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Localization of oxytocin receptor messenger ribonucleic acid in the rat brain.
Abstract
The expression of oxytocin receptor (OT-R) mRNA in the rat central nervous system was examined by in situ hybridization histochemistry using cRNA probe. Wide distribution of cells expressing OT-R mRNA was observed not only in the hypothalamus, but also in other regions. There were high levels of OT-R mRNA in the anterior olfactory nuclei, tenia tecta, olfactory tubercle, rostral most region of the frontal cortex, piriform cortex, layers 2 and 3 of the neocortex, bed nucleus of the stria terminalis, anterior medial preoptic nucleus (AV3V region), magnocellular preoptic nucleus, supraoptic nucleus, paraventricular hypothalamic nucleus, retrochiasmatic nucleus, ventromedial hypothalamic nucleus, paraventricular thalamic nucleus, central amygdaloid nucleus, medial amygdaloid nucleus, posterior cortical amygdaloid nucleus, amygdalohippocampal area, subiculum, prepositus hypoglossal nucleus, and dorsal motor nucleus of vagus. In most regions of the brain, our findings concurred with those obtained by receptor binding autoradiography using a ligand specific to OT. However, in the inferior olive nucleus, OT-R mRNA was not detected despite an abundance of binding sites showed by receptor binding autography. Despite this discrepancy OT appears to have central nervous system functions in addition to its hormonal functions.
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“Seminal animal work using histochemistry and immunohistochemistry revealed high concentrations of OXTR mRNA in the hypothalamus, amygdala, olfactory bulb, ventral pallidum, and the dorsal vagal nucleus in rodents7,8.”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [7]
In the citing paper
“oxytocin receptors are widespread throughout the hypothalamus (Yoshimura et al., 1993).”
From The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: Potential relevance for brain and behavior (2022) · cites this paper as Yoshimura et al., 1993
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Handbook of Chemical Neuroanatomy
Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,160
A PROPOSED MECHANISM OF EMOTION
PAPEZ, J. W. (1937) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1937.02260220069003 · Cited by 3,563
Structure and expression of a human oxytocin receptor
Kimura, T., Tanizawa, O., Mori, K., Brownstein, M., & Okayama, H. (1992) · Nature · doi:10.1038/356526a0 · Cited by 631
Self-citationMolecular cloning and expression of a rat Via arginine vasopressin receptor
Morel, A., O'Carroll, A.-M., Brownstein, M. J., & Lolaft, S. J. (1992) · Nature · doi:10.1038/356523a0 · Cited by 477
Tribollet, E., Barberis, C., Jard, S., Dubois-Dauphin, M., & Dreifuss, J. J. (1988) · Brain Research · doi:10.1016/0006-8993(88)91437-0 · Cited by 442
Richard, P., Moos, F., & Freund-Mercier, M. J. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.2.331 · Cited by 379
Argiolas, A., & GESSA, G. L. (1991) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80002-8 · Cited by 366
Sofroniew, M. V. (1980) · Journal of Histochemistry & Cytochemistry · doi:10.1177/28.5.7381192 · Cited by 317
Tribollet, E., Charpak, S., Schmidt, A., Dubois-Dauphin, M., & Dreifuss, J. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-05-01764.1989 · Cited by 228
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Grieb, Z. A., & Lonstein, J. S. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0062 · Cited by 30
Brethel-Haurwitz, K. M., O’Connell, K., Cardinale, E. M., Stoianova, M., Stoycos, S. A., Lozier, L. M., VanMeter, J. W., & Marsh, A. A. (2017) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2017.1731 · Cited by 25
Holschbach, M., Vitale, E. M., & Lonstein, J. S. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.04.008 · Cited by 25
Maternal behavior: activation of the central oxytocin receptor system in parturient rats?
Lin, S. H., Kiyohara, T., & Sun, B. (2003) · Neuroreport · doi:10.1097/00001756-200308060-00007 · Cited by 25
Lapp, H. E., Bartlett, A. A., Zup, S. L., Hunter, R. G., & Moore, C. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104822 · Cited by 25
Vasopressin and oxytocin receptor mRNA expression during rat telencephalon development
Chen, Q., Schreiber, S. S., & Brinton, R. D. (2000) · Neuropeptides · doi:10.1054/npep.2000.0809 · Cited by 23
Kimura, T., & Ivell, R. (1999) · Results and problems in cell differentiation · doi:10.1007/978-3-540-49421-8_7 · Cited by 22
Everett, N. A., Carey, H., Cornish, J. L., & Baracz, S. J. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120954052 · Cited by 21
On the Nature of the Mother-Infant Tie and Its Interaction With Freudian Drives
Kirsch, M., & Buchholz, M. B. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00317 · Cited by 23
Melis, M. R., Succu, S., Cocco, C., Caboni, E., Sanna, F., Boi, A., Ferri, G., & Argiolas, A. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.02.008 · Cited by 21
Oxytocin, vasopressin and their interplay with gonadal steroids
Dhakar, M. B., Stevenson, E. L., & Caldwell, H. K. (2013) · Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior · doi:10.1017/cbo9781139017855.003 · Cited by 20
Kim, S.-H., An, K., Namkung, H., Saito, A., Rannals, M. D., Moore, J. R., Mihaljevic, M. M., Saha, S., Oh, S., Kondo, M., et al. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.21010053 · Cited by 23
Identification of oxytocin expression in human and murine microglia
Maejima, Y., Yokota, S., Ono, T., Yu, Z., Yamachi, M., Hidema, S., Nollet, K. E., Nishimori, K., Tomita, H., Yaginuma, H., et al. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110600 · Cited by 20
Localization of oxytocin receptors in the prairie vole (Microtus ochrogaster) neocortex
Duchemin, A., Seelke, A. M. H., Simmons, T. C., Freeman, S. M., & Bales, K. L. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.02.017 · Cited by 19
Nakashima, T., Noguchi, T., Furukawa, T., Yamasaki, M., Makino, S., Miyata, S., & Kiyohara, T. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02548-4 · Cited by 19
Maternal Brain Adaptations in Pregnancy
Brunton, P. J., & Russell, J. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00044-2 · Cited by 18
Song, Z., Sidorowicz, H. E., & Sladek, C. D. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00610.x · Cited by 17
Zelena, D., Menant, O., Andersson, F., & Chaillou, É. (2018) · Endocrine Regulations · doi:10.2478/enr-2018-0027 · Cited by 16
Granjeiro, É. M., Marroni, S. S., Dias, D. P. M., Bonagamba, L. G. H., Costa, K. M., dos Santos, J. C., de Oliveira, J. A. C., Machado, B. H., & Garcia‐Cairasco, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099284 · Cited by 16
Central Nervous System Control of Oxytocin Secretion during Lactation
Armstrong, W. E. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00013-2 · Cited by 16
Popeski, N., & Woodside, B. C. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00673.x · Cited by 14
Pirník, Z., Železná, B., Kiss, A., & Maletı́nská, L. (2015) · Brain Research · doi:10.1016/j.brainres.2015.08.042 · Cited by 14
Powell, J. M., Inoue, K., Wallace, K. J., Seifert, A. W., Young, L. J., & Kelly, A. M. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02581-z · Cited by 13
Garcia, A. N., Depena, C., Yin, W., & Gore, A. C. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.10.004 · Cited by 13
Osako, Y., Otsuka, T., Taniguchi, M., Oka, T., & Kaba, H. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01235-0 · Cited by 13
Isotocin Regulates Growth Hormone but Not Prolactin Release From the Pituitary of Ricefield Eels
Yang, W., Zhang, N., Shi, B., Zhang, S., Zhang, L., & Zhang, W. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00166 · Cited by 13
Neuronal actions of oxytocin on the subfornical organ of male rats
Hosono, T., SCHMID, H. A., Kanosue, K., & Simon, E. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.6.e1004 · Cited by 13
The neurohypophyseal hormone oxytocin and eating behaviors: a narrative review
Iovino, M., Messana, T., Marucci, S., Triggiani, D., Giagulli, V. A., Guastamacchia, E., Piazzolla, G., Pergola, G. D., Lisco, G., & Triggiani, V. (2023) · HORMONES · doi:10.1007/s42000-023-00505-y · Cited by 14
Hidema, S., Sato, K., Mizukami, H., Takahashi, Y., Maejima, Y., Shimomura, K., & Nishimori, K. (2023) · Neuroendocrinology · doi:10.1159/000535362 · Cited by 12
Optimized Sawhorse Waveform for the Measurement of Oxytocin Release in Zebrafish
Jarošová, R., Douglass, A. D., & Johnson, M. A. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c04879 · Cited by 12
Dergacheva, O., Polotsky, V. Y., & Mendelowitz, D. (2023) · SLEEP · doi:10.1093/sleep/zsad009 · Cited by 11
Walton, S. L., Burne, T. H. J., & Gilbert, C. L. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2002.00831.x · Cited by 12
Grafe, L. A., Takacs, A. E., Yee, D. K., & Flanagan‐Cato, L. M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3979-13.2014 · Cited by 12
Martinez, L. A., Levy, M. J., & Petrulis, A. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.08.016 · Cited by 11
Grieb, Z. A., & Lonstein, J. S. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12926 · Cited by 12
Garcia, A. N., Depena, C., Bezner, K. S., Yin, W., & Gore, A. C. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.10.018 · Cited by 11
Prosocial effects of prolactin in male rats: Social recognition, social approach and social learning
Donhoffner, M. E., Saleh, S. A., Schink, O., & Wood, R. I. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.09.011 · Cited by 10
Martı́nez-Lorenzana, G., Palma‐Tirado, L., Cifuentes-Díaz, C., González‐Hernández, A., & Condés‐Lara, M. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.09.004 · Cited by 10
Novel oxytocin receptor agonists and antagonists: a patent review (2002 – 2013)
Yang, Y., Li, H., Ward, R. J., Gao, L., Wei, J., & Xu, T. (2013) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2014.845168 · Cited by 10
Murai, Y., Nakashima, T., Miyata, S., & Kiyohara, T. (1998) · Neuroscience Research · doi:10.1016/s0168-0102(97)00117-x · Cited by 9
Mitra, S., Mucha, M., Owen, S. R., & Bult‐Ito, A. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00231 · Cited by 9
Neuropeptides affecting social behavior in mammals: Oxytocin
Zhou, H., Zhu, R., Xia, Y., Zhang, X., Wang, Z., Lorimer, G. H., Ghiladi, R. A., Bayram, H., & Wang, J. (2024) · Peptides · doi:10.1016/j.peptides.2024.171223 · Cited by 6
Zingg, H. H. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50059-7 · Cited by 6
Erginousakis, I., & Papatheodoropoulos, C. (2025) · Cells · doi:10.3390/cells15010059 · Cited by 6
Malone, C. L., Rieger, N. S., Spool, J. A., Payette, A., Riters, L. V., & Marler, C. A. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114556 · Cited by 5
The role of intraamygdaloid oxytocin in spatial learning and avoidance learning
Vörös, D., Kiss, O., Taigiszer, M., László, B. R., Ollmann, T., Péczely, L., Zagorácz, O., Kertes, E., Kállai, V., Berta, B., et al. (2024) · Peptides · doi:10.1016/j.peptides.2024.171169 · Cited by 5
Osada, K., Ohta, T., Takai, R., Miyazono, S., Kashiwayanagi, M., Hidema, S., & Nishimori, K. (2018) · Biology Open · doi:10.1242/bio.029140 · Cited by 4
Neuroendocrinology, Neurochemistry, and Molecular Neurobiology of Affiliative Behavior
Hammock, E. A. D., & Young, L. J. (2006) · Springer eBooks · doi:10.1007/978-0-387-30405-2_6 · Cited by 4
The Role of Oxytocin in Parental Care
Yuan, Y., Gao, Z., & Xiao, W. (2025) · Endocrinology · doi:10.1210/endocr/bqaf129 · Cited by 3
Iovino, M., Messana, T., Lisco, G., Vanacore, A., Giagulli, V. A., Guastamacchia, E., Pergola, G. D., & Triggiani, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111735 · Cited by 3
Single transcript level atlas of oxytocin and the oxytocin receptor in the mouse brain
Ryu, V., Gumerova, A. A., Pevnev, G., Korkmaz, F., Kannangara, H. S., Cullen, L., Sultana, F., Witztum, R., Sims, S. L., Frolinger, T., et al. (2026) · eLife · doi:10.7554/elife.95215 · Cited by 2
Body weight modulates the impact of oxytocin on chronic cold-immobilization stress response
Önal, D., Korkmaz, H., Önal, G., & Pehli̇vanoğlu, B. (2024) · Peptides · doi:10.1016/j.peptides.2024.171202 · Cited by 2
The Vasopressin–Oxytocin Systems of the Neurohypophysis
Leng, G., & Luckman, S. M. (1997) · Principles of medical biology · doi:10.1016/s1569-2582(97)80163-8 · Cited by 1
Possible central role of oxytocin in neurobehaviour of male rats and mice.
Chitme, H. R., & Hiremath, G. S. (2009) · Cited by 1
Oxytocin in Lactation and Parturition
Leng, G. (2024) · Masterclass in neuroendocrinology · doi:10.1007/978-3-031-51138-7_6 · Cited by 2
Relationship between pain and anxiety in rats
Roeska, K. (2010) · Gutenberg Open Science · doi:10.25358/openscience-1591 · Cited by 1
The Role of Oxytocin in the Stress and Anxiety Response.
Mantella, R. C. (2005) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1
Timmer, M., & Sandi, C. (2010) · Infoscience (Ecole Polytechnique Fédérale de Lausanne) · doi:10.5075/epfl-thesis-4892
Effects of Oxytocin in the Medial Prefrontal Cortex: Anxiety, Maternal Care, and Maternal Aggression
Sabihi, S. (2013) · OhioLink ETD Center (Ohio Library and Information Network)
Multidetermined concern: Roles for affective and cognitive processes in empathy and altruism
Brethel-Haurwitz, K. M. (2016) · DigitalGeorgetown (Georgetown University Library)
Male Behaviors II: Neural Pathways Regulating Male Behaviors
Sharma, M., & Kumar, A. (2017) · Springer eBooks · doi:10.1007/978-981-10-3695-8_18
Sharma, K. (2020) · Louisiana State University · doi:10.31390/gradschool_dissertations.5408
Scheun, J., & Gulson, J. (2019) · Springer eBooks · doi:10.1007/978-3-319-47829-6_1406-1
Scheun, J., & Gulson, J. (2022) · Springer eBooks · doi:10.1007/978-3-319-55065-7_1406
Koulousakis, P. (2024) · Research Publications (Maastricht University) · doi:10.26481/dis.20240523pk
Can Oxytocin function as an antidepressant?
Wynberg, H. (2010) · Utrecht University Repository (Utrecht University)
Caractérisation d’outils pharmacologiques pour l’étude des récepteurs centraux de la vasopressine
Marir, R. (2013) · theses.fr (ABES) · doi:10.70675/547ee25cz6fbfz417azabc9z92de6a7a2fcc
Conséquences pharmacologiques et fonctionnelles de l'hétérodimérisation des récepteurs V1B et CRF1
Mion, J. (2013) · theses.fr (ABES) · doi:10.70675/91d47531z8447z44d1z9f7ezf39a8e060318
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Metadata
- Authors
- Yoshimura, R., Kiyama, H., Kimura, T., Araki, T., Maeno, H., Tanizawa, O., & Tohyama, M.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1993-09
- Volume
- 133
- Issue
- 3
- Pages
- 1239-1246
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2142834656
- Cited by
- 161
- References
- 29
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 4 · 2015: 6 · 2014: 10 · 2013: 8 · 2012: 2
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin receptor, mRNA localization, rat brain, hypothalamus, anterior olfactory nucleus, bed nucleus of the stria terminalis, amygdala, preoptic nucleus, inferior olive, receptor binding sites
- MeSH terms
- Animals, Autoradiography, Brain Chemistry, Cerebral Cortex, Female, Hypothalamus, RNA, Messenger, Telencephalon, Tissue Distribution, RNA Probes, Gene Expression, Rats, Wistar, In Situ Hybridization, Receptors, Vasopressin, Receptors, Oxytocin, Rats
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