Cited by 761Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

The DOI matches its Crossref record; 118 of the 121 references it cites were found in a registry or an index.

Minireview: Adiposity, Inflammation, and Atherogenesis

Lyon, Christopher J., Law, Ronald E., Hsueh, Willa A.·2003·Endocrinology

DOI 10.1210/en.2003-0285

Open this paper in CoChat — free account

Abstract

Adipose tissue is a dynamic endocrine organ that secretes a number of factors that are increasingly recognized to contribute to systemic and vascular inflammation. Several of these factors, collectively referred to as adipokines, have now been shown regulate, directly or indirectly, a number of the processes that contribute to the development of atherosclerosis, including hypertension, endothelial dysfunction, insulin resistance, and vascular remodeling. Several adipokines are preferentially expressed in visceral adipose tissue, and the secretion of proinflammatory adipokines is elevated with increasing adiposity. Not surprisingly, approaches that reduce adipose tissue depots, including surgical fat removal, exercise, and reduced caloric intake, improve proinflammatory adipokine levels and reduce the severity of their resultant pathologies. Systemic adipokine levels can also be favorably altered by treatment with several of the existing drug classes used to treat insulin resistance, hypertension, and hypercholesterolemia. Greater understanding of adipokine regulation, however, should result in the design of improved treatment strategies to control disease states associated with increase adiposity, an important outcome in view of the growing worldwide epidemic of obesity.

Integrity signals

Registry

Crossref · 10.1210/en.2003-0285

Cites

118 of 118 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (LIFE): A randomised trial against atenolol
Dahlöf, B., Devereux, R. B., Kjeldsen, S. E., Julius, S., Beevers, G., de Faire, U., Fyhrquist, F., Ibsen, H., Kristiansson, K., Lederballe-Pedersen, O., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08089-3 · Cited by 5,407
The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
Lakka, H.-M. (2002) · JAMA · doi:10.1001/jama.288.21.2709 · Cited by 5,033
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events
Ridker, P. M., Rifai, N., Rose, L., Buring, J. E., & Cook, N. R. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021993 · Cited by 3,604
C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?
Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465

Flagged first, then by citations

Show all 121 references

3 of the 121 references couldn’t be matched to a known paper.

Sorted by citations

Items 301–400 of 760

Weight cycling and cardiovascular risk factors in obesity
Graci, S., Izzo, G., Savino, S., Cattani, L., Lezzi, G., Berselli, M. E., Balzola, F., Liuzzi, A., & Petroni, M. L. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802537 · Cited by 43
Metabolic syndrome-interdependence of the cardiovascular and metabolic pathways
Caglayan, E., Blaschke, F., Takata, Y., & Hsueh, W. A. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.01.008 · Cited by 42
Self-citation
Screening of Dried Plant Seed Extracts for Adiponectin Production Activity and Tumor Necrosis Factor-Alpha Inhibitory Activity on 3T3-L1 Adipocytes
Okada, Y., Okada, M., & Sagesaka, Y. (2010) · Plant Foods for Human Nutrition · doi:10.1007/s11130-010-0184-2 · Cited by 42
“Among the pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF α) decreases insulin sensitivity and disrupts the homeostasis of lipid and glucose metabolism [2, 3 ]. A decline in adiponectin (ACRP30) production contributes to pathogenesis of insulin resistance [4].”
Background
Short-Term Effects of a New Bicarbonate/Lactate-Buffered and Conventional Peritoneal Dialysis Fluid on Peritoneal and Systemic Inflammation in CAPD Patients: A Randomized Controlled Study
Pajek, J., Kveder, R., Bren, A. F., Guček, A., Ihan, A., Osredkar, J., & Lindholm, B. (2008) · Peritoneal Dialysis International · doi:10.1177/089686080802800109 · Cited by 42
“Our results suggest that the impact of other factors, such as uremia per se, the decreased clearance of proinflammatory cytokines (41,42), carbonyl stress (43,44), bouts of exitsite and tunnel infections, and adiposity (45), may overshadow the possible benef icial ef fects of a more biocompatible dialysis solution.”
Background
Association of body mass index and diastolic function in metabolically healthy obese with preserved ejection fraction
Rozenbaum, Z., Topilsky, Y., Khoury, S., Pereg, D., & Laufer‐Perl, M. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.08.008 · Cited by 41
Adiponectin plasma levels are increased by atorvastatin treatment in subjects at high cardiovascular risk
Blanco‐Colio, L. M., Martı́n-Ventura, J. L., Gómez‐Guerrero, C., Masramon, X., de Teresa, E., Farsang, C., Gaw, A., Gensini, G., Leiter, L. A., Langer, A., et al. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.042 · Cited by 41
“Studies have demonstrated that adipocytes synthesize and secrete a number of biologically active molecules so called adipokines, including leptin, tumor necrosis factor, interleukin6, resistin and adiponectin (Lyon et al., 2003).”
Background
The relation of adipose tissue to cardiometabolic risk
Pi-Sunyer, X. (2006) · Clinical cornerstone · doi:10.1016/s1098-3597(06)80040-2 · Cited by 41
Impact of Chronic Anticholesterol Therapy on Development of Microvascular Rarefaction in the Metabolic Syndrome
Goodwill, A. G., Frisbee, S. J., Stapleton, P. A., James, M. E., & Frisbee, J. C. (2009) · Microcirculation · doi:10.3109/10739680903133722 · Cited by 41
Energy balance modulates colon tumor growth: Interactive roles of insulin and estrogen
Rondini, E. A., Harvey, A. E., Steibel, J. P., Hursting, S. D., & Fenton, J. I. (2010) · Molecular Carcinogenesis · doi:10.1002/mc.20720 · Cited by 40
“An increase in visceral adiposity is associated with increased release of several pro-inflammatory adipokines [40], whereas adiponectin levels decline.”
Background
Peripheral blood mononuclear cells as a source to detect markers of homeostatic alterations caused by the intake of diets with an unbalanced macronutrient composition
Díaz‐Rúa, R., Keijer, J., Caimari, A., van Schothorst, E. M., Palou, A., & Oliver, P. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.11.013 · Cited by 41
“Nevertheless, HF diet induced an increase in serum TNF-alpha levels, which may be due to increased adiposity in the HF-fed animals [46].”
Background
Nicorandil improves myocardial function by regulating plasma nitric oxide and endothelin-1 in coronary slow flow
Chen, Z., Chen, X., Li, S., Huo, X., Fu, X., & Dong, X. (2014) · Coronary Artery Disease · doi:10.1097/mca.0000000000000179 · Cited by 39
Lactoferrin is a novel predictor of fatal ischemic heart disease in diabetes mellitus type 2: Long-term follow-up of the HUNT 1 study
Vengen, I. T., Dale, A. C., Wiseth, R., Midthjell, K., & Videm, V. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.06.008 · Cited by 39
“nflammation also plays an important role in atherosclerosis, and t is hypothesized that diabetes worsens the atherosclerotic plaque ctivity by promoting inflammation [2].”
Background
European Society of Hypertension Working Group on Obesity Obesity-induced hypertension and target organ damage: current knowledge and future directions
Schlaich, M. P., Grassi, G. M., Lambert, G. W., Straznicky, N. E., Esler, M., Dixon, J. B., Lambert, É., Redón, J., Narkiewicz, K., & Jordan, J. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32831dafaf · Cited by 39
Cytokines in Liver Diseases
Muriel, P. (2007) · Wiley eBooks · doi:10.1002/9780470516751.ch14 · Cited by 39
“TNF-a and IL-6 (Rajala and Scherer, 2003; Lyon et al., 2003; Diehl et al., 2005).”
Background
Synergistic Actions of Thyroid-Adipokines Axis during Development
Ahmed, R. G. (2017) · Endocrinology & Metabolic Syndrome · doi:10.4172/2161-1017.1000280 · Cited by 38
“Also, the coordination in the secretion these cytokines is involved in the availability of energy during the gestation [46].”
Background
Cardiac peroxisome-proliferator-activated receptor expression in hypertension co-existing with diabetes
Lee, T.-I., Kao, Y., Chen, Y., Pan, N., Lin, Y., & Chen, Y. (2011) · Clinical Science · doi:10.1042/cs20100529 · Cited by 36
Assessment of sleep and obesity in adults and children
Bonanno, L., Metro, D., Papa, M., Finzi, G., Maviglia, A., Sottile, F., Corallo, F., & Manasseri, L. (2019) · Medicine · doi:10.1097/md.0000000000017642 · Cited by 41
Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1
Sideri, A., Stavrakis, D. G., Bowe, C., Shih, D. Q., Fleshner, P. R., Arsenescu, V., Arsenescu, R. I., Turner, J. R., Pothoulakis, C., & Karagiannides, I. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00269.2014 · Cited by 39
“OBESITY IS AN EPIDEMIC AFFECTING one out of three Americans (8, 38) and a major risk factor for chronic diseases such as diabetes, cardiovascular diseases, and cancer (17, 30).”
BackgroundMethod
Alterations in Lipid and Carbohydrate Metabolism in Patients with Classic Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency
Zimmermann, A., Grigorescu‐Sido, P., Alkhzouz, C., Patberg, K., Bucerzan, S., Schulze, E., Zimmermann, T., Rossmann, H., Geiss, H. C., Lackner, K. J., et al. (2010) · Hormone Research in Paediatrics · doi:10.1159/000313368 · Cited by 38
High-fat diet induced leptin and Wnt expression: RNA-sequencing and pathway analysis of mouse colonic tissue and tumors
Penrose, H. M., Heller, S., Cable, C., Nakhoul, H. N., Baddoo, M., Flemington, E. F., Crawford, S. E., & Savkovic, S. D. (2017) · Carcinogenesis · doi:10.1093/carcin/bgx001 · Cited by 37
Excess Body Weight, Insulin Resistance and Isolated Systolic Hypertension: Potential Pathophysiological Links
D’Elia, L., & Strazzullo, P. (2017) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-017-0240-1 · Cited by 37
“leptin, IL-1, IL-6, TNF-a, etc) impact on both dysregulation of carbohydrate and lipid metabolism and the development of atherosclerotic lesions in the arterial wall of overweight/obese individuals [20, 21].”
Background
Cerebrospinal fluid dynamics modulation by diet and cytokines in rats
Alimajstorovic, Z., Pascual-Baixauli, E., Hawkes, C. A., Sharrack, B., Loughlin, J., Romero, I. A., & Preston, J. E. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-0168-z · Cited by 37
Neopterin predicts the risk for fatal ischemic heart disease in type 2 diabetes mellitus
Vengen, I. T., Dale, A. C., Wiseth, R., Midthjell, K., & Videm, V. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.04.003 · Cited by 37
The Metabolic Syndrome: How to Approach Differing Definitions
Pi‐Sunyer, X. (2007) · Medical Clinics of North America · doi:10.1016/j.mcna.2007.06.004 · Cited by 38
No Association of Pro12Ala Polymorphism of PPAR-.GAMMA. Gene With Coronary Artery Disease in Korean Subjects
Rhee, E., Kwon, C. H., Lee, W., Kim, S. Y., Jung, C., Kim, B. J., Sung, K., Kim, B. S., Oh, K. W., Kang, J. H., et al. (2007) · Circulation Journal · doi:10.1253/circj.71.338 · Cited by 37
Monitoring and management of hypertension with obesity in adolescents
Falkner, B. E. (2017) · Integrated Blood Pressure Control · doi:10.2147/ibpc.s125094 · Cited by 40
“33 Similar elevations of these cytokines have been reported in obese adolescents.”
Effects of Two Variants of Roux-en-Y Gastric Bypass on Metabolism Behaviour: Focus on Plasma Ghrelin Concentrations Over a 2-Year Follow-up
Pérez, N., Serra, A., Granada, M. L., Rull, M., Alastrué, A., Navarro-Díaz, M., Romero, R., & Fernández-Llamazares, J. (2009) · Obesity Surgery · doi:10.1007/s11695-009-0035-0 · Cited by 36
“The different roles of adipocytokines in processes such as insulin sensitivity and vascular inflammation [ 20 , 21] have been studied.”
Background
Adipokines--targeting a root cause of cardiometabolic risk
Bakhai, A. (2008) · QJM · doi:10.1093/qjmed/hcn066 · Cited by 37
Obesity as a risk factor for severe acute pancreatitis patients
Kaťuchová, J., Bober, J., Harbul'ák, P., Hudák, A., Gajdzik, T., Kalanin, R., & Radoňak, J. (2014) · Wiener klinische Wochenschrift · doi:10.1007/s00508-014-0507-7 · Cited by 36
Body mass index and colon cancer screening: The road ahead
Tandon, K. S. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i5.1371 · Cited by 35
Effect of Peroxisome Proliferator‐activated Receptor‐α Ligands in the Interaction Between Adipocytes and Macrophages in Obese Adipose Tissue
Toyoda, T., Kamei, Y., Kato, H., Sugita, S., Takeya, M., Suganami, T., & Ogawa, Y. (2008) · Obesity · doi:10.1038/oby.2008.62 · Cited by 35
“There is considerable evidence that obesity is a state of chronic lowgrade inflammation (3,4).”
Background
Relationship between severe obesity and gut inflammation in children: what's next?
Spagnuolo, M. I., Cicalese, M. P., Caiazzo, M. A., Franzese, A., Squeglia, V., Assante, L. R., Valerio, G., Merone, R., & Guarino, A. (2010) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/1824-7288-36-66 · Cited by 35
“Obesity is associated with a chronic low-grade inflammation [6-9] and inflammatory pathways could be critical in the mechanisms underlying obesity and its complications, although the factors triggering the inflammatory response are not known, especially in humans [9].”
Background
Insulin resistance and the endothelium
Quiñones, M. J., Nicholas, S. B., & Lyon, C. J. (2005) · Current Diabetes Reports · doi:10.1007/s11892-005-0018-z · Cited by 35
Self-citation
Purple Sweet Potato Leaf Extract Induces Apoptosis and Reduces Inflammatory Adipokine Expression in 3T3-L1 Differentiated Adipocytes
Lee, S.-L., Chin, T., Tu, S.-C., Wang, Y.-J., Hsu, Y., Kao, M., & Wu, Y. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/126302 · Cited by 34
“Reduction of adipose tissue mass correlates with decrease in serum adipokine levels [29].”
The Impact of Visceral Fat Accumulation on Laparoscopy-Assisted Distal Gastrectomy for Early Gastric Cancer
Ueda, J., Ichimiya, H., Okido, M., & Kato, M. (2009) · Journal of Laparoendoscopic & Advanced Surgical Techniques · doi:10.1089/lap.2008.0113 · Cited by 34
“27 It has been shown recently that adipose tissue secretes inflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-6 (IL-6), and that IL-6 production by human adipose tissue increases with obesity.”
Inverse Relationship between Serum Lipoxin A4 Level and the Risk of Metabolic Syndrome in a Middle-Aged Chinese Population
Yu, D., Xu, Z., Yin, X., Zheng, F., Lin, X., Pan, Q., & Li, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142848 · Cited by 35
Erratum: Significant association of TREM-1 with HMGB1, TLRs and RAGE in the pathogenesis of insulin resistance in obese diabetic populations.
Subramanian, S., Pallati, P. K., Sharma, P., Agrawal, D. K., & Nandipati, K. C. (2017) · Europe PMC (PubMed Central) · Cited by 34
Glycyrrhetinic Acid Improves Insulin-Response Pathway by Regulating the Balance between the Ras/MAPK and PI3K/Akt Pathways
Zhang, Y., Yang, S., Zhang, M., Wang, Z., He, X., Hou, Y., & Bai, G. (2019) · Nutrients · doi:10.3390/nu11030604 · Cited by 39
Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3‐L1 adipocytes
Xu, A., Wong, L. C., Wang, Y., Xu, J. Y., Cooper, G. J. S., & Lam, K. S. L. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.020 · Cited by 34
Abdominal Obesity and Cardiovascular Disease Risk
Lee, Y., & Pratley, R. E. (2007) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/01.hcr.0000265014.36587.dd · Cited by 34
cAMP-response element binding protein (CREB) positively regulates mouse adiponectin gene expression in 3T3-L1 adipocytes
Kim, H. B., Kim, W., Han, K. L., Park, J. H., Lee, J., Yeo, J., & Jung, M. H. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.11.111 · Cited by 33
Serum IL-1ra, a novel biomarker predicting olanzapine-induced hypercholesterolemia and hyperleptinemia in schizophrenia
Lin, Y., Peng, Y., He, S., Xu, J., Shi, Y., Su, Y., Zhu, C., Zhang, X., Zhou, R., & Cui, D. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.020 · Cited by 34
“Many cytokines have been speculated to be involved in metabolic diseases and CVD like IR, diabetes mellitus (DM), hypertension (HTN) and coronary artery disease (CAD) (Lyon et al., 2003).”
Background
Relationship between resistin level in serum and acute coronary syndrome or stable angina pectoris
Qiao, X.-Z., Yang, Y., Xu, Z., & Yang, L.-A. (2007) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.2007.b0875 · Cited by 33
“Studies have revealed that adipocytes synthesize and secrete a number of biologically active molecules ( Lyon et al., 2003 ), so called adipokines, including tumor necrosis factor-α (TNF-α), leptin, interleukin-6 (IL-6), plasminogen activator inhibitor-1, adiponectin, and resistin (Hotamisligil and Spiegelman, 1994; M…”
Background
Obstructive sleep apnea syndrome: coagulation anomalies and treatment with continuous positive airway pressure
Toraldo, D. M., Benedetto, M. D., Scoditti, E., & Nuccio, F. D. (2015) · Sleep And Breathing · doi:10.1007/s11325-015-1227-6 · Cited by 34
“Several mechanisms, such as systemic inflammation and oxidative stress, endothelial dysfunction, disturbances of lipid metabolism and insulin resistance, also contribute to the hypercoagulable state in obesity [83].”
Background
The metabolic syndrome and the risk of thrombosis
Dentali, F., Romualdi, E., & Ageno, W. (2007) · Haematologica · doi:10.3324/haematol.11243 · Cited by 33
Antagonizing the cannabinoid receptor Type 1: A dual way to fight obesity
Cota, D., Genghini, S., Pasquali, R., & Pagotto, U. (2003) · Journal of Endocrinological Investigation · doi:10.1007/bf03348205 · Cited by 33
MK-0767, a novel dual PPARα/γ agonist, displays robust antihyperglycemic and hypolipidemic activities
Doebber, T. W., Kelly, L. J., Zhou, G., Meurer, R. D., Biswas, C., Li, Y., Wu, M. S., Ippolito, M. C., Chao, Y., Wang, P.-R., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.04.032 · Cited by 33
Metabolic Syndrome, Testosterone, and Cardiovascular Mortality in Men
Lin, J., Lee, J., Wu, C., Caffrey, J. L., Chang, M., Hwang, J., Dowling, N. F., & Lin, Y.-S. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02343.x · Cited by 32
RETRACTED ARTICLE: TREM-1 associated macrophage polarization plays a significant role in inducing insulin resistance in obese population
Subramanian, S., Pallati, P. K., Sharma, P., Agrawal, D. K., & Nandipati, K. C. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1187-7 · Cited by 32
“This may be due to its anatomical location and access to the portal circulation [45].”
Background
Retracted
Overexpressing STAMP2 Improves Insulin Resistance in Diabetic ApoE−/−/LDLR−/− Mice via Macrophage Polarization Shift in Adipose Tissues
Han, L., Tang, M., Ti, Y., Wang, Z., Wang, J., Ding, W.-Y., Wang, H., Zhang, Y., Zhang, W., & Zhong, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078903 · Cited by 32
“The unbalance of production of pro-inflammatory and antiinflammatory cytokines in adipose tissues is associated with insulin resistance [6,7].”
Background
A Framework for the Concurrent Consideration of Occupational Hazards and Obesity
Schulte, P. A., Wagner, G. R., Downes, A., & Miller, D. B. (2008) · The Annals of Occupational Hygiene · doi:10.1093/annhyg/men055 · Cited by 32
Proteomic analysis of adipocyte differentiation: Evidence that α2 macroglobulin is involved in the adipose conversion of 3T3 L1 preadipocytes
Choi, K., Wang, Y., Tse, C. A., Lam, K. S. L., Cooper, G. J. S., & Xu, A. (2004) · PROTEOMICS · doi:10.1002/pmic.200300697 · Cited by 32
Natural killer cell activity and sensitivity to positive and negative modulation in uncomplicated obese subjects: relationships to leptin and diet composition
Dovio, A., Caramello, V., Masera, R. G., Sartori, M. L., Saba, L., Tinivella, M., Prolo, P., Termine, A., Avagnina, P., & Angeli, A. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802639 · Cited by 32
Marked Increase in White Adipose Tissue Blood Perfusion in the Type 2 Diabetic GK Rat
Kampf, C., Bodin, B., Källskog, Ö., Carlsson, C., & Jansson, L. E. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2620 · Cited by 32
“These cells can, in addition to adipocytes, also express cytokines and may by themselves affect the production of adipocytokines (50).”
Background
Physical Exercise Restores Microvascular Function in Obese Rats with Metabolic Syndrome
Machado, M. V. R., Vieira, A. B., do Nascimento, A. R., Martins, R. L., Daleprane, J. B., Lessa, M. A., & Tibiriçá, E. V. (2014) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2014.0040 · Cited by 31
Anti‐contractile effects of perivascular adipose tissue in thoracic aorta from rats fed a high‐fat diet: role of aerobic exercise training
Araújo, H. N., Victorio, J. A., da Silva, C. P. V., Sponton, A. C. D. S., Vettorazzi, J. F., de Moraes, C., Davel, A. P., Zanesco, A., & Delbin, M. A. (2017) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12882 · Cited by 31
Differential changes in vascular mRNA levels between rat iliac and renal arteries produced by cessation of voluntary running
Padilla, J., Jenkins, N. T., Roberts, M. D., Arce‐Esquivel, A. A., Martin, J. S., Laughlin, M. H., & Booth, F. W. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2012.066076 · Cited by 31
“The cross-talk between adipose tissue and vascular cells is, in fact, well recognized in the literature (Esposito et al. 2002; Lyon et al. 2003; Hutley & Prins, 2005; Ritchie & Connell, 2007; Ouwens et al. 2010; Ohman et al. 2011; Vykoukal & Davies, 2011).”
Oncostatin M decreases adiponectin expression and induces dedifferentiation of adipocytes by JAK3- and MEK-dependent pathways
Song, H. Y., Kim, M. R., Lee, M. J., Jeon, E. S., Bae, Y. C., Jung, J. S., & Kim, J. H. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.014 · Cited by 32
Influence of CRP, IL6, and TNFA Gene Polymorphisms on Circulating Levels of C-Reactive Protein in Mexican Adolescents
Mendoza‐Carrera, F., Ramı́rez-López, G., Ayala-Martínez, N. A., Garcı́a-Zapién, A. G., Flores-Martínez, S. E., & Sánchez‐Corona, J. (2010) · Archives of Medical Research · doi:10.1016/j.arcmed.2010.08.015 · Cited by 31
Newly discovered endocrine functions of white adipose tissue: possible relevance in obesity-related diseases
Krug, A. W., & Ehrhart‐Bornstein, M. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-4555-z · Cited by 31
Plasma Adhesion and Inflammation Markers: Asymmetrical Dimethyl-L-Arginine and Secretory Phospholipase A2 Concentrations before and after Laparoscopic Gastric Banding in Morbidly Obese Patients
Konukoğlu, D., Uzun, H., Fırtına, S., Arica, P. Ç., Kocael, A., & Taşkın, M. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9113-3 · Cited by 31
Inflammatory Gene Expression Patterns Revealed by DNA Microarray Analysis in TNF-α-treated SGBS Human Adipocytes
Do, M., Jeong, H.-S., Choi, B.-H., Hunter, L., Langley, S., Pazmany, L., & Trayhurn, P. (2006) · Yonsei Medical Journal · doi:10.3349/ymj.2006.47.5.729 · Cited by 31
“The expression of endothelial adhesion molecules, including vascular cell adhesion molecule-1, endothelial-leukocyte adhesion molecule-1, and intracellular adhesion molecule-1, plays a pivotal role in monocyte adhesion to the arterial endothelium.(13) The expression of MCP-1, eotaxin-1, and VCAM1 in TNF- -treated SGBS…”
Background
Angiopoietin-1 Attenuates H2O2-induced SEK1/JNK Phosphorylation through the Phosphatidylinositol 3-Kinase/Akt Pathway in Vascular Endothelial Cells
Murakami, T., Takagi, H., Suzuma, K., Suzuma, I., Ohashi, H., Watanabe, D., Ojima, T., Suganami, E., Kurimoto, M., Kaneto, H., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503108200 · Cited by 31
The dipeptidyl peptidase-4 inhibitor-sitagliptin modulates calcium dysregulation, inflammation, and PPARs in hypertensive cardiomyocytes
Lee, T.-I., Kao, Y.-H., Chen, Y.-C., Huang, J.-H., Hsu, M., & Chen, Y.-J. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.08.051 · Cited by 30
Anti-TNF-α Agent Tamarind Kunitz Trypsin Inhibitor Improves Lipid Profile of Wistar Rats Presenting Dyslipidemia and Diet-induced Obesity Regardless of PPAR-γ Induction
de Carvalho, F. M. C., de Lima, V. C. O., Costa, I. D. S., Luz, A. B. S., Ladd, F. V. L., Serquiz, A. C., Bortolin, R. H., Silbiger, V. N., Maciel, B. L. L., dos Santos, E. A., et al. (2019) · Nutrients · doi:10.3390/nu11030512 · Cited by 30
Physiological process of fat loss
El-Zayat, S. R., Sibaii, H., & El-Shamy, K. A. (2019) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-019-0238-z · Cited by 40
“2) (Lyon et al. 2003; Trayhurn and Wood 2004; Eckel et al. 2005; Guerre and Millo 2011).”
Immunological & metabolic responses to a therapeutic course of Basti in obesity
Thatte, U. M., Kulkarni, A., Ghungralkar, R., Panchal, F. H., Vetale, S., Teli, P., Kumbhar, D. A., Munshi, R., Chiplunkar, S. V., & Bhalerao, S. S. (2015) · The Indian Journal of Medical Research · doi:10.4103/0971-5916.162099 · Cited by 30
Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice
Dube, M. G., Torto, R., & Kalra, S. P. (2008) · Peptides · doi:10.1016/j.peptides.2008.01.001 · Cited by 32
A Diet High in Saturated Fat and Cholesterol Accelerates Simian Immunodeficiency Virus Disease Progression
Mansfield, K. G., Carville, A., Wachtman, L. M., Goldin, B. R., Yearley, J. H., Li, W., Woods, M. N., Gualtieri, L. N., Shannon, R. P., & Wanke, C. A. (2007) · The Journal of Infectious Diseases · doi:10.1086/521680 · Cited by 30
“Rather than an inert collection of cells, white adipose tissue contains macrophages, dendritic cells, and T cells along with active vascular stromal cells, which produce a variety of proinflammatory cytokines and adipokines that may impact the immune system, including tumor necrosis factor (TNF)–a, monocyte chemoattra…”
Effect of Different Types of Dietary Fatty Acids on Subclinical Inflammation in Humans
Lesná, I. K., Suchánek, P., Brabcová, E., Kovář, J., Malínská, H., & Poledne, R. (2013) · Physiological Research · doi:10.33549/physiolres.932439 · Cited by 30
“Key words Diet • Unsaturated fatty acids • Saturated fatty acids • Inflammation Corresponding author I. Králová Lesná, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 14021 Prague 4, Czech Republic.”
BackgroundInfluential
Pathogenesis of Hypertension
Hall, M. E., & Hall, J. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-42973-3.00005-6 · Cited by 36
Elevated serum γ-glutamyltransferase levels are independently associated with insulin resistance in non-diabetic subjects
Shin, J. Y., Chang, S. J., Shin, Y. G., Seo, K.-S., & Chung, C. H. (2009) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.02.004 · Cited by 30
Hemodynamic Evaluation Before Liver Transplantation
Blei, A. T., Mazhar, S. M., Davidson, C. J., Flamm, S. L., Abecassis, M. M., & Gheorghiade, M. (2007) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318157188e · Cited by 29
Evaluation of Hypercoagulability in Obese Children With Thrombin Generation Test and Microparticle Release: Effect of Metabolic Parameters
Şıklar, Z., Öçal, G., Berberoğlu, M., Hacıhamdioğlu, B., Erdeve, Ş. S., Eğin, Y., & Akar, N. (2011) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029611404216 · Cited by 29
“Adipose tissue produces adipokines such as tumor necrosis factor (TNF) and interleukin-6 (IL-6) that contribute to systemic and vascular inflammation.(24) It was inevitable that the levels of adipokines augments with increasing adipose tissue.”
Background
Testosterone replacement therapy improves the health-related quality of life of men diagnosed with late-onset hypogonadism
Almehmadi, Y., Yassin, A. A., Nettleship, J. E., & Saad, F. (2015) · Arab Journal of Urology · doi:10.1016/j.aju.2015.10.002 · Cited by 31
Higher Sodium Intake Assessed by 24 Hour Urinary Sodium Excretion Is Associated with Non-Alcoholic Fatty Liver Disease: The PREVEND Cohort Study
van den Berg, E. H., Gruppen, E. G., Blokzijl, H., Bakker, S. J. L., & Dullaart, R. P. F. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122157 · Cited by 28
“Indeed, high sodium induces lipogenesis and inflammatory adipocytokine secretion in adipocytes, which may provide a possible mechanism for inflammatory adipogenesis in sodium-linked obesity [41], and in turn may also play a role in accelerated NAFLD development [42].”
Background
Metabolic effects associated with adipose tissue distribution.
Zahorska‐Markiewicz, B. (2006) · PubMed · Cited by 28
Association between body composition and retinal vascular caliber in children and adolescents
Xiao, W., Gong, W., Chen, Q., Ding, X., Chang, B., & He, M. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-14946 · Cited by 27
“Leptin, which is increased in obese individuals, can alter NO synthesis and lead to vasodilation.(31) Third, in obese subjects, preinflammatory factors, such as TNF-a, expressed in adipose tissue could play a direct role in venular widening.”
Background
Early and prolonged intake of partially hydrogenated fat alters the expression of genes in rat adipose tissue
Duque-Guimaraes, D. E., de Castro, J., Martínez-Botas, J., Sardinha, F. L. C., Ramos, P., Herrera, E., & do Carmo, M. D. G. T. (2009) · Nutrition · doi:10.1016/j.nut.2008.12.004 · Cited by 27
“[3] Lyon CJ, Law RE, Hsueh W.”
Background
A Proposed Inflammatory Score of Circulating Cytokines/Adipokines Associated with Resistant Hypertension, but Dependent on Obesity Parameters
de Faria, A. P., Ritter, A. M. V., Gasparetti, C. S., Corrêa, N. B., Brunelli, V., Almeida, A. R., Pires, N. F., Modolo, R., & Moreno, H. (2019) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20190032 · Cited by 27
Association Between Non-Alcoholic Fatty Liver Disease and Cardiovascular Disease: A First Message Should Pass
Picardi, A., & Gentilucci, U. V. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.02196.x · Cited by 27
“Conversely, those who consider NAFLD nothing more than an epiphenomenon can argue that all the studies in which independent associations between NAFLD and any altered cardiovascular marker of interest were found (7–10, 12,13) did not adequately control for visceral adipose tissue and insulin resistance, the undisputed…”
Background
Does orthodontic tooth movement cause an elevation in systemic inflammatory markers?
MacLaine, J., Rabie, A. B. M., & Wong, R. (2009) · European Journal of Orthodontics · doi:10.1093/ejo/cjp108 · Cited by 29
Single-nucleotide polymorphisms at five loci are associated with C-reactive protein levels in a cohort of Filipino young adults
Curocichin, G., Wu, Y., McDade, T. W., Kuzawa, C. W., Borja, J. B., Li, Q., Lange, E. M., Adair, L. S., Lange, L. A., & Mohlke, K. L. (2011) · Journal of Human Genetics · doi:10.1038/jhg.2011.106 · Cited by 27
Type 2 diabetes in Singapore: the role of exercise training for its prevention and management.
Lim, J. G., Kang, H., & Stewart, K. J. (2004) · PubMed · Cited by 27
Metabolic syndrome in drug naïve schizophrenic patients
Anjum, S., Bathla, M., Panchal, S., Singh, G. P., & Singh, M. (2017) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2017.11.006 · Cited by 26
Visfatin, resistin, hsCRP and insulin resistance in relation to abdominal obesity in women with rheumatoid arthritis.
Straburzyńska‐Lupa, A., Nowak, A., Pilaczyńska-Szczȩśniak, Ł., Straburzyńska‐Migaj, E., Romanowski, W., Karolkiewicz, J., & Śliwicka, E. (2010) · PubMed · Cited by 26
A non-invasive prediction model for non-alcoholic steatohepatitis in paediatric patients with non-alcoholic fatty liver disease
Eng, K., López, R., Liccardo, D., Nobili, V., & Alkhouri, N. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2014.07.016 · Cited by 26
Prognostic Value of Circulating Cytokines on Overall Survival and Disease-Free Survival in Cancer Patients
Visconti, L. M., Nelissen, K., Deckx, L., van den Akker, M., Adriaensen, W. J., Daniëls, L., Matheï, C., Linsen, L., Hellings, N., Stinissen, P., et al. (2014) · Biomarkers in Medicine · doi:10.2217/bmm.13.122 · Cited by 26
Plasminogen Activator Inhibitor‐1 and Diagnosis of the Metabolic Syndrome in a West African Population
Kodaman, N. M., Aldrich, M. C., Sobota, R. S., Asselbergs, F. W., Brown, N. J., Moore, J. H., & Williams, S. M. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003867 · Cited by 26
“Although circulating PAI-1 is mainly released by hepatic and endothelial cells, adipose tissue becomes a major source as visceral adiposity increases, which also has been implicated in increased inflammation and coronary heart disease.(12,13) High PAI-1 may also predispose patients to premature atherosclerosis not onl…”
Background
Human Metabolism: A Regulatory Perspective
Murray, A. D. (2019) · Physiology News · doi:10.36866/pn.116.19 · Cited by 28
The renin angiotensin system as a therapeutic target to prevent diabetes and its complications
Vijayaraghavan, K., & DEEDWANIA, P. C. (2005) · Cardiology Clinics · doi:10.1016/j.ccl.2004.11.003 · Cited by 24
“Endothelial function improves with exercise, a low-fat, low-carbohydrate diet, and with use of statins and ACE inhibitors (Table 5) [29,59,67].”
BackgroundInfluential
The relationship between visfatin and serum concentrations of C-reactive protein, interleukin 6 in patients with metabolic syndrome
Hosseinzadeh‐Attar, M. J., Golpaie, A., Foroughi, M., Hosseinpanah, F., Zahediasl, S., & Azizi, F. (2016) · Journal of Endocrinological Investigation · doi:10.1007/s40618-016-0457-1 · Cited by 25
Inflammatory mediators involved in the progression of the metabolic syndrome
Ma, K., Jin, X., Liang, X., Zhao, Q. D., & Zhang, X. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2291 · Cited by 24
“Population-based studies show significant correlations between these pro-inflammatory markers and deterioration of glycemic control, obesity and arteriosclerosis [12].”
Background
The relationships between bariatric surgery and sexual function: current evidence based medicine
Liu, S., Cao, D., Ren, Z., Li, J., Peng, L., Zhang, Q., Cheng, B., Cheng, Z., Ai, J., Zheng, X. S., et al. (2020) · BMC Urology · doi:10.1186/s12894-020-00707-1 · Cited by 24
Time-restricted feeding prevents high-fat and high-cholesterol diet-induced obesity but fails to ameliorate atherosclerosis in apolipoprotein E-knockout mice
Inoue, K.-I., Toyoda, S., Jojima, T., Abe, S., Sakuma, M., & Inoue, T. (2020) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.20-0112 · Cited by 24
Fat-to-muscle Ratio: A New Indicator for Coronary Artery Disease in Healthy Adults
Eun, Y., Lee, S. N., Song, S.-W., Kim, H.-N., Kim, S., Lee, Y.-A., Kang, S. G., Rho, J.-S., & Yoo, K. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.62871 · Cited by 24
“Fat and muscle are important body tissues for metabolic regulation [4, 5], and it is known that an imbalance between fat and muscle is associated with atherosclerosis and cardiovascular disease [6, 7].”
Background
Cardiovascular diseases and erectile dysfunction: the two faces of the coin of androgen deficiency
Yassin, A. A., Akhras, F., El‐Sakka, A. I., & Saad, F. (2010) · Andrologia · doi:10.1111/j.1439-0272.2009.01021.x · Cited by 24
“Visceral fat cells secrete a large number of cytokines which impair testicular steroidogenesis (Lyon et al., 2003; Trayhurn & Wood, 2004; Eckel et al., 2005).”
Background
The association between impaired collateral circulation and non-alcoholic fatty liver in patients with severe coronary artery disease
Arslan, U., Kocaoğlu, İ., Balcı, M. M., Duyuler, S., & Korkmaz, A. (2012) · Journal of Cardiology · doi:10.1016/j.jjcc.2012.05.003 · Cited by 24
Asthma is associated with cardiovascular disease in a representative population sample
Appleton, S., Ruffin, R. E., Wilson, D. H., Taylor, A. W., & Adams, R. (2008) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2008.04.005 · Cited by 27
“For people with asthma, processes of insulin resistance and atherosclerosis [1] may be contributed to by increases in TNF- related to their asthma, such that asthma may associate with diabetes and cardiovascular disease (CVD).”
Background
Th17 and Treg Balance in Children With Obesity and Metabolically Altered Status
Calcaterra, V., Croce, S., Vinci, F., Silvestri, A. D., Cordaro, E., Regalbuto, C., Zuccotti, G., Mameli, C., Albertini, R., & Avanzini, M. A. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.591012 · Cited by 23
“During the development of an overweight or obese state, the adipose tissue undergoes morphological and secretive changes leading to a Th1 bias and a chronic state of inflammation (1, 11–17) that is involved in the development of numerous complications, such as insulinresistance, hypertension, and dyslipidemia (18, 20,…”
Background

Authors: Lyon, C. J., Law, R. E., & Hsueh, W. A.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Hsueh, Willa A.
ORCID: Lyon, Christopher J.
Hsueh, Willa A.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2003-06-01
Volume: 144
Issue: 6
Pages: 2195-2200
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2003-0285
OpenAlex: W1981444005
Cited by: 761
References: 121
Citations by year: 2026: 6 · 2025: 4 · 2024: 7 · 2023: 11 · 2022: 15 · 2021: 12 · 2020: 16 · 2019: 42 · 2018: 23 · 2017: 31 · 2016: 20 · 2015: 39 · 2014: 31 · 2013: 31 · 2012: 37
FWCI: 9.73
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (1P01 HIG0030-01A1)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: adiposity, adipokines, atherosclerosis, vascular inflammation, visceral adipose tissue, obesity, insulin resistance, hypertension, endothelial dysfunction, vascular remodeling, bariatric surgery, physical activity, caloric restriction, anti-inflammatory agents, hypercholesterolemia
MeSH terms: Adipose Tissue, Animals, Arteriosclerosis, Humans, Obesity, Vasculitis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Minireview: Adiposity, Inflammation, and Atherogenesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks