Cited by 131Hypothalamic control of reproductive hormonesNeuroendocrine regulation and behaviorRegulation of Appetite and Obesity

The DOI matches its Crossref record; 90 of the 91 references it cites were found in a registry or an index.

Identification of Prolactin-Sensitive GABA and Kisspeptin Neurons in Regions of the Rat Hypothalamus Involved in the Control of Fertility

Kokay, Ilona C., Petersen, Sandra L., Grattan, David R.·2011·Endocrinology

DOI 10.1210/en.2010-0668

Open this paper in CoChat — free account

Abstract

High levels of circulating prolactin are known to cause infertility, but the precise mechanisms by which prolactin influences the neuroendocrine axis are yet to be determined. We used dual-label in situ hybridization to investigate whether prolactin-receptor (PRLR) mRNA is expressed in GnRH neurons. In addition, because γ-aminobutyric acidergic and kisspeptin neurons in the rostral hypothalamus are known to regulate GnRH neurons and, hence, might mediate the actions of prolactin, we investigated whether these neurons coexpress PRLR mRNA. (35)S-labeled RNA probes to detect PRLR mRNA were hybridized together with digoxigenin-labeled probes to detect either GnRH, Gad1/Gad2, or Kiss1 mRNA in the rostral hypothalamus of ovariectomized (OVX), estradiol-treated rats. Additional sets of serial sections were cut through the arcuate nucleus of OVX rats, without estradiol replacement, to examine coexpression of PRLR mRNA in the arcuate population of kisspeptin neurons. PRLR mRNA was highly expressed throughout the rostral preoptic area, particularly in periventricular regions surrounding the third ventricle, and there was a high degree of colocalization of PRLR mRNA in both Gad1/Gad2 and Kiss1 mRNA-containing cells (86 and 85.5%, respectively). In contrast, only a small number of GnRH neurons (<5%) was found to coexpress PRLR mRNA. In the arcuate nucleus of OVX rats, the majority of Kiss1 mRNA-containing cells also coexpressed PRLR mRNA. These data are consistent with the hypothesis that, in addition to a direct action on a small subpopulation of GnRH neurons, prolactin actions on GnRH neurons are predominantly mediated indirectly, through known afferent pathways.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/en.2010-0668

Cites

90 of 90 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54
Messager, S., Chatzidaki, E. E., Ma, D., Hendrick, A. G., Zahn, D., Dixon, J., Thresher, R. R., Malinge, I., Lomet, D., Carlton, M. B. L., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409330102 · Cited by 1,242
A role for kisspeptins in the regulation of gonadotropin secretion in the mouse
Gottsch, M. L., Cunningham, M. J., Smith, J. T., Popa, S. M., Acohido, B. V., Crowley, W. F., Seminara, S., Clifton, D. K., & Steiner, R. A. (2004) · Endocrinology · doi:10.1210/en.2004-0431 · Cited by 1,161
Regulation of Kiss1 gene expression in the brain of the female mouse
Smith, J. T., Cunningham, M. J., Rissman, E. F., Clifton, D. K., & Steiner, R. A. (2005) · Endocrinology · doi:10.1210/en.2005-0488 · Cited by 1,102
Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty
Han, S.-K., Gottsch, M. L., Lee, K. J., Popa, S. M., Smith, J. T., Jakawich, S. K., Clifton, D. K., Steiner, R. A., & Herbison, A. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3328-05.2005 · Cited by 1,036
Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat
Irwig, M. S., Fraley, G. S., Smith, J. T., Acohido, B. V., Popa, S. M., Cunningham, M. J., Gottsch, M. L., Clifton, D. K., & Steiner, R. A. (2004) · Neuroendocrinology · doi:10.1159/000083140 · Cited by 930
Postnatal Development of Kisspeptin Neurons in Mouse Hypothalamus; Sexual Dimorphism and Projections to Gonadotropin-Releasing Hormone Neurons
Clarkson, J., & Herbison, A. E. (2006) · Endocrinology · doi:10.1210/en.2006-0787 · Cited by 875
Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse
Navarro, V. M., Gottsch, M. L., Chavkin, C., Okamura, H., Clifton, D. K., & Steiner, R. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1569-09.2009 · Cited by 779
Multimodal Influence of Estrogen upon Gonadotropin-Releasing Hormone Neurons
Herbison, A. E. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0332 · Cited by 618
Kiss1 Neurons in the Forebrain as Central Processors for Generating the Preovulatory Luteinizing Hormone Surge
Smith, J. T., Popa, S. M., Clifton, D. K., Hoffman, G. E., & Steiner, R. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1618-06.2006 · Cited by 605
Definition of Estrogen Receptor Pathway Critical for Estrogen Positive Feedback to Gonadotropin-Releasing Hormone Neurons and Fertility
Wintermantel, T. M., Campbell, R. E., Porteous, R. W., Bock, D., Gröne, H., Todman, M. G., Korach, K. S., Greiner, E. F., Pérez, C. A., Schütz, G., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.023 · Cited by 598
Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats
ADACHI, S., YAMADA, S., TAKATSU, Y., MATSUI, H., KINOSHITA, M., TAKASE, K., SUGIURA, H., OHTAKI, T., MATSUMOTO, H., UENOYAMA, Y., et al. (2007) · Journal of Reproduction and Development · doi:10.1262/jrd.18146 · Cited by 580
Kisspeptin–GPR54 Signaling Is Essential for Preovulatory Gonadotropin-Releasing Hormone Neuron Activation and the Luteinizing Hormone Surge
Clarkson, J., d'Anglemont de Tassigny, X., Moreno, A. S., Colledge, W. H., & Herbison, A. E. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1775-08.2008 · Cited by 512
Sexual Differentiation of Kiss1 Gene Expression in the Brain of the Rat
Kauffman, A. S., Gottsch, M. L., Roa, J., Byquist, A. C., Crown, A., Clifton, D. K., Hoffman, G. E., Steiner, R. A., & Tena‐Sempere, M. (2007) · Endocrinology · doi:10.1210/en.2006-1540 · Cited by 504
Frontiers in Neuroendocrinology
Ball, J. B. (1975) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-197501000-00019 · Cited by 427
Estrogen positive feedback to gonadotropin-releasing hormone (GnRH) neurons in the rodent: The case for the rostral periventricular area of the third ventricle (RP3V)
Herbison, A. E. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.006 · Cited by 351
Distribution of Kisspeptin Neurones in the Adult Female Mouse Brain
Clarkson, J., D’Anglemont de Tassigny, X., Colledge, W. H., Caraty, A., & Herbison, A. E. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01892.x · Cited by 346
Prolactin: A Pleiotropic Neuroendocrine Hormone
Grattan, D. R., & Kokay, I. C. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01736.x · Cited by 321
Activation of A-Type γ-Aminobutyric Acid Receptors Excites Gonadotropin-Releasing Hormone Neurons
DeFazio, R. A., Heger, S., Ojeda, S. R., & Moenter, S. M. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0163 · Cited by 287
Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: morphologic evidence of interrelated function within the arcuate nucleus
Burke, M. C., Letts, P. A., Krajewski, S. J., & Rance, N. E. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.21086 · Cited by 280
Different distributions of GAD65 and GAD67 mRNAS suggest that the two glutamate decarboxylases play distinctive functional roles
Feldblum, S., Erlander, M. G., & Tobin, A. J. (1993) · Journal of Neuroscience Research · doi:10.1002/jnr.490340612 · Cited by 280
Structural Interactions between Kisspeptin and GnRH Neurons in the Mediobasal Hypothalamus of the Male Rhesus Monkey (Macaca mulatta) as Revealed by Double Immunofluorescence and Confocal Microscopy
Ramaswamy, S., Guerriero, K. A., Gibbs, R. B., & Plant, T. M. (2008) · Endocrinology · doi:10.1210/en.2008-0438 · Cited by 279
Luteinizing hormone-releasing hormone neurons express Fos protein during the proestrous surge of luteinizing hormone.
Lee, W.-S., Smith, M. S., & Hoffman, G. E. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.13.5163 · Cited by 272
Glutamic Acid Decarboxylase-Containing Axons Synapse on LHRH Neurons in the Rat Medial Preoptic Area
Léránth, C., MacLusky, N. J., Sakamoto, H., Shanabrough, M., & Naftolin, F. N. (2008) · Neuroendocrinology · doi:10.1159/000124127 · Cited by 272
New Evidence for Estrogen Receptors in Gonadotropin-Releasing Hormone Neurons
Herbison, A. E., & Pape, J. (2001) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0219 · Cited by 257
Comparative localization of mRNAs encoding two forms of glutamic acid decarboxylase with nonradioactive in situ hybridization methods
Esclapez, M., Tillakaratne, N. J. K., Tobin, A. J., & Houser, C. R. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903310305 · Cited by 249
Tonotopic organization of auditory cortical fields delineated by parvalbumin immunoreactivity in macaque monkeys
Kosaki, H., Hashikawa, T., He, J., & Jones, E. G. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970922)386:2 · Cited by 202
Dual-phenotype GABA/glutamate neurons in adult preoptic area: sexual dimorphism and function
Ottem, E. N., Godwin, J. G., Krishnan, S., & Petersen, S. L. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2267-04.2004 · Cited by 201
Self-citation
LHRH immunopositive cells and their projections to the median eminence and organum vasculosum of the lamina terminalis
King, J. C., Tobet, S. A., Snavely, F. L., & Arimura, A. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902090307 · Cited by 195
Effect of GABA on GnRH Neurons Switches from Depolarization to Hyperpolarization at Puberty in the Female Mouse
Han, S., Ábrahám, I. M., & Herbison, A. E. (2002) · Endocrinology · doi:10.1210/endo.143.4.8724 · Cited by 183
Integration of the regulation of reproductive function and energy balance: lactation as a model
Smith, M. S., & Grove, K. L. (2002) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(02)00002-x · Cited by 181
Distribution of prolactin‐responsive neurons in the mouse forebrain
Brown, R. S. E., Kokay, I. C., Herbison, A. E., & Grattan, D. R. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22208 · Cited by 180
Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-tracing and monosodium glutamate lesions in the rat
Krajewski, S. J., Burke, M. C., Anderson, M. J., McMullen, N. T., & Rance, N. E. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.053 · Cited by 178
Hyperprolactinemia: Etiology, Diagnosis, and Management
Mah, P. M., & Webster, J. A. (2002) · Seminars in Reproductive Medicine · doi:10.1055/s-2002-36709 · Cited by 153
Inhibition of Metastin (Kisspeptin-54)-GPR54 Signaling in the Arcuate Nucleus-Median Eminence Region during Lactation in Rats
Yamada, S., Uenoyama, Y., Kinoshita, M., Iwata, K., Takase, K., Matsui, H., Adachi, S., Inoue, K., Maeda, K., & Tsukamura, H. (2007) · Endocrinology · doi:10.1210/en.2006-1529 · Cited by 152
Breast feeding, birth spacing and their effects on child survival
Thapa, S., Short, R. V., & Potts, M. (1988) · Nature · doi:10.1038/335679a0 · Cited by 150
Endogenous GABA Release Inhibits the Firing of Adult Gonadotropin-Releasing Hormone Neurons
Han, S., Todman, M. G., & Herbison, A. E. (2003) · Endocrinology · doi:10.1210/en.2003-1333 · Cited by 147
Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice
Grattan, D. R., Jasoni, C. L., Liu, X., Anderson, G. M., & Herbison, A. E. (2007) · Endocrinology · doi:10.1210/en.2007-0403 · Cited by 145
Self-citation
Late-onset neurodegeneration in mice with increased dosage of the proteolipid protein gene
Anderson, T. J., Schneider, A., Barrie, J. A., Klugmann, M., McCulloch, M. C., Kirkham, D., Kyriakides, E., Nave, K., & Griffiths, I. R. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980518)394:4 · Cited by 132
Endogenous γ-Aminobutyric Acid Can Excite Gonadotropin-Releasing Hormone Neurons
Moenter, S. M., & DeFazio, R. A. (2005) · Endocrinology · doi:10.1210/en.2005-0788 · Cited by 131
Hyperprolactinemia in Men: Clinical and Biochemical Features and Response to Treatment
Rosa, M. D., Zarrilli, S., Sarno, A. D., Milano, N., Gaccione, M., Boggia, B., Lombardi, G., & Colao, A. (2003) · Endocrine · doi:10.1385/endo:20:1-2:75 · Cited by 131
Neural signals that regulate GnRH neurones directly during the oestrous cycle
Smith, M., & Jennes, L. (2001) · Reproduction · doi:10.1530/rep.0.1220001 · Cited by 125
Ovarian steroids differentially regulate the expression of PRL-R in neuroendocrine dopaminergic neuron populations: a double label confocal microscopic study
Lerant, A. A., & Freeman, M. E. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00583-6 · Cited by 119
Neurobiological mechanisms underlying kisspeptin activation of gonadotropin-releasing hormone (GnRH) neurons at puberty
Clarkson, J., Han, S., Liu, X., Lee, K., & Herbison, A. E. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.01.026 · Cited by 115
Neurons containing messenger RNA encoding glutamate decarboxylase in rat hypothalamus demonstrated by in situ hybridization, with special emphasis on cell groups in medial preoptic area, anterior hypothalamic area and dorsomedial hypothalamic nucleus
Okamura, H., Abitbol, M. M., Julien, J.-F., Dumas, S., Bérod, A., Geffard, M., Kitahama, K., Bobillier, P., Mallet, J. J., & Wiklund, L. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90252-y · Cited by 109
Hyperprolactinemia Decreases the Luteinizing Hormone-Releasing Hormone Concentration in Pituitary Portal Plasma: A Possible Role forβ-Endorphin as a Mediator*
Sarkar, D. K., & Yen, S. S. C. (1985) · Endocrinology · doi:10.1210/endo-116-5-2080 · Cited by 104
PULSATILE GONADOTROPHIN SECRETION IN HYPERPROLACTINAEMIC AMENORRHOEA AND THE RESPONSE TO BROMOCRIPTINE THERAPY
MOULT, P. J. A., REES, L. H., & BESSER, G. M. (1982) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1982.tb03159.x · Cited by 104
The Suppression of Pulsatile Luteinizing Hormone Secretion during Lactation in the Rat*
Fox, S. R., & Smith, M. S. (1984) · Endocrinology · doi:10.1210/endo-115-6-2045 · Cited by 100
Prolactin Receptor mRNA Localization in the Hypothalamus by in situ Hybridization
Chiu, S., & Wise, P. M. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00572.x · Cited by 99
Kisspeptin regulates prolactin release through hypothalamic dopaminergic neurons
Szawka, R. E., Ribeiro, A. B., Leite, C. M., Helena, C. V. V., Franci, C. R., Anderson, G. M., Hoffman, G. E., & Anselmo-Franci, J. A. (2010) · Endocrinology · doi:10.1210/en.2009-1414 · Cited by 97
Periventricular Preoptic Area Neurons Coactivated with Luteinizing Hormone (LH)-Releasing Hormone (LHRH) Neurons at the Time of the LH Surge Are LHRH Afferents
Le, W. W., Berghorn, K. A., Rassnick, S., & Hoffman, G. E. (1999) · Endocrinology · doi:10.1210/endo.140.1.6403 · Cited by 95
Gamma-Aminobutyric Acid Neurons in the Preoptic/Anterior Hypothalamic Area Synchronize the Phasic Activity of the Gonadotropin-Releasing Hormone Pulse Generator in Ovariectomized Rats
Jarry, H., Leonhardt, S., & Wuttke, W. (2008) · Neuroendocrinology · doi:10.1159/000125727 · Cited by 95
Alterations in Hypothalamic KiSS-1 System in Experimental Diabetes: Early Changes and Functional Consequences
Castellano, J. M., Navarro, V. M., Roa, J., Pineda, R., Sanchez-Garrido, M. A., García-Galiano, D., Vigo, E., Diéguez, C., Aguilar, E., Pinilla, L., et al. (2008) · Endocrinology · doi:10.1210/en.2008-0849 · Cited by 94
Chapter 2 Hypothalamic Neural Systems Controlling the Female Reproductive Life Cycle
(2009) · International Review of Cell and Molecular Biology · doi:10.1016/s1937-6448(08)02002-9 · Cited by 93
Hyperprolactinemia Alters the Frequency and Amplitude of Pulsatile Luteinizing Hormone Secretion in the Ovariectomized Rat
Cohen-Becker, I. R., SELMANOFF, M. K., & Wise, P. M. (2008) · Neuroendocrinology · doi:10.1159/000124459 · Cited by 93
Kisspeptin and GPR54: Discovery of a Novel Pathway in Reproduction
Seminara, S. B., & Crowley, W. F. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01731.x · Cited by 90
γ-Aminobutyric Acid Neurons Integrate and Rapidly Transmit Permissive and Inhibitory Metabolic Cues to Gonadotropin-Releasing Hormone Neurons
Sullivan, S. D., & Moenter, S. M. (2003) · Endocrinology · doi:10.1210/en.2003-1374 · Cited by 87
Several GABAA receptor subunits are expressed in LHRH neurons of juvenile female rats1This work was supported by grants from the National Institutes of Health, HD25123 (S.R.O.), P30 Population Center Grant HD18185 and RR00163 for the operation of the Oregon Regional Primate Research Center.1
Jung, H., Shannon, E. M., Fritschy, J., & Ojeda, S. R. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01152-9 · Cited by 87
Hormonal and neurotransmitter regulation of GnRH gene expression and related reproductive behaviors
Sagrillo, C. A., Grattan, D., McCarthy, M., & Selmanoff, M. (1996) · Behavior Genetics · doi:10.1007/bf02359383 · Cited by 87
Regulation of Food Intake and Gonadotropin-Releasing Hormone/Luteinizing Hormone during Lactation: Role of Insulin and Leptin
Xu, J., Kirigiti, M. A., Grove, K. L., & Smith, M. S. (2009) · Endocrinology · doi:10.1210/en.2009-0190 · Cited by 80
Non-classical estrogen modulation of presynaptic GABA terminals modulates calcium dynamics in gonadotropin-releasing hormone (GnRH) neurons
Romanò, N., Lee, K., Ábrahám, I., Jasoni, C., & Herbison, A. (2008) · Endocrinology · doi:10.1210/en.2008-0424 · Cited by 80
Detection of Prolactin Receptor Gene Expression in the Sheep Pituitary Gland and Visualization of the Specific Translation of the Signal in Gonadotrophs
Tortonese, D. J., Brooks, J., INGLETON, P. M., & McNeilly, A. S. (1998) · Endocrinology · doi:10.1210/endo.139.12.6365 · Cited by 79
Expression of mRNA for Prolactin Receptor (Long Form) in Dopamine and Pro‐Opiomelanocortin Neurones in the Arcuate Nucleus of Non‐Pregnant and Lactating Rats
Kokay, I. C., & Grattan, D. R. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01374.x · Cited by 77
Endogenous Opioid Peptides Contribute to Suckling-Induced Prolactin Release by Suppressing Tyrosine Hydroxylase Activity and Messenger Ribonucleic Acid Levels in Tuberoinfundibular Dopaminergic Neurons*
Arbogast, L. A., & Voogt, J. L. (1998) · Endocrinology · doi:10.1210/endo.139.6.6052 · Cited by 67
Mechanism of anovulation in hyperprolactinemic amenorrhea determined by pulsatile gonadotropin-releasing hormone injection combined with human chorionic gonadotropin
Matsuzaki, T., Azuma, K., Irahara, M., Yasui, T., & Aono, T. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57176-3 · Cited by 66
Development of Gonadotropin-Releasing Hormone-1 Secretion in Mouse Nasal Explants
Constantin, S., Caraty, A., Wray, S., & Duittoz, A. H. (2009) · Endocrinology · doi:10.1210/en.2008-1711 · Cited by 64
Prolactin and schizophrenia: clinical consequences of hyperprolactinaemia
Meaney, A. M., & O’Keane, V. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01775-7 · Cited by 64
Offspring control of cerebrospinal fluid GABA concentrations in lactating rats
Qureshi, G. A., Hansen, S., & Södersten, P. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90080-2 · Cited by 62
Opioid Receptor Subtypes Involved in the Regulation of Prolactin Secretion During Pregnancy and Lactation
Andrews, Z. B., & Grattan, D. R. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.00975.x · Cited by 58
Direct effects of prolactin and dopamine on the gonadotroph response to GnRH
Henderson, H. L., Townsend, J. S., & Tortonese, D. J. (2008) · Journal of Endocrinology · doi:10.1677/joe-07-0536 · Cited by 55
Suppression of pulsatile LH secretion, pituitary GnRH receptor content and pituitary responsiveness to GnRH by hyperprolactinemia in the male rat
Fox, S. R., Hoefer, M. T., Bartke, A., & Smith, M. S. (2008) · Neuroendocrinology · doi:10.1159/000124844 · Cited by 54
Suppression of basal spontaneous gonadotropin-releasing hormone neuronal activity during lactation: role of inhibitory effects of neuropeptide Y.
Xu, J., Kirigiti, M. A., Cowley, M. A., Grove, K. L., & Smith, M. (2009) · Endocrinology · doi:10.1210/en.2008-0962 · Cited by 51
Interaction of opioid peptide-containing terminals with dopaminergic perikarya in the rat hypothalamus
Fitzsimmons, M. D., Olschowka, J. A., Wiegand, S. J., & Hoffman, G. E. (1992) · Brain Research · doi:10.1016/0006-8993(92)90338-a · Cited by 49
Inhibition of Tuberoinfundibular Dopaminergic Neural Activity During Suckling: Involvement of μ and κ Opiate Receptor Subtypes
Callahan, P., Baumann, M. H., & Rabii, J. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.05207.x · Cited by 47
GABAA Receptors Mediate Excitation in Adult Rat GnRH Neurons1
Watanabe, M., Sakuma, Y., & Kato, M. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.074583 · Cited by 45
Effect of Pulsatile Gonadotropin-Releasing Hormone on the Release of Luteinizing Hormone and Follicle-Stimulating Hormone in Vitro by Anterior Pituitaries from Lactating and Cycling Rats*
Smith, M. S. (1982) · Endocrinology · doi:10.1210/endo-110-3-882 · Cited by 43
GABAergic Transmission to Gonadotropin-Releasing Hormone (GnRH) Neurons Is Regulated by GnRH in a Concentration-Dependent Manner Engaging Multiple Signaling Pathways
Chen, P., & Moenter, S. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2509-09.2009 · Cited by 42
Dose-Dependent Suppression of Postcastration Luteinizing Hormone Secretion Exerted by Exogenous Prolactin Administration in Male Rats: A Model for Studying Hyperprolactinemic Hypogonadism
Park, S.-K., & SELMANOFF, M. K. (2008) · Neuroendocrinology · doi:10.1159/000125748 · Cited by 42
Regulation of Glutamic Acid Decarboxylase 65 and 67 Gene Expression by Ovarian Steroids: Identification of Two Functionally Distinct Populations of GABA Neurones in the Preoptic Area
Curran-Rauhut, M. A., & Petersen, S. L. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2002.00780.x · Cited by 41
Ovulation and normal luteal function during LHRH treatment of women with hyperprolactinaemic amenorrhoea
POLSON, D. W., SAGLE, M., MASON, H. D., ADAMS, J., JACOBS, H. S., & FRANKS, S. (1986) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1986.tb03282.x · Cited by 40
Graded Hyperprolactinemia First Suppresses LH Pulse Frequency and Then Pulse Amplitude in Castrated Male Rats
Park, S.-K., Keenan, M. W., & SELMANOFF, M. K. (2008) · Neuroendocrinology · doi:10.1159/000126575 · Cited by 39
Pregnancy after intravenous pulsatile gonadotropin-releasing hormone in a hyperprolactinaemic woman resistant to treatment with dopamine agonists
Lecomte, P., Lecomte, C., Lansac, J., Gallier, J., Sonier, C. B., & Simonetta, C. (1997) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(97)00091-2 · Cited by 35
Effect of pituitary transplants on the LH-RH concentrations in the medial basal hypothalamus and hypophyseal portal blood
Koike, K., Aono, T., Miyake, A., Tasaka, K., Chatani, F., & Kurachi, K. (1984) · Brain Research · doi:10.1016/0006-8993(84)91093-x · Cited by 28
Prolactin- and testosterone-induced inhibition of LH secretion after orchidectomy: role of preoptic and tuberoinfundibular γ-aminobutyric acidergic neurones
Grattan, D. R., & SELMANOFF, M. K. (1994) · Journal of Endocrinology · doi:10.1677/joe.0.1430165 · Cited by 28
Lactation Alters γ-Aminobutyric Acid Neuronal Activity in the Hypothalamus and Cerebral Cortex in the Rat
Kornblatt, J. J., & Grattan, D. R. (2001) · Neuroendocrinology · doi:10.1159/000054634 · Cited by 27
Immunocytochemical colocalization of GABA-B receptor subunits in gonadotropin-releasing hormone neurons of the sheep
Sliwowska, J. H., Billings, H. J., Goodman, R. L., & Lehman, M. N. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.03.039 · Cited by 26
Prolactin in cerebrospinal fluid increases the synthesis and release of hypothalamic γ-aminobutyric acid
Locatelli, V., Apud, J. A., Gudelsky, G. A., Cocchi, D., MASOTTO, C., Casanueva, F. F., Racagni, G., & Müller, E. E. (1985) · Journal of Endocrinology · doi:10.1677/joe.0.1060323 · Cited by 21
Effects of immunoneutralization of dynorphin1–17 and dynorphin1–18 on the activity of central dopaminergic neurons in the male rat
Manzanares, J., Wagner, E. J., Lookingland, K. J., & Moore, K. E. (1992) · Brain Research · doi:10.1016/0006-8993(92)91011-3 · Cited by 20
Diencephalic GABAergic Neurons in vitro Respond to Prolactin with a Rapid Increase in Intracellular Free Calcium
Kolbinger, W., Beyer, C., Föhr, K. J., Reisert, I., & Pilgrim, C. (2008) · Neuroendocrinology · doi:10.1159/000126222 · Cited by 19
Evidence that γ-Aminobutyric Acid Is Part of the Neural Circuit Mediating Estradiol Negative Feedback in Anestrous Ewes
Bogusz, A. L., Hardy, S. L., Lehman, M. N., Connors, J. M., Hileman, S. M., Sliwowska, J. H., Billings, H. J., McManus, C. J., Valent, M., Singh, S. R., et al. (2008) · Endocrinology · doi:10.1210/en.2007-1362 · Cited by 13
GABAergic Biochemical Parameters of the Tuberoinfundibular Neurons following Chronic Hyperprolactinemia
Felman, K., & Tappaz, M. (2008) · Neuroendocrinology · doi:10.1159/000125172 · Cited by 11

Flagged first, then by citations

1 of the 91 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Evans, 1982, Hypogonadism in hyperprolactinemia: proposed mechanisms, 77
Petersen, 1993, GABAA receptor subunit mRNAs in cells of the preoptic area: colocalization with LHRH mRNA using dual label in situ hybridization histochemistry., Endocr J, 1, 29

Sorted by citations

Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms
Pinilla, L., Aguilar, E., Diéguez, C., Millar, R. P., & Tena‐Sempere, M. (2012) · Physiological Reviews · doi:10.1152/physrev.00037.2010 · Cited by 843
60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-prolactin axis
Grattan, D. R. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0213 · Cited by 379
New insights in prolactin: pathological implications
Bernard, V., Young, J., Chanson, P., & Binart, N. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.36 · Cited by 244
Metabolic regulation of kisspeptin — the link between energy balance and reproduction
Navarro, V. M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0363-7 · Cited by 240
Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration
Sonigo, C., Bouilly, J., Carré, N., Tolle, V., Caraty, A., Tello, J., Simony-Conesa, F.-J., Millar, R., Young, J., & Binart, N. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63937 · Cited by 197

See all 131

Authors: Kokay, I. C., Petersen, S. L., & Grattan, D. R.
Affiliations: University of Otago (NZ)
University of Massachusetts Amherst (US)
Corresponding author: Grattan, David R.
ORCID: Petersen, Sandra L.
Grattan, David R.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2010-12-22
Volume: 152
Issue: 2
Pages: 526-535
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2010-0668
OpenAlex: W2133123261
Cited by: 131
References: 91
Citations by year: 2025: 5 · 2024: 14 · 2023: 7 · 2022: 4 · 2021: 6 · 2020: 12 · 2019: 10 · 2018: 13 · 2017: 8 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 5 · 2012: 9
FWCI: 7.96
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: prolactin, prolactin receptor, kisspeptin neurons, GABAergic neurons, GnRH neurons, hypothalamus, arcuate nucleus, preoptic area, fertility control, neuroendocrine regulation, infertility, estradiol, ovariectomy
MeSH terms: Animals, Female, Fertility, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Hypothalamus, Neurons, Ovariectomy, Proteins, Receptors, Prolactin, Rats, Sprague-Dawley, In Situ Hybridization, Rats, Kisspeptins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Identification of Prolactin-Sensitive GABA and Kisspeptin Neurons in Regions of the Rat Hypothalamus Involved in the Control of Fertility

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks