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The Role of GH and IGF-I in Mediating Anabolic Effects of Testosterone on Androgen-Responsive Muscle
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“IGF-1 receptor signaling in muscle may not be obligatory to mediate the anabolic effects of testosterone on skeletal muscle (69)”
From Dysregulation of the Hypothalamic-Pituitary-Testicular Axis due to Energy Deficit (2021) · cites this paper as [69]
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Cites
Rommel, C., Bodine, S. C., Clarke, B. A., Rossman, R., Nunez, L., Stitt, T. N., Yancopoulos, G. D., & Glass, D. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1009 · Cited by 1,583
Musarò, A., McCullagh, K., Paul, A., Houghton, L., Dobrowolny, G., Molinaro, M., Barton, E. R., L Sweeney, H., & Rosenthal, N. (2001) · Nature Genetics · doi:10.1038/84839 · Cited by 1,137
Self-citationTestosterone dose-response relationships in healthy young men
Bhasin, S., Woodhouse, L., Casaburi, R., Singh, A. B., Bhasin, D., Berman, N., Chen, X., Yarasheski, K. E., Magliano, L., Dzekov, C., et al. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.6.e1172 · Cited by 967
Self-citationBhasin, S., Woodhouse, L., Casaburi, R., Singh, A. B., Mac, R. P., Lee, M., Yarasheski, K. E., Sinha-Hikim, I., Dzekov, C., Dzekov, J., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1184 · Cited by 544
Self-citationFerrando, A. A., Sheffield-Moore, M., Yeckel, C. W., Gilkison, C., Jiang, J., Achacosa, A., Lieberman, S. A., Tipton, K., Wolfe, R. R., & Urban, R. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00362.2001 · Cited by 522
Sinha-Hikim, I., Artaza, J., Woodhouse, L., Gonzalez-Cadavid, N., Singh, A. B., Lee, M. I., Storer, T. W., Casaburi, R., Shen, R., & Bhasin, S. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00502.2001 · Cited by 464
Self-citationSinha-Hikim, I., Roth, S. M., Lee, M. I., & Bhasin, S. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00370.2002 · Cited by 344
Self-citationSir-Petermann, T., Codner, E., Pérez, V., Echiburú, B., Maliqueo, M., Ladrón de Guevara, A., Preisler, J., Crisosto, N., Sánchez, F., Cassorla, F., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2836 · Cited by 260
Self-citationThe role of sexual steroids in the modulation of growth hormone (GH) secretion in humans.
Devesa, J., Lois, N., Arce, V., Diaz, M. J., Lima, L., & Tresguerres, J. A. F. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90179-9 · Cited by 98 · cited 1×
“T stimulates pulsatile GH secretion, and its administration increases circulating GH and IGF-I levels in boys with constitutional delay of puberty and community-dwelling men (2, 39, 40).”
Background
Research works printed but not linked: 42
- Bhasin, 2006, Drug insight: testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging., Nat Clin Pract Endocrinol Metab, 2, 146, 10.1038/ncpendmet0120 · DOI · Paper page
- Storer, 2008, Changes in muscle mass, muscle strength, and power but not physical function are related to testosterone dose in healthy older men., J Am Geriatr Soc, 56, 1991, 10.1111/j.1532-5415.2008.01927.x · DOI · Paper page
- MacLean, 2008, Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice., FASEB J, 22, 2676, 10.1096/fj.08-105726 · DOI · Paper page
- Ophoff, 2009, Androgen signaling in myocytes contributes to the maintenance of muscle mass and fiber type regulation but not to muscle strength or fatigue., Endocrinology, 150, 3558, 10.1210/en.2008-1509 · DOI
- Joubert, 1994, Testosterone-induced masculinization of the rat levator ani muscle during puberty, Dev Biol., 162, 104, 10.1006/dbio.1994.1070 · DOI
- Nnodim, 2001, Testosterone mediates satellite cells activation in denervated rat levator ani muscle., Anat Rec, 263, 19, 10.1002/ar.1072 · DOI
- Lee, 2002, Androgen receptor enhances myogenin expression and accelerates differentiation., Biochem Biophys Res Commun, 294, 408, 10.1016/S0006-291X(02)00504-1 · DOI
- Benjamin, 2004, Use of artificial androgen receptor coactivators to alter myoblast proliferation., J Steroid Biochem Mol Biol, 91, 111, 10.1016/j.jsbmb.2004.02.007 · DOI
- Diel, 2008, C2C12 myoblastoma cell differentiation and proliferation is stimulated by androgens and associated with a modulation of myostatin and Pax7 expression., J Mol Endocrinol, 40, 231, 10.1677/JME-07-0175 · DOI
- Doumit, 1996, Testosterone up-regulates androgen receptors and decreases differentiation of porcine myogenic satellite cells in vitro., Endocrinology, 137, 1385, 10.1210/endo.137.4.8625915 · DOI
- Chen, 2008, Generation and analysis of an androgen-responsive myoblast cell line indicates that androgens regulate myotube protein accretion., J Endocrinol Invest, 31, 910, 10.1007/BF03346441 · DOI
- Vlahopoulos, 2005, Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene., J Biol Chem, 280, 7786, 10.1074/jbc.M413992200 · DOI
- Lewis, 2002, Role of IGF-I and IGF-binding proteins within diaphragm muscle in modulating the effects of nandrolone., Am J Physiol Endocrinol Metab, 282, 483, 10.1152/ajpendo.00191.2001 · DOI
- Lewis, 2007, Skeletal muscle adaptations to testosterone and resistance training in men with COPD., Appl Physiol, 103, 1299, 10.1152/japplphysiol.00150.2007 · DOI
- Liu, 1993, Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)., Cell, 75, 59
- Matheny Jr, 2010, Minireview: mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration., Endocrinology, 151, 865, 10.1210/en.2009-1217 · DOI
- Yang, 2002, Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation., FEBS Lett, 522, 156, 10.1016/S0014-5793(02)02918-6 · DOI · Paper page
- Hill, 2003, Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage., J Physiol, 549, 409, 10.1113/jphysiol.2002.035832 · DOI · Paper page
- Fernández, 2002, Muscle-specific inactivation of the IGF-I receptor induces compensatory hyperplasia in skeletal muscle., J Clin Invest, 109, 347, 10.1172/JCI0213503 · DOI
- Kim, 2005, Intact insulin and insulin-like growth factor-I receptor signaling is required for growth hormone effects on skeletal muscle growth and function in vivo., Endocrinology, 146, 1772, 10.1210/en.2004-0906 · DOI
- Coleman, 1995, Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice., J Biol Chem, 270, 12109, 10.1074/jbc.270.20.12109 · DOI · Paper page
- Coolican, 1997, The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways., J Biol Chem, 272, 6653, 10.1074/jbc.272.10.6653 · DOI · Paper page
- Jacquemin, 2007, IL-13 mediates the recruitment of reserve cells for fusion during IGF-1-induced hypertrophy of human myotubes., J Cell Sci, 120, 670, 10.1242/jcs.03371 · DOI
- Foulstone, 2004, Differential signalling mechanisms predisposing primary human skeletal muscle cells to altered proliferation and differentiation: roles of IGF-I and TNFα., Exp Cell Res, 294, 223, 10.1016/j.yexcr.2003.10.034 · DOI
- Hameed, 2003, Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise., J Physiol, 547, 247, 10.1113/jphysiol.2002.032136 · DOI
- Cheema, 2005, Mechanical signals and IGF-I gene splicing in vitro in relation to development of skeletal muscle., J Cell Physiol, 202, 67, 10.1002/jcp.20107 · DOI
- Horsley, 2001, Regulation of the growth of multinucleated muscle cells by an NFATC2-dependent pathway., J Cell Biol, 153, 329, 10.1083/jcb.153.2.329 · DOI
- Musarò, 1999, IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1., Nature, 400, 581, 10.1038/23060 · DOI
- Galvin, 2003, IGF-1 receptor mediates differentiation of primary cultures of mouse skeletal myoblasts., Mol Cell Endocrinol, 200, 19, 10.1016/S0303-7207(02)00420-3 · DOI
- Kaliman, 1996, Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells., J Biol Chem, 271, 19146, 10.1074/jbc.271.32.19146 · DOI
- Keenan, 1993, Androgen-stimulated pubertal growth: the effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-I in the treatment of short stature and delayed puberty., J Clin Endocrinol Metab, 76, 996
- Venken, 2007, Impact of androgens, growth hormone, and IGF-I on bone and muscle in male mice during puberty., J Bone Miner Res, 22, 72, 10.1359/jbmr.060911 · DOI
- Barton, 2006, The ABCs of IGF-I isoforms: impact on muscle hypertrophy and implications for repair., Appl Physiol Nutr Metab, 31, 791, 10.1139/h06-054 · DOI
- Powers, 1975, A direct effect of testosterone on muscle cells in tissue culture., Endocrinology, 97, 1043, 10.1210/endo-97-4-1043 · DOI
- Joubert, 1995, Testosterone treatment results in quiescent satellite cells being activated and recruited into cell cycle in rat levator ani muscle., Dev Biol, 169, 286, 10.1006/dbio.1995.1144 · DOI
- Kamanga-Sollo, 2004, IGF-I mRNA levels in bovine satellite cell cultures: effects of fusion and anabolic steroid treatment., J Cell Physiol, 201, 181, 10.1002/jcp.20000 · DOI
- Eriksson, 2005, Skeletal muscle morphology in power-lifters with and without anabolic steroids., Histochem Cell Biol, 124, 167, 10.1007/s00418-005-0029-5 · DOI
- Buresová, 1972, Differential effects of castration and denervation on protein synthesis in the levator ani muscle of the rat., J Endocrinol, 54, 3, 10.1677/joe.0.0540003 · DOI
- Sar, 1977, Androgen concentration in motor neurons of cranial nerves and spinal cord., Science, 197, 77, 10.1126/science.867053 · DOI · Paper page
- Breedlove, 1980, Hormone accumulation in a sexually dimorphic motor nucleus of the rat spinal cord., Science, 210, 564, 10.1126/science.7423210 · DOI
- Spangenburg, 2008, A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy., J Physiol, 586, 283, 10.1113/jphysiol.2007.141507 · DOI
- Johansen, 2007, Androgen receptor expression in the levator ani muscle of male mice., J Neuroendocrinol, 19, 823, 10.1111/j.1365-2826.2007.01592.x · DOI
Cited by
Dubois, V., Laurent, M., Boonen, S., Vanderschueren, D., & Claessens, F. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0883-3 · Cited by 197
Hormone Replacement Therapy and Physical Function in Healthy Older Men. Time to Talk Hormones?
Giannoulis, M. G., Martin, F. C., Nair, K. S., Umpleby, A. M., & Sonksen, P. (2012) · Endocrine Reviews · doi:10.1210/er.2012-1002 · Cited by 132
Testosterone improves the regeneration of old and young mouse skeletal muscle
Serra, C., Tangherlini, F., Rudy, S., Lee, D., Toraldo, G., Sandor, N. L., Zhang, A., Jasuja, R., & Bhasin, S. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gls083 · Cited by 87
Self-citationAnabolic androgenic steroids and carcinogenicity focusing on Leydig cell: a literature review
Salerno, M., Cascio, O., Bertozzi, G., Sessa, F., Messina, A., Monda, V., Cipolloni, L., Biondi, A., Daniele, A., & Pomara, C. (2018) · Oncotarget · doi:10.18632/oncotarget.24767 · Cited by 71
Androgens affect myogenesis in vitro and increase local igf-1 expression
SCULTHORPE, N., SOLOMON, A. M., SINANAN, A. C. M., BOULOUX, P.-M. G., GRACE, F., & LEWIS, M. P. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318237c5c0 · Cited by 59
Metadata
- Authors
- Serra, C., Bhasin, S., Tangherlini, F., Barton, E. R., Ganno, M., Zhang, A., Shansky, J., Vandenburgh, H. H., Travison, T. G., Jasuja, R., & Morris, C.
- Affiliations
- Section of Endocrinology (C.S., S.B., F.T., M.G., A.Z., T.G.T., R.J.), Diabetes and Nutrition, and the Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts 02118
- Department of Anatomy and Cell Biology (E.R.B.), School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
- Myomics, Inc. (J.S., H.H.V.), Providence, Rhode Island 02906
- Pfizer Research, Tissue Repair (C.M.), Cambridge, Massachusetts 02139
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2011-01-01
- Volume
- 152
- Issue
- 1
- Pages
- 193-206
- ISSN
- 0013-7227
- 1945-7170
- Cited by
- 78
- References
- 9
- Language
- en
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