Physical inactivity, insulin resistance, and the oxidative-inflammatory loop

Gratas-Delamarche, A.; Derbré, F.; Vincent, S.; Cillard, J.

doi:10.3109/10715762.2013.847528

Cited by 99Adipokines, Inflammation, and Metabolic DiseasesExercise and Physiological ResponsesAdipose Tissue and Metabolism

Physical inactivity, insulin resistance, and the oxidative-inflammatory loop

Gratas-Delamarche, A., Derbré, F., Vincent, S., Cillard, J.·2014·Free Radical Research

DOI 10.3109/10715762.2013.847528

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Abstract

Epidemiological data indicate that physical inactivity, a main factor of global energetic imbalance, is involved in the worldwide epidemic of obesity and metabolic disorders such as insulin resistance. Although the complex pathogenesis of insulin resistance is not fully understood, literature data accumulated during the past decades clearly indicate that the activation of the oxidative-inflammatory loop plays a major role. By activating the oxidative-inflammatory loop in insulin-sensitive tissues, fat gain and adipose tissue dysfunction likely contribute to induce insulin resistance during chronic and prolonged physical inactivity. However, in the past years, evidence has emerged showing that early insulin resistance also occurs after very short-term exposure to physical inactivity (1-7 days) without any fat gain or energetic imbalance. The possible role of liver disturbances or endothelial dysfunction is suggested, but further studies are necessary to really conclude. Inactive skeletal muscle probably constitutes the primary triggering tissue for the development of early insulin resistance. In the present review, we discuss on the current knowledge about the effect of physical inactivity on whole-body and peripheral insulin sensitivity, and how local inflammation and oxidative stress arising with physical inactivity could potentially induce insulin resistance. We assume that early muscle insulin resistance allows the excess nutrients to shift in the storage tissues to withstand starvation through energy storage. We also consider when chronic and prolonged, physical inactivity over an extended period of time is an underestimated contributor to pathological insulin resistance and hence indirectly to numerous chronic diseases.

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Sedentary lifestyles, characterised by inactive skeletal muscle, sarcopenia and adipose tissue accumulation, are associated with moderate-to-high levels of reactive oxygen species, which can deplete antioxidant defences resulting in oxidation of proteins, lipids and DNA.
“Sedentary lifestyles, characterised by inactive skeletal muscle, sarcopenia and adipose tissue accumulation, are associated with moderate-to-high levels of reactive oxygen species, which can deplete antioxidant defences resulting in oxidation of proteins, lipids and DNA (Bjork et al. 2012; Derbre et al. 2014; Gratas-Delamarche et al. 2014; Le Lay and Simard 2014).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Gratas-Delamarche et al. 2014
Regular moderate-intensity exercise stimulates optimal reactive oxygen species production above resting values, but not to the levels associated with chronic sedentary behaviour.
“Regular moderate-intensity exercise stimulates optimal reactive oxygen species production above resting values, but not to the levels associated with chronic sedentary behaviour (Bjork et al. 2012; Derbre et al. 2014; Gratas-Delamarche et al. 2014; Le Lay and Simard 2014).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Gratas-Delamarche et al. 2014

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Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation
Marchio, P., Guerra‐Ojeda, S., Vila, J. M., Aldasoro, M., Víctor, V. M., & Mauricio, M. D. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8563845 · Cited by 628 · see citing works
Role of mitochondrial reactive oxygen species in homeostasis regulation
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Antioxidant and Anti‐Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus
Li, Z., Geng, Y., Jiang, J., & Kong, W. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/289264 · Cited by 385 · see citing works
Berberine and Its Role in Chronic Disease
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The Pathogenesis of Diabetes Mellitus by Oxidative Stress and Inflammation: Its Inhibition by Berberine
Ma, X., Chen, Z., Wang, L., Wang, G., Wang, Z., Dong, X., Wen, B., & Zhang, Z. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00782 · Cited by 189 · see citing works
Disrupted Skeletal Muscle Mitochondrial Dynamics, Mitophagy, and Biogenesis during Cancer Cachexia: A Role for Inflammation
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The Relevance of a Physical Active Lifestyle and Physical Fitness on Immune Defense: Mitigating Disease Burden, With Focus on COVID-19 Consequences
Filgueira, T. O., Castoldi, Â., Santos, L. E. R., de Amorim, G. J., Fernandes, M. S. D. S., Anastácio, W. D. L. D. N., Campos, E. Z., Santos, T. M., & Souto, F. O. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.587146 · Cited by 152 · see citing works
Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients.
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Anti-inflammatory phytochemicals for the treatment of diabetes and its complications: Lessons learned and future promise
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Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation
Xu, Z., Feng, W., Shen, Q., Yu, N., Yu, K., Wang, S., Chen, Z., Shioda, S., & Guo, Y. (2017) · Aging and Disease · doi:10.14336/ad.2016.0620 · Cited by 143 · see citing works
Is immunosenescence influenced by our lifetime “dose” of exercise?
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Oxidative stress following spinal cord injury: From molecular mechanisms to therapeutic targets
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Irisin: ‘fat’ or artefact
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Inflammation-induced ROS generation causes pancreatic cell death through modulation of Nrf2/NF-κB and SAPK/JNK pathway
Choudhury, S., Ghosh, S., Gupta, P., Mukherjee, S., & Chattopadhyay, S. (2015) · Free Radical Research · doi:10.3109/10715762.2015.1075016 · Cited by 96 · see citing works
Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories
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Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties
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Metabolic Inflexibility Is an Early Marker of Bed-Rest–Induced Glucose Intolerance Even When Fat Mass Is Stable
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Anti-Hyperglycemic and Anti-Inflammatory Activities of Polyphenolic-Rich Extract of Syzygium cumini Linn Leaves in Alloxan-Induced Diabetic Rats
Ajiboye, B. O., Ojo, O. A., Akuboh, O. S., Okesola, M. A., Idowu, O. T., & Amuzat, A. O. (2018) · Journal of Evidence-Based Integrative Medicine · doi:10.1177/2515690x18770630 · Cited by 52 · see citing works
Skeletal muscle as a treatment target for older adults with diabetes mellitus: The importance of a multimodal intervention based on functional category
Omura, T., & Araki, A. (2022) · Geriatrics & Gerontology International · doi:10.1111/ggi.14339 · Cited by 47 · see citing works
Psychophysiological foundations of human physical activity behavior and motivation: theories, systems, mechanisms, evolution, and genetics
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Antidiabetic effects of Brucea javanica seeds in type 2 diabetic rats
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Association of circulating irisin levels with normal weight obesity, glycemic and lipid profile
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Physical Activity and Insulin Resistance in 6,500 NHANES Adults: The Role of Abdominal Obesity
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Muscle Regeneration with Intermuscular Adipose Tissue (IMAT) Accumulation Is Modulated by Mechanical Constraints
Pagano, A. F., Demangel, R., Brioche, T., Jublanc, É., Bertrand‐Gaday, C., Candau, R. B., Dechesne, C. A., Dani, C., Bonnieu, A., Py, G., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144230 · Cited by 39 · see citing works
From physical inactivity to immobilization: Dissecting the role of oxidative stress in skeletal muscle insulin resistance and atrophy
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Ethyl acetate fraction of Cissus quadrangularis stem ameliorates hyperglycaemia-mediated oxidative stress and suppresses inflammatory response in nicotinamide/streptozotocin induced type 2 diabetic rats
Lekshmi, R., Rajesh, R., & Mini, S. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.06.014 · Cited by 37 · see citing works
Interaction Between Depression, Obesity, and Type 2 Diabetes: A Complex Picture
Sevilla-González, M. D. R., Quintana-Mendoza, B. M., & Aguilar-Salinas, C. A. (2017) · Archives of Medical Research · doi:10.1016/j.arcmed.2018.02.004 · Cited by 35 · see citing works
Anti-inflammatory effects of tyrosol in streptozotocin-induced diabetic Wistar rats
Ramasamy, C., & Pari, L. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.08.043 · Cited by 29 · see citing works
Insulin-Like Proteins in Plant Sources: A Systematic Review
Costa, I. D. S., de Medeiros, A. F., Piuvezam, G., de Medeiros, G. C. B. S., Maciel, B. L. L., & Morais, A. H. D. A. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s256883 · Cited by 29 · see citing works
Sex differences in the link between blood cobalt concentrations and insulin resistance in adults without diabetes
Chen, Y., Huang, H., He, X., Duan, W., & Mo, X. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-021-00966-w · Cited by 28 · see citing works
Eco-friendly chitosan-based nanostructures in diabetes mellitus therapy: Promising bioplatforms with versatile therapeutic perspectives
Taheriazam, A., Entezari, M., Firouz, Z. M., Hajimazdarany, S., Heydargoy, M. H., Moghadassi, A. H. A., Moghadaci, A., sadrani, A., Motahhary, M., Nashtifani, A. H., et al. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115912 · Cited by 28 · see citing works
Association between Organophosphate Pesticide Exposure and Insulin Resistance in Pesticide Sprayers and Nonfarmworkers
Seesen, M., Lucchini, R. G., Siriruttanapruk, S., Sapbamrer, R., Hongsibsong, S., Woskie, S., & Kongtip, P. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17218140 · Cited by 24 · see citing works
Antidiabetic Activity and Chemical Composition of Sanbai Melon Seed Oil
Wang, F., Hai-li, L., Zhao, H., Zhang, Y. P., Qiu, P., Li, J., & Wang, S. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/5434156 · Cited by 23 · see citing works
Impact of Physical Activity on Oxidative Stress Markers in Patients with Metastatic Breast Cancer
Delrieu, L., Touillaud, M. S., Pérol, O., Morelle, M., Martin, A., Friedenreich, C. M., Mury, P., Dufresne, A., Bachelot, T., Heudel, P., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6694594 · Cited by 22 · see citing works
Gongronema latifolium leaf extract modulates hyperglycaemia, inhibits redox imbalance and inflammation in alloxan-induced diabetic nephropathy
Ojo, O. A., Osukoya, O. A., Ekakitie, L. I., Ajiboye, B. O., Oyinloye, B. E., Agboinghale, P. E., & Kappo, A. P. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00533-0 · Cited by 21 · see citing works
A comprehensive review of recent advances in the extraction and therapeutic potential of berberine
Huang, S., & Huang, G. (2025) · RSC Advances · doi:10.1039/d5ra02170g · Cited by 20 · see citing works
Effects of naringin on learning and memory dysfunction induced by gp120 in rats
Qin, S., Chen, Q., Wu, H., Liu, C., Hu, J., Zhang, D., & Xu, C. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.04.020 · Cited by 20 · see citing works
Tadalafil Transdermal Delivery with Alpha-lipoic Acid Self Nanoemulsion for Treatment of Erectile Dysfunction by Diabetes Mellitus
Fahmy, U. A., & Aljaeid, B. M. (2018) · International Journal of Pharmacology · doi:10.3923/ijp.2018.945.951 · Cited by 19 · see citing works
Muscle Resting and TGF-β Inhibitor Treatment Prevent Fatty Infiltration Following Skeletal Muscle Injury
Pagano, A. F., Arc‐Chagnaud, C., Brioche, T., Chopard, A., & Py, G. (2019) · Cellular Physiology and Biochemistry · doi:10.33594/000000121 · Cited by 19 · see citing works
Exercise and Arterial Modulation in Children: The EXAMIN YOUTH Study
Endes, K., Köchli, S., Zahner, L., & Hanssen, H. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00043 · Cited by 18 · see citing works
Mechanisms of action of natural products on type 2 diabetes
Wang, T., Wang, Y., Shi, M.-Y., & Liu, L. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i11.1603 · Cited by 14 · see citing works
Synthesis and anti-inflammatory effects of a series of novel 9-O-substituted berberine derivatives
Liu, Z., Wang, X., Zhang, H., Zhang, S., Li, Y., Liu, Y., & Peng, D. (2017) · Medicinal Chemistry Research · doi:10.1007/s00044-017-1787-z · Cited by 14 · see citing works
Skeletal muscle ceramides do not contribute to physical-inactivity-induced insulin resistance
Appriou, Z., Nay, K., Pierre, N., Saligaut, D., Lefeuvre‐Orfila, L., Martin, B., Cavey, T., Ropert, M., Loréal, O., Rannou‐Bekono, F., et al. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0850 · Cited by 14 · see citing works
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Fetuin-A as a Potential Biomarker of Metabolic Variability Following 60 Days of Bed Rest
Ward, K., Mulder, E. R., Frings‐Meuthen, P., O’Gorman, D. J., & Cooper, D. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.573581 · Cited by 13 · see citing works
Berberine Protests the Heart from Ischemic Reperfusion Injury via Interference with Oxidative and Inflammatory Pathways
Abdulredha, A. J., Abosaooda, M., Al-Amran, F. G., & Hadi, N. R. (2021) · Medical Archives · doi:10.5455/medarh.2021.75.174-179 · Cited by 13 · see citing works
Relationship of Chronic Systemic Inflammation to Both Chronic Lifestyle-Related Diseases and Osteoarthritis: The Case for Lifestyle Medicine for Osteoarthritis
Prather, H., & Cheng, J. (2023) · HSS Journal® The Musculoskeletal Journal of Hospital for Special Surgery · doi:10.1177/15563316231193753 · Cited by 12 · see citing works
Regular exercise, overweight/obesity and sedentary lifestyle cause adaptive changes in thiol–disulfide homeostasis
Göl, M., ÖZKAYA, B., Yıldırım, C., & Bal, R. (2019) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201920180547 · Cited by 12 · see citing works
Relationship between quality of life, depression and anxiety in type 1 and type 2 diabetes
Çakmak, S. (2020) · Dusunen Adam The Journal of Psychiatry and Neurological Sciences · doi:10.14744/dajpns.2020.00075 · Cited by 11 · see citing works
Exercise and the Immune System
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Physical inactivity and insulin resistance- Role of oxidative stress
Gratas‐Delamarche, A. (2012) · HAL
Self-citation
From physical inactivity to immobilization: Dissecting the role of oxidative stress in skeletal muscle insulin resistance and atrophy
Pierre, N., Appriou, Z., Gratas‐Delamarche, A., & Derbré, F. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.12.028 · Cited by 37 · see citing works
Self-citation
Insights into the development of insulin resistance: Unraveling the interaction of physical inactivity, lipid metabolism and mitochondrial biology
Handy, R. M., & Holloway, G. P. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1151389 · Cited by 38 · see citing works
physical inactivity: association with insulin sensitivity
Rimbert, V., Boirie‌, Y., Bedu, M., Hocquette, J.-F., Ritz, P., & Morio, B. (2013)
Tissue Specific Insulin Resistance Following Voluntary Physical Activity
Otis, J. S., Sarvas, J. L., Khaper, N., & Lees, S. J. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000476940.95062.1d

Authors: Gratas-Delamarche, A., Derbré, F., Vincent, S., & Cillard, J.
Affiliations: École Normale Supérieure Paris-Saclay (FR)
Corresponding author: Derbré, F.
ORCID: Derbré, F.
Venue: Free Radical Research
Publisher: Informa UK Limited
Published: 2013-10-17
Volume: 48
Issue: 1
Pages: 93-108
ISSN: 1029-2470 (ISSN-L)
1071-5762
DOI: 10.3109/10715762.2013.847528
OpenAlex: W2154187478
Cited by: 99
References: 202
Citations by year: 2026: 3 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 11 · 2018: 9 · 2017: 6 · 2016: 8 · 2015: 6 · 2014: 3 · 2013: 2
FWCI: 0.75
Type: journal article
Language: en
Open access: closed
Locations: Free Radical Research (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: physical inactivity, insulin resistance, oxidative stress, inflammation, skeletal muscle insulin sensitivity, adipose tissue dysfunction, obesity, energy imbalance, endothelial dysfunction, liver dysfunction, energy storage
MeSH terms: Animals, Humans, Inflammation, Insulin Resistance, Motor Activity, Oxidation-Reduction, Sedentary Behavior

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Physical inactivity, insulin resistance, and the oxidative-inflammatory loop

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