Cited by 131Hypothalamic control of reproductive hormonesNeuroendocrine regulation and behaviorRegulation of Appetite and Obesity

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Identification of Prolactin-Sensitive GABA and Kisspeptin Neurons in Regions of the Rat Hypothalamus Involved in the Control of Fertility

Kokay, Ilona C., Petersen, Sandra L., Grattan, David R.·2011·Endocrinology

DOI 10.1210/en.2010-0668

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Abstract

High levels of circulating prolactin are known to cause infertility, but the precise mechanisms by which prolactin influences the neuroendocrine axis are yet to be determined. We used dual-label in situ hybridization to investigate whether prolactin-receptor (PRLR) mRNA is expressed in GnRH neurons. In addition, because γ-aminobutyric acidergic and kisspeptin neurons in the rostral hypothalamus are known to regulate GnRH neurons and, hence, might mediate the actions of prolactin, we investigated whether these neurons coexpress PRLR mRNA. (35)S-labeled RNA probes to detect PRLR mRNA were hybridized together with digoxigenin-labeled probes to detect either GnRH, Gad1/Gad2, or Kiss1 mRNA in the rostral hypothalamus of ovariectomized (OVX), estradiol-treated rats. Additional sets of serial sections were cut through the arcuate nucleus of OVX rats, without estradiol replacement, to examine coexpression of PRLR mRNA in the arcuate population of kisspeptin neurons. PRLR mRNA was highly expressed throughout the rostral preoptic area, particularly in periventricular regions surrounding the third ventricle, and there was a high degree of colocalization of PRLR mRNA in both Gad1/Gad2 and Kiss1 mRNA-containing cells (86 and 85.5%, respectively). In contrast, only a small number of GnRH neurons (<5%) was found to coexpress PRLR mRNA. In the arcuate nucleus of OVX rats, the majority of Kiss1 mRNA-containing cells also coexpressed PRLR mRNA. These data are consistent with the hypothesis that, in addition to a direct action on a small subpopulation of GnRH neurons, prolactin actions on GnRH neurons are predominantly mediated indirectly, through known afferent pathways.

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Authors: Kokay, I. C., Petersen, S. L., & Grattan, D. R.
Affiliations: University of Otago (NZ)
University of Massachusetts Amherst (US)
Corresponding author: Grattan, David R.
ORCID: Petersen, Sandra L.
Grattan, David R.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2010-12-22
Volume: 152
Issue: 2
Pages: 526-535
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2010-0668
OpenAlex: W2133123261
Cited by: 131
References: 91
Citations by year: 2025: 5 · 2024: 14 · 2023: 7 · 2022: 4 · 2021: 6 · 2020: 12 · 2019: 10 · 2018: 13 · 2017: 8 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 5 · 2012: 9
FWCI: 7.96
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: prolactin, prolactin receptor, kisspeptin neurons, GABAergic neurons, GnRH neurons, hypothalamus, arcuate nucleus, preoptic area, fertility control, neuroendocrine regulation, infertility, estradiol, ovariectomy
MeSH terms: Animals, Female, Fertility, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Hypothalamus, Neurons, Ovariectomy, Proteins, Receptors, Prolactin, Rats, Sprague-Dawley, In Situ Hybridization, Rats, Kisspeptins

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Identification of Prolactin-Sensitive GABA and Kisspeptin Neurons in Regions of the Rat Hypothalamus Involved in the Control of Fertility

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