Roles of Chemokine Ligand-2 (CXCL2) and Neutrophils in Influencing Endothelial Cell Function and Inflammation of Human Adipose Tissue
Abstract
The hypertrophied white adipose tissue (WAT) during human obesity produces inflammatory mediators, including cytokines (IL-6 and TNFα) and chemokines ([C-C motif] chemokine ligand 2 and IL-8). These inflammatory factors are preferentially produced by the nonadipose cells, particularly the adipose tissue infiltrating macrophages. We identified the chemokine (C-X-C motif) ligand 2 (CXCL2) by a transcriptomic approach. Because CXCL2 could represent a WAT-produced chemokine, we explored its role in obesity-associated inflammation. CXCL2 levels in serum and mRNA in WAT were higher in obese subjects compared with lean ones. CXCL2 secretions were higher in sc and visceral (vis) WAT from obese compared with lean subjects. In vis WAT, CXCL2 mRNA expression was higher in macrophages compared with other WAT cells and positively correlated with the inflammatory macrophage markers TNFα and IL-6. CXCL2 triggered the in vitro adhesion of the neutrophils, its selective cell targets, to endothelial cells (ECs) of vis WAT (vis WAT-ECs). Immunohistological analysis indicated that activated neutrophils were adherent to the endothelium of vis WAT from human obese subjects. Blood neutrophils from obese subjects released high levels of proinflammatory mediators (IL-8, chemokine motif ligand 2 [CCL2], matrix metalloproteinase [MMP] 9, and myeloperoxidase [MPO]). Visceral WAT-ECs, treated by neutrophil-conditioned media prepared from obese subjects, displayed an increase of the expression of inflammatory molecules associated with senescence and angiogenic capacities. To conclude, CXCL2, a WAT-produced chemokine being up-regulated in obesity, stimulates neutrophil adhesion to vis WAT-ECs. Activated neutrophils in obesity may influence vis WAT-ECs functions and contribute to WAT inflammation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Preadipocytes, mature adipocytes, and endothelial cells can become senescent during obesity.
“Surprisingly, preadipocytes and mature adipocytes as well as endothelial cells can become senescent during obesity (105-109).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [106]
Cites
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190 · see citing works
Neutrophils in the activation and regulation of innate and adaptive immunity
Mantovani, A., Cassatella, M. A., Costantini, C., & Jaillon, S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3024 · Cited by 3,045 · see citing works
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961 · see citing works
Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682 · see citing works
Adipokines: inflammation and the pleiotropic role of white adipose tissue
Trayhurn, P., & Wood, I. S. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041213 · Cited by 2,210 · see citing works
Four faces of cellular senescence
Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,016 · see citing works
Inflammatory networks during cellular senescence: causes and consequences.
Freund, A., Orjalo, A. V., Desprez, P.-Y., & Campisi, J. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.03.003 · Cited by 1,354 · see citing works
Bouhlel, M. A., Derudas, B., Rigamonti, E., Dièvart, R., Brozek, J., Haulon, S., Zawadzki, C., Jude, B., Torpier, G., Marx, N., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.010 · Cited by 1,325 · see citing works
Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation
McDonald, B., Pittman, K., Menezes, G. B., Hirota, S. A., Slaba, I., Waterhouse, C. C. M., Beck, P. L., Muruve, D. A., & Kubes, P. (2010) · Science · doi:10.1126/science.1195491 · Cited by 1,210 · see citing works
Tsou, C.-L., Peters, W., Si, Y., Slaymaker, S., Aslanian, A. M., Weisberg, S. P., Mack, M., & Charo, I. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29919 · Cited by 1,152 · see citing works
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
Talukdar, S., Oh, D. Y., Bandyopadhyay, G. K., Li, D., Xu, J., McNelis, J., Lu, M. M., Li, P., Yan, Q., Zhu, Y., et al. (2012) · Nature Medicine · doi:10.1038/nm.2885 · Cited by 966 · see citing works
Kamei, N., Tobe, K., Suzuki, R., Ohsugi, M., Watanabe, T., Kubota, N., Ohtsuka-Kowatari, N., Kumagai, K., Sakamoto, K. Q., Kobayashi, M., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601284200 · Cited by 918 · see citing works
Reduced Adipose Tissue Oxygenation in Human Obesity
Pasarica, M., Sereda, O. R., Redman, L. M., Albarado, D. C., Hymel, D. T., Roan, L. E., Rood, J. C., Burk, D. H., & Smith, S. R. (2009) · Diabetes · doi:10.2337/db08-1098 · Cited by 786 · see citing works
Cancello, R., Tordjman, J., Poitou, C., Guilhem, G., Bouillot, J. L., Hugol, D., Coussieu, C., Basdevant, A., Hen, A. B., Bedossa, P., et al. (2006) · Diabetes · doi:10.2337/db06-0133 · Cited by 607 · see citing works
Self-citationFrom Blood Monocytes to Adipose Tissue-Resident Macrophages
Curat, C. A., Miranville, A., Sengenès, C., Diehl, M., Tonus, C., Busse, R., & Bouloumié, A. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1285 · Cited by 600 · see citing works
Neutrophils cascading their way to inflammation
Sadik, C. D., Kim, N. D., & Luster, A. D. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.06.008 · Cited by 577 · see citing works
The role of chemokines in neutrophil biology
Kobayashi, Y. (2007) · Frontiers in bioscience · doi:10.2741/2853 · Cited by 544 · see citing works
Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding
Elgazar-Carmon, V., Rudich, A., Hadad, N., & Lévy, R. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800132-jlr200 · Cited by 488 · see citing works
Cottam, D. R., Mattar, S. G., Barinas-Mitchell, E., Eid, G., Kuller, L., Kelley, D. E., & Schauer, P. R. (2004) · Obesity Surgery · doi:10.1381/096089204323093345 · Cited by 461 · see citing works
Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages
Bourlier, V., Zakaroff‐Girard, A., Miranville, A., Barros, S. D., Maumus, M., Sengenès, C., Galitzky, J., Lafontan, M., Karpe, F., Frayn, K. N., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.724096 · Cited by 373 · see citing works
Increased Macrophage Migration Into Adipose Tissue in Obese Mice
Oh, D. Y., Morinaga, H., Talukdar, S., Bae, E. J., & Olefsky, J. M. (2011) · Diabetes · doi:10.2337/db11-0860 · Cited by 365 · see citing works
Lacasa, D., Taleb, S., Keophiphath, M., Miranville, A., & Clement, K. (2007) · Endocrinology · doi:10.1210/en.2006-0687 · Cited by 334 · see citing works
Self-citationPlatelet Chemokines in Vascular Disease
Gleissner, C. A., von Hundelshausen, P., & Ley, K. F. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.169417 · Cited by 313 · see citing works
Zeyda, M., & Stulnig, T. M. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.07.003 · Cited by 307 · see citing works
Ionita, M. G., van den Borne, P., Catanzariti, L. M., Moll, F. L., de Vries, J. P. P. M., Pasterkamp, G., Vink, A., & de Kleijn, D. P. V. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.209296 · Cited by 304 · see citing works
Emerging mechanisms of neutrophil recruitment across endothelium
Williams, M. R., Azcutia, V., Newton, G. A., Alcaide, P., & Luscinskas, F. W. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.06.009 · Cited by 299 · see citing works
Mechanisms underlying neutrophil-mediated monocyte recruitment
Soehnlein, O., Lindbom, L., & Weber, C. (2009) · Blood · doi:10.1182/blood-2009-06-221630 · Cited by 297 · see citing works
Increased Hepatic Myeloperoxidase Activity in Obese Subjects with Nonalcoholic Steatohepatitis
Rensen, S. S., Slaats, Y., Nijhuis, J., Jans, A., Bieghs, V., Driessen, A., Malle, E., Greve, J. W., & Buurman, W. A. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080999 · Cited by 290 · see citing works
Villaret, A., Galitzky, J., Decaunes, P., Estève, D., Marques, M.-A., Sengenès, C., Chiotasso, P., Tchkonia, T., Lafontan, M., Kirkland, J. L., et al. (2010) · Diabetes · doi:10.2337/db10-0398 · Cited by 282 · see citing works
Neutrophil Activation in Morbid Obesity, Chronic Activation of Acute Inflammation
Nijhuis, J., Rensen, S. S., Slaats, Y., van Dielen, F. M. H., Buurman, W. A., & Greve, J. W. M. (2009) · Obesity · doi:10.1038/oby.2009.113 · Cited by 263 · see citing works
CCL5 Promotes Macrophage Recruitment and Survival in Human Adipose Tissue
Kéophiphath, M., Rouault, C., Divoux, A., Clément, K., & Lacasa, D. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.197442 · Cited by 230 · see citing works
Self-citationBruun, J. M., Lihn, A. S., Madan, A. K., Pedersen, S. B., Schiøtt, K. M., Fain, J. N., & Richelsen, B. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00269.2003 · Cited by 215 · see citing works
Macrophage heterogeneity and tissue lipids
Gordon, S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30992 · Cited by 207 · see citing works
Chemokines in the vascular inflammatory response of atherosclerosis
Zernecke, A., & Weber, C. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp391 · Cited by 204 · see citing works
CXC Ligand 5 Is an Adipose-Tissue Derived Factor that Links Obesity to Insulin Resistance
Carine Chavey, A., Lazennec, G., Lagarrigue, S., Clapé, C., Iankova, I., Teyssier, J., Annicotte, J., Schmidt, J., Mataki, C., Yamamoto, H., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.002 · Cited by 182 · see citing works
Wang, C.-Y., Kim, H.-H., Hiroi, Y., Sawada, N., Salomone, S., Benjamin, L. E., Walsh, K., Moskowitz, M. A., & Liao, J. K. (2009) · Science Signaling · doi:10.1126/scisignal.2000143 · Cited by 177 · see citing works
Neutrophils Infiltrate Resistance-Sized Vessels of Subcutaneous Fat in Women With Preeclampsia
Leik, C. E., & Walsh, S. W. (2004) · Hypertension · doi:10.1161/01.hyp.0000130483.83154.37 · Cited by 115 · see citing works
Ghanim, H., Aljada, A., Daoud, N., Deopurkar, R., Chaudhuri, A., & Dandona, P. (2007) · Diabetologia · doi:10.1007/s00125-006-0508-9 · Cited by 96 · see citing works
Control of granule exocytosis in neutrophils
Lacy, P. (2008) · Frontiers in bioscience · doi:10.2741/3099 · Cited by 94 · see citing works
Neutrophil Infiltration and Systemic Vascular Inflammation in Obese Women
Shah, T. J., Leik, C. E., & Walsh, S. W. (2009) · Reproductive Sciences · doi:10.1177/1933719109348252 · Cited by 83 · see citing works
Keratinocyte-derived Chemokine in Obesity
Neels, J. G., Badeanlou, L., Hester, K. D., & Samad, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.018556 · Cited by 73 · see citing works
A Potential Role of the CXC Chemokine GROα in Atherosclerosis and Plaque Destabilization
Breland, U. M., Halvorsen, B. L., Fosse, J. H., Øie, E., Paulsson‐Berne, G., Yndestad, A., Smith, C., Otterdal, K., Hedin, U., Wæhre, T., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.162305 · Cited by 64 · see citing works
Seveau, S. M., Keller, H. U., Maxfield, F. R., Piller, F., & Halbwachs‐Mecarelli, L. (2000) · Blood · doi:10.1182/blood.v95.8.2462.007k36_2462_2470 · Cited by 42 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Roles for chemokines in liver disease
Marra, F., & Tacke, F. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.06.043 · Cited by 829 · see citing works
The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.
Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732 · see citing works
Zhang, Y., Chandra, V., Riquelme, E. M., Dutta, P., Quesada, P. R., Rakoski, A. I., Zoltan, M. A., Arora, N., Baydogan, S., Horne, W. T., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190354 · Cited by 447 · see citing works
Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies
Musso, G., Cassader, M., & Gambino, R. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.3 · Cited by 415 · see citing works
Dalmas, E., Toubal, A., Alzaid, F., Blazek, K., Eames, H. L., Lebozec, K., Pini, M., Hainault, I., Montastier, E., Denis, R. G. P., et al. (2015) · Nature Medicine · doi:10.1038/nm.3829 · Cited by 205 · see citing works
Self-citationHuman Adipocytes Induce Inflammation and Atrophy in Muscle Cells During Obesity
Pellegrinelli, V., Rouault, C., Rodríguez‐Cuenca, S., Albert, V., Edom‐Vovard, F., Vidal‐Puig, A., Clément, K., Butler-Browne, G. S., & Lacasa, D. (2015) · Diabetes · doi:10.2337/db14-0796 · Cited by 197 · see citing works
Self-citationParallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity
Trim, W. V., Turner, J. E., & Thompson, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00169 · Cited by 167 · see citing works
Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes
Oral, E. A., Reilly, S. M., Gomez, A. V., Meral, R., Butz, L., Ajluni, N., Chenevert, T. L., Korytnaya, E., Neidert, A., HENCH, R. P., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.006 · Cited by 164 · see citing works
Tang, H., Gao, Y., Li, Z., Miao, Y., Huang, Z., Liu, X., Xie, L., Li, H., Wen, W., Zheng, Y., et al. (2020) · Clinical and Translational Medicine · doi:10.1002/ctm2.200 · Cited by 155 · see citing works
Caër, C., Rouault, C., Roy, T. L., Poitou, C., Aron‐Wisnewsky, J., Torcivia, A., Bichet, J.-C., Clément, K., Guerre-Millo, M., & André, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-02660-w · Cited by 157 · see citing works
Self-citationChemokines and Chemokine Receptors: Orchestrating Tumor Metastasization
Marcuzzi, E., Angioni, R., Molon, B., & Calì, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010096 · Cited by 158 · see citing works
Yu, Z., Nanthakumar, N. N., & Newburg, D. S. (2016) · Journal of Nutrition · doi:10.3945/jn.116.230706 · Cited by 142 · see citing works
Innate Immune Cells in the Adipose Tissue in Health and Metabolic Disease
Michailidou, Z., Gomez-Salazar, M. A., & Alexaki, V. I. (2021) · Journal of Innate Immunity · doi:10.1159/000515117 · Cited by 137 · see citing works
Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice
Bijnen, M., Josefs, T., Cuijpers, I., Maalsen, C. J., van de Gaar, J., Vroomen, M., Wijnands, E., Rensen, S. S., Greve, J. W. M., Hofker, M. H., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-313654 · Cited by 134 · see citing works
Caputo, T., Gilardi, F., & Desvergne, B. (2017) · FEBS Letters · doi:10.1002/1873-3468.12742 · Cited by 111 · see citing works
Regulation and functional roles of chemokines in liver diseases
Cao, S., Liu, M., Sehrawat, T. S., & Shah, V. H. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00444-2 · Cited by 105 · see citing works
Adipocytes, Innate Immunity and Obesity: A Mini-Review
Blaszczak, A. M., Jalilvand, A., & Hsueh, W. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.650768 · Cited by 108 · see citing works
Rouault, C., Marcelin, G., Adriouch, S., Rose, C., Genser, L., Ambrosini, M., Bichet, J.-C., Zhang, Y., Marquet, F., Aron-Wisnewsky, J., et al. (2021) · Diabetologia · doi:10.1007/s00125-020-05307-0 · Cited by 95 · see citing works
Self-citationReggio, S., Rouault, C., Poitou, C., Bichet, J.-C., Prifti, E., Bouillot, J., Rizkalla, S. W., Lacasa, D., Tordjman, J., & Clément, K. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-4304 · Cited by 91 · see citing works
Self-citationRuebel, M. L., Cotter, M., Sims, C. R., Moutos, D. M., Badger, T. M., Cleves, M. A., Shankar, K., & Andres, A. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3524 · Cited by 89 · see citing works
The NEDD8-activating enzyme inhibitor MLN4924 reduces ischemic brain injury in mice
Yu, H., Luo, H., Chang, L., Wang, S., Geng, X., Kang, L., Zhong, Y., Cao, Y., Wang, R., Yang, X., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2111896119 · Cited by 76 · see citing works
Green, I. D., Pinello, N., Song, R., Lee, Q., Halstead, J. M., Kwok, C., Wong, A. C. H., Nair, S. S., Clark, S. J., Roediger, B., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa435 · Cited by 74 · see citing works
Spotlight on the Mechanism of Action of Semaglutide
Papakonstantinou, I. P., Tsioufis, K. P., & Katsi, V. K. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46120872 · Cited by 80 · see citing works
Shantaram, D., Hoyd, R., Blaszczak, A. M., Antwi, L., Jalilvand, A., Wright, V. P., Liu, J., Smith, A. J., Bradley, D. P., Lafuse, W. P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48935-5 · Cited by 70 · see citing works
Pellegrinelli, V., Rouault, C., Veyrie, N., Clément, K., & Lacasa, D. (2013) · Diabetes · doi:10.2337/db13-0537 · Cited by 70 · see citing works
Self-citationLeukocyte Heterogeneity in Adipose Tissue, Including in Obesity
Weinstock, A., Silva, H. M., Moore, K. J., Schmidt, A. M., & Fisher, E. A. A. (2020) · Circulation Research · doi:10.1161/circresaha.120.316203 · Cited by 67 · see citing works
Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics
Brassington, K., Selemidis, S., Bozinovski, S., & Vlahos, R. (2022) · Clinical Science · doi:10.1042/cs20210835 · Cited by 65 · see citing works
Maxwell, A. J., Ding, J., You, Y., Dong, Z., Chehade, H., Alvero, A. B., Mor, Y., Drăghici, S., & Mor, G. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4covr0920-552rr · Cited by 56 · see citing works
Xue, D., Tabib, T., Morse, C., & Lafyatis, R. (2019) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2019.11.012 · Cited by 54 · see citing works
Crosstalk Between Mast Cells and Adipocytes in Physiologic and Pathologic Conditions
Komi, D. E. A., Shafaghat, F., & Christian, M. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08785-7 · Cited by 55 · see citing works
Padmanabhan, J., Chen, K., Sivaraj, D., Henn, D., Kuehlmann, B. A., Kussie, H. C., Zhao, E. T., Kahn, A., Bonham, C. A., Dohi, T., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01091-5 · Cited by 57 · see citing works
Conditioning solid tumor microenvironment through inflammatory chemokines and S100 family proteins
Nasser, M. W., Elbaz, M., Ahirwar, D. K., & Ganju, R. K. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.05.002 · Cited by 48 · see citing works
Kawanishi, N., Niihara, H., Mizokami, T., Yada, K., & Suzuki, K. (2015) · Physiological Reports · doi:10.14814/phy2.12534 · Cited by 47 · see citing works
Verdú, E., Homs, J., & Boadas‐Vaello, P. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182413333 · Cited by 54 · see citing works
Gilleron, J., Bouget, G., Ivanov, S., Méziat, C., Ceppo, F., Vergoni, B., Djedaini, M., Soprani, A., Dumas, K., Jacquel, A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.083 · Cited by 46 · see citing works
Wang, G., Liu, Z., Li, M., Yu, L., Alvi, S. S., Ansari, I. A., & Khan, M. S. (2019) · BioMed Research International · doi:10.1155/2019/7284767 · Cited by 46 · see citing works
Adipose tissue immune cells in obesity, type 2 diabetes mellitus and cardiovascular diseases
Cinkajzlová, A., Mráz, M., & Haluzík, M. (2021) · Journal of Endocrinology · doi:10.1530/joe-21-0159 · Cited by 46 · see citing works
Multifaceted Breast Cancer: The Molecular Connection With Obesity
Feola, A., Ricci, S., Kouidhi, S., Rizzo, A., Penon, A., Formisano, P., Giordano, A., Carlo, A. D., & Domenico, M. D. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25475 · Cited by 45 · see citing works
Specialized Proresolving Mediators: Enhancing Nonalcoholic Steatohepatitis and Fibrosis Resolution
Musso, G., Gambino, R., Cassader, M., Paschetta, E., & Sircana, A. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.01.003 · Cited by 44 · see citing works
Bas-Prior, J. M. D., Crescenti, A., Arola‐Arnal, A., Oms‐Oliu, G., Arola, L., & Caimari, A. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.159 · Cited by 43 · see citing works
Impact of bariatric surgery on type 2 diabetes: contribution of inflammation and gut microbiome?
Debédat, J., Amouyal, C., Aron‐Wisnewsky, J., & Clément, K. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00738-3 · Cited by 40 · see citing works
Self-citationMarthandan, S., Menzel, U., Priebe, S., Groth, M., Guthke, R., Platzer, M., Hemmerich, P., Kaether, C., & Diekmann, S. (2016) · Biological Research · doi:10.1186/s40659-016-0095-2 · Cited by 39 · see citing works
Yang, H. S., Graham, L. C., Reagan, A. M., Grabowska, W. A., Schott, W. H., & Howell, G. R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1527-z · Cited by 39 · see citing works
Organogermanium suppresses cell death due to oxidative stress in normal human dermal fibroblasts
Takeda, T., Doiyama, S., Azumi, J., Shimada, Y., Tokuji, Y., Yamaguchi, H., Nagata, K., Sakamoto, N., Aso, H., & Nakamura, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-49883-7 · Cited by 38 · see citing works
Cimini, F. A., Barchetta, I., Ciccarelli, G., Leonetti, F., Silecchia, G., Chiappetta, C., Cristofano, C. D., Capoccia, D., Bertoccini, L., Ceccarelli, V., et al. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3358 · Cited by 39 · see citing works
Activation of the adipocyte CREB/CRTC pathway in obesity
Yoon, Y., Liu, W., de Velde, S. V., Matsumura, S., Wiater, E., Huang, L., & Montminy, M. (2021) · Communications Biology · doi:10.1038/s42003-021-02735-5 · Cited by 39 · see citing works
Orchestration of the Adipose Tissue Immune Landscape by Adipocytes
Bradley, D. P., Deng, T., Shantaram, D., & Hsueh, W. A. (2024) · Annual Review of Physiology · doi:10.1146/annurev-physiol-042222-024353 · Cited by 38 · see citing works
Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET
Barron, A. M., Tokunaga, M., Zhang, M., Ji, B., Suhara, T., & Higuchi, M. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0700-x · Cited by 36 · see citing works
Characterization of immune cells in psoriatic adipose tissue
Rose, S. M., Stansky, E., Dagur, P. K., Samsel, L., Weiner, E., Jahanshad, A., Doveikis, J., Naik, H. B., Playford, M. P., McCoy, J. P., et al. (2014) · Journal of Translational Medicine · doi:10.1186/s12967-014-0258-2 · Cited by 34 · see citing works
Transcriptional Regulation of Chemokine Genes: A Link to Pancreatic Islet Inflammation?
Burke, S. J., & Collier, J. J. (2015) · Biomolecules · doi:10.3390/biom5021020 · Cited by 33 · see citing works
Liang, J., Li, N., Zhang, Y., Hou, C., Yang, X., Shimizu, T., Wang, X., Ikenaka, K., Fan, K., & Ma, J. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00152 · Cited by 34 · see citing works
Neutrophils as indicators of obesity‐associated inflammation: A systematic review and meta‐analysis
Gomez‐Casado, G., Jimenez‐Gonzalez, A., Rodríguez-Muñoz, A., Tinahones, F. J., González‐Mesa, E., Murri, M., & Ortega‐Gómez, A. (2024) · Obesity Reviews · doi:10.1111/obr.13868 · Cited by 31 · see citing works
Dai, H., Wei, G., Wang, Y., Ma, N., Chang, G., & Shen, X. (2020) · Journal of Dairy Science · doi:10.3168/jds.2020-18198 · Cited by 31 · see citing works
Characterization of Dermal Stem Cells of Diabetic Patients
Ferroni, L., Gardin, C., Paola, L. D., Campo, G. C., Cimaglia, P., Bellin, G., Pinton, P., & Zavan, B. (2019) · Cells · doi:10.3390/cells8070729 · Cited by 30 · see citing works
Peruzzi, C. P., Nascimento, S., Gauer, B., Nardi, J., Saüer, E., Göethel, G., Cestonaro, L. V., Fão, N., Cattani, S. A., Paim, C., et al. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-3693-4 · Cited by 28 · see citing works
Budden, K. F., Gellatly, S. L., Vaughan, A., Amorim, N. M. L., Horvat, J. C., Hansbro, N. G., Wood, D., Hugenholtz, P., Dennis, P. G., Wark, P. A. B., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010252 · Cited by 28 · see citing works
Hsieh, C., Lin, C., He, J.-T., Chiang, M., Wang, Y., Tsai, Y.-C., Hung, C., & Chang, P. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0915-0 · Cited by 26 · see citing works
Hu, D., Mo, X., Luo, J., Wang, F., Huang, C., Xie, H., & Jin, L. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110698 · Cited by 25 · see citing works
Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging
Chen, J., Fan, Z., Zhu, D., Guo, Y., Ye, K., Dai, D., Guo, Z. J., Hu, Z., Miao, Y., & Qu, Q. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.728188 · Cited by 26 · see citing works
Altamura, S., Lombardi, F., Palumbo, P., Cinque, B., Ferri, C., Pinto, R. D., & Pietropaoli, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413633 · Cited by 22 · see citing works
Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice
Bijnen, M., Josefs, T., Cuijpers, I., van de Gaar, J., Vroomen, M. A. M., Wijnands, E., Rensen, S. S., Greve, J. W. M., Hofker, M. H., Biessen, E. A. L., et al. (2017) · Journal of Hepatology · doi:10.1016/s0168-8278(17)31630-6 · Cited by 22 · see citing works
Thompson, D., Sorenson, J., Greenmyer, J. R., Brissette, C. A., & Watt, J. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234993 · Cited by 23 · see citing works
Pan, Y. C., Nishikawa, T., Chang, C. Y., Tai, J. A., & Kaneda, Y. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2020.12.011 · Cited by 21 · see citing works
Identification of key pathways and core genes involved in atherosclerotic plaque progression
Yang, R., Yao, L., Du, C., & Wu, Y. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-193 · Cited by 21 · see citing works
Sputnik-V reactogenicity and immunogenicity in the blood and mucosa: a prospective cohort study
Yegorov, S., Kadyrova, I., Negmetzhanov, B., Kolesnikova, Y. A., Kolesnichenko, S. I., Korshukov, I., Baiken, Y., Matkarimov, B. T., Miller, M. S., Hortelano, G., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-17514-3 · Cited by 21 · see citing works
Glycogen synthase kinase 3 activity enhances liver inflammation in MASH
Khoury, M., Guo, Q., Furuta, K., Correia, C., Meroueh, C., Kim Lee, H. S., Warasnhe, K., Valenzuela-Pérez, L., Mazar, A. P., Kim, I., et al. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101073 · Cited by 17 · see citing works
Host transcriptome response to Borrelia burgdorferi sensu lato
Thompson, D., Watt, J. A., & Brissette, C. A. (2020) · Ticks and Tick-borne Diseases · doi:10.1016/j.ttbdis.2020.101638 · Cited by 16 · see citing works
Mice with Fabp4-Cre ablation of Arid5b are resistant to diet-induced obesity and hepatic steatosis
Whitson, R. H., Li, S.-L., Zhang, G., Larson, G. P., & Itakura, K. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111246 · Cited by 16 · see citing works
Sabikunnahar, B., Caldwell, S. K., Varnum, S., Hogan, T. C., Cooper, A., Lahue, K. G., Bivona, J. J., Cousens, P. M., Symeonides, M., Ballif, B. A., et al. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200215 · Cited by 16 · see citing works
Almengló, C., Fu, X., Flores-Arias, M. T., Fernández, Á. L., Viñuela, J. E., Martínez‐Cereijo, J. M., Durán, D., Rodríguez‐Mañero, M., González‐Juanatey, J. R., & Eiras-Penas, S. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17466 · Cited by 13 · see citing works
Nagar, N., Naidu, G., Panda, S. K., Gulati, K., Singh, R. P., & Poluri, K. M. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111944 · Cited by 11 · see citing works
Liu, X.-H., Zhang, Y., Chang, L., Wei, Y., Huang, N., Zhou, J., Cheng, C., Zhang, J., Xu, J., Li, Z., et al. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111813 · Cited by 11 · see citing works
Ghoshal, S., Mukherjee, S. K., Chakraborty, M., Msengi, E. N., Haubner, J., & Chakraborty, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042059 · Cited by 10 · see citing works
Skin as an immune organ and the site of biomimetic, non-invasive vaccination
Chopra, A., & Gupta, A. (2022) · Medicine in Novel Technology and Devices · doi:10.1016/j.medntd.2022.100196 · Cited by 10 · see citing works
Dai, L., Liu, Z., Guo, L., Chai, Y., Yang, Y., Wang, Y., Ma, Y., Shi, C., & Zhang, W. (2023) · Veterinary Sciences · doi:10.3390/vetsci10020107 · Cited by 10 · see citing works
Dhanraj, P., van Heerden, M. B., Pepper, M. S., & Ambele, M. A. (2021) · Biology · doi:10.3390/biology10080717 · Cited by 10 · see citing works
Implant-induced inflammatory angiogenesis is up-regulated in obese mice
Orellano, L. A. A., de Almeida, S. A., Pereira, L. X., Machado, C. T., Viana, C. T. R., Andrade, S. P., & Campos, P. P. (2020) · Microvascular Research · doi:10.1016/j.mvr.2020.104014 · Cited by 9 · see citing works
Anti-inflammatory effects of troxerutin are mediated through elastase inhibition
Vidhya, R., & Anuradha, C. V. (2020) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2020.1806870 · Cited by 9 · see citing works
Long Non-Coding RNA Expression Profiling in Obesity Mice with Folic Acid Supplement
Ma, F., Li, W., Tang, R., Liu, Z., Ouyang, S., Cao, D., Li, Y., & Wu, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477486 · Cited by 9 · see citing works
Identification and Validation of CXCL2 as a Key Gene for Childhood Obesity
He, E., Chang, K., Dong, L., Jia, M., Sun, W., & Cui, H. (2023) · Biochemical Genetics · doi:10.1007/s10528-023-10566-8 · Cited by 8 · see citing works
Zou, Y., Yang, X., Chen, C., Ma, H., Cao, H., Jiang, J., Wei, X., & Zhang, X. (2024) · Parasites & Vectors · doi:10.1186/s13071-023-06053-z · Cited by 7 · see citing works
Molecular Mapping of Hydrogen Sulfide Targets in Normal Human Keratinocytes
Gross-Amat, O., Guillen, M., Gimeno, J., Salzet, M., Lebonvallet, N., Misery, L., Auxenfans, C., & Nataf, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134648 · Cited by 7 · see citing works
Starost, L. J., Karassek, S., Sano, Y., Kanda, T., Kim, K., Dobrindt, U., Rüter, C., & Schmidt, M. A. (2016) · Toxins · doi:10.3390/toxins8100291 · Cited by 6 · see citing works
Geles, K., Vlachavas, E., Papadodima, O., Pilalis, E. D., Vorgias, C. E., Georgakilas, A. G., & Chatziioannou, A. A. (2017) · Cancers · doi:10.3390/cancers9120160 · Cited by 6 · see citing works
Gene-body mass index interactions are associated with methotrexate toxicity in rheumatoid arthritis
Aslibekyan, S. W., Sha, J., Redden, D. T., Moreland, L. W., O’Dell, J. R., Curtis, J. R., Mikuls, T. R., Reynolds, R. J., Danila, M. I., & Bridges, S. L. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204263 · Cited by 6 · see citing works
Baudin, J., Hernández-Baixauli, J., Romero‐Giménez, J., Yang, H., Mulero, F., Puiggròs, F., Mardinoğlu, A., Arola, L., & Caimari, A. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117326 · Cited by 5 · see citing works
Pitchai, A., Shinde, A., Swihart, J. N., Robison‡, K. M., & Shannahan, J. H. (2024) · Nanomaterials · doi:10.3390/nano14201642 · Cited by 5 · see citing works
Adipose Structure (White, Brown, Beige)
Peirce, V. J., Pellegrinelli, V., & Vidal‐Puig, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-11251-0_23 · Cited by 5 · see citing works
Self-citationEffect of Fibroblast Signaling on Macrophage Polarization.
LoPresti, S. T., Kulkarni, M. M., Julian, D. R., Johnson, Z. I., Lantonio, B. L., Ismail, N., Yates, C., & Brown, B. N. (2025) · American Journal of Pathology · doi:10.1016/j.ajpath.2025.04.002 · Cited by 3 · see citing works
Calvo-Pinilla, E., Jiménez-Cabello, L., Utrilla-Trigo, S., Illescas-Amo, M., & Ortego, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042065 · Cited by 4 · see citing works
Overfeeding induces adipose tissue release of distinct mitochondria
Goodman, J. H., Berland, C., Soni, R. K., & Ferrante, A. W. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115318 · Cited by 4 · see citing works
Snyder‐Talkington, B. N., Dong, C., Castranova, V., Qian, Y. R., & Guo, N. L. (2019) · Toxicology Reports · doi:10.1016/j.toxrep.2019.05.010 · Cited by 4 · see citing works
Bone marrow neutrophil density regulates myelopoiesis during obesity and weight loss
Waterbury, Q. T., Qian, J., Zheng, H., Dirnberger, A. S., Olson, O. C., White, R. A., Wu, F., Kobayashi, H., Malagola, E., Ochiai, Y., et al. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20242174 · Cited by 3 · see citing works
Flexible adipocytes guided nano-anchoring medicine: A precision therapeutic strategy for obesity
Luo, M., Huang, J. Z., Qin, S., Peng, C., & Li, D. (2026) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2026.101666 · Cited by 3 · see citing works
Wyczanska, M., Thalmeier, F., Keller, U., Klaus, R., Narasimhan, H., Ji, X., Schraml, B. U., Wackerbarth, L. M., & Lange-Sperandio, B. (2024) · Scientific Reports · doi:10.1038/s41598-024-55469-9 · Cited by 3 · see citing works
Bmal1 deficiency in neutrophils alleviates symptoms induced by high-fat diet
Leinweber, B., Pilorz, V., Olejniczak, I., Skrum, L., Begemann, K., Heyde, I., Stenger, S., Sadik, C. D., & Oster, H. (2025) · iScience · doi:10.1016/j.isci.2025.112038 · Cited by 3 · see citing works
Jin, Y., Kim, D.-W., Choi, Y. J., Song, I., & Chung, Y. (2022) · Genes · doi:10.3390/genes13030459 · Cited by 3 · see citing works
Chen, D., Zhou, Z., Dai, X., Gao, M., Huang, B., Liang, T., Shi, R., Zou, L., Li, H., Bünger, C. E., et al. (2014) · Frontiers of Materials Science · doi:10.1007/s11706-014-0234-z · Cited by 3 · see citing works
Transcriptome profiling of poly(I:C)-induced RAW 264.7 mouse macrophages in response to panaxadiol
Yang, Z., Guo, D., Shen, L., Mao, G., Dai, J., Chen, S., & Yan, J. (2019) · Biologia · doi:10.2478/s11756-019-00288-x · Cited by 3 · see citing works
Rohringer, S., Specht, S. J., Schmitt, A.-M., Topcu, S., Schneider, K. H., Enayati, M., Grasl, C., Ehrmann, K., Baudis, S., Kiss, H., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102089 · Cited by 2 · see citing works
- Authors
- Rouault, C., Pellegrinelli, V., Schilch, R., Cotillard, A., Poitou, C., Tordjman, J., Sell, H., Clément, K., & Lacasa, D.
- Affiliations
- Inserm (FR)
- Deutsches Diabetes-Zentrum e.V. (DE)
- Corresponding author
- Lacasa, Danièle
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2013-03-01
- Volume
- 154
- Issue
- 3
- Pages
- 1069-1079
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2051659042
- Cited by
- 119
- References
- 44
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 13 · 2023: 7 · 2022: 10 · 2021: 10 · 2020: 16 · 2019: 11 · 2018: 6 · 2017: 10 · 2016: 11 · 2015: 6 · 2014: 6 · 2013: 2
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- CXCL2, neutrophils, endothelial cells, white adipose tissue, obesity, adipose tissue inflammation, visceral adipose tissue, subcutaneous adipose tissue, adipose tissue macrophages, neutrophil adhesion, chemokines, interleukin-6, TNF-α, interleukin-8, MMP-9, myeloperoxidase, endothelial cell senescence, angiogenesis
- MeSH terms
- Adult, Cell Adhesion, Female, Humans, Inflammation, Neutrophils, Obesity, Morbid, RNA, Messenger, Case-Control Studies, Neutrophil Activation, Inflammation Mediators, Chemokines, Endothelial Cells, Adipose Tissue, White, Chemokine CXCL2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review