Cited by 737Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice

Münzberg, Heike, Flier, Jeffrey S., Bjørbæk, Christian·2004·Endocrinology

DOI 10.1210/en.2004-0726

Open this paper in CoChat — free account

Abstract

Leptin resistance in diet-induced obese (DIO) mice is characterized by elevated serum leptin and a decreased response to exogenous leptin and is caused by unknown defects in the central nervous system. Leptin normally acts on several brain nuclei, but a detailed description of leptin resistance within individual brain regions has not been reported. We first mapped leptin-responsive cells in brains from DIO mice using phospho-signal transducer and activator of transcription (P-STAT3) immunohistochemistry. After 16 wk of high-fat-diet feeding, leptin-activated P-STAT3 staining within the arcuate nucleus (ARC) was dramatically decreased. In contrast, other hypothalamic and extrahypothalamic nuclei remained leptin sensitive. Reduced leptin-induced P-STAT3 in the ARC could also be detected after 4 wk and as early as 6 d of a high-fat diet. To examine potential mechanisms for leptin-resistant STAT3 activation in the ARC of DIO mice, we measured mRNA levels of candidate signaling molecules in the leptin receptor-STAT3 pathway. We found that the level of suppressor of cytokine signaling 3 (SOCS-3), an inhibitor of leptin signaling, is specifically increased in the ARC of DIO mice. The study suggests that the ARC is selectively leptin resistant in DIO mice and that this may be caused by elevated suppressor of cytokine signaling 3 in this hypothalamic nucleus. Defects in leptin action in the ARC may play a role in the pathogenesis of leptin-resistant obesity.

Integrity signals

Registry

Crossref · 10.1210/en.2004-0726

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Congenital leptin deficiency is associated with severe early-onset obesity in humans
Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Recombinant Leptin for Weight Loss in Obese and Lean Adults: A Randomized, Controlled, Dose-Escalation Trial
Heymsfield, S. B., Greenberg, A. S., Fujioka, K., Dixon, R. M., Kushner, R., Hunt, T., Lubina, J. A., Patane, J., Self, B., Hunt, P., et al. (1999) · JAMA · doi:10.1001/jama.282.16.1568 · Cited by 1,422
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15693 · Cited by 1,374
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance
Caro, J. F., Kolaczynski, J. W., Nyce, M. R., Ohannesian, J. P., Opentanova, I., Goldman, W. H., Lynn, R. B., Zhang, P.-L., Sinha, M. K., & Considine, R. V. (1996) · The Lancet · doi:10.1016/s0140-6736(96)03173-x · Cited by 1,175
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215693 · Cited by 1,105

Show all 61 references

Sorted by citations

Items 201–300 of 733

A novel peptide protects against diet-induced obesity by suppressing appetite and modulating the gut microbiota
Li, Z., Zhang, B., Wang, N., Zuo, Z., Hong Kui, W. E. I., & Zhao, F. (2022) · Gut · doi:10.1136/gutjnl-2022-328035 · Cited by 83
Complex Regulation of Mammalian Target of Rapamycin Complex 1 in the Basomedial Hypothalamus by Leptin and Nutritional Status
Villanueva, E. C., Münzberg, H., Cota, D., Leshan, R. L., Kopp, K., Ishida-Takahashi, R., Jones, J. C., Fingar, D. C., Seeley, R. J., & Myers, M. G. (2009) · Endocrinology · doi:10.1210/en.2009-0642 · Cited by 82
Implications of crosstalk between leptin and insulin signaling during the development of diet-induced obesity
Morrison, C. D., Huypens, P., Stewart, L. K., & Gettys, T. W. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.09.005 · Cited by 83
Maintenance of the thyroid axis during diet-induced obesity in rodents is controlled at the central level
Perello, M., Çakir, I., Cyr, N. E., Romero, A., Stuart, R. C., Chiappini, F., Hollenberg, A. N., & Nillni, E. A. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00448.2010 · Cited by 80
Signal Transducer and Activator of Transcription-3 Is Required in Hypothalamic Agouti-Related Protein/Neuropeptide Y Neurons for Normal Energy Homeostasis
Gong, L., Yao, F., Hockman, K., Heng, H. H., Morton, G. J., Takeda, K., Akira, S., Low, M. J., Rubinstein, M., & MacKenzie, R. G. (2008) · Endocrinology · doi:10.1210/en.2007-0945 · Cited by 80
The neuroanatomical function of leptin in the hypothalamus
van Swieten, M. M. H., Pandit, R., Adan, R. A. H., & Plasse, G. (2014) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2014.05.004 · Cited by 87
Palmitic acid induces central leptin resistance and impairs hepatic glucose and lipid metabolism in male mice
Cheng, L., Yu, Y., Szabo, A., Wu, Y., Wang, H., Camer, D., & Huang, X. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.12.011 · Cited by 80
Hypothalamic Astrocytes in Obesity
García‐Cáceres, C., Yi, C., & Tschöp, M. H. (2012) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.11.003 · Cited by 77
High-fat diet exposure induces IgG accumulation in hypothalamic microglia
Yi, C., Tschöp, M. H., Woods, S. C., & Hofmann, S. M. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.009464 · Cited by 79
Hindbrain Leptin Stimulation Induces Anorexia and Hyperthermia Mediated by Hindbrain Melanocortin Receptors
Skibicka, K. P., & Grill, H. J. (2008) · Endocrinology · doi:10.1210/en.2008-1316 · Cited by 80
Insulin action in the brain: Roles in energy and glucose homeostasis
Dodd, G. T., & Tiganis, T. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12513 · Cited by 77
Short-term exposure to air pollution (PM2.5) induces hypothalamic inflammation, and long-term leads to leptin resistance and obesity via Tlr4/Ikbke in mice.
Campolim, C. M., Weissmann, L., Ferreira, C. K. D. O., Zordão, O. P., Dornellas, A. P. S., de Castro, G., Zanotto, T. M., Boico, V. F., Quaresma, P. G. F., Lima, R. P. A., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-67040-3 · Cited by 76
Evidence that diet-induced hyperleptinemia, but not hypothalamic gliosis, causes ghrelin resistance in NPY/AgRP neurons of male mice.
Briggs, D. I., Lockie, S., Benzler, J., Wu, Q., Stark, R., Reichenbach, A., Hoy, A., Lemus, M., Coleman, H., Parkington, H., et al. (2014) · Endocrinology · doi:10.1210/en.2013-1861 · Cited by 72
Induction of Leptin Resistance by Activation of cAMP-Epac Signaling
Fukuda, M., Williams, K. W., Gautron, L., & Elmquist, J. K. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.016 · Cited by 76
Suppression of leptin-induced hypothalamic JAK/STAT signalling and feeding response during pregnancy in the mouse
Ladyman, S. R., Fieldwick, D., & Grattan, D. R. (2012) · Reproduction · doi:10.1530/rep-12-0112 · Cited by 77
The role of intracerebroventricular administration of leptin in the stimulation of prothyrotropin releasing hormone neurons in the hypothalamic paraventricular nucleus
Perello, M., Stuart, R. C., & Nillni, E. A. (2006) · Endocrinology · doi:10.1210/en.2005-1533 · Cited by 74
Leptin Stimulates Neuropeptide Y and Cocaine Amphetamine-Regulated Transcript Coexpressing Neuronal Activity in the Dorsomedial Hypothalamus in Diet-Induced Obese Mice
Lee, S. J., Verma, S., Simonds, S. E., Kirigiti, M. A., Kievit, P., Lindsley, S. R., Loche, A., Smith, M. S., Cowley, M. A., & Grove, K. L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0837-13.2013 · Cited by 76
Obesity and inflammation: A new look at an old problem
Mehta, S., & Farmer, J. A. (2007) · Current Atherosclerosis Reports · doi:10.1007/s11883-007-0009-4 · Cited by 75
Intracellular Leptin-Signaling Pathways in Hypothalamic Neurons: The Emerging Role of Phosphatidylinositol-3 Kinase-Phosphodiesterase-3B-cAMP Pathway
Sahu, A. (2011) · Neuroendocrinology · doi:10.1159/000326785 · Cited by 74
Induction of Cardiac Uncoupling Protein-2 Expression and Adenosine 5′-Monophosphate-Activated Protein Kinase Phosphorylation during Early States of Diet-Induced Obesity in Mice
Somoza, B., Guzmán‐Ruiz, R., Cano, V., Merino, B., Ramos, P., Díez‐Fernández, C., Fernández‐Alfonso, M. S., & Ruiz‐Gayo, M. (2006) · Endocrinology · doi:10.1210/en.2006-0914 · Cited by 74
Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis
Kocalis, H. E., Hagan, S. L., George, L., Turney, M. K., Siuta, M., Laryea, G. N., Morris, L. C., Muglia, L. J., Printz, R. L., Stanwood, G. D., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.01.014 · Cited by 76
Hypothalamic ER stress: A bridge between leptin resistance and obesity
Ramírez, S., & Claret, M. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.04.025 · Cited by 75
Modulation of central leptin sensitivity and energy balance in a rat model of diet‐induced obesity
Fam, B. C., Morris, M. J., Hansen, M. J., Kebede, M. A., Andrikopoulos, S., Proietto, J., & Thorburn, A. W. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00653.x · Cited by 72
New Pharmacological Perspectives for the Leptin Receptor in the Treatment of Obesity
Roujeau, C., Jockers, R., & Dam, J. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00167 · Cited by 71
Central mechanisms of adiposity in adult female mice with androgen excess
Nohara, K., Laque, A., Allard, C., Münzberg, H., & Mauvais‐Jarvis, F. (2014) · Obesity · doi:10.1002/oby.20719 · Cited by 68
Deficiency of p62/Sequestosome 1 Causes Hyperphagia Due to Leptin Resistance in the Brain
Harada, H., Warabi, E., Matsuki, T., Yanagawa, T., Okada, K., Uwayama, J., Ikeda, A., Nakaso, K., Kirii, K., Noguchi, N., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2954-12.2013 · Cited by 69
Neural Responses to Macronutrients: Hedonic and Homeostatic Mechanisms
Tulloch, A. J., Murray, S. M., Vaicekonyte, R., & Avena, N. M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.058 · Cited by 67
Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway
Gil, S. Y., Youn, B., Byun, K., Hu, H., NamKoong, C., Jang, P., Lee, J., Jo, Y., Kang, G. M., Kim, H.-K., et al. (2013) · Nature Communications · doi:10.1038/ncomms2896 · Cited by 67
Nutritional State Affects the Expression of the Obesity‐Associated Genes Etv5, Faim2, Fto, and Negr1
Boender, A. J., van Rozen, A. J., & Adan, R. A. H. (2012) · Obesity · doi:10.1038/oby.2012.128 · Cited by 67
Autoimmune responses and inflammation in type 2 diabetes
Prasad, M., Chen, E. W., Toh, S.-A. E. S., & Gascoigne, N. R. J. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0220-243r · Cited by 68
Selective contribution of interleukin‐6 and leptin to brain inflammatory signals induced by systemic LPS injection in mice
Rummel, C. D., Inoue, W., Sachot, C., Poole, S., Hübschle, T., & Luheshi, G. N. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21850 · Cited by 65
Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status
Mitchell, S. E., Nogueiras, R., Morris, A. C., Tovar, S. A., Grant, C., Cruickshank, M., Rayner, D. V., Diéguez, C., & Williams, L. M. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.173328 · Cited by 68
Region-specific diet-induced and leptin-induced cellular leptin resistance includes the ventral tegmental area in rats
Matheny, M. E., Shapiro, A. M., Tümer, N., & Scarpace, P. J. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.11.002 · Cited by 64
Neuronal Expression of Glucosylceramide Synthase in Central Nervous System Regulates Body Weight and Energy Homeostasis
Nordström, V., Willershäuser, M., Herzer, S., Rozman, J., Halbach, O. V. B. U., Meldner, S., Rothermel, U., Kaden, S., Roth, F. C., Waldeck, C., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001506 · Cited by 67
IRS2 Signaling in LepR-b Neurons Suppresses FoxO1 to Control Energy Balance Independently of Leptin Action
Sadagurski, M., Leshan, R. L., Patterson, C. M., Rozzo, A., Kuznetsova, A., Skorupski, J. C., Jones, J. C., DePinho, R. A., Myers, M. G., & White, M. F. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.011 · Cited by 66
Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period
Qiu, X., Dao, H., Wang, M., Heston, A., Garcia, K. M., Sangal, A., Dowling, A. R., Faulkner, L. D., Molitor, S. C., Elias, C. F., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121974 · Cited by 66
Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia
Tsunekawa, T., Banno, R., Mizoguchi, A., Sugiyama, M., Tominaga, T., Onoue, T., Hagiwara, D., Ito, Y., Iwama, S., Goto, M., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.01.007 · Cited by 63
Leptin and aging: Review and questions with particular emphasis on its role in the central regulation of energy balance
Balaskó, M., Soós, S., Székely, M., & Pétervári, E. (2014) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2014.08.006 · Cited by 64
High-fructose diet leads to visceral adiposity and hypothalamic leptin resistance in male rats — do glucocorticoids play a role?
Bursać, B. N., Teofilović, A., Nestorović, N. M., Veličković, N. A., Milutinović, D. V., Matić, G. M., & Djordjevic, A. D. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.12.005 · Cited by 70
PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding
Long, L., Toda, C., Jeong, J. K., Horváth, T. L., & Diano, S. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76220 · Cited by 67
Sexually dimorphic responses to fat loss after caloric restriction or surgical lipectomy
Shi, H., Strader, A. D., Woods, S. C., & Seeley, R. J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00710.2006 · Cited by 67
Amylin-mediated control of glycemia, energy balance, and cognition
Mietlicki‐Baase, E. G. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.02.034 · Cited by 66
Integration of reward signalling and appetite regulating peptide systems in the control of food‐cue responses
Reichelt, A. C., Westbrook, R. F., & Morris, M. J. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13321 · Cited by 62
Combined Neural Inactivation of Suppressor of Cytokine Signaling-3 and Protein-Tyrosine Phosphatase-1B Reveals Additive, Synergistic, and Factor-Specific Roles in the Regulation of Body Energy Balance
Briançon, N., McNay, D. E. G., Maratos–Flier, E., & Flier, J. S. (2010) · Diabetes · doi:10.2337/db10-0481 · Cited by 61
Self-citation
gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor
Janoschek, R., Plum, L., Koch, L., Münzberg, H., Diano, S., Shanabrough, M., Müller, W., Horváth, T. L., & Brüning, J. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600425103 · Cited by 59
Insulin Resistance in Brain and Possible Therapeutic Approaches
Çetinkalp, Ş., Simsir, I. Y., & Ertek, S. (2014) · Current Vascular Pharmacology · doi:10.2174/1570161112999140206130426 · Cited by 60
Leptin Selectively Regulates Nutrients Metabolism in Nile Tilapia Fed on High Carbohydrate or High Fat Diet
Liu, C., He, A., Ning, L., Luo, Y., Li, D., Zhang, M., Chen, L., & Du, Z. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00574 · Cited by 58
Incendiary Leptin
Seoane‐Collazo, P., Martínez‐Sánchez, N., Milbank, E., & Contreras, C. (2020) · Nutrients · doi:10.3390/nu12020472 · Cited by 61
Expanding applications of deep brain stimulation: a potential therapeutic role in obesity and addiction management
Halpern, C. H., Torres-Martinez, N., Hurtig, H. I., Wolf, J. A., Stephen, J. H., Oh, M. Y., Williams, N. N., Dichter, M. A., Jaggi, J. L., Caplan, A. L., et al. (2011) · Acta Neurochirurgica · doi:10.1007/s00701-011-1166-3 · Cited by 58
Differential leptin access into the brain — A hierarchical organization of hypothalamic leptin target sites?
Münzberg, H. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.04.020 · Cited by 61
The effect of high-fat diet-induced obesity on cardiovascular toxicity in wistar albino rats
Bhandari, U., Kumar, V., Khanna, N., & Panda, B. P. (2010) · Human & Experimental Toxicology · doi:10.1177/0960327110389499 · Cited by 63
Effects of chronic weight perturbation on energy homeostasis and brain structure in mice
Ravussin, Y., Gutman, R., Diano, S., Shanabrough, M., Borók, E., Sármán, B., Lehmann, A., LeDuc, C. A., ROSENBAUM, M. S., Horváth, T. L., et al. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00429.2010 · Cited by 55
Suppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models
Rupp, A. C., Tomlinson, A. J., Affinati, A. H., Yacawych, W. T., Duensing, A. M., True, C., Lindsley, S. R., Kirigiti, M. A., MacKenzie, A., Polex-Wolf, J., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci157515 · Cited by 55
“27) with GFP in the DMH, with smaller populations of cells in the adjacent ARC and very few cells in the lateral hypothalamic area and VMH (Figure 2, C and D).”
The role of immune dysfunction in obesity-associated cancer risk, progression, and metastasis
Kulkarni, A., & Bowers, L. W. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03752-z · Cited by 56
Central and peripheral leptin resistance in obesity and improvements of exercise
Peng, J., Yin, L., & Wang, X. (2021) · Hormones and Behavior · doi:10.1016/j.yhbeh.2021.105006 · Cited by 63
Leptin physiology and pathophysiology in energy homeostasis, immune function, neuroendocrine regulation and bone health
Stefanakis, K., Upadhyay, J., Ramirez-Cisneros, A., Patel, N., Sahai, A., & Mantzoros, C. S. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156056 · Cited by 65
SOCS3 deficiency in leptin receptor-expressing cells mitigates the development of pregnancy-induced metabolic changes
Zampieri, T. T., Ramos-Lobo, A. M., Furigo, I. C., Pedroso, J. A. B., Buonfiglio, D. D. C., & Donato, J. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.12.005 · Cited by 59
New aspects of melanocortin signaling: A role for PRCP in α-MSH degradation
Diano, S. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.09.001 · Cited by 61
Insulin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland
Garcia, R. A. P., Afeche, S. C., Scialfa, J. H., do Amaral, F. G., dos Santos, S. H. J., Lima, F. B., Young, M. E., & Cipolla‐Neto, J. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.10.016 · Cited by 56
Diabetes and Suppressors of Cytokine Signaling Proteins
Rønn, S. G., Billestrup, N., & Mandrup-Poulsen, T. R. (2007) · Diabetes · doi:10.2337/db06-1068 · Cited by 55
Leptin Receptors
Cottrell, E. C., & Mercer, J. G. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-24716-3_1 · Cited by 56
Low-Fat Diet With Caloric Restriction Reduces White Matter Microglia Activation During Aging
Yin, Z., Raj, D. D. A., Schaafsma, W., van der Heijden, R. A., Kooistra, S. M., Reijne, A. C., Zhang, X., Moser, J., Brouwer, N., Heeringa, P., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00065 · Cited by 58
Anorexigenic Hormones Leptin, Insulin, and α-Melanocyte-Stimulating Hormone Directly Induce Neurotensin (NT) Gene Expression in Novel NT-Expressing Cell Models
Cui, H., Cai, F., & Belsham, D. D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2269-05.2005 · Cited by 55
Perinatal overfeeding in rats results in increased levels of plasma leptin but unchanged cerebrospinal leptin in adulthood
López, M., Tovar, S. A., Vazquez, M. J., Nogueiras, R., Seoane, L. M., Garcia, M. D. C., Señarís, R. M., & Diéguez, C. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803425 · Cited by 54
Loss of Hypothalamic Response to Leptin During Pregnancy Associated with Development of Melanocortin Resistance
Ladyman, S. R., Tups, A., Augustine, R. A., Swahn‐Azavedo, A., Kokay, I. C., & Grattan, D. R. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01862.x · Cited by 54
Neurobiology of Nutrition and Obesity
Morrison, C. D., & Berthoud, H. (2007) · Nutrition Reviews · doi:10.1301/nr.2007.dec.517-534 · Cited by 71
Physiological Models of Leptin Resistance
Tups, A. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01916.x · Cited by 53
Hypothalamic microglia as potential regulators of metabolic physiology.
Valdearcos, M., Myers, M. G., & Koliwad, S. K. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0040-0 · Cited by 52
Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals
Kanoski, S. E., Zhao, S., Guarnieri, D. J., Dileone, R., Yan, J., Jonghe, B. C. D., Bence, K. K., Hayes, M. R., & Grill, H. J. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00205.2012 · Cited by 52
Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP/NPY neurons in mice
Wei, W., Pham, K., Gammons, J. W., Sutherland, D., Liu, Y., Smith, A., Kaczorowski, C. C., & O’Connell, K. M. S. (2015) · Scientific Reports · doi:10.1038/srep16810 · Cited by 55
Combined Soluble Fiber-Mediated Intestinal Microbiota Improve Insulin Sensitivity of Obese Mice
Xu, C., Liu, J., Gao, J., Wu, X., Cui, C., Wei, H., Zheng, R., & Peng, J. (2020) · Nutrients · doi:10.3390/nu12020351 · Cited by 54
Leptin Action in the Ventromedial Hypothalamic Nucleus Is Sufficient, But Not Necessary, to Normalize Diabetic Hyperglycemia
Meek, T. H., Matsen, M. E., Dorfman, M. D., Guyenet, S. J., Damian, V. M., Hồng, N. T., Taborsky, G. J., & Morton, G. J. (2013) · Endocrinology · doi:10.1210/en.2013-1328 · Cited by 51
Hyperleptinemia directly affects testicular maturation at different sexual stages in mice, and suppressor of cytokine signaling 3 is involved in this process
Yuan, M., Huang, G., Li, J., Zhang, J., Li, F. Y., Li, K., Gao, B., Zeng, L., Shan, W., Lin, P., et al. (2014) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-12-15 · Cited by 52
Cellular Leptin Resistance Impairs the Leptin-Mediated Suppression of Neuropeptide Y Secretion in Hypothalamic Neurons
Dhillon, S. S., McFadden, S. A., Chalmers, J. A., Centeno, M.-L., Kim, G. L., & Belsham, D. D. (2011) · Endocrinology · doi:10.1210/en.2011-0178 · Cited by 52
Oestradiol and Diet Modulate Energy Homeostasis and Hypothalamic Neurogenesis in the Adult Female Mouse
Bless, E. P., Reddy, T. P., Acharya, K. D., Beltz, B. S., & Tetel, M. J. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12206 · Cited by 49
Leptin Resistance During Pregnancy in the Rat
Ladyman, S. R. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01628.x · Cited by 50
The LIM Domain Only 4 Protein Is a Metabolic Responsive Inhibitor of Protein Tyrosine Phosphatase 1B That Controls Hypothalamic Leptin Signaling
Pandey, N. R., Zhou, X. Y., Qin, Z., Zaman, T., Gomez-Smith, M., Keyhanian, K., Anisman, H., Brunel, J. M., Stewart, A. F. R., & Chen, H. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0746-13.2013 · Cited by 52
Leptin in normal physiology and leptin resistance
Li, S., & Li, X. (2015) · 中国科学通报：英文版 · doi:10.1007/s11434-015-0951-4 · Cited by 52
Hypothalamic Phosphatidylinositol 3‐Kinase‐Phosphodiesterase 3B‐Cyclic AMP Pathway of Leptin Signalling is Impaired Following Chronic Central Leptin Infusion
Sahu, A., & Metlakunta, A. S. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01362.x · Cited by 50
Integration of sensory information via central thermoregulatory leptin targets
Rezai-Zadeh, K. P., & Münzberg, H. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.02.014 · Cited by 52
Food and beverage consumption and food addiction among women in the Nurses' Health Studies
Lemeshow, A. R., Rimm, E. B., Hasin, D. S., Gearhardt, A. N., Flint, A., Field, A. E., & Genkinger, J. M. (2017) · Appetite · doi:10.1016/j.appet.2017.10.038 · Cited by 49
Antioxidant bilirubin works in multiple ways to reduce risk for obesity and its health complications
DiNicolantonio, J. J., McCarty, M. F., & O’Keefe, J. H. (2018) · Open Heart · doi:10.1136/openhrt-2018-000914 · Cited by 52
Hypertension in obesity: is leptin the culprit?
Simonds, S. E., & Cowley, M. A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.004 · Cited by 50
Moderate Long-Term Modulation of Neuropeptide Y in Hypothalamic Arcuate Nucleus Induces Energy Balance Alterations in Adult Rats
Sousa-Ferreira, L., Garrido, M., Nascimento-Ferreira, I., Nóbrega, C., Santos-Carvalho, A., Álvaro, A. R., Rosmaninho‐Salgado, J., Kaster, M. P., Kügler, S., de Almeida, L. P., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022333 · Cited by 48
Maternal protein restriction in mice causes adverse metabolic and hypothalamic effects in the F1 and F2 generations
Peixoto‐Silva, N., Frantz, E. D. C., Mandarim‐de‐Lacerda, C. A., & Mulder, A. D. R. P. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511001735 · Cited by 48
Hypothalamic Dysfunction in Obesity and Metabolic Disorders
Carmo‐Silva, S., & Cavadas, C. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-63260-5_4 · Cited by 53
Preoptic leptin signaling modulates energy balance independent of body temperature regulation
Yu, S., Cheng, H., François, M., Qualls‐Creekmore, E., Huesing, C., He, Y., Jiang, Y., Gao, H., Xu, Y., Zsombok, A., et al. (2018) · eLife · doi:10.7554/elife.33505 · Cited by 45
Leptin resistance and the response to positive energy balance
Morrison, C. D. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.04.009 · Cited by 51
Obesity, Sympathetic Overdrive, and Hypertension
Rahmouni, K. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.148932 · Cited by 49
Cooperative interaction between leptin and amylin signaling in the ventral tegmental area for the control of food intake
Mietlicki‐Baase, E. G., Olivos, D. R., Jeffrey, B. A., & Hayes, M. R. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00087.2015 · Cited by 47
Metabolic actions of hypothalamic SIRT1
Coppari, R. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.01.002 · Cited by 47
Central signalling cross‐talk between insulin and leptin in glucose and energy homeostasis
Boucsein, A., Kamstra, K., & Tups, A. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12944 · Cited by 48
JAK-STAT and feeding
Ladyman, S. R., & Grattan, D. R. (2013) · JAK-STAT · doi:10.4161/jkst.23675 · Cited by 48
Leptin, diabetes, and the brain
Morton, G. J., & Meek, T. H. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.105568 · Cited by 47
Ire1α in Pomc Neurons Is Required for Thermogenesis and Glycemia
Yao, T. S., Deng, Z., Gao, Y., Sun, J. M., Kong, X., Huang, Y., He, Z., Xu, Y., Chang, Y., Yu, K.-J., et al. (2016) · Diabetes · doi:10.2337/db16-0533 · Cited by 46
Potential relationship between dietary long-chain saturated fatty acids and hypothalamic dysfunction in obesity
Sergi, D., & Williams, L. M. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz056 · Cited by 48
AAV-mediated leptin receptor installation improves energy balance and the reproductive status of obese female Koletsky rats
Keen‐Rhinehart, E., Kalra, S. P., & Kalra, P. S. (2005) · Peptides · doi:10.1016/j.peptides.2005.05.027 · Cited by 47
A talk between fat tissue, gut, pancreas and brain to control body weight
Wilson, J. L., & Enriori, P. J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.08.022 · Cited by 39
Inactivation ofSocs3in the Hypothalamus Enhances the Hindbrain Response to Endogenous Satiety Signals via Oxytocin Signaling
Matarazzo, V. A., Schaller, F., Nédélec, E., Bénani, A., Pénicaud, L., Muscatelli, F., Moyse, E., & Bauer, Š. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1669-12.2012 · Cited by 45
Inter-organ metabolic communication involved in energy homeostasis: Potential therapeutic targets for obesity and metabolic syndrome
Yamada, T., Oka, Y., & Katagiri, H. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.09.006 · Cited by 46

Authors: Münzberg, H., Flier, J. S., & Bjørbæk, C.
Affiliations: Beth Israel Deaconess Medical Center (US)
Corresponding author: Bjørbæk, Christian
ORCID: Flier, Jeffrey S.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2004-11-01
Volume: 145
Issue: 11
Pages: 4880-4889
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2004-0726
OpenAlex: W2045522606
Cited by: 737
References: 61
Citations by year: 2026: 7 · 2025: 20 · 2024: 16 · 2023: 14 · 2022: 23 · 2021: 22 · 2020: 30 · 2019: 46 · 2018: 30 · 2017: 28 · 2016: 34 · 2015: 45 · 2014: 49 · 2013: 56 · 2012: 51
FWCI: 13.59
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association
Deutsche Forschungsgemeinschaft
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK060673, R01 DK60673, R37DK028082, R37 DK 28082)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: leptin resistance, diet-induced obesity, hypothalamus, arcuate nucleus, STAT3 signaling, SOCS3, leptin receptor, high-fat diet, obesity pathogenesis
MeSH terms: Suppressor of Cytokine Signaling 3 Protein, Animals, Arcuate Nucleus of Hypothalamus, Body Weight, Dietary Fats, Dorsomedial Hypothalamic Nucleus, Eating, Hyperphagia, Male, Mice, Inbred C57BL, Obesity, Repressor Proteins, RNA, Messenger, Transcription Factors, Ventromedial Hypothalamic Nucleus, Signal Transduction, Leptin, Suppressor of Cytokine Signaling Proteins, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks