Cited by 133Ovarian function and disordersReproductive Biology and FertilitySexual Differentiation and Disorders

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Physiological and Pathological Androgen Actions in the Ovary

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Astapova, Olga, Minor, Briaunna M N, Hammes, Stephen R·2019·Endocrinology

DOI 10.1210/en.2019-00101PMC PMC6937455

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Abstract

Androgens, although traditionally thought to be male sex steroids, play important roles in female reproduction, both in healthy and pathological states. This mini-review focuses on recent advances in our knowledge of the role of androgens in the ovary. Androgen receptor (AR) is expressed in oocytes, granulosa cells, and theca cells, and is temporally regulated during follicular development. Mouse knockout studies have shown that AR expression in granulosa cells is critical for normal follicular development and subsequent ovulation. In addition, androgens are involved in regulating dynamic changes in ovarian steroidogenesis that are critical for normal cycling. Androgen effects on follicle development have been incorporated into clinical practice in women with diminished ovarian reserve, albeit with limited success in available literature. At the other extreme, androgen excess leads to disordered follicle development and anovulatory infertility known as polycystic ovary syndrome (PCOS), with studies suggesting that theca cell AR may mediate many of these negative effects. Finally, both prenatal and postnatal animal models of androgen excess have been developed and are being used to study the pathophysiology of PCOS both within the ovary and with regard to overall metabolic health. Taken together, current scientific consensus is that a careful balance of androgen activity in the ovary is necessary for reproductive health in women.

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Authors: Astapova, O., Minor, B. M. N., & Hammes, S. R.
Affiliations: University of Rochester Medicine (US)
Corresponding author: Hammes, Stephen R
ORCID: Astapova, Olga
Minor, Briaunna M N
Hammes, Stephen R
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2019-03-26
Volume: 160
Issue: 5
Pages: 1166-1174
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2019-00101
PMC: PMC6937455
OpenAlex: W2923411756
Cited by: 133
References: 70
Citations by year: 2026: 9 · 2025: 17 · 2024: 30 · 2023: 26 · 2022: 21 · 2021: 18 · 2020: 10 · 2019: 2
FWCI: 1.80
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: Endocrinology (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Department of Health (F32HD097939-01)
National Institutes of Health
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords: androgens, androgen receptor, ovary, folliculogenesis, ovulation, ovarian steroidogenesis, menstrual cycle, diminished ovarian reserve, polycystic ovary syndrome, hyperandrogenism, theca cells, granulosa cells, oocytes, anovulatory infertility, reproductive health
MeSH terms: Androgens, Animals, Female, Ovarian Follicle, Granulosa Cells, Humans, Receptors, Androgen, Theca Cells, Gene Expression, Mice, Knockout

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Physiological and Pathological Androgen Actions in the Ovary

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