Temporal Changes in Plasma Adrenocorticotropin Concentration after Repeated Neurotropic Stress in Male and Female Rats
Abstract
To test the ability of the pituitary gland to secrete ACTH in response to repeated stress, 90-day-old male and female rats were subjected first to a 3-min psychological stress and then to a second identical stress 5, 10, or 15 min after the onset of the first stress. After decapitation 5, 10, 15, 20, 25, or 35 min after the onset of the second stress, plasma ACTH concentration was determined by bioassay, and plasma corticosterone was measured by a fluorometric method. Although the rate of increase in plasma corticosterone levels after the first stress was about 1.4 μg/100 ml-min in males and 2.1 μg/100 ml-min in females, 5-15 min after the onset of the first stress, no rapid inhibition of the second stress response appeared. Gradual hypersecretion of ACTH occurred in males after exposure to the second stress, and the resultant peak increment in plasma ACTH concentration was 2–3 times greater than the one observed in once-stressed rats. In females, a rapid and significant increase in plasma ACTH concentration occurred, but the ratio was only 0.6:0.9 compared to the control group. These results suggest that the fast feedback inhibition mechanism by endogenous corticosterone is overcome by a more powerful facilitatory effect of the first stress on subsequent ACTH release and that these two antagonistic systems which regulate ACTH release in response to subsequent stress may be sex-related in their onset and magnitude.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
After stress, CRH release from PVN neurons triggers a larger ACTH response in female than male rats.
“following exposure to a stressor, the release of CRH from PVN neurons triggers a larger ACTH response in female than in male rats”
From Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017) · cites this paper as Le Mevel, Abitbol, Beraud, & Maniey, 1979
Cited by
Sorted by citations
Robinson, T. E., & Becker, J. B. (1986) · Brain Research Reviews · doi:10.1016/0165-0173(86)90002-0 · Cited by 1,796 · see citing works
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586 · see citing works
Neuroendocrine pharmacology of stress
Carrasco, G. A., & Van de Kar, L. D. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01285-8 · Cited by 914 · see citing works
Oyola, M. G., & Handa, R. J. (2017) · Stress · doi:10.1080/10253890.2017.1369523 · Cited by 710 · see citing works
VIAU, V., & MEANEY, M. J. (1991) · Endocrinology · doi:10.1210/endo-129-5-2503 · Cited by 666 · see citing works
Yehuda, R. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950190065010 · Cited by 449 · see citing works
Handa, R. J., Nunley, K. M., Lorens, S. A., Louie, J. P., McGivern, R. F., & Bollnow, M. R. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90018-3 · Cited by 325 · see citing works
Shanks, N., Larocque, S., & Meaney, M. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00376.1995 · Cited by 278 · see citing works
Kaufman, J., Birmaher, B., Perel, J., Dahl, R. E., Moreci, P., Nelson, B., Wells, W., & Ryan, N. D. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00470-2 · Cited by 263 · see citing works
Stress Activation of Cortex and Hippocampus Is Modulated by Sex and Stage of Estrus
Figueiredo, H. F., Dolgas, C. M., & Herman, J. P. (2002) · Endocrinology · doi:10.1210/endo.143.7.8888 · Cited by 237 · see citing works
Curtis, A. L., Bethea, T., & Valentino, R. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300875 · Cited by 222 · see citing works
Testosterone suppression of CRH-stimulated cortisol in men
Rubinow, D. R., Roca, C. A., Schmidt, P. J., Danaceau, M. A., Putnam, K., Cizza, G., Chrousos, G., & Nieman, L. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300742 · Cited by 163 · see citing works
Neuroendocrine response during stress with relation to gender differences
Jezová, D., Juránková, E., Mosnárová, A., Kriška, M., & Škultétyová, I. (1996) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-1996-1183 · Cited by 159 · see citing works
Stress-induced sensitization: the hypothalamic–pituitary–adrenal axis and beyond
Belda, X., Fuentes, S., Daviu, N., Nadal, R., & Armario, A. (2015) · Stress · doi:10.3109/10253890.2015.1067678 · Cited by 123 · see citing works
Age-Dependent and Gender-Dependent Regulation of Hypothalamic-Adrenocorticotropic-Adrenal Axis
Veldhuis, J. D., Sharma, A., & Roelfsema, F. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.02.002 · Cited by 110 · see citing works
- Authors
- MEVEL, L. J. C., ABITBOL, S., BERAUD, G., & MANIEY, J.
- Affiliations
- Université de Rennes (FR)
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1979-09
- Volume
- 105
- Issue
- 3
- Pages
- 812-817
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2080256190
- Cited by
- 133
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 4
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- ACTH, ACTH secretion, repeated stress, psychological stress, corticosterone, product inhibition, sex differences, pituitary gland, hypothalamic-pituitary-adrenal axis, rats
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Corticosterone, Female, Humans, Male, Pituitary Gland, Sex Factors, Stress, Psychological, Time Factors, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
