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Cited by 36T-cell and B-cell ImmunologyGrowth Hormone and Insulin-like Growth FactorsHematopoietic Stem Cell Transplantation

Effects of Insulin-Like Growth Factor Administration and Bone Marrow Transplantation on Thymopoiesis in Aged Mice 1

Montecino-Rodriguez, Encarnacion, Clark, Ross, Dorshkind, Kenneth·1998·Endocrinology
DOI 10.1210/en.139.10.4120
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Abstract

There has been considerable interest in using hormone replacement therapy to rejuvenate the involuted thymus during aging. GH and insulin-like growth factor-I (IGF-I), a mediator of GH actions, have been of particular interest because of their thymopoietic effects and the fact that their serum concentrations decline during aging. However, treatment of aging rodents with either GH or IGF-I does not restore thymus cellularity to levels present in young animals, suggesting that additional defects might limit the magnitude of their effects. In particular, deficiencies have been reported to accumulate in the bone marrow T cell precursor compartment during aging. In view of this, 18-month-old mice were administered either recombinant IGF-I, bone marrow cells from young mice, or a combination of IGF-I and young bone marrow cells. Thymus cellularity in the latter group of mice was significantly higher than in animals treated with hormone or bone marrow transplantation alone, suggesting that optimal therapies for restoring thymus cellularity must address both endocrine and hematopoietic defects that accumulate during aging. Results from in vitro studies using fetal thymic organ cultures suggest that IGF-I acts by potentiating thymic colonization by bone marrow T cell precursors and/or that the hormone affects some other event soon after thymus colonization.

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Crossref · 10.1210/endo.139.10.6263

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42 of 42 references verified0 citation errors · 0 not checkable

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  • Thymus size is increased in old mice given either growth hormone or IGF-1.

    “numerous studies (42) have shown that thymus size is increased in old mice administered either hormone (101, 103).”

    From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [101]

  • Growth hormone and IGF-1 bind to receptors expressed on thymocytes and thymic epithelial cells.

    “GH and IGF-1 bind to receptors expressed on thymocytes (101) and thymic epithelial cells (102)”

    From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [101]

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Authors
Montecino-Rodriguez, E., Clark, R., & Dorshkind, K.
Venue
Endocrinology
Publisher
The Endocrine Society
Published
1998-10
Volume
139
Issue
10
Pages
4120-4126
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
DOI
10.1210/en.139.10.4120
OpenAlex
W4251460696
Cited by
36
References
40
Citations by year
2018: 1 · 2013: 1
FWCI
0.48
Type
journal article
Language
en
Open access
closed
Locations
Endocrinology (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords
insulin-like growth factor I, thymopoiesis, thymus aging, bone marrow transplantation, thymus cellularity, T cell precursors, growth hormone, hormone replacement therapy, thymic organ culture, aged mice

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