Insulin signaling effects on memory and mood
Open accessAbstract
The escalating obesity/diabetes epidemic is an important health-care issue that has crucial socio-economic ramifications. The complications of diabetes/obesity phenotypes extend to the central nervous system (CNS), including the hippocampus, a brain region that is particularly vulnerable to hyperglycemia and insulin resistance. Deficits in hippocampal synaptic plasticity observed in diabetes ultimately have deleterious consequences upon cognitive function. For example, recent studies using brain imaging technologies have identified cerebral atrophy in diabetic patients, suggesting that the neuroanatomical changes observed in experimental models of diabetes may accurately reflect what is occurring in the clinical setting. Deficits in insulin receptor (IR) signaling and impairments in hypothalamic-pituitary-adrenal (HPA) axis function also contribute to the neurological complications of diabetes phenotypes. The pathophysiological similarities between diabetes and stress-related mood disorders suggest that common mechanistic mediators may be involved in the etiology and progression of the neurological complications of these disorders. When combined with the accumulating evidence from pre-clinical models, these data support the hypothesis that a long-term consequence of diabetes/obesity phenotypes is accelerated brain aging that results in neuropsychological deficits and increased vulnerability to co-morbidities such as depressive illness.
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CNS insulin signaling is important for many aspects of neuronal survival and function.
“it is now clear that CNS insulin signaling is important for many aspects of neuronal survival and function (Broughton and Partridge, 2009; de la Monte and Wands, 2005; Reagan, 2007; Zhao and Alkon, 2001; Zhao et al., 2004).”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as Reagan, 2007
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- Authors
- Reagan, L. P.
- Affiliations
- University of South Carolina (US)
- Corresponding author
- Reagan, Lawrence P
- ORCID
- Reagan, Lawrence P
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 7
- Issue
- 6
- Pages
- 633-637
- ISSN
- 1471-4892 (ISSN-L)
- PMC
- PMC2193628
- OpenAlex
- W2057121506
- Cited by
- 118
- References
- 52
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 11 · 2013: 12 · 2012: 9
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of South Carolina
- National Institutes of Health
- South Carolina Research Foundation, University of South Carolina
- National Institute of Neurological Disorders and Stroke (R01NS047728, NS 047728)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- insulin signaling, insulin resistance, diabetes mellitus, obesity, hippocampus, synaptic plasticity, cognitive impairment, brain atrophy, insulin receptor, hypothalamic-pituitary-adrenal axis, stress, mood disorders, depression, brain aging, hyperglycemia
- MeSH terms
- Affect, Aging, Animals, Brain, Diabetes Mellitus, Humans, Insulin, Memory, Receptor, Insulin, Signal Transduction
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