Cited by 761Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

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Minireview: Adiposity, Inflammation, and Atherogenesis

Lyon, Christopher J., Law, Ronald E., Hsueh, Willa A.·2003·Endocrinology

DOI 10.1210/en.2003-0285

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Abstract

Adipose tissue is a dynamic endocrine organ that secretes a number of factors that are increasingly recognized to contribute to systemic and vascular inflammation. Several of these factors, collectively referred to as adipokines, have now been shown regulate, directly or indirectly, a number of the processes that contribute to the development of atherosclerosis, including hypertension, endothelial dysfunction, insulin resistance, and vascular remodeling. Several adipokines are preferentially expressed in visceral adipose tissue, and the secretion of proinflammatory adipokines is elevated with increasing adiposity. Not surprisingly, approaches that reduce adipose tissue depots, including surgical fat removal, exercise, and reduced caloric intake, improve proinflammatory adipokine levels and reduce the severity of their resultant pathologies. Systemic adipokine levels can also be favorably altered by treatment with several of the existing drug classes used to treat insulin resistance, hypertension, and hypercholesterolemia. Greater understanding of adipokine regulation, however, should result in the design of improved treatment strategies to control disease states associated with increase adiposity, an important outcome in view of the growing worldwide epidemic of obesity.

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Authors: Lyon, C. J., Law, R. E., & Hsueh, W. A.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Hsueh, Willa A.
ORCID: Lyon, Christopher J.
Hsueh, Willa A.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2003-06-01
Volume: 144
Issue: 6
Pages: 2195-2200
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2003-0285
OpenAlex: W1981444005
Cited by: 761
References: 121
Citations by year: 2026: 6 · 2025: 4 · 2024: 7 · 2023: 11 · 2022: 15 · 2021: 12 · 2020: 16 · 2019: 42 · 2018: 23 · 2017: 31 · 2016: 20 · 2015: 39 · 2014: 31 · 2013: 31 · 2012: 37
FWCI: 9.73
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (1P01 HIG0030-01A1)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: adiposity, adipokines, atherosclerosis, vascular inflammation, visceral adipose tissue, obesity, insulin resistance, hypertension, endothelial dysfunction, vascular remodeling, bariatric surgery, physical activity, caloric restriction, anti-inflammatory agents, hypercholesterolemia
MeSH terms: Adipose Tissue, Animals, Arteriosclerosis, Humans, Obesity, Vasculitis

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