Appearance and transient expression of oxytocin receptors in fetal, infant, and peripubertal rat brain studied by autoradiography and electrophysiology
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The development of oxytocin (OT) receptors in the rat brain and spinal cord was studied by in vitro light microscopic autoradiography and by electrophysiology. OT receptors were labeled using a monoiodinated OT antagonist in tissue sections from animals aged between embryonic day 12 (E12) and postnatal day 90 (PN90); the response of ongoing spike activity to the addition of OT was assessed in neurons located in the dorsal motor nucleus of the vagus nerve of the neonate. Specific binding was detected first at E14 in a region that later differentiated into the dorsal motor nucleus of the vagus nerve. Many other regions were progressively labeled between E20 and PN5. From PN5 to PN16, the distribution of binding sites remained essentially unchanged but differed markedly from that characteristic of the adult. The change- over from the “infant pattern” to the “adult pattern” occurred in 2 stages: the first change took place between PN16 and PN22, a time corresponding to the preweaning period; the second change occurred after PN35 and thus coincided with the onset of puberty. During the first transition period, binding was reduced or disappeared in several areas intensely labeled at earlier stages, in particular, in the cingulate cortex and the dorsal hippocampus. At the same time, binding sites appeared in the ventral hippocampus. At puberty, high densities of OT binding sites appeared in the ventromedial hypothalamic nucleus and the olfactory tubercle. Electrophysiological activity was recorded from vagal neurons in slices obtained from animals sacrificed at PN1- PN12. OT and a selective OT agonist reversibly increased the firing rate of these neurons in a concentration-dependent manner. The neuronal responsiveness was similar to that reported previously in the adult. These results suggest that OT binding sites detected by autoradiography in the developing rat brain represent, at least in some areas, functional neuronal receptors.
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The vagus is densely populated with oxytocin receptors in rodents.
“The vagus is densely populated with oxytocin receptors in rodents19,21–26”
From Voluntary upregulation of heart rate variability through biofeedback is improved by mental contemplative training (2019) · cites this paper as [21]
The ‘Appearance and distribution of OT binding sites’ section (page unavailable) reports oxytocin binding in the rat dorsal motor nucleus of the vagus nerve throughout the ages studied, although labeling was less intense in adults. This supports receptor presence in a vagal brain nucleus, but does not establish that the vagus nerve itself is densely populated with receptors. The ‘densely packed’ description in the Figure 8 caption refers to neurons, not receptors. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThe vagus nerve is densely populated by oxytocin receptors.
“The vagus nerve is densely populated by oxytocin receptors19,21–26”
From Voluntary upregulation of heart rate variability through biofeedback is improved by mental contemplative training (2019) · cites this paper as [21]
The section on appearance and distribution of OT binding sites reports labeling in the dorsal motor nucleus of the vagus nerve in developing rats, with weaker labeling in adults. The electrophysiology section also reports that oxytocin excited neurons in that nucleus. Neither passage establishes that the vagus nerve itself is densely populated by oxytocin receptors; no page number is available in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredIn rodents, oxytocin receptors are found in the olfactory system, striatum, bed nucleus of the stria terminalis, basolateral and medial amygdala, hippocampus, insula, anterior cingulate cortex/medial prefrontal cortex, hypothalamus, brainstem, and spinal cord.
“In rodents, OTR are found in the olfactory system (olfactory bulb and accessory nucleus), striatum, BNST (bed nucleus of the stria terminalis), basolateral and medial amygdala, hippocampus, insula, ACC/mPFC (medial PFC), hypothalamus, in addition to the brainstem and spinal cord (Tribollet et al. 1989).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Tribollet et al. 1989
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- Authors
- Tribollet, E., Charpak, S., Schmidt, A., Dubois-Dauphin, M., & Dreifuss, J.
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1989-05-01
- Volume
- 9
- Issue
- 5
- Pages
- 1764-1773
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6569831
- OpenAlex
- W1586317361
- Cited by
- 228
- References
- 49
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 11 · 2020: 5 · 2019: 7 · 2018: 12 · 2017: 6 · 2016: 11 · 2015: 5 · 2014: 13 · 2013: 12 · 2012: 7
- FWCI
- 20.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin receptor, receptor development, brain development, dorsal motor nucleus of the vagus, vagal neurons, ventral hippocampus, ventromedial hypothalamus, olfactory tubercle, cingulate cortex, puberty, neonatal brain, receptor binding sites
- MeSH terms
- Animals, Animals, Newborn, Autoradiography, Binding Sites, Brain, Electrophysiology, Fetus, Neurons, Oxytocin, Rats, Inbred Strains, Receptors, Angiotensin, Receptors, Oxytocin, Rats
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