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Cited by 445Stress Responses and CortisolEstrogen and related hormone effectsAdrenal Hormones and Disorders

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Chronic estrogen-induced alterations in adrenocorticotropin and corticosterone secretion, and glucocorticoid receptor-mediated functions in female rats

Burgess, L H, Handa, R J·1992·Endocrinology
DOI 10.1210/endo.131.3.1324155
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Abstract

The effect of estrogen (E) on the hypothalamic-pituitary-adrenal axis was investigated in female Sprague-Dawley rats. Animals were bilaterally ovariectomized (OVX), and a Silastic capsule (0.5 cm) containing 17 beta-estradiol was sc implanted. Control animals received a blank capsule. Animals were killed 21 days later. In E-treated rats, we found significantly higher corticosterone (CORT) peak levels 20 min after a 5-sec footshock (1.0 mamp) or exposure to ether vapors (P less than 0.05) compared to those in OVX controls. In addition, the recovery of the ACTH and CORT responses to footshock stress was significantly prolonged (P less than 0.05) in the presence of E. Furthermore, the ACTH and CORT secretory responses to ether stress could be suppressed by exogenous RU 28362 (a specific glucocorticoid receptor agonist; 40 micrograms/100 g BW for 4 days) in OVX controls (P less than 0.05), but not in E-treated animals. These data suggest that E can impair glucocorticoid receptor-mediated delayed or slow negative feedback. Consequently, we examined the influence of E on mineralocorticoid and glucocorticoid receptor concentrations using in vitro binding assays. E did not alter mineralocorticoid or glucocorticoid receptor concentrations in any of the brain regions examined. The administration of RU 28362 (40 micrograms/100 g BW for 4 days) to OVX control or E-treated rats significantly down-regulated hippocampal glucocorticoid receptor (P less than 0.02) in control rats only. In contrast, aldosterone administration (40 micrograms/100 g BW for 4 days) significantly down-regulated hippocampal glucocorticoid receptor (P less than 0.0008) in both control and E-treated animals. Thus, E treatment results in a loss of the glucocorticoid receptor's ability to autoregulate; this suggests that E may cause a functional impairment of the glucocorticoid receptor even though receptor binding appears normal. These findings suggest that hyperactivation of the hypothalamic-pituitary-adrenal axis after stress in E-treated rats is due in part to impaired glucocorticoid receptor-mediated slow negative feedback.

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Crossref · 10.1210/endo.131.3.1324155

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Metadata

Authors
Burgess, L. H., & Handa, R. J.
Affiliations
Loyola University Chicago (US)
ORCID
Handa, R J
Venue
Endocrinology
Publisher
The Endocrine Society
Published
1992-09
Volume
131
Issue
3
Pages
1261-1269
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
DOI
10.1210/endo.131.3.1324155
OpenAlex
W2092107317
Cited by
445
References
36
Citations by year
2025: 2 · 2024: 5 · 2023: 5 · 2022: 2 · 2021: 11 · 2020: 8 · 2019: 14 · 2018: 10 · 2017: 8 · 2016: 13 · 2015: 13 · 2014: 19 · 2013: 20 · 2012: 10
FWCI
4.86
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
estrogen, hypothalamic-pituitary-adrenal axis, ACTH secretion, corticosterone, glucocorticoid receptor, negative feedback, RU 28362, aldosterone, hippocampus, ovariectomy, stress response, mineralocorticoid receptor, female rats, receptor autoregulation
MeSH terms
Adrenocorticotropic Hormone, Androstanols, Animals, Brain, Corticosterone, Cytosol, Dexamethasone, Drug Implants, Electroshock, Estradiol, Female, Hippocampus, Organ Specificity, Ovariectomy, Rats, Inbred Strains, Receptors, Glucocorticoid, Receptors, Steroid, Silicone Elastomers, Stress, Psychological, Time Factors, Rats

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