The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Ghrelin and Des-Octanoyl Ghrelin Promote Adipogenesis Directly in Vivo by a Mechanism Independent of the Type 1a Growth Hormone Secretagogue Receptor
Open accessAbstract
Ghrelin promotes fat accumulation, despite potent stimulation of the lipolytic hormone, GH. The function of the major circulating isoform of ghrelin, des-octanoyl ghrelin, is unclear, because it does not activate the GH secretagogue receptor (GHS-R1a) and lacks the endocrine activities of ghrelin. We have now addressed these issues by infusing ghrelin, des-octanoyl ghrelin, or synthetic GHS-R1a agonists into three rat models with moderate, severe, or total GH deficiency. We show that in the context of significant GH secretion, the adipogenic effect of systemic ghrelin infusion is pattern dependent. However, this adipogenic action is not mediated by the pituitary hormones. Using a novel unilateral local infusion strategy, we demonstrate that ghrelin promotes bone marrow adipogenesis in vivo by a direct peripheral action. Surprisingly, this effect was also observed with des-octanoyl ghrelin, whereas a potent synthetic GHS-R1a agonist was ineffective. Thus, these adipogenic effects are mediated by a receptor other than GHS-R1a. This is the first in vivo demonstration of a direct adipogenic effect of des-octanoyl ghrelin, a major circulating form of ghrelin that lacks GH-releasing activity. We suggest that the ratio of ghrelin and des-octanoyl ghrelin production could help regulate the balance between adipogenesis and lipolysis in response to nutritional status.
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Cites
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
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A role for ghrelin in the central regulation of feeding
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“Firstly, activation of hypothalamic feeding centers by ghrelin (7, 8) may increase substrate availability, thereby giving rise to adipogenesis.”
BackgroundLeptin Inhibits Bone Formation through a Hypothalamic Relay
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Cited by
Müller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.03.005 · Cited by 1,034
Ghrelin and the short- and long-term regulation of appetite and body weight
Cummings, D. E. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.022 · Cited by 620
Korner, J., Bessler, M., Cirilo, L. J., Conwell, I. M., Daud, A., Restuccia, N. L., & Wardlaw, S. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1076 · Cited by 417
Exercise-induced suppression of acylated ghrelin in humans
Broom, D. R., Stensel, D. J., Bishop, N. C., Burns, S. F., & Miyashita, M. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00759.2006 · Cited by 294
Liu, J., Prudom, C. E., Nass, R., Pezzoli, S. S., Oliveri, M. C., Johnson, M. L., Veldhuis, P., Gordon, D. A., Howard, A. D., Witcher, D. R., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2235 · Cited by 248
Ghrelin regulation of glucose metabolism
Poher, A.-L., Tschöp, M. H., & Müller, T. D. (2018) · Peptides · doi:10.1016/j.peptides.2017.12.015 · Cited by 186
Actions and therapeutic pathways of ghrelin for gastrointestinal disorders
Camilleri, M., Papathanasopoulos, A., & Odunsi, S. T. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.72 · Cited by 115
Role of endogenous ghrelin in growth hormone secretion, appetite regulation and metabolism
Dimaraki, E. V., & Jaffe, C. A. (2007) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-006-9022-0 · Cited by 84
Bahrami-Nejad, Z., Zhao, M. L., Tholen, S., Hunerdosse, D., Tkach, K. E., van Schie, S., Chung, M., & Teruel, M. N. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.012 · Cited by 65
Stievenard, A., Méquinion, M., Andrews, Z. B., Destée, A., Chartier-Harlin, M.-C., Viltart, O., & Vanbesien-Mailliot, C. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.021 · Cited by 39
A talk between fat tissue, gut, pancreas and brain to control body weight
Wilson, J. L., & Enriori, P. J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.08.022 · Cited by 39
Metadata
- Authors
- Thompson, N. M., Gill, D. A. S., Davies, R., Loveridge, N., Houston, P. A., Robinson, I. C. A. F., & Wells, T.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2004-01-01
- Volume
- 145
- Issue
- 1
- Pages
- 234-242
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2077982572
- Cited by
- 416
- References
- 4
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
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