The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Androgens Regulate Phosphodiesterase Type 5 Expression and Functional Activity in Corpora Cavernosa
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“In animals, the pharmacological activity of PDE5 inhibitors appears to be androgen-dependent;1,9 indeed the expression of PDE5 in humans also appears to be androgen-dependent.1”
From Treatment Strategy for Non-Responders to PDE5 Inhibitors (2013) · cites this paper as [1]
In the citing paper
“PDE5 inhibitors are the first-line therapy for most men with ED who do not have a specific contraindication to their use.1”
From Treatment Strategy for Non-Responders to PDE5 Inhibitors (2013) · cites this paper as [1]
In the citing paper
“In animals, the pharmacological activity of PDE5 inhibitors appears to be androgen-dependent;1,9 indeed the expression of PDE5 in humans also appears to be androgen-dependent.1”
From Treatment Strategy for Non-Responders to PDE5 Inhibitors (2013) · cites this paper as [1]
In the citing paper
“There is robust evidence that phosphodiesterase type 5 (PDE5) inhibitors are effective, safe, and well-tolerated in the treatment of erectile dysfunction (ED).”
From Treatment Strategy for Non-Responders to PDE5 Inhibitors (2013) · cites this paper as [1]
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Citations
Cites
Wang, C. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2839 · Cited by 359
Aversa, A., Isidori, A. M., Spera, G., Lenzi, A., & Fabbri, A. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01764.x · Cited by 343
Self-citationKWAN, M., GREENLEAF, W. J., MANN, J., CRAPO, L., & DAVIDSON, J. M. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-3-557 · Cited by 339
PHARMACOLOGY OF PHOSPHODIESTERASE‐5 INHIBITORS
Corbin, J., & Francis, S. (2002) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2002.tb11296.x · Cited by 260
Bancroft, J., Tennent, G., Loucas, K., & Cass, J. (1974) · British Journal of Psychiatry · doi:10.1192/bjp.125.3.310 · Cited by 181
Research works printed but not linked: 40
- Francis, 2001, Cyclic nucleotide phosphodiesterases: relating structure and function., Prog Nucleic Acid Res Mol Biol, 65, 1
- Schudt, 1999, Therapeutic potential of selective PDE inhibitors in asthma., Pulm Pharmacol Ther, 12, 123, 10.1006/pupt.1999.0182 · DOI
- Movsesian, 1999, β-Adrenergic receptor agonists and cyclic nucleotide phosphodiesterase inhibitors: shifting the focus from inotropy to cyclic adenosine monophosphate., J Am Coll Cardiol, 34, 318, 10.1016/S0735-1097(99)00220-X · DOI
- Lin, 2003, Phosphodiesterases as therapeutic targets., Urology, 61, 685, 10.1016/S0090-4295(02)02439-1 · DOI
- Manganiello, 2003, Cyclic nucleotide phosphodiesterase 5 and sildenafil: promises realized., Mol Pharmacol, 63, 1209, 10.1124/mol.63.6.1209 · DOI
- Francis, 1988, Purification of cGMP-binding protein phosphodiesterase from rat lung., Methods Enzymol, 159, 722, 10.1016/0076-6879(88)59067-5 · DOI
- Loughney, 1998, Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3′,5′-cyclic nucleotide phosphodiesterase., Gene, 216, 139, 10.1016/S0378-1119(98)00303-5 · DOI
- Stacey, 1998, Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase (PDE5)., Biochem Biophys Res Commun, 247, 249, 10.1006/bbrc.1998.8769 · DOI
- Yanaka, 1998, Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene., Eur J Biochem, 255, 391, 10.1046/j.1432-1327.1998.2550391.x · DOI
- Lin, 2002, Human PDE5A gene encodes three PDE5 isoforms from two alternate promoters., Int J Impot Res, 14, 15, 10.1038/sj.ijir.3900802 · DOI
- Corbin, 1999, Cyclic GMP phosphodiesterase-5: target of sildenafil., J Biol Chem, 274, 13729, 10.1074/jbc.274.20.13729 · DOI
- Lin, 2001, Identification and regulation of human PDE5A gene promoter., Biochem Biophys Res Commun, 280, 684, 10.1006/bbrc.2000.4220 · DOI
- Filippi, 2002, Endothelium-dependency of yohimbine-induced corpus cavernosum relaxation., Int J Impot Res, 14, 295, 10.1038/sj.ijir.3900890 · DOI
- Filippi, 2002, Estrogens, but not androgens, regulate expression and functional activity of oxytocin receptor in rabbit epididymis., Endocrinology, 143, 4271, 10.1210/en.2002-220384 · DOI
- Pinzani, 2001, Type-2 somatostatin receptor mRNA levels in breast and colon cancer determined by a quantitative RT-PCR assay based on dual label fluorogenic probe and the TaqMan technology., Regul Pept, 99, 79, 10.1016/S0167-0115(01)00235-X · DOI
- Casini Raggi, 2002, Quantitative evaluation of somatostatin receptor subtype 2 expression in sporadic colorectal tumor and in the corresponding normal mucosa., Clin Cancer Res, 8, 419
- D’Amati, 2002, Type 5 phosphodiesterase expression in the human vagina., Urology, 60, 191, 10.1016/S0090-4295(02)01663-1 · DOI
- Giordano, 2001, Expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in mouse tissues and cell lines using an antibody against the enzyme amino-terminal domain., Biochim Biophys Acta, 1539, 16, 10.1016/S0167-4889(01)00086-6 · DOI
- Filippi, 2002, Identification, localization and functional activity of oxytocin receptors in epididymis., Mol Cell Endocrinol, 193, 89, 10.1016/S0303-7207(02)00101-6 · DOI
- Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding., Anal Biochem, 72, 248, 10.1016/0003-2697(76)90527-3 · DOI · Paper page
- Moreland, 1998, Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells, Life Sci, 62, PL309, 10.1016/S0024-3205(98)00158-1 · DOI
- Maggi, 2000, Erectile dysfunction: from biochemical pharmacology to advances in medical therapy., Eur J Endocrinol, 143, 143, 10.1530/eje.0.1430143 · DOI
- Filippi, 2003, Effects of NCX 4050, a new NO donor, in rabbit and human corpus cavernosum., Int J Androl, 26, 101, 10.1046/j.1365-2605.2003.00403.x · DOI
- De Lean, 1978, Simultaneous analysis of families of sigmoidal curves: applications to biossay, radioligand assay, and physiological dose-response curves, Am J Physiol, 235, E97
- Shukla, 2003, Nitric oxide donating aspirins: novel drugs for the treatment of saphenous vein graft failure., Ann Thorac Surg 2003, 75, 1437, 10.1016/S0003-4975(02)04892-0 · DOI
- Lin, 2003, Isolation of two isoforms of phosphodiesterase 5 from rat penis., Int J Impot Res, 15, 129, 10.1038/sj.ijir.3900983 · DOI
- Kuthe, 2000, Gene expression of the phosphodiesterases 3A and 5A in human corpus cavernosum penis., Eur Urol 2000, 38, 108
- Kotera, 1999, Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases., Eur J Biochem, 262, 866, 10.1046/j.1432-1327.1999.00450.x · DOI
- Traish, 1999, Effects of castration and androgen replacement on erectile function in a rabbit model., Endocrinology, 140, 1861, 10.1210/endo.140.4.6655 · DOI · Paper page
- Traish, 2003, Effects of medical or surgical castration on erectile function in an animal model., J Androl, 24, 381, 10.1002/j.1939-4640.2003.tb02686.x · DOI
- Guay, 2001, Efficacy and safety of sildenafil citrate for treatment of erectile dysfunction in a population with associated organic risk factors., J Androl, 22, 793, 10.1002/j.1939-4640.2001.tb02582.x · DOI · Paper page
- Yassin, 2003, Combination therapy of tadalafil and testosterone in hypogonadal non-responders, Int J Impot Res S, 6, S27
- Penson, 1996, Androgen and pituitary control of penile nitric oxide synthase and erectile function in the rat., Biol Reprod, 55, 567, 10.1095/biolreprod55.3.567 · DOI
- Mills, 1999, The role of androgens in the erectile response: A 1999 Perspective., Mol Urol, 3, 75
- Mills, 1999, Androgenic maintenance of the erectile response in the rat., Steroids, 64, 605, 10.1016/S0039-128X(99)00040-9 · DOI
- Zitzmann, 2001, Testosterone levels in healthy men and the relation to behavioural and physical characteristics: facts and constructs., Eur J Endocrinol, 144, 183, 10.1530/eje.0.1440183 · DOI · Paper page
- Shirozu, 1995, Penile tumescence in the human fetus at term—a preliminary report., Early Hum Dev, 41, 159, 10.1016/0378-3782(95)01618-D · DOI
- Bancroft, 1983, Changes in erectile responsiveness during androgen replacement therapy., Arch Sex Behav, 12, 59, 10.1007/BF01542116 · DOI
- Wegner, 1995, Efficacy of linsidomine chlorhydrate, a direct nitric oxide donor, in the treatment of human erectile dysfunction: results of a double-blind cross over trial., Int J Impot Res, 7, 233
- Martinez-Pineiro, 1998, Prospective comparative study with intracavernous sodium nitroprusside and prostaglandin E1 in patients with erectile dysfunction., Eur Urol, 34, 350, 10.1159/000019754 · DOI
Cited by
Yafi, F. A., Jenkins, L., Albersen, M., Corona, G., Isidori, A. M., Goldfarb, S., Maggi, M., Nelson, C. J., Parish, S., Salonia, A., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.3 · Cited by 853
Effects of testosterone on sexual function in men: results of a meta‐analysis
Isidori, A. M., Giannetta, E., Gianfrilli, D., Greco, E. A., Bonifacio, V., Aversa, A., Isidori, A., Fabbri, A., & Lenzi, A. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02350.x · Cited by 492
Self-citationTraish, A. M., Goldstein, I., & Kim, N. N. (2007) · European Urology · doi:10.1016/j.eururo.2007.02.034 · Cited by 268
Testosterone supplementation and sexual function: A meta-analysis study
Corona, G., Isidori, A. M., Buvat, J., Aversa, A., Rastrelli, G., Hackett, G., Rochira, V., Sforza, A., Lenzi, A., Mannucci, E., et al. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12536 · Cited by 263
Self-citationEndocrine Aspects of Male Sexual Dysfunctions
Buvat, J., Maggi, M., Gooren, L., Guay, A. T., Kaufman, J., Morgentaler, A., Schulman, C., Tan, H. M., Torres, L. O., Yassin, A., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01780.x · Cited by 221
Self-citation
Metadata
- Authors
- Morelli, A., Filippi, S., Mancina, R., Luconi, M., Vignozzi, L., Marini, M., Orlando, C., Vannelli, G. B., Aversa, A., Natali, A., Forti, G., Giorgi, M., Jannini, E. A., Ledda, F., & Maggi, M.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2004-05-01
- Volume
- 145
- Issue
- 5
- Pages
- 2253-2263
- ISSN
- 0013-7227
- 1945-7170
- Cited by
- 286
- References
- 5
- Language
- en
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.