Metformin Inhibits Human Androgen Production by Regulating Steroidogenic Enzymes HSD3B2 and CYP17A1 and Complex I Activity of the Respiratory Chain

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Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652

Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis

Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.6.0318 · Cited by 2,776

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

OWEN, M. R., DORAN, E., & HALESTRAP, A. P. (2000) · Biochemical Journal · doi:10.1042/bj3480607 · Cited by 2,157

The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report

Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., Janssen, O. E., Legro, R. S., Norman, R. J., Taylor, A. E., et al. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.06.035 · Cited by 2,132

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Shaw, R. J., Lamia, K. A., Vasquez, D., Koo, S.-H., Bardeesy, N., DePinho, R. A., Montminy, M., & Cantley, L. C. (2005) · Science · doi:10.1126/science.1120781 · Cited by 1,950

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I

El-Mir, M.-Y., Nogueira, V., Fontaine, E., Avéret, N., Rigoulet, M., & Leverve, X. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.223 · Cited by 1,399

Metformin Inhibits Hepatic Gluconeogenesis in Mice Independently of the LKB1/AMPK Pathway via a Decrease in Hepatic Energy State

Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, K., Andreelli, F., & Viollet, B. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40671 · Cited by 1,181

Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis

Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/er.18.6.774 · Cited by 1,167

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Foretz, M., Guigas, B., Bertrand, L., Pollak, M., & Viollet, B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.09.018 · Cited by 1,501

Metformin-induced mitochondrial Complex I inhibition: facts, uncertainties, and consequences

Fontaine, E. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00753 · Cited by 269

Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases

Mirabelli, M., Chiefari, E., Arcidiacono, B., Corigliano, D. M., Brunetti, F. S., Maggisano, V., Russo, D., Foti, D. P., & Brunetti, A. (2020) · Nutrients · doi:10.3390/nu12041066 · Cited by 272

Role of insulin and insulin resistance in androgen excess disorders

Ünlühızarcı, K., Karaca, Z., & Keleştimur, F. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i5.616 · Cited by 199

Polycystic Ovary Syndrome and Oxidative Stress—From Bench to Bedside

Żeber‐Lubecka, N., Ciebiera, M., & Hennig, E. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814126 · Cited by 162

Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK

Jin, J., Ma, Y., Tong, X., Yang, W., Dai, Y., Pan, Y., Ren, P., Liu, L., Fan, H., Zhang, Y., et al. (2020) · Human Reproduction · doi:10.1093/humrep/deaa077 · Cited by 139

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Hefetz-Sela, S., & Scherer, P. E. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.008 · Cited by 136

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Aliper, A. M., Jellen, L. C., Cortese, F., Artemov, A. V., Karpinsky‐Semper, D., Moskalev, A., Swick, A. G., & Zhavoronkov, A. A. (2017) · Aging · doi:10.18632/aging.101319 · Cited by 112

Intersection of Polycystic Ovary Syndrome and the Gut Microbiome

Rizk, M. G., & Thackray, V. G. (2021) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa177 · Cited by 104

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Sam, S., & Ehrmann, D. A. (2017) · Diabetologia · doi:10.1007/s00125-017-4306-3 · Cited by 93

Mutations in SDHD lead to autosomal recessive encephalomyopathy and isolated mitochondrial complex II deficiency

Jackson, C. B., Nuoffer, J., Hahn, D., Prokisch, H., Haberberger, B., Gautschi, M., Häberli, A., Gallati, S., & Schaller, A. (2013) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2013-101932 · Cited by 84

Metformin overdose causes platelet mitochondrial dysfunction in humans

Protti, A., Lecchi, A., Fortunato, F., Artoni, A., Greppi, N., Vecchio, S., Fagiolari, G., Moggio, M. G., Comi, G. P., Mistraletti, G., et al. (2012) · Critical Care · doi:10.1186/cc11663 · Cited by 71

Direct effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma

Shao, R., Li, X., Feng, Y., Lin, J.-F., & Billig, H. (2014) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-33-41 · Cited by 66

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Saadati, S., Mason, T., Godini, R., Vanky, E., Teede, H. J., & Mousa, A. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16422 · Cited by 89

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Chaudhary, S., & Kulkarni, A. (2024) · Current Diabetes Reports · doi:10.1007/s11892-024-01539-1 · Cited by 64

Nicotinamide and its metabolite N1-Methylnicotinamide alleviate endocrine and metabolic abnormalities in adipose and ovarian tissues in rat model of Polycystic Ovary Syndrome

Nejabati, H. R., Samadi, N., Shahnazi, V., Mihanfar, A., Fattahi, A., Latifi, Z., Bahrami‐Asl, Z., Roshangar, L., & Nouri, M. (2020) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2020.109093 · Cited by 54

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Pau, C. T., Keefe, C. C., Duran, J. M., & Welt, C. K. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4021 · Cited by 50

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Jensterle, M., Kravos, N. A., Ferjan, S., Goričar, K., Dolžan, V., & Janež, A. (2020) · Endocrine Connections · doi:10.1530/ec-19-0449 · Cited by 47

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Garzia, E., Galiano, V., Marfia, G., Navone, S. E., Grossi, E., & Marconi, A. M. (2022) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00876-0 · Cited by 50

Resveratrol inhibits androgen production of human adrenocortical H295R cells by lowering CYP17 and CYP21 expression and activities

Marti, N., Bouchoucha, N., Sauter, K., & Flück, C. E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174224 · Cited by 46

Differential Regulation of Human 3β-Hydroxysteroid Dehydrogenase Type 2 for Steroid Hormone Biosynthesis by Starvation and Cyclic Amp Stimulation: Studies in the Human Adrenal NCI-H295R Cell Model

Udhane, S. S., Kempná, P., Hofer, G., Mullis, P. E., & Flück, C. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068691 · Cited by 41

Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis

Udhane, S. S., Pandey, A. V., Hofer, G., Mullis, P. E., & Flück, C. E. (2015) · Scientific Reports · doi:10.1038/srep10132 · Cited by 38

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Soldat-Stanković, V., Popović-Pejičić, S., Stanković, S., Prtina, A., Malešević, G., Bjekić-Macut, J., Livadas, S., Ognjanović, S., Mastorakos, G., Micić, D., et al. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01691-5 · Cited by 37

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Baralić, K., Jorgovanović, D., Živančević, K., Djordjević, A. B., Miljaković, E. A., Miljković, M., Kotur‐Stevuljević, J., Antonijević, B., & Đukić-Ćosić, D. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.129296 · Cited by 36

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Current and future aspects of several adjunctive treatment strategies in polycystic ovary syndrome

Banaszewska, B., Pawelczyk, L. A., & Spaczyński, R. (2019) · Reproductive Biology · doi:10.1016/j.repbio.2019.09.006 · Cited by 33

A marriage of two “Methusalem” drugs for the treatment of psoriasis?

Glossmann, H. H., & Reider, N. (2013) · Dermato-Endocrinology · doi:10.4161/derm.23874 · Cited by 32

Basic research in PCOS: are we reaching new frontiers?

Ben‐Shlomo, I., & Younis, J. S. (2014) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2014.02.011 · Cited by 31

Combined transcriptome and metabolome analyses of metformin effects reveal novel links between metabolic networks in steroidogenic systems

Udhane, S. S., Legeza, B., Marti, N., Hertig, D., Diserens, G., Nuoffer, J., Vermathen, P., & Flück, C. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-09189-y · Cited by 31

NLRP3 Inflammasome-dependent Pathway is Involved in the Pathogenesis of Polycystic Ovary Syndrome

Wang, B., Shi, M., Yu, C., Pan, H., Shen, H., Du, Y., Zhang, Y., Liu, B., Xi, D., Sheng, J., et al. (2023) · Reproductive Sciences · doi:10.1007/s43032-023-01348-z · Cited by 29

The Framingham Study on Cardiovascular Disease Risk and Stress-Defenses: A Historical Review

Abohelwa, M., Kopel, J. J., Shurmur, S. W., Ansari, M. M., Awasthi, S., & Awasthi, S. (2023) · Journal of Vascular Diseases · doi:10.3390/jvd2010010 · Cited by 43

Current Advances in Cellular Approaches for Pathophysiology and Treatment of Polycystic Ovary Syndrome

Tsai, Y.-R., Liao, Y.-N., & Kang, H. (2023) · Cells · doi:10.3390/cells12172189 · Cited by 33

Sustained Maternal Hyperandrogenism During PCOS Pregnancy Reduced by Metformin in Non-obese Women Carrying a Male Fetus

Andræ, F., Abbott, D. H., Stridsklev, S., Schmedes, A., Odsæter, I. H., Vanky, E., & Salvesen, Ø. O. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa605 · Cited by 28

Role and mechanism of the p-JAK2/p-STAT3 signaling pathway in follicular development in PCOS rats

Wang, H., Feng, X., Wang, T. A., Pan, J., Zheng, Z., Su, Y., Weng, H., Zhang, L., Chen, L., Zhou, L. H., et al. (2022) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2022.114138 · Cited by 27

Hypothesis: Metformin is a potential reproductive toxicant

Petersson, M. T., Skakkebæk, N. E., Mathiesen, E. R., Kristensen, D. M., Kjær, K. H., Andersson, A., & Lindahl‐Jacobsen, R. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1000872 · Cited by 24

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Krysiak, R. G., der Grinten, H. L. C., Reisch, N., Touraine, P. A., & Falhammar, H. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae026 · Cited by 25

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Barros, S., Ribeiro, M., Coimbra, A. M., Pinheiro, M., Morais, H., Alves, N., Montes, R., Rodil, R., Quintana, J. B., Santos, M. M., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.157361 · Cited by 25

Are Fish Populations at Risk? Metformin Disrupts Zebrafish Development and Reproductive Processes at Chronic Environmentally Relevant Concentrations

Barros, S., Alves, N., Pinheiro, M., Ribeiro, M., Morais, H., Montes, R., Rodil, R., Quintana, J. B., Coimbra, A. M., Santos, M. M., et al. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c05719 · Cited by 22

Cellular and Animal Studies: Insights into Pathophysiology and Therapy of PCOS

Indran, I. R., Lee, B. H., & Yong, E. (2016) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2016.03.006 · Cited by 21

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Kvandová, M., Púzserová, A., & Bališ, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241511986 · Cited by 20

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Sciannimanico, S. M., Grimaldi, F., Vescini, F., Pergola, G. D., Iacoviello, M., Licchelli, B., Guastamacchia, E., Giagulli, V. A., & Triggiani, V. (2019) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530319666190507125847 · Cited by 21

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Street, M. E., Cirillo, F., Catellani, C., Dauriz, M., Lazzeroni, P., Sartori, C., & Moghetti, P. (2020) · Minerva Pediatrics · doi:10.23736/s0026-4946.20.05861-2 · Cited by 19

Peer group normalization and urine to blood context in steroid metabolomics: The case of CAH and obesity

Vitkin, E. I., Ben‐Dor, A., Shmoish, M., Hartmann, M. F., Yakhini, Z., Wudy, S. A., & Hochberg, Z. (2014) · Steroids · doi:10.1016/j.steroids.2014.07.003 · Cited by 17

Key signalling pathways underlying the aetiology of polycystic ovary syndrome

Walters, K. A., Moreno-Asso, A., Stepto, N. K., Pankhurst, M. W., Paris, V. R., & Rodgers, R. J. (2022) · Journal of Endocrinology · doi:10.1530/joe-22-0059 · Cited by 19

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Kononova, Y. A., Likhonosov, N. P., & Babenko, A. Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042363 · Cited by 17

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Nie, P., Wang, M., Mo, Y., Zhou, H., Zha, Q., Lash, G. E., & Li, P. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1526709 · Cited by 19

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Dattolo, A., Torres, M., Frías-Toral, E., Paganelli, A., Zhang, M., Madonna, S., Mercurio, L., Cucalón, G., Garbarino, F., Albanesi, C., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06175-1 · Cited by 13

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Saito, R., Terasaki, N., Yamazaki, M., Masutomi, N., Tsutsui, N., & Okamoto, M. (2016) · Journal of Toxicology · doi:10.1155/2016/4041827 · Cited by 13

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Haas, J., & Bentov, Y. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.01.012 · Cited by 13

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Roberts, C.-T., Raabe, N., Wiegand, L., Shahib, A. K., & Rastegar, M. (2024) · Pharmaceuticals · doi:10.3390/ph17121601 · Cited by 13

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Blackwell, B. R., Ankley, G. T., Biales, A. D., Cavallin, J. E., Cole, A. R., Collette, T. W., Ekman, D. R., Hofer, R. N., Huang, W., Jensen, K. M., et al. (2022) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5450 · Cited by 12

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Yan, Y., Kover, K. L., & Moore, W. V. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.91148 · Cited by 13

Metformin and Pancreatic Cancer Metabolism

Cantoria, M. J., Patel, H., Boros, L. G., & Meuillet, E. J. (2014) · InTech eBooks · doi:10.5772/57432 · Cited by 13

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Nayak, G., Salian, S. R., Agarwal, P., Poojary, P. S., Rao, A. C., Kumari, S., Kalthur, S. G., Shreya, A. B., Mutalik, S., Adiga, S. K., et al. (2020) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-020-01709-6 · Cited by 10

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Short-Term Fasting Attenuates Overall Steroid Hormone Biosynthesis in Healthy Young Women

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Paternal Use of Metformin During the Sperm Development Period Preceding Conception and Risk for Major Congenital Malformations in Newborns

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Pau, C. T., Cheang, K. I., Modi, B. P., Kasippillai, T., Keefe, C. C., Shulleeta, M., Evans, W. S., Pal, L., Strauss, J. F., Nestler, J. E., et al. (2016) · Pharmacogenomics · doi:10.2217/pgs-2016-0079 · Cited by 9

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Sulong, N. A., Lee, V. S., Fei, C. C., & Johan, M. R. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-01903-y · Cited by 9

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Walther, A., Penz, M. S., Ijacic, D., & Rice, T. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00207 · Cited by 8

Metformin modulates corticosteroids hormones in adrenals cells promoting Mycobacterium tuberculosis elimination in human macrophages

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Zhang, C. Y., Wang, M., He, N., Ahmed, M. F. E. M., Wang, Y., Zhao, R., Yu, X., Jin, J., Song, J., Zuo, Q., et al. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26279 · Cited by 7

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du Toit, T., Groessl, M., Pignatti, E., Swart, A. C., & Flück, C. E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199721 · Cited by 5

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Zhang, Y., Cao, S., Liang, J.-X., Hu, S.-H., Guo, X.-F., Chun-jing, S., & Ge, L.-N. (2024) · Medicine · doi:10.1097/md.0000000000039030 · Cited by 5

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Gasser, B. A., Kurz, J., Dick, B., & Mohaupt, M. G. (2022) · Life · doi:10.3390/life12060867 · Cited by 5

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