Cited by 319Effects and risks of endocrine disrupting chemicalsNeuroendocrine regulation and behaviorSexual Differentiation and Disorders

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Gestational Exposure to Bisphenol A Produces Transgenerational Changes in Behaviors and Gene Expression

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Wolstenholme, Jennifer T., Edwards, Michelle, Shetty, Savera R. J., Gatewood, Jessica D., Taylor, Julia A., Rissman, Emilie F., Connelly, Jessica J.·2012·Endocrinology

DOI 10.1210/en.2012-1195PMC PMC3404345

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Abstract

Bisphenol A (BPA) is a plasticizer and an endocrine-disrupting chemical. It is present in a variety of products used daily including food containers, paper, and dental sealants and is now widely detected in human urine and blood. Exposure to BPA during development may affect brain organization and behavior, perhaps as a consequence of its actions as a steroid hormone agonist/antagonist and/or an epigenetic modifier. Here we show that BPA produces transgenerational alterations in genes and behavior. Female mice received phytoestrogen-free chow with or without BPA before mating and throughout gestation. Plasma levels of BPA in supplemented dams were in a range similar to those measured in humans. Juveniles in the first generation exposed to BPA in utero displayed fewer social interactions as compared with control mice, whereas in later generations (F2 and F4), the effect of BPA was to increase these social interactions. Brains from embryos (embryonic d 18.5) exposed to BPA had lower gene transcript levels for several estrogen receptors, oxytocin, and vasopressin as compared with controls; decreased vasopressin mRNA persisted into the F4 generation, at which time oxytocin was also reduced but only in males. Thus, exposure to a low dose of BPA, only during gestation, has immediate and long-lasting, transgenerational effects on mRNA in brain and social behaviors. Heritable effects of an endocrine-disrupting chemical have implications for complex neurological diseases and highlight the importance of considering gene-environment interactions in the etiology of complex disease.

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Authors: Wolstenholme, J. T., Edwards, M., Shetty, S. R. J., Gatewood, J. D., Taylor, J. A., Rissman, E. F., & Connelly, J. J.
Affiliations: Departments of Biochemistry and Molecular Genetics (J.T.W., M.E., S.R.J.S., J.D.G., E.F.R.)
University of Missouri (US)
University of Virginia (US)
Corresponding author: Rissman, Emilie F.
ORCID: Wolstenholme, Jennifer T.
Taylor, Julia A.
Rissman, Emilie F.
Connelly, Jessica J.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2012-06-15
Volume: 153
Issue: 8
Pages: 3828-3838
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2012-1195
PMC: PMC3404345
OpenAlex: W2124958203
Cited by: 319
References: 79
Citations by year: 2026: 4 · 2025: 12 · 2024: 13 · 2023: 16 · 2022: 15 · 2021: 22 · 2020: 24 · 2019: 24 · 2018: 29 · 2017: 31 · 2016: 29 · 2015: 29 · 2014: 38 · 2013: 25 · 2012: 8
FWCI: 22.14
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Endocrinology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Autism Speaks (AS4802)
National Institutes of Health
National Institute of Mental Health (R01MH086711)
National Institute of Environmental Health Sciences (F32ES019404)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords: bisphenol A, endocrine disruptors, transgenerational effects, prenatal exposure, social behavior, estrogen receptor, oxytocin, vasopressin, brain gene expression, epigenetic modifications, gene-environment interaction, developmental neurotoxicity
MeSH terms: Bisphenol A Compounds, Animals, Benzhydryl Compounds, Female, Male, Mice, Inbred C57BL, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Social Behavior, Gene Expression, Oligonucleotide Array Sequence Analysis, Mice, Endocrine Disruptors, Real-Time Polymerase Chain Reaction

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Gestational Exposure to Bisphenol A Produces Transgenerational Changes in Behaviors and Gene Expression

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