Exercise-induced suppression of acylated ghrelin in humans
Abstract
Ghrelin is an orexigenic hormone secreted from endocrine cells in the stomach and other tissues. Acylation of ghrelin is essential for appetite regulation. Vigorous exercise induces appetite suppression, but this does not appear to be related to suppressed concentrations of total ghrelin. This study examined the effect of exercise and feeding on plasma acylated ghrelin and appetite. Nine male subjects aged 19-25 yr participated in two, 9-h trials (exercise and control) in a random crossover design. Trials began at 0800 in the morning after an overnight fast. In the exercise trial, subjects ran for 60 min at 72% of maximum oxygen uptake between 0800 and 0900. After this, they rested for 8 h and consumed a test meal at 1100. In the control trial, subjects rested for 9 h and consumed a test meal at 1100. Area under the curve values for plasma acylated ghrelin concentration (assessed from venous blood samples) were lower over the first 3 h and the full 9 h of the exercise trial compared with the control trial: 317+/-135 vs. 510+/-186 pg.ml(-1).3 h and 917+/-342 vs. 1,401+/-521 pg.ml(-1).9 h (means+/-SE) respectively (P<0.05). Area under the curve values for hunger (assessed using a visual scale) were lower over the first 3 h of the exercise trial compared with the control trial (P=0.013). These findings demonstrate that plasma acylated ghrelin concentration and hunger are suppressed during running.
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A single bout of vigorous intensity exercise suppresses appetite during and in the immediate post-exercise period.
“evidence suggests a single bout of vigorous intensity exercise suppresses appetite during and in the immediate post-exercise period (Broom et al., 2007).”
From Influence of water-based exercise on energy intake, appetite, and appetite-related hormones in adults: A systematic review and meta-analysis (2023) · cites this paper as Broom et al., 2007
Vigorous land-based exercise suppresses hunger at intensities typically greater than 60-65% of VO2max.
“It is well established that vigorous land-based exercise suppresses hunger at intensities typically >60-65% of VO 2 max (Broom et al., 2007;Holliday & Blannin, 2017).”
From Influence of water-based exercise on energy intake, appetite, and appetite-related hormones in adults: A systematic review and meta-analysis (2023) · cites this paper as Broom et al., 2007
Morning exercise can suppress daytime hunger and levels of acylated ghrelin.
“Morning exercise can suppress daytime hunger and levels of acylated ghrelin (Broom et al., 2007).”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Broom et al., 2007
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- Authors
- Broom, D. R., Stensel, D. J., Bishop, N. C., Burns, S. F., & Miyashita, M.
- Affiliations
- Loughborough University (GB)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2007-06
- Volume
- 102
- Issue
- 6
- Pages
- 2165-2171
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2171137693
- Cited by
- 294
- References
- 55
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 10 · 2023: 12 · 2022: 11 · 2021: 16 · 2020: 12 · 2019: 14 · 2018: 13 · 2017: 25 · 2016: 11 · 2015: 18 · 2014: 26 · 2013: 30 · 2012: 18
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- SHURA (Sheffield Hallam University Research Archive) (Sheffield Hallam University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- ghrelin, acylated ghrelin, physical activity, appetite regulation, hunger, running, plasma ghrelin concentration, meal ingestion, appetite suppression
- MeSH terms
- Acylation, Adult, Appetite, Exercise Test, Physical Exertion, Humans, Male, Physical Endurance, Running, Peptide Hormones, Ghrelin
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