Cited by 112Stress Responses and CortisolRegulation of Appetite and ObesityAdrenal Hormones and Disorders

Shaping the stress response: Interplay of palatable food choices, glucocorticoids, insulin and abdominal obesity

Warne, James P.·2009·Molecular and Cellular Endocrinology

Abstract

Activity of the hypothalamo-pituitary-adrenal (HPA) axis is regulated by a negative feedback loop that dampens central drive of the axis via the actions of the secreted glucocorticoids. Conversely, under conditions of chronic stress, glucocorticoids delivered centrally increase hypothalamic paraventricular nucleus (PVN) corticotrophin-releasing factor (CRF) expression and the response to restraint. However, HPA axis activity and PVN CRF mRNA expression under chronic stress conditions are often reduced, implying other indirect peripheral or extra-hypothalamic glucocorticoid actions. Glucocorticoids chronically increase palatable food intake, which increases abdominal fat depots and circulating insulin levels, both of which negatively correlate with PVN CRF mRNA expression and may in turn dampen the response to stress. Such an effect is dependent on food choices, rather than total calories ingested. Considering stress is omnipresent in the workplace, palatable food ingestion may represent a means to combat the feeling of stress which is ultimately maladaptive when unresolved.

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Registry

Crossref · 10.1016/j.mce.2008.09.036

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  • Chronic high glucocorticoids and increases in insulin have synergistic effects on increasing highly palatable food intake and abdominal fat deposition.

    “Chronic high GCs and increases in insulin have synergistic effects on increasing HP food intake and abdominal fat deposition”

    From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Warne, 2009

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Authors
Warne, J. P.
Affiliations
University of California, San Francisco (US)
Corresponding author
Warne, James P.
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
2009-03
Volume
300
Issue
1-2
Pages
137-146
ISSN
0303-7207 (ISSN-L)
OpenAlex
W1967852835
Cited by
112
References
119
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 10 · 2015: 5 · 2014: 10 · 2013: 13 · 2012: 9
FWCI
0.45
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular and Cellular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
hypothalamic-pituitary-adrenal axis, glucocorticoids, chronic stress, corticotropin-releasing factor, paraventricular nucleus, palatable food intake, food choice, insulin, abdominal obesity, stress response, restraint stress, negative feedback
MeSH terms
Animals, Corticotropin-Releasing Hormone, Eating, Food Preferences, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Insulin, Obesity, Pituitary-Adrenal System, Stress, Physiological, Feedback, Physiological

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