Chronic streptozotocin diabetes in rats facilitates the acute stress response without altering pituitary or adrenal responsiveness to secretagogues.
Abstract
We have used streptozotocin (STZ)-induced diabetes in rats to determine whether this represents a sustained stimulus to the adrenocortical system and whether STZ-diabetic rats are able to mount an acute stress response. Furthermore, we compared pituitary responsiveness to CRF and/or arginine vasopressin, and adrenal responsiveness to ACTH in STZ- vs. vehicle-treated rats. We also compared the efficacy of dexamethasone inhibitory feedback in STZ-diabetic and control rats. Our results show that STZ-treated rats chronically hypersecrete corticosterone (B) as evidenced by their decreased thymus weights, their increased urinary B excretion, and their elevated mean plasma B levels during the light hours of the day. Despite the evidence for sustained hypersecretion of B, STZ-treated rats showed greater and more prolonged ACTH and B responses to the acute stress of histamine injection. However, when tested separately, neither pituitary nor adrenal responsiveness to their secretagogues were increased in STZ-diabetic compared to control rats. Dexamethasone inhibition of stress-induced B secretion was tested using two different paradigms: pentobarbital-anesthetized rats were given iv injections of acid saline, and awake rats were given ip injections of histamine. In both experiments the STZ-treated rats were relatively resistant to glucocorticoid inhibition of stress responses. This finding, taken together with the exaggerated ACTH and B responses to stress, strongly suggests that the facilitatory effects of chronic STZ-diabetes are a consequence of changes in sensitivity of central neural components of the adrenocortical system to stimulatory and/or inhibitory inputs, in conjunction with changes in glucocorticoid feedback sensitivity.
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Elevated plasma glucagon and corticosterone levels are implicated in the pathogenesis of hyperglycemia in uDM.
“Elevated plasma glucagon and corticosterone levels are implicated in the pathogenesis of hyperglycemia in uDM (29 -31).”
From Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia (2011) · cites this paper as [31]
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580 · see citing works
Corticosteroid inhibition of acth secretion
KELLER-WOOD, M. E., & DALLMAN, M. F. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-1 · Cited by 1,219 · see citing works
Gold, P. W., Loriaux, D. L., Roy, A., Kling, M. A., Calabrese, J. R., Kellner, C. H., Nieman, L. K., Post, R. M., Pickar, D., Gallucci, W. T., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605223142101 · Cited by 766 · see citing works
Regulation of ACTH Secretion: Variations on a Theme of B
DALLMAN, M. F., AKANA, S. F., CASCIO, C. S., DARLINGTON, D. N., JACOBSON, L., & LEVIN, N. (1987) · Proceedings of the 1986 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571143-2.50010-1 · Cited by 655 · see citing works
Abnormal Hypothalamic–Pituitary–Adrenal Function in Anorexia Nervosa
Gold, P. W., Gwirtsman, H. E., Avgerinos, P. C., Nieman, L. K., Gallucci, W. T., Kaye, W. H., Jimerson, D. C., Ebert, M. H., Rittmaster, R. S., Loriaux, D. L., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605223142102 · Cited by 455 · see citing works
Intracellular Receptor Concentration Limits Glucocorticoid-Dependent Enhancer Activity*
Vanderbilt, J. N., Miesfeld, R. L., Maler, B. A., & Yamamoto, K. R. (1987) · Molecular Endocrinology · doi:10.1210/mend-1-1-68 · Cited by 349 · see citing works
Dallman, M. F., & Jones, M. T. (1973) · Endocrinology · doi:10.1210/endo-92-5-1367 · Cited by 246 · see citing works
Habituation to repeated stress is stressor specific
Jean Kant, G., Eggleston, T., Landman-Roberts, L., Kenion, C. C., Driver, G. C., & Meyerhoff, J. L. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90286-2 · Cited by 225 · see citing works
Corticosterone: narrow range required for normal body and thymus weight and ACTH
Akana, S. F., Cascio, C. S., Shinsako, J., & Dallman, M. F. (1985) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1985.249.5.r527 · Cited by 199 · see citing works
́cs, K. J. K., & Makara, G. B. (1988) · Brain Research · doi:10.1016/0006-8993(88)90435-0 · Cited by 185 · see citing works
Increased Rate of Response of the Pituitary-Adrenal System in Rats Adapted to Chronic Stress
Sakellaris, P. C., & Vernikos-Danellis, J. (1975) · Endocrinology · doi:10.1210/endo-97-3-597 · Cited by 161 · see citing works
DALLMAN, M. F., LEVIN, N., CASCIO, C. S., AKANA, S. F., JACOBSON, L., & KUHN, R. W. (1989) · Endocrinology · doi:10.1210/endo-124-6-2844 · Cited by 153 · see citing works
Pituitary-Adrenal Function in Rats Chronically Exposed to Cold
Vernikos-Danellis, J., Dallman, M. F., BONNER, C., Katzen, A. L., & Shinsako, J. (1982) · Endocrinology · doi:10.1210/endo-110-2-413 · Cited by 149 · see citing works
Psychological Stress and Metabolic Control in Patients with Type I Diabetes Mellitus
Kemmer, F. W., Bisping, R., Steingrüber, H.-J., Baar, H., Hardtmann, F., Schlaghecke, R., & Berger, M. (1986) · New England Journal of Medicine · doi:10.1056/nejm198604243141704 · Cited by 148 · see citing works
Decreased Sensitivity to Glucocorticoid Fast Feedback in Chronically Stressed Rats
Young, E. A., Akana, S. F., & Dallman, M. F. (2008) · Neuroendocrinology · doi:10.1159/000125388 · Cited by 130 · see citing works
Characterization of Corticosterone Feedback Regulation of ACTH Secretiona
Dallman, M. F., Akana, S. F., Jacobson, L., Levin, N. W., Cascio, C. S., & Shinsako, J. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb24976.x · Cited by 129 · see citing works
Armario, A., Restrepo, C., Castellanos, J. M., & Balasch, J. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90304-2 · Cited by 116 · see citing works
Márquez, C., & Armario, A. (1987) · Physiology & Behavior · doi:10.1016/0031-9384(87)90182-x · Cited by 111 · see citing works
Dallman, M. F., DEMANINCOR, D., & Shinsako, J. (1974) · Endocrinology · doi:10.1210/endo-95-1-65 · Cited by 95 · see citing works
Corticosterone acts on the brain to inhibit adrenalectomy-induced adrenocorticotropin secretion
LEVIN, N., SHINSAKO, J., & DALLMAN, M. F. (1988) · Endocrinology · doi:10.1210/endo-122-2-694 · Cited by 87 · see citing works
Daniels-Severs, A. E., Goodwin, A., Keiland, L. C., & Vernikos, J. (2008) · Pharmacology · doi:10.1159/000136408 · Cited by 81 · see citing works
Abnormal Regulation of Adrenal Function in Rats with Streptozotocin Diabetes
Nicola, A. F. D., Fridman, O., del Castillo, E., & FOGLIA, V. G. (1977) · Hormone and Metabolic Research · doi:10.1055/s-0028-1093502 · Cited by 76 · see citing works
BIOASSAY OF ADRENOCORTICOTROPIC HORMONE1
Simpson, M. E., Evans, H. M., & Li, C. H. (1943) · Endocrinology · doi:10.1210/endo-33-5-261 · Cited by 67 · see citing works
Jacobson, A. M., Rand, L. I., & Hauser, S. T. (1985) · Psychosomatic Medicine · doi:10.1097/00006842-198507000-00007 · Cited by 59 · see citing works
The Influence of Streptozotocin Diabetes on Adrenal Function in Male Rats
Nicola, A. F. D., Fridman, O., del Castillo, E., & FOGLIA, V. G. (1976) · Hormone and Metabolic Research · doi:10.1055/s-0028-1093620 · Cited by 52 · see citing works
Measurement of hormones and blood gases during hypoxia in conscious cannulated rats
Raff, H., & Fagin, K. D. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.56.5.1426 · Cited by 50 · see citing works
Pollard, I., Bassett, J. R., & Cairncross, K. D. (2008) · Neuroendocrinology · doi:10.1159/000122539 · Cited by 49 · see citing works
The effects of progressive relaxation on stress and diabetic control
Lammers, C. A., Naliboff, B. D., & Straatmeyer, A. J. (1984) · Behaviour Research and Therapy · doi:10.1016/0005-7967(84)90127-x · Cited by 48 · see citing works
Calogero, A. E., Kamilaris, T. C., JOHNSON, E. O., TARTAGLIA, M. E., & Chrousos, G. P. (1990) · Endocrinology · doi:10.1210/endo-127-4-1574 · Cited by 41 · see citing works
Physiological changes in rat hypothalamic CRF: Circadian, stress and steroid suppression
Moldow, R. L., & Fischman, A. J. (1982) · Peptides · doi:10.1016/0196-9781(82)90024-9 · Cited by 40 · see citing works
Disturbances of the Hypothalamo-Hypophysial-Adrenocortical System in the Alloxan Diabetic Rat*
L’age, M., Langholz, J., Fechner, W., & SALZMANN, H. (1974) · Endocrinology · doi:10.1210/endo-95-3-760 · Cited by 38 · see citing works
Gibson, M. J., DeNicola, A. F., & Krieger, D. T. (2008) · Neuroendocrinology · doi:10.1159/000124155 · Cited by 35 · see citing works
Logsdon, C. D., Akana, S. F., MEYER, C., Dallman, M. F., & Williams, J. A. (1987) · Endocrinology · doi:10.1210/endo-121-4-1242 · Cited by 34 · see citing works
Physiological responses to acute stress in alloxan and streptozotocin diabetic rats
Lee, J. H., Konarska, M., & McCarty, R. C. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90062-0 · Cited by 31 · see citing works
SEIDEN, G., & Brodish, A. (1972) · Endocrinology · doi:10.1210/endo-90-5-1401 · Cited by 28 · see citing works
The overnight dexamethasone suppression test: clinical and theoretical review.
Gwirtsman, H. E., Gerner, R. H., & Sternbach, H. A. (1982) · PubMed · Cited by 23 · see citing works
KELLER-WOOD, M. E., Shinsako, J., & Dallman, M. F. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110840 · Cited by 22 · see citing works
Altered responses to environmental stress in streptozotocin-diabetic rats
Bellush, L. L., & Henley, W. N. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90136-r · Cited by 19 · see citing works
Adrenal, Pituitary and Urinary Ascorbic Acid Levels in Rats Subjected to Hypothermic Environment
Katsh, S., Katsh, G. F., & Osher, P. (1954) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1954.178.3.457 · Cited by 16 · see citing works
Closed-loop feedback control of the nyctohemeral rise in adrenocortical system function.
Akana, S. F., Shinsako, J., & Mf, D. (1985) · PubMed · Cited by 16 · see citing works
Woods, J. W. (1957) · The Journal of Physiology · doi:10.1113/jphysiol.1957.sp005717 · Cited by 13 · see citing works
Regulation of receptors for gluco and mineralocorticoids.
Nicola, A. F. D., Tornello, S., Coirini, H., Heller, C. L., Ortí, E., White, A., & Marusic, E. T. (1982) · PubMed · Cited by 5 · see citing works
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1 of the 44 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Björntorp, P. A., & Rosmond, R. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00422-6 · Cited by 584 · see citing works
Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system
Whitnall, M. H. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90035-q · Cited by 582 · see citing works
Bhatnagar, S., & Dallman, M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00577-0 · Cited by 511 · see citing works
Stress, Feedback and Facilitation in the Hypothalamo‐Pituitary‐Adrenal Axis
Dallman, M., Akana, S., Scribner, K. A., Bradbury, M. J., Walker, C., Strack, A. M., & Cascio, C. S. (1992) · Journal of neuroendocrinology · doi:10.1111/j.1365-2826.1992.tb00200.x · Cited by 418 · see citing works
Sullivan, R. M., & Gratton, A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02834.1999 · Cited by 377 · see citing works
Glucocorticoids and insulin: reciprocal signals for energy balance
Strack, A. M., Sebastian, R. J., Schwartz, M. W., & Dallman, M. F. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.268.1.r142 · Cited by 334 · see citing works
Tannenbaum, B. M., Brindley, D. N., Tannenbaum, G. S., Dallman, M. F., McArthur, M. D., & Meaney, M. J. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.6.e1168 · Cited by 289 · see citing works
Effect of melatonin and vitamin E on diabetes-induced learning and memory impairment in rats
Tuzcu, M., & Baydaş, G. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.03.024 · Cited by 272 · see citing works
Makino, S., Smith, M. A., & Gold, P. W. (1995) · Endocrinology · doi:10.1210/endo.136.8.7628364 · Cited by 265 · see citing works
Magariños, A. M., & McEwen, B. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.20.11056 · Cited by 262 · see citing works
Factors affecting the circadian rhythm in plasma cortisol concentrations in the horse
IRVINE, C. H. G., & Alexander, S. L. (1994) · Domestic Animal Endocrinology · doi:10.1016/0739-7240(94)90030-2 · Cited by 253 · see citing works
Seale, J. V., Wood, S. A., Atkinson, H. C., Harbuz, M. S., & Lightman, S. L. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.01258.x · Cited by 235 · see citing works
Chronic stress, metabolism, and metabolic syndrome
Tamashiro, K. L., Sakai, R. R., Shively, C. A., Karatsoreos, I. N., & Reagan, L. P. (2011) · Stress · doi:10.3109/10253890.2011.606341 · Cited by 222 · see citing works
Links between cognitive impairment in insulin resistance: An explanatory model
Convit, A. J. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.018 · Cited by 198 · see citing works
Alexander, S. L., & Irvine, C. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1570425 · Cited by 188 · see citing works
German, J. P., Thaler, J. P., Wisse, B. E., Oh-I, S., Sarruf, D. A., Matsen, M. E., Fischer, J. D., Taborsky, G. J., Schwartz, M. W., & Morton, G. J. (2011) · Endocrinology · doi:10.1210/en.2010-0890 · Cited by 169 · see citing works
Akana, S. F., Dallman, M. F., BRADBURY, M. J., Scribner, K. A., Strack, A. M., & Walker, C. D. (1992) · Endocrinology · doi:10.1210/endo.131.1.1319329 · Cited by 168 · see citing works
Chronic Stress‐Induced Effects of Corticosterone on Brain: Direct and Indirect
Dallman, M. F., Akana, S. F., Strack, A. M., SCRIBNER, K. S., Pecoraro, N. C., la Fleur, S. E., Houshyar, H., & Gómez-Oliver, F. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.017 · Cited by 167 · see citing works
Suckling is a persistent stimulus to the adrenocortical system of the rat
Walker, C. D., Lightman, S. L., Steele, M. K., & Dallman, M. F. (1992) · Endocrinology · doi:10.1210/endo.130.1.1309321 · Cited by 162 · see citing works
Leptin Deficiency Causes Insulin Resistance Induced by Uncontrolled Diabetes
German, J. P., Wisse, B. E., Thaler, J. P., Oh-I, S., Sarruf, D. A., Ogimoto, K., Kaiyala, K. J., Fischer, J. D., Matsen, M. E., Taborsky, G. J., et al. (2010) · Diabetes · doi:10.2337/db09-1918 · Cited by 159 · see citing works
Bhatnagar, S., Viau, V., Chu, A., Soriano, L., Meijer, O. C., & Dallman, M. F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05564.2000 · Cited by 152 · see citing works
Resistance to Glucocorticoid Feedback in Obesity
Jessop, D. S., Dallman, M. F., Fleming, D., & Lightman, S. L. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7826 · Cited by 141 · see citing works
Baydaş, G., Nedzvetsky, V. S., Tuzcu, M., Yaşar, A., & Кириченко, С. В. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01294-9 · Cited by 135 · see citing works
Bhatnagar, S., & Meaney, M. J. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00672.x · Cited by 127 · see citing works
Saravia, F., Revsin, Y., Deniselle, M. C. G., González, S. L., Roig, P., Lima, A. E., Homo‐Delarche, F., & Nicola, A. F. D. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03675-2 · Cited by 124 · see citing works
From Malthus to motive: How the HPA axis engineers the phenotype, yoking needs to wants
Pecoraro, N. C., Dallman, M. F., Warne, J. P., Ginsberg, A. B., Laugero, K. D., la Fleur, S. E., Houshyar, H., Gómez-Oliver, F., Bhargava, A., & Akana, S. F. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.07.004 · Cited by 120 · see citing works
Insulin signaling effects on memory and mood
Reagan, L. P. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.10.012 · Cited by 118 · see citing works
Chronic Stress and Energy Balance: Role of the Hypothalamo‐Pituitary‐Adrenal Axis
Dallman, M. F., & Bhatnagar, S. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070410 · Cited by 117 · see citing works
Baydaş, G., Nedzvetsky, V. S., Nerush, P. A., Кириченко, С. В., & Yoldaş, T. K. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00561-7 · Cited by 114 · see citing works
Warne, J. P. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.09.036 · Cited by 112 · see citing works
The As and Ds of stress: Metabolic, morphological and behavioral consequences
Reagan, L. P., Grillo, C. A., & Piroli, G. G. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.050 · Cited by 111 · see citing works
Meaney, M. J., Bhatnagar, S., Larocque, S., McCormick, C. M., Shanks, N. M., SHARMA, S., Smythe, J. W., Viau, V., & Plotsky, P. M. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb49924.x · Cited by 111 · see citing works
Hanson, E. S., & Dallman, M. F. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00757.x · Cited by 109 · see citing works
Diabetes as a chronic metabolic stressor: Causes, consequences and clinical complications
Reagan, L. P. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.02.004 · Cited by 101 · see citing works
Chan, O. T. M., Inouye, K., Vranić, M., & Matthews, S. G. (2002) · Endocrinology · doi:10.1210/endo.143.5.8809 · Cited by 100 · see citing works
Houshyar, H., Galigniana, M. D., Pratt, W. B., & Woods, J. H. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00714.x · Cited by 93 · see citing works
Chan, O. T. M., Chan, S., Inouye, K., Vranić, M., & Matthews, S. G. (2001) · Endocrinology · doi:10.1210/endo.142.11.8474 · Cited by 89 · see citing works
Effects of neonatal stimulation on later cognitive function and hippocampal nerve growth factor
Pham, T. M., Söderström, S., Henriksson, B. G., & Mohammed, A. H. S. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)02252-8 · Cited by 86 · see citing works
Chung, K. K. K., Martı́nez, M., & Herbert, J. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00459-5 · Cited by 83 · see citing works
Roy, M. S., Roy, A., Gallucci, W. T., Collier, B., Young, K., Kamilaris, T. C., & Chrousos, G. P. (1993) · Metabolism · doi:10.1016/0026-0495(93)90235-g · Cited by 82 · see citing works
Miyata, S., Hirano, S., & Kamei, J. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300354 · Cited by 80 · see citing works
Akana, S. F., & Dallman, M. F. (1997) · Endocrinology · doi:10.1210/endo.138.8.5291 · Cited by 79 · see citing works
Aksu, İ., Ateş, M., Baykara, B., Kıray, M., Şişman, A. R., Büyük, E., Baykara, B., Çetinkaya, C., Gümüş, H., & Uysal, N. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.10.045 · Cited by 78 · see citing works
Facilitation and Feedback in the Hypothalamo‐Pituitary‐Adrenal Axis during Food Restriction in Rats
García‐Belenguer, S., Oliver, C., & Mormède, P. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00537.x · Cited by 74 · see citing works
Terrence Deak, B., Nguyen, K. T., Cotter, C. S., Fleshner, M., Watkins, L. R., Maier, S. F., & Spencer, R. L. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02050-8 · Cited by 72 · see citing works
Toufexis, D. J., & Walker, C. (1996) · Brain Research · doi:10.1016/0006-8993(96)00627-0 · Cited by 71 · see citing works
Torpy, D. J., & Chrousos, G. P. (1996) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(96)80014-8 · Cited by 67 · see citing works
Chan, O. T. M., Inouye, K., Akirav, E. M., Park, E., Riddell, M. C., Vranić, M., & Matthews, S. G. (2004) · Endocrinology · doi:10.1210/en.2004-0607 · Cited by 64 · see citing works
Thorré, K., Chaouloff, F., Sarre, S., MEEUSEN, R. R., Ebinger, G., & Michotte, Y. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00841-x · Cited by 63 · see citing works
Bhatnagar, S., Mitchell, J. B., Betito, K., Boksa, P., & Meaney, M. J. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(94)00161-8 · Cited by 59 · see citing works
Regulation of GLUT-3 glucose transporter in the hippocampus of diabetic rats subjected to stress
Reagan, L. P., Magariños, A. M., Lucas, L., Bueren, A. M. V., McCall, A. L., & McEwen, B. S. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.5.e879 · Cited by 56 · see citing works
Glucose, stress, and hippocampal neuronal vulnerability
Reagan, L. P. (2002) · International review of neurobiology · doi:10.1016/s0074-7742(02)51009-6 · Cited by 55 · see citing works
Corticotropin-Releasing Factor, Corticosteroids, Stress, and Sugar
Dallman, M. F., Viau, V., Bhatnagar, S., Gómez-Oliver, F., Laugero, K. D., & Bell, M. E. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50011-1 · Cited by 51 · see citing works
Walker, C. D., Scribner, K. A., Stern, J. S., & Dallman, M. F. (1992) · Endocrinology · doi:10.1210/endo.131.6.1332842 · Cited by 51 · see citing works
Akana, S. F., Hanson, E. S., Horsley, C. J., Strack, A. M., Bhatnagar, S., BRADBURY, M. J., Milligan, E. D., & Dallman, M. F. (1996) · Stress · doi:10.3109/10253899609001094 · Cited by 49 · see citing works
Regulation of pituitary-adrenocortical activity by free fatty acids in vivo and in vitro
Widmaier, E. P., Margenthaler, J. A., & Sarel, I. (1995) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(95)90019-5 · Cited by 45 · see citing works
Chan, O. T. M., Inouye, K., Akirav, E. M., Park, E., Riddell, M. C., Matthews, S. G., & Vranić, M. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00674.2004 · Cited by 41 · see citing works
Adrenal Hypersensitivity Precedes Chronic Hypercorticism in Streptozotocin-Induced Diabetes Mice
Revsin, Y., van Wijk, D. C. W. A., Saravia, F., Oitzl, M. S., Nicola, A. F. D., & de Kloet, E. R. (2008) · Endocrinology · doi:10.1210/en.2007-1340 · Cited by 40 · see citing works
Altemus, M. M., Smith, M. A., Diep, V., Aulakh, C. S., & Murphy, D. L. (1994) · Anxiety · doi:10.1002/anxi.3070010602 · Cited by 39 · see citing works
Warne, J. P., Foster, M. T., Horneman, H. F., Pecoraro, N. C., Ginsberg, A. B., Akana, S. F., & Dallman, M. F. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.135996 · Cited by 36 · see citing works
Stress in the Racing Horse: Coping vs Not Coping.
Alexander, S. L., & IRVINE, C. H. G. (1998) · Journal of Equine Science · doi:10.1294/jes.9.77 · Cited by 36 · see citing works
Zelena, D., Filaretova, L. P., Mergl, Z., Barna, I., Tóth, Z., & Makara, G. B. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00118.2005 · Cited by 36 · see citing works
Chintamaneni, K., Bruder, E. D., & Raff, H. (2014) · Endocrinology · doi:10.1210/en.2013-1736 · Cited by 35 · see citing works
Variations in maternal care influence vulnerability to stress-induced binge eating in female rats
Hancock, S. M., MENARD, J., & Olmstead, M. C. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.05.007 · Cited by 35 · see citing works
Zelena, D., Barna, I., Mlynarik, M., Gupta, O. P., Ježová, D., & Makara, G. B. (2005) · Neuroendocrinology · doi:10.1159/000087034 · Cited by 33 · see citing works
Moreira, T. J., Malec, E., Östenson, C.-G., Efendić, S., & Liljequist, S. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.02.034 · Cited by 28 · see citing works
Grzęda, E., Rj, W., & Wisniewski, K. (2007) · PubMed · Cited by 26 · see citing works
la Fleur, S. E., Manalo, S. L., Roy, M., Houshyar, H., & Dallman, M. F. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04125.x · Cited by 26 · see citing works
Diabetes, Insulin and Alzheimer's Disease
Craft, S., & Christen, Y. (2010) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-642-04300-0 · Cited by 24 · see citing works
Inouye, K., Chan, O. T. M., Yue, J. T. Y., Matthews, S. G., & Vranić, M. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00389.2004 · Cited by 24 · see citing works
Direct evidence of acute stress-induced facilitation of ACTH response to subsequent stress in rats
Andrés, R. M., Martı́, O., & Armario, A. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.3.r863 · Cited by 24 · see citing works
Akirav, E. M., Chan, O. T. M., Inouye, K., Riddell, M. C., Matthews, S. G., & Vranić, M. (2004) · Metabolism · doi:10.1016/j.metabol.2004.06.024 · Cited by 23 · see citing works
Extreme posture elevates corticosterone in a forced ambulation model of chronic stress in rats
Neufeld, J. H., Breen, L., & Hauger, R. L. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90005-1 · Cited by 21 · see citing works
Zelena, D., Mergl, Z., & Makara, G. B. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.10.009 · Cited by 20 · see citing works
Farias-Silva, E., Santos, I. N., do Amaral, M. E. C., Kassisse, D. M. G., & Spadari-Bratfisch, R. C. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.040 · Cited by 19 · see citing works
Acute-Stress-Induced Facilitation of the Hypothalamic-Pituitary-Adrenal Axis
Wong, Y. N., Cassano, W. J., & D’mello, A. P. (2000) · Neuroendocrinology · doi:10.1159/000054556 · Cited by 19 · see citing works
Hepatic Glucocorticoid Receptor Action and Glucose Homeostasis
Chang, M., & Wang, J.-C. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf030 · Cited by 19 · see citing works
Psychoneuroendocrine outcomes of short-term crowding stress
Chaouloff, F., & Zamfir, O. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90089-x · Cited by 18 · see citing works
Coiro, V., Volpi, R., Capretti, L., Speroni, G., Caffarra, P., Scaglioni, A., Malvezzi, L., Castelli, A., Caffarri, G., Rossi, G., et al. (1995) · Metabolism · doi:10.1016/0026-0495(95)90064-0 · Cited by 24 · see citing works
Hypothalamic-Pituitary-Adrenal Axis in WBN/Kob Rats with Non-lnsulin Dependent Diabetes Mellitus.
Tojo, C., Takao, T., Nishioka, T., Numata, Y., Suemaru, S., & Hashimoto, K. (1996) · Endocrine Journal · doi:10.1507/endocrj.43.233 · Cited by 16 · see citing works
Warne, J. P., Horneman, H. F., Ginsberg, A. B., Pecoraro, N. C., Foster, M. T., Akana, S. F., & Dallman, M. F. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01593.x · Cited by 16 · see citing works
Ikeda, K., Wada, Y., Sanematsu, H., Foster, H. E., Shin, D., Rm, W., & Latifpour, J. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1680163 · Cited by 16 · see citing works
Sakimura, K., Maekawa, T., Sasagawa, K., Ishii, Y., Shinichi, K. U. M. E., & Ohta, T. (2018) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12965 · Cited by 14 · see citing works
Dipeptide metabolite, glutamyl-glutamate mediates microbe-host interaction to boost spermatogenesis
Juhász, B., Horváth, K., Kuti, D., Shen, J. X., Feuchtinger, A., Zhang, C., Bata‐Vidács, I., Nagy, I., Kukolya, J., Witting, M. A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-73216-y · Cited by 14 · see citing works
Warne, J. P., Foster, M. T., Horneman, H. F., Pecoraro, N. C., de Jong, H. K., Ginsberg, A. B., Akana, S. F., & Dallman, M. F. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00336.2007 · Cited by 12 · see citing works
Protective effects of a calcium channel blocker on apoptosis in thymus of neonatal STZ-diabetic rats
Dağıstanlı, F. K., Duman, B. S., & Öztürk, M. (2005) · Acta Histochemica · doi:10.1016/j.acthis.2005.03.005 · Cited by 11 · see citing works
Stress and Critical Illness: The Integrated Immune/Hypothalamic-Pituitary-Adrenal Axis Response
Torpy, D. J., & Chrousos, G. P. (1997) · Journal of Intensive Care Medicine · doi:10.1177/088506669701200503 · Cited by 10 · see citing works
Takao, T., Tojo, C., Nishioka, T., & Hashimoto, K. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02222-2 · Cited by 10 · see citing works
Feeding and stress interact through the serotonin 2C receptor in developing mice
Akana, S. F. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.03.017 · Cited by 10 · see citing works
Huang, Q., Timofeeva, E., & Richard, D. (2006) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.02103 · Cited by 10 · see citing works
Metabolic Effect of the Hepatic Branch of the Vagal Nerve in One‐Anastomosis Gastric Bypass (OAGB)
Ruíz-Tóvar, J., & Llavero, C. (2020) · World Journal of Surgery · doi:10.1007/s00268-020-05405-5 · Cited by 8 · see citing works
Noguchi, T., Makino, S., Maruyama, H., & Hashimoto, K. (2006) · Neuroendocrinology · doi:10.1159/000096824 · Cited by 7 · see citing works
Leptin and HPA axis activity in diabetic rats: Effects of adrenergic agonists
Clark, K. A., Jacob, E. B., MohanKumar, P. S., & MohanKumar, S. M. J. (2018) · Brain Research · doi:10.1016/j.brainres.2018.11.025 · Cited by 7 · see citing works
High Sensitivity of Gastric Mucosa to Ulcerogenic Effect of Indomethacin in Rats with Diabetes
Podvigina, T. T., Bagaeva, T. R., Bobryshev, P. Y., & Filaretova, L. P. (2011) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-011-1449-y · Cited by 6 · see citing works
Yonguç, G. N., Özdemir, M. B., Küçükatay, V., Şahiner, A. M., Akçılar, R., Adıgüzel, E., & Akdoğan, I. (2014) · Journal of Neurological Sciences-turkish · Cited by 6 · see citing works
Warne, J. P., Horneman, H. F., Akana, S. F., Foster, M. T., & Dallman, M. F. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01766.x · Cited by 6 · see citing works
Signals from the hypothalamus to the pituitary during chronic immune responses
Harbuz, M. S., & Lightman, S. L. (1997) · Springer eBooks · doi:10.1007/978-1-4471-0931-0_2 · Cited by 6 · see citing works
Law, V., Payne, L. C., & Weigent, D. A. (1994) · Journal of Neuroimmunology · doi:10.1016/0165-5728(94)90178-3 · Cited by 6 · see citing works
Retrospective and perspective on the occasion of receiving the SSIBs Distinguished Research Award
Dallman, M. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.047 · Cited by 5 · see citing works
Shinbori, C., Shirayama, Y., Mitani, H., Saito, M., & Satoh, K. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9611-2 · Cited by 4 · see citing works
- Authors
- SCRIBNER, K. A., WALKER, C.-D., CASCIO, C. S., & DALLMAN, M. F.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1991-07
- Volume
- 129
- Issue
- 1
- Pages
- 99-108
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2124250661
- Cited by
- 112
- References
- 44
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2020: 1 · 2018: 2 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, San Francisco
- National Institute of Diabetes and Digestive and Kidney Diseases (DK28172)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- streptozotocin-induced diabetes, chronic diabetes, acute stress response, corticosterone, ACTH secretion, pituitary responsiveness, vasopressin, corticotropin-releasing factor, glucocorticoid negative feedback, thymus weight, adrenal response
- MeSH terms
- Adrenal Glands, Adrenocorticotropic Hormone, Animals, Arginine Vasopressin, Circadian Rhythm, Corticosterone, Corticotropin-Releasing Hormone, Dexamethasone, Diabetes Mellitus, Experimental, Histamine, Male, Pituitary Gland, Rats, Inbred Strains, Stress, Physiological, Rats
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