A. (1999) · Anatomy and Embryology · doi:10.1007/s004290050242 · Cited by 146

Gene therapy progress and prospects: the eye

Bainbridge, J. W., Tan, M. H., & Ali, R. R. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302812 · Cited by 144

Response of Retinoblastoma with Vitreous Tumor Seeding to Adenovirus-Mediated Delivery of Thymidine Kinase Followed by Ganciclovir

Chévez-Barrios, P., Chintagumpala, M., Mieler, W., Paysse, E., Boniuk, M., Kozinetz, C., Hurwitz, M. Y., & Hurwitz, R. L. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2004.00.1883 · Cited by 143

Antibacterial activity and cytotoxicity of PEGylated poly(amidoamine) dendrimers

Lopez, A. I., Reins, R. Y., McDermott, A. M., Trautner, B. W., & Cai, C. (2009) · Molecular BioSystems · doi:10.1039/b904746h · Cited by 142

Subconjunctivally administered celecoxib-PLGA microparticles sustain retinal drug levels and alleviate diabetes-induced oxidative stress in a rat model

Ayalasomayajula, S. P., & Kompella, U. B. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.02.019 · Cited by 141

A review of implantable intravitreal drug delivery technologies for the treatment of posterior segment eye diseases

Choonara, Y. E., Pillay, V., Danckwerts, M. P., Carmichael, T. R., & du Toit, L. C. (2009) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21987 · Cited by 139

Cationic Vectors in Ocular Drug Delivery

Rabinovich‐Guilatt, L., Couvreur, P., Lambert, G., & Dubernet, C. (2004) · Journal of drug targeting · doi:10.1080/10611860400015910 · Cited by 139

Vitreous Is a Barrier in Nonviral Gene Transfer by Cationic Lipids and Polymers

Pitkänen, L., Ruponen, M., Nieminen, J., & Urtti, A. (2003) · Pharmaceutical Research · doi:10.1023/a:1023238530504 · Cited by 134

Preparation and evaluation of liposomal formulations of tropicamide for ocular delivery

Nagarsenker, M. S., Londhe, V. Y., & Nadkarni, G. D. (1999) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(99)00265-3 · Cited by 134

Biodegradable Ocular Inserts for Sustained Delivery of Brimonidine Tartarate: Preparation and In Vitro/In Vivo Evaluation

Aburahma, M. H., & Mahmoud, A. A. K. (2011) · AAPS PharmSciTech · doi:10.1208/s12249-011-9701-3 · Cited by 133

P-glycoprotein expression in human retinal pigment epithelium.

Kennedy, B. G., & Mangini, N. J. (2002) · PubMed · Cited by 130

PLGA–PEG–PLGA hydrogel for ocular drug delivery of dexamethasone acetate

Gao, Y., Sun, Y., Ren, F., & Gao, S. (2010) · Drug Development and Industrial Pharmacy · doi:10.3109/03639041003680826 · Cited by 130

Molecular Evidence and Functional Expression of P-Glycoprotein (MDR1) in Human and Rabbit Cornea and Corneal Epithelial Cell Lines

Dey, S., Patel, J., Anand, B. S., Jain-Vakkalagadda, B., Kaliki, P., Pal, D., Ganapathy, V., & Mitra, A. K. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-1142 · Cited by 128

Topical use of Coenzyme Q10-loaded liposomes coated with trimethyl chitosan: Tolerance, precorneal retention and anti-cataract effect

Zhang, J., & Wang, S. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.01.001 · Cited by 128

Effect of circulation on the disposition and ocular tissue distribution of 20 nm nanoparticles after periocular administration.

Amrite, A. C., Edelhauser, H. F., Singh, S. R., & Kompella, U. B. (2008) · PubMed Central · Cited by 125

In vivo gene delivery into ocular tissues by eye drops of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) polymeric micelles

Liaw, J., Chang, S.-F., & Hsiao, F.-C. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301485 · Cited by 125

Topical and systemic absorption in delivery of dexamethasone to the anterior and posterior segments of the eye

Sigurðsson, H. H., Konrádsdóttir, F., Loftsson, Þ., & Stefánsson, E. (2007) · Acta Ophthalmologica Scandinavica · doi:10.1111/j.1600-0420.2007.00885.x · Cited by 122

Lentiviral Gene Transfer of Rpe65 Rescues Survival and Function of Cones in a Mouse Model of Leber Congenital Amaurosis

Bemelmans, A., Kostic, C., Crippa, S. V., Hauswirth, W. W., Lem, J., Munier, F. L., Seeliger, M. W., Wenzel, A., & Arsenijévic, Y. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030347 · Cited by 121

Dexamethasone transport and ocular delivery from poly(hydroxyethyl methacrylate) gels

KIM, J., & Chauhan, A. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.11.049 · Cited by 120

Distribution of Brimonidine into Anterior and Posterior Tissues of Monkey, Rabbit, and Rat Eyes

Acheampong, A., Shackleton, M., John, B. A., Burke, J. E., Wheeler, L. A., & Tang-Liu, D. D.-S. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.4.421 · Cited by 120

Delivery of Ciliary Neurotrophic Factor via Lentiviral-Mediated Transfer Protects Axotomized Retinal Ganglion Cells for an Extended Period of Time

van Adel, B. A., Kostic, C., Déglon, N., Ball, A. K., & Arsenijévic, Y. (2003) · Human Gene Therapy · doi:10.1089/104303403321070801 · Cited by 114

Duane's Ophthalmology

Mannis, M. J. (1993) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)71425-4 · Cited by 110

Cyclodextrin microparticles for drug delivery to the posterior segment of the eye: aqueous dexamethasone eye drops

Loftsson, Þ., Hreinsdóttir, D., & Stefánsson, E. (2007) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.59.5.0002 · Cited by 110

Ocular gene delivery using lentiviral vectors

Balaggan, K. S., & Ali, R. R. (2011) · Gene Therapy · doi:10.1038/gt.2011.153 · Cited by 108

Adeno-Associated Virus Type 5: Transduction Efficiency and Cell-Type Specificity in the Primate Retina

Lotery, A. J., Yang, G. S., Mullins, R. F., Russell, S. R., Schmidt, M., Stone, E. M., Lindbloom, J. D., Chiorini, J. A., Kotin, R. M., & Davidson, B. L. (2003) · Human Gene Therapy · doi:10.1089/104303403322542301 · Cited by 107

Nanoparticle applications in ocular gene therapy

Cai, X., Conley, S. M., & Naash, M. I. (2007) · Vision Research · doi:10.1016/j.visres.2007.07.012 · Cited by 107

Bovine and Porcine Transscleral Solute Transport: Influence of Lipophilicity and the Choroid–Bruch’s Layer

Cheruvu, N. P. S., & Kompella, U. B. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0404 · Cited by 107

Preparation and ocular pharmacokinetics of ganciclovir liposomes

Shen, Y., & Tu, J. (2007) · The AAPS Journal · doi:10.1208/aapsj0903044 · Cited by 106

Mechanism of Corneal Permeation of L-Valyl Ester of Acyclovir: Targeting the Oligopeptide Transporter on the Rabbit Cornea

Anand, B. S., & Mitra, A. K. (2002) · Pharmaceutical Research · doi:10.1023/a:1019806411610 · Cited by 105

Molecular Design for Enhancement of Ocular Penetration

Shirasaki, Y. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21200 · Cited by 101

Sustained Release of an Anti-Glaucoma Drug: Demonstration of Efficacy of a Liposomal Formulation in the Rabbit Eye

Natarajan, J. V., Chattopadhyay, S., Ang, M., Darwitan, A., Foo, S. E. M., Zhen, M., Koo, M., Wong, T. T. L., & Venkatraman, S. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024513 · Cited by 100

Pharmacokinetics of Topical Ocular Drug Delivery: Potential Uses for the Treatment of Diseases of the Posterior Segment and Beyond

Koevary, S. B. (2003) · Current Drug Metabolism · doi:10.2174/1389200033489488 · Cited by 99

Treatment of Experimental Autoimmune Uveoretinitis with Intravitreal Injection of Tacrolimus (FK506) Encapsulated in Liposomes

Zhang, R., He, R., Jiang, Q., Guo, J., Xue, K., & Yuan, Y.-F. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4373 · Cited by 98

Thermoresponsive hydrogels as a new ocular drug delivery platform to the posterior segment of the eye.

Derwent, J. J. K., & Mieler, W. F. (2008) · PubMed · Cited by 97

Subconjunctivally implantable hydrogels with degradable and thermoresponsive properties for sustained release of insulin to the retina

Misra, G. P., Singh, R. S., Alemán, T. S., Jacobson, S. G., Gardner, T. W., & Lowe, T. L. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.08.025 · Cited by 96

Effect of Eye Pigmentation on Transscleral Drug Delivery

Cheruvu, N. P. S., Amrite, A. C., & Kompella, U. B. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0214 · Cited by 95

Vitreous Penetration of Orally Administered Valacyclovir

Huynh, T. H., Johnson, M. W., Comer, G. M., & Fish, D. N. (2008) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2007.11.016 · Cited by 94

A Nonionic Surfactant/Chitosan Micelle System in an Innovative Eye Drop Formulation

Pepić, I., Hafner, A., Lovrić, J., Pirkić, B., & Filipović‐Grčić, J. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22137 · Cited by 94

Recombinant AAV-mediated gene transfer to the retina: gene therapy perspectives

Rolling, F. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302366 · Cited by 93

Pharmacokinetics and tolerance study of intravitreal injection of dexamethasone-loaded nanoparticles in rabbits

Zhang, L. (2009) · International Journal of Nanomedicine · doi:10.2147/ijn.s6428 · Cited by 93

Inhibition of in vitro VEGF expression and choroidal neovascularization by synthetic dendrimer peptide mediated delivery of a sense oligonucleotide

Marano, R. J., Wimmer, N., Kearns, P. S., Thomas, B. G., Tóth, I., Brankov, M., & Rakoczy, P. E. (2004) · Experimental Eye Research · doi:10.1016/j.exer.2004.06.023 · Cited by 92

Subconjunctival Carboplatin in Fibrin Sealant in the Treatment of Transgenic Murine Retinoblastoma

VANQUILL, K., Dioguardi, P. K., TONG, C., Gilbert, J. A., AABERGJR, T., Grossniklaus, H. E., EDELHAUSER, H., & OBRIEN, J. (2005) · Ophthalmology · doi:10.1016/j.ophtha.2004.11.060 · Cited by 91

Kinetics of macromolecules injected into the subretinal space

Marmor, M. F., Negi, A., & Maurice, D. M. (1985) · Experimental Eye Research · doi:10.1016/0014-4835(85)90138-1 · Cited by 90

Ocular Drug Delivery; Impact of in vitro Cell Culture Models.

Barar, J., Asadi, M., Mortazavi‐Tabatabaei, S. A., & Omidi, Y. (2009) · PubMed Central · Cited by 90

Nanosized Dendritic Polyguanidilyated Translocators for Enhanced Solubility, Permeability, and Delivery of Gatifloxacin

Durairaj, C., Kadam, R. S., Chandler, J., Hutcherson, S. L., & Kompella, U. B. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5388 · Cited by 86

Stable and efficient intraocular gene transfer using pseudotyped EIAV lentiviral vectors

Balaggan, K. S., Binley, K. E., Esapa, M., Iqball, S., Askham, Z., Kan, O., Tschernutter, M., Bainbridge, J. W., Naylor, S., & Ali, R. R. (2005) · The Journal of Gene Medicine · doi:10.1002/jgm.845 · Cited by 86

Oral omega-6 essential fatty acid treatment in contact lens associated dry eye

Kokke, K. H., Morris, J. A., & Lawrenson, J. G. (2008) · Contact Lens and Anterior Eye · doi:10.1016/j.clae.2007.12.001 · Cited by 86

Pharmacokinetics of Erythromycin in Rabbit Corneas after Single-Dose Infusion: Role of P-Glycoprotein as a Barrier to in Vivo Ocular Drug Absorption

Dey, S., Gunda, S., & Mitra, A. K. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.069583 · Cited by 85

Micellar solutions of triblock copolymer surfactants with pilocarpine

Pepić, I., Jalšenjak, N., & Jalšenjak, I. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.11.032 · Cited by 84

Expression of Multidrug Resistance-Associated Protein (MRP) in Human Retinal Pigment Epithelial Cells and Its Interaction with BAPSG, a Novel Aldose Reductase Inhibitor

Aukunuru, J., Sunkara, G., Bandi, N., Thoreson, W. B., & Kompella, U. B. (2001) · Pharmaceutical Research · doi:10.1023/a:1011060705599 · Cited by 82

Preparation and characterization of puerarin–dendrimer complexes as an ocular drug delivery system

Yao, W., Sun, K., Mu, H., Liang, N., Liu, Y., Chen, Y., Liang, R., & Wang, A. (2010) · Drug Development and Industrial Pharmacy · doi:10.3109/03639041003610799 · Cited by 82

Effect of hydroxypropyl beta cyclodextrin complexation on aqueous solubility, stability, and corneal permeation of acyl ester prodrugs of ganciclovir

Tirucherai, G., & Mitra, A. K. (2003) · AAPS PharmSciTech · doi:10.1208/pt040345 · Cited by 81

Suppression and Regression of Choroidal Neovascularization by the Multitargeted Kinase Inhibitor Pazopanib

Takahashi, K. (2009) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2009.27 · Cited by 80

Charged nanoparticles delivery to the eye using hydrogel iontophoresis

Eljarrat‐Binstock, E., Orucov, F., Aldouby, Y., Frucht‐Pery, J., & Domb, A. J. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.11.016 · Cited by 78

Effect of 2-Hydroxypropyl-β-cyclodextrin on the Ocular Absorption of Dexamethasone and Dexamethasone Acetate

Usayapant, A., Karara, A. H., & Narurkar, M. M. (1991) · Pharmaceutical Research · doi:10.1023/a:1015838215268 · Cited by 77

Luteinizing hormone-releasing hormone agonist and transferrin functionalizations enhance nanoparticle delivery in a novel bovine ex vivo eye model.

Kompella, U. B., Sundaram, S., Raghava, S., & Escobar, E. R. (2006) · PubMed · Cited by 77

Molecular mechanism involved in the transport of a prodrug dopamine glycosyl conjugate

Dalpiaz, A., Filosa, R., Caprariis, P. D., Conte, G. M., Bortolotti, F., Biondi, C., Scatturin, A., Prasad, P. D., & Pavan, B. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.11.051 · Cited by 76

Drug Elimination Kinetics Following Subconjunctival Injection Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Kim, S. H., Csaky, K. G., Wang, N. S., & Lutz, R. J. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9408-z · Cited by 74

A primary culture model of rabbit conjunctival epithelial cells exhibiting tight barrier properties

Saha, P., Kim, K.-J., & Lee, V. H. L. (1996) · Current Eye Research · doi:10.3109/02713689608995151 · Cited by 73

Solubilization of tropicamide by hydroxypropyl-β-cyclodextrin and water-soluble polymers: in vitro/in vivo studies

Cappello, B., Carmignani, C., Iervolino, M., Rotonda, M. I. L., & Saettone, M. F. (2001) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00648-7 · Cited by 72

Role of P-Glycoprotein in Restricting Propranolol Transport in Cultured Rabbit Conjunctival Epithelial Cell Layers

Yang, J. J., Kim, K.-J., & Lee, V. H. L. (2000) · Pharmaceutical Research · doi:10.1023/a:1007508714259 · Cited by 70

Characterization of cyclosporin A transport in cultured rabbit corneal epithelial cells: P-glycoprotein transport activity and binding to cyclophilin.

Kawazu, K., Yamada, K., Nakamura, M., & Ota, A. (1999) · PubMed · Cited by 70

Interactions of the Dipeptide Ester Prodrugs of Acyclovir with the Intestinal Oligopeptide Transporter: Competitive Inhibition of Glycylsarcosine Transport in Human Intestinal Cell Line-Caco-2

Anand, B. S., Patel, J., & Mitra, A. K. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.044313 · Cited by 70

Characterization of Human Corneal Epithelial Cell Model As a Surrogate for Corneal Permeability Assessment: Metabolism and Transport

Xiang, C. D., Batugo, M. R., Gale, D. C., Zhang, T., Ye, J., Li, C., Zhou, S., Wu, E. Y., & Zhang, E. Y. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.026286 · Cited by 70

Existence of a p-glycoprotein drug efflux pump in cultured rabbit conjunctival epithelial cells.

Saha, P., Yang, J. J., & Lee, V. H. L. (1998) · PubMed · Cited by 68

Dipeptide Monoester Ganciclovir Prodrugs for Treating HSV-1-Induced Corneal Epithelial and Stromal Keratitis: In Vitro and In Vivo Evaluations

Majumdar, S., Nashed, Y. E., Patel, K., Jain, R., Itahashi, M., Neumann, D. M., Hill, J. M., & Mitra, A. K. (2005) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2005.21.463 · Cited by 68

P-Glycoprotein expression in human retinal pigment epithelium cell lines

Constable, P. A., Lawrenson, J. G., Dolman, D. E. M., Arden, G. B., & Abbott, N. J. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2005.10.029 · Cited by 68

Freeze-fracture quantitative comparison of rabbit corneal epithelial and endothelial membranes

McLaughlin, B. J., Caldwell, R. B., Sasaki, Y., & Wood, T. O. (1985) · Current Eye Research · doi:10.3109/02713689509000002 · Cited by 68

Topically effective ocular hypotensive acetazolamide and ethoxyzolamide formulations in rabbits

Loftsson, Þ., Friðriksdóttir, H., Stefánsson, E., Thórisdóttir, S., Gudmundsson, Ó. S., & Sigthórsson, T. (1994) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1994.tb03835.x · Cited by 65

The growth factor response in ischemic rat retina and superior colliculus after brimonidine pre-treatment

Lönngren, U., Näpänkangas, U., Lafuente, M. P., Mayor, S., Lindqvist, N., Vidal‐Sanz, M., & Hallböök, F. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.09.005 · Cited by 65

Current prodrug strategies via membrane transporters/receptors

Anand, B. S., Dey, S., & Mitra, A. K. (2002) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2.6.607 · Cited by 65

Intravitreal Pharmacokinetics of Plain and Liposome-Entrapped Fluconazole in Rabbit Eyes

Gupta, S. K., Velpandian, T., Dhingra, N., & Jaiswal, J. K. (2000) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2000.16.511 · Cited by 64

Ocular Distribution of Intravenously Administered Lipid Formulations of Amphotericin B in a Rabbit Model

Goldblum, D., Rohrer, K., Frueh, B. E., Theurillat, R., Thormann, W., & Zimmerli, S. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.12.3719-3723.2002 · Cited by 63

Effluxing ABC transporters in human corneal epithelium

Vellonen, K., Mannermaa, E., Turner, H. C., Häkli, M., Wolosin, J. M., Tervo, T., Honkakoski, P., & Urtti, A. O. (2009) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21878 · Cited by 62

Beta-cyclodextrins as vehicles in eye-drop formulations: an evaluation of their effects on rabbit corneal epithelium.

Jansen, T., Xhonneux, B., Mesens, J., & Borgers, M. J. (1990) · PubMed · Cited by 60

In Vitro Corneal Permeability of Diclofenac Sodium in Formulations Containing Cyclodextrins Compared to the Commercial Product Voltaren Ophtha

Reer, O., Bock, T. K., & Müller, B. W. (1994) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600830928 · Cited by 60

Pharmacokinetics and Posterior Segment Biodistribution of ESBA105, an Anti–TNF-α Single-Chain Antibody, upon Topical Administration to the Rabbit Eye

Furrer, E., Berdugo, M., Stella, C., Béhar‐Cohen, F., Gurny, R., Feige, U., Lichtlen, P., & Urech, D. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2370 · Cited by 59

Studies with an Orally Bioavailable αV Integrin Antagonist in Animal Models of Ocular Vasculopathy: Retinal Neovascularization in Mice and Retinal Vascular Permeability in Diabetic Rats

Santulli, R. J., Kinney, W. A., Ghosh, S., DeCorte, B. L., Liu, L., Tuman, R. W., Zhao, Z., Huebert, N. D., Bursell, S. E., Clermont, A. C., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.131656 · Cited by 59

Molecular evidence and functional expression of a novel drug efflux pump (ABCC2) in human corneal epithelium and rabbit cornea and its role in ocular drug efflux

Karla, P. K., Pal, D., Quinn, T., & Mitra, A. K. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.11.031 · Cited by 59

Subconjunctival Topotecan in Fibrin Sealant in the Treatment of Transgenic Murine Retinoblastoma

Tsui, J. Y., Dalgard, C. L., Quill, K. R. V., Lee, L., Grossniklaus, H. E., Edelhauser, H. F., & O’Brien, J. M. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0653 · Cited by 58

Stable RAAV-Mediated Transduction of Rod and Cone Photoreceptors in the Canine Retina

Bainbridge, J. W. B., Mistry, A., Schlichtenbrede, F. C., Smith, A., Broderick, C., De Alwis, M., Georgiadis, A., Taylor, P. M., Squires, M., Sethi, C., et al. (2003) · Gene Therapy · doi:10.1038/sj.gt.3301990 · Cited by 58

Molecular Expression and Functional Evidence of a Drug Efflux Pump (BCRP) in Human Corneal Epithelial Cells

Karla, P. K., Earla, R., Boddu, S. H., Johnston, T. P., Pal, D., & Mitra, A. K. (2009) · Current Eye Research · doi:10.1080/02713680802518251 · Cited by 58

Identification of a Na+-Dependent Cationic and Neutral Amino Acid Transporter, B0,+, in Human and Rabbit Cornea

Jain-Vakkalagadda, B., Pal, D., Gunda, S., Nashed, Y. E., Ganapathy, V., & Mitra, A. K. (2004) · Molecular Pharmaceutics · doi:10.1021/mp0499499 · Cited by 57

Ultrasound-Enhanced Transcorneal Drug Delivery

Zderic, V., Clark, J. I., Martin, R. W., & Vaezy, S. (2004) · Cornea · doi:10.1097/01.ico.0000134189.33549.cc · Cited by 57

Binding of Betaxolol, Metoprolol and Oligonucleotides to Synthetic and Bovine Ocular Melanin, and Prediction of Drug Binding to Melanin in Human Choroid-Retinal Pigment Epithelium

Pitkänen, L., Ranta, V., Moilanen, H., & Urtti, A. O. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9342-0 · Cited by 56

Expression and Localization of Carnitine/Organic Cation Transporter OCTN1 and OCTN2 in Ocular Epithelium

Garrett, Q., Xu, S., Simmons, P. A., Vehige, J. G., Flanagan, J., & Willcox, M. D. P. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1528 · Cited by 55

Doxycycline-Mediated Inhibition of Choroidal Neovascularization

Samtani, S., Amaral, J., Campos, M. M., Fariss, R. N., & Becerra, S. P. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-3174 · Cited by 55

Transscleral Diffusion of Carboplatin

Simpson, A. E. (2002) · Archives of Ophthalmology · doi:10.1001/archopht.120.8.1069 · Cited by 55

Identification and Functional Characterization of a Na + -Independent Large Neutral Amino Acid Transporter, LAT1, in Human and Rabbit Cornea

Jain-Vakkalagadda, B., Dey, S., Pal, D., & Mitra, A. K. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0907 · Cited by 54

Modulation of P-Glycoprotein–Mediated Efflux by Prodrug Derivatization: An Approach Involving Peptide Transporter–Mediated Influx Across Rabbit Cornea

Katragadda, S., Talluri, R. S., & Mitra, A. K. (2006) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2006.22.110 · Cited by 54

Lentiviral-vector-mediated expression of murine IL-1 receptor antagonist or IL-10 reduces the severity of endotoxin-induced uveitis

Trittibach, P. C., Barker, S. E., Broderick, C. A., Natkunarajah, M., Durán, Y., Robbie, S. J., Bainbridge, J. W., Smith, A. J., Sarra, G., Dick, A. D., et al. (2008) · Gene Therapy · doi:10.1038/gt.2008.109 · Cited by 54

Corneal Absorption and Anterior Chamber Pharmacokinetics of Dipeptide Monoester Prodrugs of Ganciclovir (GCV): In Vivo Comparative Evaluation of These Prodrugs with Val-GCV and GCV in Rabbits

Gunda, S., Hariharan, S., & Mitra, A. K. (2006) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2006.22.465 · Cited by 52

Treatment of cytomegalovirus retinitis in AIDS patients with intravitreal ganciclovir.

Ausayakhun, S., Yuvaves, P., Ngamtiphakom, S., & Prasitsilp, J. (2005) · PubMed · Cited by 52

Vitreal Pharmacokinetics of Biotinylated Ganciclovir: Role of Sodium-Dependent Multivitamin Transporter Expressed on Retina

Janoria, K. G., Boddu, S. H. S., Wang, Z., Paturi, D., Samanta, S., Pal, D., & Mitra, A. K. (2009) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2008.0040 · Cited by 51

Intravitreal toxicology and duration of efficacy of a novel antiviral lipid prodrug of ganciclovir in liposome formulation.

Cheng, L., Hostetler, K. Y., Chaidhawangul, S., Gardner, M. F., Beadle, J. R., Keefe, K., Bergeron-Lynn, G., SEVERSON, G. M., Soules, K. A., Mueller, A. J., et al. (2000) · PubMed · Cited by 49

Synthesis, metabolism and cellular permeability of enzymatically stable dipeptide prodrugs of acyclovir

Talluri, R. S., Samanta, S., Gaudana, R., & Mitra, A. K. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.05.024 · Cited by 49

Considerations in the use of hydroxypropyl-β-cyclodextrin in the formulation of aqueous ophthalmic solutions of hydrocortisone

Bary, A. R. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00108-9 · Cited by 49

Prolonged Transgene Expression with Lentiviral Vectors in the Aqueous Humor Outflow Pathway of Nonhuman Primates

Poeschla, E. M., Barraza, R., Rasmussen, C., Loewen, N., Cameron, J. D., Gabelt, B. T., Teo, W., & Kaufman, P. L. (2008) · Human Gene Therapy · doi:10.1089/hum.2008.086 · Cited by 48

Drug Delivery to the Eye

Mitra, A. K., Anand, B. S., & Duvvuri, S. (2005) · Advances in organ biology · doi:10.1016/s1569-2590(05)10012-3 · Cited by 47

Preservation of aqueous outflow facility after second-generation FIV vector-mediated expression of marker genes in anterior segments of human eyes.

Loewen, N. A., Bahler, C. K., Teo, W., Whitwam, T., Peretz, M., Xu, R., Fautsch, M. P., Johnson, D. H., & Poeschla, E. M. (2002) · PubMed · Cited by 47

Corneal Permeation of Ganciclovir: Mechanism of Ganciclovir Permeation Enhancement by Acyl Ester Prodrug Design

Tirucherai, G., Dias, C. S., & Mitra, A. K. (2002) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/108076802321021081 · Cited by 47

Concentrations of Betaxolol in Ocular Tissues of Patients with Glaucoma and Normal Monkeys after 1 Month of Topical Ocular Administration

Holló, G., Whitson, J. T., Faulkner, R. D., McCue, B. A., Curtis, M., Wieland, H., Chastain, J. E., Sanders, M., DeSantis, L. M., Przydryga, J., et al. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0945 · Cited by 47

Expression of Multidrug Resistance Associated Protein 5 (MRP5) on Cornea and Its Role in Drug Efflux

Karla, P. K., Quinn, T., Herndon, B., Thomas, P., Pal, D., & Mitra, A. K. (2009) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2008.0084 · Cited by 47

Transcorneal Permeation of l- and d-Aspartate Ester Prodrugs of Acyclovir: Delineation of Passive Diffusion Versus Transporter Involvement

Majumdar, S., Hingorani, T., Srirangam, R., Gadepalli, R. S., Rimoldi, J. M., & Repka, M. A. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9730-0 · Cited by 46

Pharmacokinetic Study of Dexamethasone Disodium Phosphate using Intravitreal, Subconjunctival, and Intravenous Delivery Routes in Rabbits

Hosseini, K., Matsushima, D., Johnson, J. A., Widera, G., Nyam, K., Kim, L., Xu, Y., Yao, Y., & Cormier, M. (2008) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2007.0117 · Cited by 46

In Vitro Evaluation of a Targeted and Sustained Release System for Retinoblastoma Cells Using Doxorubicin as a Model Drug

Boddu, S. H. S., Jwala, J., Chowdhury, M. R., & Mitra, A. K. (2010) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2010.0048 · Cited by 46

Ocular Pharmacokinetics of Cephalosporins using Microdialysis

Macha, S., & Mitra, A. K. (2001) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/108076801753266866 · Cited by 46

Long-Term, Targeted Genetic Modification of the Aqueous Humor Outflow Tract Coupled with Noninvasive Imaging of Gene Expression In Vivo

Loewen, N. A., Fautsch, M. P., Teo, W., Bahler, C. K., Johnson, D. H., & Poeschla, E. M. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0366 · Cited by 46

Transcorneal Iontophoresis for Delivery of Ciprofloxacin Hydrochloride

Vaka, S. R. K., Sammeta, S. M., Day, L. B., & Murthy, S. N. (2008) · Current Eye Research · doi:10.1080/02713680802270945 · Cited by 46

Functional and molecular analysis of d-serine transport in retinal Müller cells

Dun, Y., Mysona, B. A., Itagaki, S., Martin-Studdard, A., Ganapathy, V., & Smith, S. B. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2006.09.015 · Cited by 46

Amino acid prodrugs of acyclovir as possible antiviral agents against ocular HSV-1 infections: Interactions with the neutral and cationic amino acid transporter on the corneal epithelium

Anand, B. S., Katragadda, S., Nashed, Y. E., & Mitra, A. K. (2004) · Current Eye Research · doi:10.1080/02713680490504614 · Cited by 46

Down-regulation of NOSII gene expression by iontophoresis of anti-sense oligonucleotide in endotoxin-induced uveitis

Voigt, M., de Kozak, Y., Halhal, M., Courtois, Y., & Béhar‐Cohen, F. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00656-3 · Cited by 45

Sustained Subconjunctival Protein Delivery Using a Thermosetting Gel Delivery System

Rieke, E. R., Amaral, J., Becerra, S. P., & Lutz, R. J. (2010) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2009.0059 · Cited by 45

Effect of P-glycoprotein on the ocular disposition of a model substrate, quinidine

Duvvuri, S., Gandhi, M. D., & Mitra, A. K. (2003) · Current Eye Research · doi:10.1076/ceyr.27.6.345.18187 · Cited by 45

Vitreous Penetration of Orally Administered Famciclovir

Chong, D. Y., Johnson, M. W., Huynh, T. H., Hall, E. F., Comer, G. M., & Fish, D. N. (2009) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2009.02.010 · Cited by 45

Expression of ABC-Transporters in Human Corneal Tissue and the Transformed Cell Line, HCE-T

Becker, U., Ehrhardt, C., Schneider‐Daum, N., Baldes, C., Schaefer, U. F., Ruprecht, K. W., Kim, K., & Lehr, C. (2007) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2006.0095 · Cited by 45

Widespread expression of an exogenous gene in the eye after intravenous administration.

Zhu, C., Zhang, Y., & Pardridge, W. M. (2002) · PubMed · Cited by 44

Transscleral permeability and intraocular concentrations of cisplatin from a collagen matrix

Gilbert, J. A., Simpson, A. E., Rudnick, D. E., Geroski, D. H., Aaberg, T. M., & Edelhauser, H. F. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00151-2 · Cited by 44

OCULAR SIDE EFFECTS ASSOCIATED WITH PERIBULBAR INJECTIONS OF TRIAMCINOLONE ACETONIDE FOR DIABETIC MACULAR EDEMA

Chew, E. Y., Glassman, A. R., Beck, R. W., Bressler, N. M., Fish, G. E., Ferris, F. L., & Kinyoun, J. L. (2010) · Retina · doi:10.1097/iae.0b013e3181f049a8 · Cited by 44

Penetration of moxifloxacin into the human aqueous humour after oral administration

Kampougeris, G. (2005) · British Journal of Ophthalmology · doi:10.1136/bjo.2004.050054 · Cited by 44

Novel Nanoparticulate Gel Formulations of Steroids for the Treatment of Macular Edema

Boddu, S. H. S., Jwala, J., Vaishya, R. D., Earla, R., Karla, P. K., Pal, D., & Mitra, A. K. (2010) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2009.0074 · Cited by 42

Methylprednisolone Delivery to the Back of the Eye using Hydrogel Iontophoresis

Eljarrat‐Binstock, E., Orucov, F., Frucht‐Pery, J., Pe’er, J., & Domb, A. J. (2008) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2007.0097 · Cited by 42

Methotrexate Delivery to the Eye Using Transscleral Hydrogel Iontophoresis

Eljarrat‐Binstock, E., Domb, A. J., Orucov, F., Frucht‐Pery, J., & Pe’er, J. (2007) · Current Eye Research · doi:10.1080/02713680701528674 · Cited by 42

Aqueous and Vitreous Penetration of Levofloxacin after Topical and/or Oral Administration

Sakamoto, H., Sakamoto, M., Hata, Y., Kubota, T., & Ishibashi, T. (2007) · European Journal of Ophthalmology · doi:10.1177/112067210701700316 · Cited by 40

Transcorneal Permeation in a Corneal Device of Non-Steroidal Anti-Inflammatory Drugs in Drug Delivery Systems

Valls, R., Vega, E., García, M. L., Egea, M. A., & Vall�s, J. (2008) · The Open Medicinal Chemistry Journal · doi:10.2174/1874104500802010066 · Cited by 40

Effect of hydrophobic and hydrophilic additives on sol–gel transition and release behavior of timolol maleate from polycaprolactone-based hydrogel

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Mechanism of L-Ascorbic Acid Uptake by Rabbit Corneal Epithelial Cells: Evidence for the Involvement of Sodium-Dependent Vitamin C Transporter 2

Talluri, R. S., Katragadda, S., Pal, D., & Mitra, A. K. (2006) · Current Eye Research · doi:10.1080/02713680600693629 · Cited by 40

Ocular distribution of intravenously administered micafungin in rabbits

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Ocular Sustained Release Nanoparticles Containing Stereoisomeric Dipeptide Prodrugs of Acyclovir

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Fibrin-Enmeshed Tobramycin Liposomes: Single Application Topical Therapy of Pseudomonas Keratitis

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Does orally administered doxycycline reach the tear film?

Smith, V. A., Khan-Lim, D., Anderson, L., Cook, S. D., & Dick, A. D. (2008) · British Journal of Ophthalmology · doi:10.1136/bjo.2007.125989 · Cited by 39

Looking Inside Adenovirus

Harrison, S. C. (2010) · Science · doi:10.1126/science.1194922 · Cited by 38

Effect of Poly(amidoamine) Dendrimers on Corneal Penetration of Puerarin

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Effect of Acylation on the Ocular Disposition of Acyclovir II: Corneal Permeability and Anti-HSV 1 Activity of 2′-Esters in Rabbit Epithelial Keratitis

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Ocular drug delivery systems: An overview

Patel, A. (2013) · World Journal of Pharmacology · doi:10.5497/wjp.v2.i2.47 · Cited by 894

Advances in Biomaterials for Drug Delivery

Fenton, O. S., Olafson, K. N., Pillai, P. S., Mitchell, M. J., & Langer, R. (2018) · Advanced Materials · doi:10.1002/adma.201705328 · Cited by 890

Emerging Targets in Photopharmacology

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Nanostructured lipid carriers for site-specific drug delivery

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An overview of clinical and commercial impact of drug delivery systems

Anselmo, A. C., & Mitragotri, S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.03.053 · Cited by 525

Ophthalmic Drug Delivery system - A Review

Patel, H. A., Patel, J. K., Patel, K. N., & Patel, R. R. (2010) · Der pharmacia lettre · Cited by 22

A Review on Ophthalmic Drug Delivery System

Sanap, A. R. (2024) · Research Journal of Science and Technology · doi:10.52711/2349-2988.2024.00013 · Cited by 4

Recent Trends in Ocular Drug Delivery: A Short Review

Kumar, A., Malviya, R., & Sharma, P. K. (2011) · Cited by 35

Ocular drug delivery systems.

Malhotra, B. M. B., Kharkwal, H., & Pradhan, A. (2016) · CABI eBooks · doi:10.1079/9781780644479.0160 · Cited by 3

Ocular drug delivery: present innovations and future challenges

Gote, V., Sikder, S., Sicotte, J., & Pal, D. (2019) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.256933 · Cited by 441