Effect of Synthetic Luteinizing Hormone Releasing Hormone (LH-RH) on the Release of Gonadotropins in Cushing's Disease

BOCCUZZI, GIUSEPPE; ANGELI, ALBERTO; BISBOCCI, DANIELA; FONZO, DOMENICO; GAIDANO, GIAN PIERO; CERESA, FRANCO

doi:10.1210/jcem-40-5-892

Cited by 96Pituitary Gland Disorders and TreatmentsHypothalamic control of reproductive hormonesAdrenal Hormones and Disorders

Effect of Synthetic Luteinizing Hormone Releasing Hormone (LH-RH) on the Release of Gonadotropins in Cushing's Disease

BOCCUZZI, GIUSEPPE, ANGELI, ALBERTO, BISBOCCI, DANIELA, FONZO, DOMENICO, GAIDANO, GIAN PIERO, CERESA, FRANCO·1975·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-40-5-892

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Abstract

The effect of intravenous synthetic luteinizing hormone releasing hormone (LH-RH) on plasma radioimmunoassayable levels of gonadotropins was investigated in 6 women suffering from Cushing's disease with bilateral adrenal hyperplasia. In five of six cases no significant variation of plasma LH levels was found following stimulation; in one case the response to LH-RH was present although slightly reduced below the normal range. By contrast in all cases the plasma FSH response was similar to that recorded in normal subjects. The explanation of impaired LH response is not clear but the possibility that endogenous hypercortisolism affects the pituitary responsiveness to LH-RH has to be considered.

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In patients with Cushing's syndrome, long-term hypercortisolemia has been associated with decreased LH and FSH concentrations and hypogonadotropic amenorrhea, irrespective of coexistent hyperandrogenemia.
“In patients with Cushing's syndrome, long-term hypercortisolemia has been associated with decreased LH and FSH concentrations and hypogonadotropic amenorrhea, irrespective of coexistent hyperandrogenemia [18,19].”
From Suppression of the Hypothalamic-Pituitary-Ovarian Axis in Normal Women by Glucocorticoids1 (1993) · cites this paper as [18]

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Authors: BOCCUZZI, G., ANGELI, A., BISBOCCI, D., FONZO, D., GAIDANO, G. P., & CERESA, F.
Affiliations: University of Turin (IT)
ORCID: FONZO, DOMENICO
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1975-05
Volume: 40
Issue: 5
Pages: 892-895
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-40-5-892
OpenAlex: W2068719758
Cited by: 96
References: 0
Citations by year: 2025: 1 · 2023: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 2 · 2013: 1
FWCI: 4.63
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Funders: Consiglio Nazionale delle Ricerche
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: Cushing's disease, gonadotropin-releasing hormone, gonadotropin secretion, luteinizing hormone, follicle-stimulating hormone, bilateral adrenal hyperplasia, hypercortisolism, pituitary responsiveness, LH-RH stimulation test
MeSH terms: Adult, Aged, Amenorrhea, Cushing Syndrome, Estradiol, Female, Follicle Stimulating Hormone, Humans, Hydrocortisone, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Middle Aged, Pituitary Gland, Progesterone, Testosterone, Time Factors, 17-Hydroxycorticosteroids, 17-Ketosteroids

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Effect of Synthetic Luteinizing Hormone Releasing Hormone (LH-RH) on the Release of Gonadotropins in Cushing's Disease

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