Cited by 436Estrogen and related hormone effectsNeurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behavior

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Novel Actions of Estrogen Receptor-β on Anxiety-Related Behaviors

Lund, Trent D., Rovis, Tomislav, Chung, Wilson C. J., Handa, Robert J.·2005·Endocrinology

DOI 10.1210/en.2004-1158

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Abstract

Estrogens are reported to have both anxiogenic and anxiolytic properties. This dichotomous neurobiological response to estrogens may be mediated by the existence of two distinct estrogen receptor (ER) systems, ERalpha and ERbeta. In brain, ERalpha plays a critical role in regulating reproductive neuroendocrine function, whereas ERbeta may be more important in regulating nonreproductive functions. To determine whether estrogen's anxiolytic actions could be mediated by ERbeta, we examined anxiety-related behaviors after treatment with ER subtype-selective agonists. Ovariectomized female rats, divided into four treatment groups, were injected with the selective ERbeta agonist diarylpropionitrile (DPN), the ERalpha-selective agonist propyl-pyrazole-triol (PPT), 17beta-estradiol, or vehicle daily for 4d. After injections, behavior was monitored in the elevated plus maze or open field. Rats treated with DPN showed significantly decreased anxiety-related behaviors in both behavioral paradigms. In the elevated plus maze, DPN significantly increased the number of open arm entries and time spent on the open arms of the maze. Furthermore, DPN significantly reduced, whereas PPT increased, anxiogenic behaviors such as the number of fecal boli and time spent grooming. In the open field, DPN-treated females made more rears, interacted more with a novel object, and spent more time in the middle of the open field than did control or PPT-treated rats. To confirm that DPN's anxiolytic actions a…

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Authors: Lund, T. D., Rovis, T., Chung, W. C. J., & Handa, R. J.
Affiliations: Colorado State University (US)
Corresponding author: Lund, Trent D.
ORCID: Rovis, Tomislav
Chung, Wilson C. J.
Handa, Robert J.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2005-02
Volume: 146
Issue: 2
Pages: 797-807
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2004-1158
OpenAlex: W2162934389
Cited by: 436
References: 0
Citations by year: 2026: 5 · 2025: 8 · 2024: 20 · 2023: 13 · 2022: 19 · 2021: 16 · 2020: 14 · 2019: 10 · 2018: 34 · 2017: 17 · 2016: 18 · 2015: 18 · 2014: 20 · 2013: 29 · 2012: 25
FWCI: 11.07
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS039951)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: estrogen receptor beta, anxiety-like behavior, diarylpropionitrile, propyl pyrazole triol, estradiol, tamoxifen, elevated plus maze, open field, ovariectomized rats, estrogen receptor alpha
MeSH terms: Animals, Anxiety, Behavior, Animal, Binding, Competitive, Blood-Brain Barrier, Brain, Fear, Female, Male, Nitriles, Phenols, Propionates, Pyrazoles, Receptors, Progesterone, Uterus, Up-Regulation, Rats, Sprague-Dawley, Estrogen Receptor alpha, Estrogen Receptor beta, Rats

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Novel Actions of Estrogen Receptor-β on Anxiety-Related Behaviors

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