The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Transforming Growth Factor-β Gene Family Members and Bone*
Abstract
EARLY efforts to purify a bone-derived growth factor from rat bone culture medium revealed its biological and biochemical similarity to transforming growth factor-β type 1 (TGF-β1) extracted from human blood platelets. Cartilage inducing factors (CIF-A and CIF-B) from bovine bone matrix were then identified as TGF-β isoforms, and it soon became evident that bone cells synthesize TGF-βs and that bone matrix was a major repository of these factors in the organism. The TGF-β supergene family comprises at least five closely related proteins termed TGF-β1 through TGF-β5 in addition to a growing number of more distant but highly homologous growth regulators. Several of the closely related TGF-β isoforms occur in many animals, and appear to control development, growth, and differentiation in humans as well as a variety of other species. More importantly from the skeletal tissue perspective, some of the less closely related gene family members, activin-A and the bone morphogenetic proteins (BMPs), are also expressed by bone cells, stored in bone matrix, and increase bone cell activity in vivo and in vitro.
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Citations
Cites
Metcalf, D. (1989) · Nature · doi:10.1038/339027a0 · Cited by 1,023
Andres, J. L., Stanley, K., Cheifetz, S., & Massagué, J. (1989) · The Journal of cell biology · doi:10.1083/jcb.109.6.3137 · Cited by 354
Cited by
Vanderschueren, D., Vandenput, L., Boonen, S., Lindberg, M. K., Bouillon, R., & Ohlsson, C. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0003 · Cited by 717
HUNZIKER, E. B., & ROSENBERG, L. C. (1996) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-199605000-00012 · Cited by 616
Alliston, T., Choy, L., Ducy, P., Karsenty, G., & Derynck, R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.9.2254 · Cited by 526
Growth factors for bone growth and repair: IGF, TGFβ and BMP
Linkhart, T. A., Mohan, S., & Baylink, D. J. (1996) · Bone · doi:10.1016/s8756-3282(96)00138-x · Cited by 440
Liu, D., Black, B. L., & Derynck, R. (2001) · Genes & Development · doi:10.1101/gad.925901 · Cited by 399
Metadata
- Authors
- CENTRELLA, M., HOROWITZ, M. C., WOZNEY, J. M., & MCCARTHY, T. L.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 1994-02
- Volume
- 15
- Issue
- 1
- Pages
- 27-39
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2077046161
- Cited by
- 487
- References
- 2
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- CENTRELLA, M., HOROWITZ, M. C., WOZNEY, J. M., & MCCARTHY, T. L. (1994). Transforming Growth Factor-β Gene Family Members and Bone*. Endocrine Reviews. https://doi.org/10.1210/edrv-15-1-27
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
