Shaping the stress response: Interplay of palatable food choices, glucocorticoids, insulin and abdominal obesity
Abstract
Activity of the hypothalamo-pituitary-adrenal (HPA) axis is regulated by a negative feedback loop that dampens central drive of the axis via the actions of the secreted glucocorticoids. Conversely, under conditions of chronic stress, glucocorticoids delivered centrally increase hypothalamic paraventricular nucleus (PVN) corticotrophin-releasing factor (CRF) expression and the response to restraint. However, HPA axis activity and PVN CRF mRNA expression under chronic stress conditions are often reduced, implying other indirect peripheral or extra-hypothalamic glucocorticoid actions. Glucocorticoids chronically increase palatable food intake, which increases abdominal fat depots and circulating insulin levels, both of which negatively correlate with PVN CRF mRNA expression and may in turn dampen the response to stress. Such an effect is dependent on food choices, rather than total calories ingested. Considering stress is omnipresent in the workplace, palatable food ingestion may represent a means to combat the feeling of stress which is ultimately maladaptive when unresolved.
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Chronic high glucocorticoids and increases in insulin have synergistic effects on increasing highly palatable food intake and abdominal fat deposition.
“Chronic high GCs and increases in insulin have synergistic effects on increasing HP food intake and abdominal fat deposition”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Warne, 2009
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THE ROLE OF BOMBESIN AND BOMBESIN RECEPTORS IN THE REGULATION OF PHYSIOLOGICAL FUNCTIONS OF THE BODY
Sinyakin, I. А., Анатольевна, Б. Т., & Mironenko, E. (2021) · Современные проблемы науки и образования · doi:10.17513/spno.30529 · Cited by 1 · see citing works
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- Authors
- Warne, J. P.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Warne, James P.
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 300
- Issue
- 1-2
- Pages
- 137-146
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W1967852835
- Cited by
- 112
- References
- 119
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 10 · 2015: 5 · 2014: 10 · 2013: 13 · 2012: 9
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- hypothalamic-pituitary-adrenal axis, glucocorticoids, chronic stress, corticotropin-releasing factor, paraventricular nucleus, palatable food intake, food choice, insulin, abdominal obesity, stress response, restraint stress, negative feedback
- MeSH terms
- Animals, Corticotropin-Releasing Hormone, Eating, Food Preferences, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Insulin, Obesity, Pituitary-Adrenal System, Stress, Physiological, Feedback, Physiological
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