Cited by 761Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

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Minireview: Adiposity, Inflammation, and Atherogenesis

Lyon, Christopher J., Law, Ronald E., Hsueh, Willa A.·2003·Endocrinology

DOI 10.1210/en.2003-0285

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Abstract

Adipose tissue is a dynamic endocrine organ that secretes a number of factors that are increasingly recognized to contribute to systemic and vascular inflammation. Several of these factors, collectively referred to as adipokines, have now been shown regulate, directly or indirectly, a number of the processes that contribute to the development of atherosclerosis, including hypertension, endothelial dysfunction, insulin resistance, and vascular remodeling. Several adipokines are preferentially expressed in visceral adipose tissue, and the secretion of proinflammatory adipokines is elevated with increasing adiposity. Not surprisingly, approaches that reduce adipose tissue depots, including surgical fat removal, exercise, and reduced caloric intake, improve proinflammatory adipokine levels and reduce the severity of their resultant pathologies. Systemic adipokine levels can also be favorably altered by treatment with several of the existing drug classes used to treat insulin resistance, hypertension, and hypercholesterolemia. Greater understanding of adipokine regulation, however, should result in the design of improved treatment strategies to control disease states associated with increase adiposity, an important outcome in view of the growing worldwide epidemic of obesity.

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Obesidad abdominal: un estandarte del riesgo cardiometabólico
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Adiponectin Ameliorates Endotoxin-Induced Acute Cardiac Injury
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“Some studies suggested adipose tissue secretes factors such as adipokines that contribute to systemic and vascular inflammation, development of atherosclerosis and diabetes complications [8].”
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Vasoactive Factors and Inflammatory Mediators Produced in Adipose Tissue
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High dietary and lifestyle inflammatory scores are associated with increased risk of chronic kidney disease in Iranian adults
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“It has been revealed that adiposity is linked to the higher levels of various inflammatory indicators such as IL-6, TNF-α, and adipokines [37, 38] that, in this way, indirectly lead to disruption of kidney function [39].”
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Inflammatory Markers in Pediatric Obesity
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Metabolic Syndrome and Myocardial Infarction in Women
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Glycemic Associations With Endothelial Function and Biomarkers Among 5 Ethnic Groups: The Multi‐Ethnic Study of Atherosclerosis and the Mediators of Atherosclerosis in South Asians Living in America Studies
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“Resistance is a risk factor not only for diabetes but also for dyslipidemia (1, 2), hypertension (3), cardiovascular disease (2, 4), colon cancer (5, 6), and possibly breast cancer (7).”
Background
Predicted Fat Mass, Lean Body Mass, and Risk of Hypertension: Results from a Chinese Male Cohort Study
Li, M., Lin, J., Liang, S., Huang, S., Wen, Z. X., & Mo, Z. (2022) · Obesity Facts · doi:10.1159/000524653 · Cited by 14
Reduction of PP2A Cα stimulates adipogenesis by regulating the Wnt/GSK-3β/β-catenin pathway and PPARγ expression
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Differential effects of energy balance on experimentally-induced colitis
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“In addition, there is a greater likelihood that insulin resistance and endothelial dysfunction will progress to type 2 diabetes and atherosclerosis in people with central obesity [11].”
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GW4064, a farnesoid X receptor agonist, upregulates adipokine expression in preadipocytes and HepG2 cells
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Correlation between Insulin Resistance Surrogates and Echocardiographic Findings in Asymptomatic Patients with Morbid Obesity: A Cross-Sectional Study
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Reduced plasma adiponectin in NASH
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Expression of Steroid Receptor RNA Activator 1 (SRA1) in the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity
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“Adicionalmente, o TNF-α atua sinergicamente com outras citocinas (interleucina 6 – IL-6, proteína C Reativa – PCR e Resistina), também secretadas pelos adipócitos durante a ativação de processos inflamatórios, ampliando o risco de injúrias endoteliais, diminuindo os fatores de relaxamento e elevando os fatores de cont…”
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Degradation of proinsulin C-peptide in kidney and placenta extracts by a specific endoprotease activity
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CYP450, COX-2 and Obesity Related Renal Damage
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Síndrome metabólica e artrite idiopática juvenil
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“Concomitant production of inflammatory and vasoconstrictor factors (TNFa, IL-6, angiotensin-II, endothelin-1, and other metabolites of arachidonic acid) would lead to retinal arteriolar narrowing (26,27).”
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Body-mass Index and Health
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Authors: Lyon, C. J., Law, R. E., & Hsueh, W. A.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Hsueh, Willa A.
ORCID: Lyon, Christopher J.
Hsueh, Willa A.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2003-06-01
Volume: 144
Issue: 6
Pages: 2195-2200
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2003-0285
OpenAlex: W1981444005
Cited by: 761
References: 121
Citations by year: 2026: 6 · 2025: 4 · 2024: 7 · 2023: 11 · 2022: 15 · 2021: 12 · 2020: 16 · 2019: 42 · 2018: 23 · 2017: 31 · 2016: 20 · 2015: 39 · 2014: 31 · 2013: 31 · 2012: 37
FWCI: 9.73
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (1P01 HIG0030-01A1)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: adiposity, adipokines, atherosclerosis, vascular inflammation, visceral adipose tissue, obesity, insulin resistance, hypertension, endothelial dysfunction, vascular remodeling, bariatric surgery, physical activity, caloric restriction, anti-inflammatory agents, hypercholesterolemia
MeSH terms: Adipose Tissue, Animals, Arteriosclerosis, Humans, Obesity, Vasculitis

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