The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Dietary Curcumin Significantly Improves Obesity-Associated Inflammation and Diabetes in Mouse Models of Diabesity
Open accessAbstract
Obesity is a major risk factor for the development of type 2 diabetes, and both conditions are now recognized to possess significant inflammatory components underlying their pathophysiologies. We tested the hypothesis that the plant polyphenolic compound curcumin, which is known to exert potent antiinflammatory and antioxidant effects, would ameliorate diabetes and inflammation in murine models of insulin-resistant obesity. We found that dietary curcumin admixture ameliorated diabetes in high-fat diet-induced obese and leptin-deficient ob/ob male C57BL/6J mice as determined by glucose and insulin tolerance testing and hemoglobin A1c percentages. Curcumin treatment also significantly reduced macrophage infiltration of white adipose tissue, increased adipose tissue adiponectin production, and decreased hepatic nuclear factor-κB activity, hepatomegaly, and markers of hepatic inflammation. We therefore conclude that orally ingested curcumin reverses many of the inflammatory and metabolic derangements associated with obesity and improves glycemic control in mouse models of type 2 diabetes. This or related compounds warrant further investigation as novel adjunctive therapies for type 2 diabetes in man.
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Citations
Cites
Obesity is associated with macrophage accumulation in adipose tissue
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IKK-β links inflammation to obesity-induced insulin resistance
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Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
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“The liver weights of the curcumin-fed ob/ob mice did not weigh significantly less than controls, an effect potentially attributable to the complete absence of leptin in these mice, which has been shown be associated with severe and refractory hepatosteatosis (47, 48).”
BackgroundRausch, M. E., Weisberg, S., Vardhana, P., & Tortoriello, D. V. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803744 · Cited by 585
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Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy†
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“The liver weights of the curcumin-fed ob/ob mice did not weigh significantly less than controls, an effect potentially attributable to the complete absence of leptin in these mice, which has been shown be associated with severe and refractory hepatosteatosis (47, 48).”
Background
Cited by
Aggarwal, B. B., & Sung, B. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.11.002 · Cited by 1,140
Possible anti-obesity therapeutics from nature--a review
Yun, J. W. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2010.07.011 · Cited by 619
Zhao, C., Yang, C., Wai, S. T. C., Zhang, Y., P. Portillo, M., Paoli, P., Wu, Y., San Cheang, W., Liu, B., Carpéné, C., et al. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1501658 · Cited by 199
Thota, R. N., Acharya, S. H., & Garg, M. L. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-0967-x · Cited by 127
Lee, H.-I., McGregor, R. A., Choi, M.-S., Seo, K.-I., Jung, U. J., Yeo, J., Kim, M.-J., & Lee, M.-K. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.09.014 · Cited by 79
Metadata
- Authors
- Weisberg, S. P., Leibel, R., & Tortoriello, D. V.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2008-04-10
- Volume
- 149
- Issue
- 7
- Pages
- 3549-3558
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2128009708
- Cited by
- 480
- References
- 11
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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