The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Gonadotropin-Inhibitory Hormone Neurons Interact Directly with Gonadotropin-Releasing Hormone-I and -II Neurons in European Starling Brain
Abstract
Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic dodecapeptide (SIKPSAYLPLRF-NH2) that directly inhibits gonadotropin synthesis and release from quail pituitary. The action of GnIH is mediated by a novel G-protein coupled receptor. This gonadotropin-inhibitory system may be widespread in vertebrates, at least birds and mammals. In these higher vertebrates, histological evidence suggests contact of GnIH immunoreactive axon terminals with GnRH neurons, thus indicating direct regulation of GnRH neuronal activity by GnIH. In this study we investigated the interaction of GnIH and GnRH-I and -II neurons in European starling (Sturnus vulgaris) brain. Cloned starling GnIH precursor cDNA encoded three peptides that possess characteristic LPXRF-amide (X = L or Q) motifs at the C termini. Starling GnIH was further identified as SIKPFANLPLRF-NH2 by mass spectrometry combined with immunoaffinity purification. GnIH neurons, identified by in situ hybridization and immunocytochemistry (ICC), were clustered in the hypothalamic paraventricular nucleus. GnIH immunoreactive fiber terminals were present in the external layer of the median eminence in addition to the preoptic area and midbrain, where GnRH-I and GnRH-II neuronal cell bodies exist, respectively. GnIH axon terminals on GnRH-I and -II neurons were shown by GnIH and GnRH double-label ICC. Furthermore, the expression of starling GnIH receptor mRNA was identified in both GnRH-I and GnRH-II neurons by in situ hybridization combined with GnRH ICC. The cellular localization of GnIH receptor has not previously been identified in any vertebrate brain. Thus, GnIH may regulate reproduction of vertebrates by directly modulating GnRH-I and GnRH-II neuronal activity, in addition to influencing the pituitary gland.
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Cites
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
Kozak, M. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.20.8125 · Cited by 5,087
Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence
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Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence
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Photoperiodic Control of Seasonality in Birds
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Self-citationA Novel Avian Hypothalamic Peptide Inhibiting Gonadotropin Release
Tsutsui, K., Saigoh, E., Ukena, K., Teranishi, H., Fujisawa, Y., Kikuchi, M., Ishii, S., & Sharp, P. J. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3350 · Cited by 828
Self-citationNew neuropeptides containing carboxy-terminal RFamide and their receptor in mammals
Hinuma, S., Shintani, Y., Fukusumi, S., Iijima, N., Matsumoto, Y., Hosoya, M., Fujii, R., Watanabe, T., Kikuchi, K., Terao, Y., et al. (2000) · Nature Cell Biology · doi:10.1038/35036326 · Cited by 565
Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals
Kriegsfeld, L. J., Mei, D. F., Bentley, G. E., Ubuka, T., Mason, A. O., Inoue, K., Ukena, K., Tsutsui, K., & Silver, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511003103 · Cited by 552
Self-citationPrimary Structure of the Ovine Hypothalamic Luteinizing Hormone-Releasing Factor (LRF)
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Cited by
Smith, J. T., Coolen, L. M., Kriegsfeld, L. J., Sari, I. P., Jaafarzadehshirazi, M. R., Maltby, M., Bateman, K., Goodman, R. L., Tilbrook, A. J., Ubuka, T., et al. (2008) · Endocrinology · doi:10.1210/en.2008-0581 · Cited by 387
Self-citationKirby, E. D., Geraghty, A. C., Ubuka, T., Bentley, G. E., & Kaufer, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901176106 · Cited by 379
Self-citationDucret, E., Anderson, G. M., & Herbison, A. E. (2009) · Endocrinology · doi:10.1210/en.2008-1623 · Cited by 295
Ubuka, T., Inoue, K., Fukuda, Y., Mizuno, T., Ukena, K., Kriegsfeld, L. J., & Tsutsui, K. (2012) · Endocrinology · doi:10.1210/en.2011-1110 · Cited by 279
Self-citationUbuka, T., Morgan, K., Pawson, A. J., Osugi, T., Chowdhury, V. S., Minakata, H., Tsutsui, K., Millar, R. P., & Bentley, G. E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008400 · Cited by 261
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Metadata
- Authors
- Ubuka, T., Kim, S., Huang, Y.-C., Reid, J., Jiang, J., Osugi, T., Chowdhury, V. S., Tsutsui, K., & Bentley, G. E.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2007-09-27
- Volume
- 149
- Issue
- 1
- Pages
- 268-278
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2166905473
- Cited by
- 265
- References
- 38
- FWCI
- 14.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ubuka, T., Kim, S., Huang, Y.-C., Reid, J., Jiang, J., Osugi, T., Chowdhury, V. S., Tsutsui, K., & Bentley, G. E. (2008). Gonadotropin-Inhibitory Hormone Neurons Interact Directly with Gonadotropin-Releasing Hormone-I and -II Neurons in European Starling Brain. Endocrinology. https://doi.org/10.1210/en.2007-0983
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