Cited by 133Ovarian function and disordersReproductive Biology and FertilitySexual Differentiation and Disorders

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Physiological and Pathological Androgen Actions in the Ovary

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Astapova, Olga, Minor, Briaunna M N, Hammes, Stephen R·2019·Endocrinology

DOI 10.1210/en.2019-00101PMC PMC6937455

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Abstract

Androgens, although traditionally thought to be male sex steroids, play important roles in female reproduction, both in healthy and pathological states. This mini-review focuses on recent advances in our knowledge of the role of androgens in the ovary. Androgen receptor (AR) is expressed in oocytes, granulosa cells, and theca cells, and is temporally regulated during follicular development. Mouse knockout studies have shown that AR expression in granulosa cells is critical for normal follicular development and subsequent ovulation. In addition, androgens are involved in regulating dynamic changes in ovarian steroidogenesis that are critical for normal cycling. Androgen effects on follicle development have been incorporated into clinical practice in women with diminished ovarian reserve, albeit with limited success in available literature. At the other extreme, androgen excess leads to disordered follicle development and anovulatory infertility known as polycystic ovary syndrome (PCOS), with studies suggesting that theca cell AR may mediate many of these negative effects. Finally, both prenatal and postnatal animal models of androgen excess have been developed and are being used to study the pathophysiology of PCOS both within the ovary and with regard to overall metabolic health. Taken together, current scientific consensus is that a careful balance of androgen activity in the ovary is necessary for reproductive health in women.

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Chamberlain, N. L., Driver, E. D., & Miesfeld, R. L. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.15.3181 · Cited by 1,149
Androgens stimulate early stages of follicular growth in the primate ovary
Vendola, K. A., Zhou, J., Adesanya, O. O., Weil, S. J., & Bondy, C. A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2081 · Cited by 712
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Yeh, S., Tsai, M.-Y., Xu, Q., Mu, X., Lardy, H. A., Huang, K., Lin, H., Yeh, S.-D., Altuwaijri, S., Zhou, X., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212474399 · Cited by 683
Androgen and follicle stimulating hormone interactions in primate ovarian follicle development
Weil, S., Vendola, K., Zhou, J., & Bondy, C. A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.8.5929 · Cited by 592
Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome
Abbott, D. H., Barnett, D. K., Bruns, C. M., & Dumesic, D. A. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi013 · Cited by 555
Long Polyglutamine Tracts in the Androgen Receptor Are Associated with ReducedTrans-Activation, Impaired Sperm Production, and Male Infertility1
Tut, T. G., Ghadessy, F. J., Trifiro, M. A., Pinsky, L., & Yong, E. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.11.4385 · Cited by 520
A New Rat Model Exhibiting Both Ovarian and Metabolic Characteristics of Polycystic Ovary Syndrome
Mannerås, L., Cajander, S. B., Holmäng, A. B., Seleskovic, Z., Lystig, T., Lönn, M., & Stener‐Victorin, E. (2007) · Endocrinology · doi:10.1210/en.2007-0168 · Cited by 488
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Cai, C., He, H. H., Chen, S., Coleman, I. M., Wang, H., Fang, Z., Chen, S., Nelson, P. S., Liu, X., Brown, M. A., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.09.001 · Cited by 456
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Tut, T. G. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.11.3777 · Cited by 365
Androgen Receptor Gene Expression in the Primate Ovary: Cellular Localization, Regulation, and Functional Correlations
Weil, S. J., Vendola, K., Zhou, J., Adesanya, O. O., Wang, J., Okafor, J., & Bondy, C. A. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.7.4917 · Cited by 359
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Sonneveld, E. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfi005 · Cited by 352
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Shiina, H., Μatsumoto, T., Sato, T., Igarashi, K., Miyamoto, J., Takemasa, S., Sakari, M., Takada, I., Nakamura, T., METZGER, D., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506736102 · Cited by 332
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Hu, Y., Wang, P., Yeh, S., Wang, R.-S., Xie, C. L., Xu, Q., Zhou, X., Chao, H., Tsai, M., & Chang, C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404372101 · Cited by 316
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Sullivan, S. D., & Moenter, S. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308058101 · Cited by 309
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Sen, A., Prizant, H., Light, A., Biswas, A., Hayes, E. T., Lee, H., Barad, D. H., Gleicher, N., & Hammes, S. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318978111 · Cited by 283
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Abbott, D. H., Dumesic, D. A., Eisner, J. R., Colman, R. J., & Kemnitz, J. W. (1998) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(98)00019-8 · Cited by 228
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Steckler, T. L., Wang, J., Bartol, F. F., Roy, S. K., & Padmanabhan, V. (2005) · Endocrinology · doi:10.1210/en.2004-1444 · Cited by 209
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van Houten, E. L. A. F., Kramer, P., McLuskey, A., Karels, B., Themmen, A. P. N., & Visser, J. A. (2012) · Endocrinology · doi:10.1210/en.2011-1754 · Cited by 190
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Roland, A. V., Nunemaker, C. S., Keller, S. R., & Moenter, S. M. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0217 · Cited by 184
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Foecking, E. M., Szabo, M., Schwartz, N. B., & Levine, J. E. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.105.039800 · Cited by 165
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Moore, A. M., Prescott, M., & Campbell, R. E. (2012) · Endocrinology · doi:10.1210/en.2012-1954 · Cited by 153
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Hillier, S. G., TETSUKA, M., & Fraser, H. M. (1997) · Human Reproduction · doi:10.1093/humrep/12.1.107 · Cited by 149
Developmental regulation of androgen receptor in rat ovary
TETSUKA, M., Whitelaw, P. F., Bremner, W. J., Millar, M. R., Smyth, C. D., & Hillier, S. G. (1995) · Journal of Endocrinology · doi:10.1677/joe.0.1450535 · Cited by 138
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Harlow, C. R., Shaw, H. J., Hillier, S. G., & Hodges, J. K. (1988) · Endocrinology · doi:10.1210/endo-122-6-2780 · Cited by 112
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Hickey, T. E., Marrocco, D. L., Gilchrist, R. B., Norman, R. J., & Armstrong, D. T. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.026484 · Cited by 71
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Xu, N., Chua, A. K., Jiang, H., Liu, N., & Goodarzi, M. O. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1042 · Cited by 71
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Tehrani, F. R., Noroozzadeh, M., Zahediasl, S., Piryaei, A., & Azizi, F. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.078055 · Cited by 68
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Prenatal Programming of Reproductive Neuroendocrine Function: The Effect of Prenatal Androgens on the Development of Estrogen Positive Feedback and Ovarian Cycles in the Ewe1
Unsworth, W. P., Taylor, J. A., & Robinson, J. E. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.104.035691 · Cited by 67
Reduced reproductive performance in androgen-resistant Tfm / Tfm female mice
Lyon, M. F., & Glenister, P. H. (1980) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1980.0040 · Cited by 66
Testosterone, not 5α-Dihydrotestosterone, Stimulates LRH-1 Leading to FSH-Independent Expression of Cyp19 and P450scc in Granulosa Cells
Wu, Y.-G., Bennett, J., Talla, D., & Stocco, C. O. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0367 · Cited by 65
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Franks, S., & Berga, S. L. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.11.029 · Cited by 64
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Hogg, K., McNeilly, A. S., & Duncan, W. C. (2011) · Endocrinology · doi:10.1210/en.2010-1219 · Cited by 62
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Li, J., Yuan, H., Chen, Y., Wu, H., Wu, H., & Li, L. (2015) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2015.06.028 · Cited by 55
CAG repeat polymorphism in androgen receptor gene is not directly associated with polycystic ovary syndrome but influences serum testosterone levels
Škrgatić, L., Baldani, D. P., Cerne, J. Z., Ferk, P., & Geršak, K. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.11.006 · Cited by 55
The effect of dehydroepiandrosterone supplementation on ovarian response is associated with androgen receptor in diminished ovarian reserve women
Hu, Q., Hong, L., Nie, M., Wang, Q., Fang, Y., Dai, Y., Zhai, Y., Wang, S., Yin, C., & Yang, X. (2017) · Journal of Ovarian Research · doi:10.1186/s13048-017-0326-3 · Cited by 54
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Hasegawa, T., Kamada, Y., Hosoya, T., Fujita, S., Nishiyama, Y., Iwata, N., Hiramatsu, Y., & Otsuka, F. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.07.002 · Cited by 49
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Yazawa, T., Kawabe, S., Kanno, M., Mizutani, T., Imamichi, Y., Ju, Y., Matsumura, T., Yamazaki, Y., Usami, Y., Kuribayashi, M., et al. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.02.004 · Cited by 46
Effects of testosterone, dihydrotestosterone, and 17β-estradiol on human ovarian tissue survival in culture
Otala, M., Mäkinen, S., Tuuri, T., Sjöberg, J., Pentikäinen, V., Matikainen, T., & Dunkel, L. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.06.032 · Cited by 37
Early prenatal androgenization results in diminished ovarian reserve in adult female rhesus monkeys
Dumesic, D. A., Patankar, M. S., Barnett, D. K., Lesnick, T. G., Hutcherson, B. A., & Abbott, D. H. (2009) · Human Reproduction · doi:10.1093/humrep/dep324 · Cited by 33
The role of androgen receptor activity mediated by the CAG repeat polymorphism in the pathogenesis of PCOS.
Băculescu, N. (2013) · Europe PMC (PubMed Central) · Cited by 32
Orphan Nuclear Receptor NR4A1 Is a Negative Regulator of DHT-Induced Rat Preantral Follicular Growth
Xue, K., Liu, J., Murphy, B. D., & Tsang, B. K. (2012) · Molecular Endocrinology · doi:10.1210/me.2012-1200 · Cited by 29
Membrane Androgen Receptor ZIP9 Induces Croaker Ovarian Cell Apoptosis via Stimulatory G Protein Alpha Subunit and MAP Kinase Signaling
Converse, A., Zhang, C., & Thomas, P. (2017) · Endocrinology · doi:10.1210/en.2017-00087 · Cited by 29
Androgens Regulate Ovarian Gene Expression Through Modulation of Ezh2 Expression and Activity
Ma, X., Hayes, E. T., Biswas, A., Seger, C., Prizant, H., Hammes, S. R., & Sen, A. (2017) · Endocrinology · doi:10.1210/en.2017-00145 · Cited by 28
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Jahromi, M. S., Hill, J. W., Tehrani, F. R., & Zadeh–Vakili, A. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.05.052 · Cited by 27
Genome-wide identification of aberrantly methylated promoters in ovarian tissue of prenatally androgenized rats
Zhang, D., Cong, J., Huanhuan, S., Wu, Q., & Wu, X. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.07.1203 · Cited by 24
Role of testosterone in normal female function.
Ohno, S., Christian, L., & Attardi, B. (1973) · PubMed · Cited by 20
Negative Regulation of the Androgen Receptor Gene Through a Primate-Specific Androgen Response Element Present in the 5′ UTR
Hay, C. W., Watt, K., Hunter, I., Lavery, D. N., MacKenzie, A., & McEwan, I. J. (2014) · Hormones and Cancer · doi:10.1007/s12672-014-0185-y · Cited by 20
Size matters: Associations between the androgen receptor CAG repeat length and the intrafollicular hormone milieu
Borgbo, T., Maçek, M., Chrudimská, J., Jeppesen, J. V., Hansen, L. L., & Andersen, C. Y. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.09.015 · Cited by 18
Androgens promote the acquisition of maturation competence in bovine oocytes
Makita, M., & Miyano, T. (2015) · Journal of Reproduction and Development · doi:10.1262/jrd.2014-161 · Cited by 17
Epigenetic pattern changes in prenatal female Sprague-Dawley rats following exposure to androgen
Xia, Y., Shen, S., Zhang, X., Deng, Z., Zou, X., Wang, H., Yi, L., Gao, Q., & Wang, Y. (2015) · Reproduction Fertility and Development · doi:10.1071/rd14292 · Cited by 15
Identification of androgen receptor phosphorylation in the primate ovary in vivo
McEwan, I. J., McGuinness, D., Hay, C. W., Millar, R. P., Saunders, P. T. K., & Fraser, H. M. (2010) · Reproduction · doi:10.1530/rep-10-0140 · Cited by 15
Mechanism underlying the retarded nuclear translocation of androgen receptor splice variants
Liu, Y., Wang, Y., Wang, F., Pan, J., Xu, J.-J., Li, J., Zhou, C., Ding, G., Wu, Y., Liu, X., et al. (2018) · Science China Life Sciences · doi:10.1007/s11427-018-9379-x · Cited by 8
Paxillin and embryonic PolyAdenylation Binding Protein (ePABP) engage to regulate androgen-dependent Xenopus laevis oocyte maturation - A model of kinase-dependent regulation of protein expression
Miedlich, S. U., Taya, M., Young, M. R., & Hammes, S. R. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.03.028 · Cited by 8
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Wartalski, K., Knet, M., Hoja-Łukowicz, D., Tabarowski, Z., & Duda, M. (2016) · Acta Histochemica · doi:10.1016/j.acthis.2016.03.008 · Cited by 7

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Authors: Astapova, O., Minor, B. M. N., & Hammes, S. R.
Affiliations: University of Rochester Medicine (US)
Corresponding author: Hammes, Stephen R
ORCID: Astapova, Olga
Minor, Briaunna M N
Hammes, Stephen R
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2019-03-26
Volume: 160
Issue: 5
Pages: 1166-1174
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2019-00101
PMC: PMC6937455
OpenAlex: W2923411756
Cited by: 133
References: 70
Citations by year: 2026: 9 · 2025: 17 · 2024: 30 · 2023: 26 · 2022: 21 · 2021: 18 · 2020: 10 · 2019: 2
FWCI: 1.80
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: Endocrinology (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Department of Health (F32HD097939-01)
National Institutes of Health
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords: androgens, androgen receptor, ovary, folliculogenesis, ovulation, ovarian steroidogenesis, menstrual cycle, diminished ovarian reserve, polycystic ovary syndrome, hyperandrogenism, theca cells, granulosa cells, oocytes, anovulatory infertility, reproductive health
MeSH terms: Androgens, Animals, Female, Ovarian Follicle, Granulosa Cells, Humans, Receptors, Androgen, Theca Cells, Gene Expression, Mice, Knockout

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Physiological and Pathological Androgen Actions in the Ovary

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