Almost exclusive androgenic action of dehydroepiandrosterone in the rat mammary gland.

Sourla, Antigone; Martel, Céline; Labrie, Claude; Labrie, Fernand

doi:10.1210/endo.139.2.5762

Cited by 49Estrogen and related hormone effectsEffects and risks of endocrine disrupting chemicalsHormonal and reproductive studies

Almost exclusive androgenic action of dehydroepiandrosterone in the rat mammary gland.

Sourla, Antigone, Martel, Céline, Labrie, Claude, Labrie, Fernand·1998·Endocrinology

DOI 10.1210/endo.139.2.5762

Open this paper in CoChat — free account

Abstract

To determine the relative role of the androgenic and/or estrogenic components of the action of dehydroepiandrosterone (DHEA) on the histomorphology and structure of the rat mammary gland, ovariectomized (OVX) female animals received DHEA administered alone or in combination with the pure antiandrogen flutamide or the pure antiestrogen EM-800 for 12 months. We have also evaluated the effect of estradiol (E2) and dihydrotestosterone constantly released from SILASTIC brand silicon implants as well as medroxyprogesterone acetate released from poly(lactide-co-glycolide) microspheres. While 1-yr OVX resulted in a severe atrophy of the mammary gland, treatment of OVX animals with DHEA stimulated lobuloalveolar and ductal growth, as well as the secretory activity of the acinar cells, thus resulting in a lobuloalveolar type of development of the mammary gland. The addition of FLU to DHEA almost completely prevented the stimulatory effect observed with DHEA alone, whereas addition of the antiestrogen EM-800 had no significant effect on the action of DHEA on the mammary gland. At the doses used, medroxyprogesterone acetate and dihydrotestosterone also stimulated ductal and alveolar development, although to a lesser degree than that achieved with DHEA. The stimulatory effect of estradiol was mainly expressed on ductal growth with a smaller stimulatory effect on lobuloalveolar development. The above-indicated stimulatory effects on lobuloalveolar development were also reflected in significant increases of the total and parenchymal gland surface areas of the mammary gland. The present study shows that androgens induce a marked lobuloalveolar type of development of the mammary gland in the rat. Moreover, these data indicate the highly predominant or almost exclusive androgenic component in the potent stimulatory action of DHEA on the histomorphology and structure of the rat mammary gland. In fact, blockade of the potential estrogenic component of DHEA action by EM-800 did not affect the stimulatory action of DHEA on mammary gland histomorphology, whereas the antiandrogen FLU almost completely blocked the effect of DHEA.

Integrity signals

Registry

Crossref · 10.1210/endo.139.2.5762

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

DHEA exerts an almost exclusively androgenic effect in the rat mammary gland.
“we have recently shown that DHEA exerts an almost exclusively androgenic effect in the rat mammary gland (177).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [177]

Extension of Multiple Range Tests to Group Means with Unequal Numbers of Replications
Kramer, C. Y. (1956) · Biometrics · doi:10.2307/3001469 · Cited by 3,146 · see citing works
Estrogens, Progestogens, Normal Breast Cell Proliferation, and Breast Cancer Risk
Pike, M. C., SPICER, D. V., Dahmoush, L., & Press, M. F. (1993) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036102 · Cited by 1,009 · see citing works
The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology
Labrie, F., Luu-The, V., Lin, S.-X., Claude, L., Simard, J., Breton, R., & Bélanger, A. (1997) · Steroids · doi:10.1016/s0039-128x(96)00174-2 · Cited by 480 · see citing works
Self-citation
Chronological Changes in Sex Steroid, Gonadotropin and Prolactin Secretion in Aging Female Rats Displaying Different Reproductive States1
Lu, K. H., HOPPER, B. R., Vargo, T. M., & Yen, S. S. C. (1979) · Biology of Reproduction · doi:10.1095/biolreprod21.1.193 · Cited by 402 · see citing works
Biological and molecular bases of mammary carcinogenesis.
Russo, J., & Russo, I. H. (1987) · PubMed · Cited by 344 · see citing works
A Correlative Morphologic Study of Human Breast and Endometrium in the Menstrual Cycle
Longacre, T. A., & Bartow, S. A. (1986) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198606000-00003 · Cited by 287 · see citing works
DHEA and peripheral androgen and estrogen formation: intracrinology
LABRIE, F., BÉLANGER, A., SIMARD, J., LUU‐THE, V., & LABRIE, C. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17369.x · Cited by 280 · see citing works
Self-citation
Cell turnover in the “resting” human breast: influence of parity, contraceptive pill, age and laterality
Anderson, T. J., Ferguson, D. J. P., & Raab, G. M. (1982) · British Journal of Cancer · doi:10.1038/bjc.1982.213 · Cited by 241 · see citing works
Distribution of 17β-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues.
Martel, C., Rhéaume, E., Takahashi, M., Trudel, C., Couët, J., Luu-The, V., Simard, J., & Labrie, F. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90390-5 · Cited by 231 · see citing works
Self-citation
Inhibition of spontaneous breast cancer formation in female C3H(Avy/a) mice by long-term treatment with dehydroepiandrosterone.
Schwartz, A. G. (1979) · PubMed · Cited by 218 · see citing works
Oral contraceptive use influences resting breast proliferation
Anderson, T. J., Battersby, S., King, R. J. B., McPherson, K., & Going, J. J. (1989) · Human Pathology · doi:10.1016/s0046-8177(89)80003-6 · Cited by 199 · see citing works
Hormonal synergism in mammary growth
LYONS, W. R. (1958) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1958.0071 · Cited by 185 · see citing works
Androgenic activity of dehydroepiandrosterone and androstenedione in the rat ventral prostate.
LABRIE, C., BELANGER, A., & LABRIE, F. (1988) · Endocrinology · doi:10.1210/endo-123-3-1412 · Cited by 167 · see citing works
Self-citation
(S)-(+)-4-[7-(2,2-Dimethyl-1-oxopro- poxy)-4-methyl-2-[4-[2-(1-piperidinyl)- ethoxy]phenyl]-2H-1-benzopyran-3-yl]- phenyl 2,2-Dimethylpropanoate (EM-800): A Highly Potent, Specific, and Orally Active Nonsteroidal Antiestrogen
Gauthier, S., Caron, B., Cloutier, J., Dory, Y. L., Favre, A., Larouche, D., Mailhot, J., Ouellet, C., Schwerdtfeger, A., Leblanc, G., et al. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm970095o · Cited by 156 · see citing works
Self-citation
Lactogenic and Growth Hormone-Like Activities in Pregnancy Determined by Radioreceptor Assays
Kelly, P. A., Tsushima, T., & Shiu, R. P. C. (1976) · Endocrinology · doi:10.1210/endo-99-3-765 · Cited by 156 · see citing works
Pathogenesis of Mammary Carcinomas Induced in Rats by 7, 12-Dimethylbenz[a]anthracene2
Russo, J., Saby, J., Isenberg, W. M., & Russo, I. H. (1977) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/59.2.435 · Cited by 131 · see citing works
Inhibitory Effect of LHRH and Its Agonists on Testicular Gonadotrophin Receptors and Spermatogenesis in the Rat
Labrie, F., AUCLAIR, C., Cusan, L., Kelly, P. A., Pelletier, G., & Ferland, L. (1978) · International Journal of Andrology · doi:10.1111/j.1365-2605.1978.tb00024.x · Cited by 130 · see citing works
Self-citation
Evaluation of tamoxifen doses with and without fluoxymesterone in advanced breast cancer.
TORMEY, D. C., LIPPMAN, M. E., EDWARDS, B. K., & CASSIDY, J. G. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-98-2-139 · Cited by 128 · see citing works
Oral contraceptive (OCP) use increases proliferation and decreases oestrogen receptor content of epithelial cells in the normal human breast
Williams, G., Anderson, E. L., Howell, A., Watson, R., Covne, J., Roberts, S. A., & Potten, C. S. (1991) · International Journal of Cancer · doi:10.1002/ijc.2910480209 · Cited by 128 · see citing works
Synandrogenic and Antiandrogenic Effect of Progestins: Comparison with Nonprogestational Antiandrogens1
Mowszowicz, I., Brown-Bieber, D., Chung, K. W., Bullock, L. P., & Bardin, C. W. (1974) · Endocrinology · doi:10.1210/endo-95-6-1589 · Cited by 121 · see citing works
Induction of androgen receptor formation by epithelium-mesenchyme interaction in embryonic mouse mammary gland.
Heuberger, B., Fitzka, I., Wasner, G., & Kratochwil, K. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.9.2957 · Cited by 112 · see citing works
Development and loss of androgen responsiveness in the embryonic rudiment of the mouse mammary gland
Kratochwil, K. (1977) · Developmental Biology · doi:10.1016/0012-1606(77)90305-0 · Cited by 109 · see citing works
Fluoxymesterone Therapy in Advanced Breast Cancer
Kennedy, B. J. (1958) · New England Journal of Medicine · doi:10.1056/nejm195810022591404 · Cited by 100 · see citing works
Cell types and morphogenesis in the mammary gland.
Dulbecco, R., Henahan, M., & Armstrong, B. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.23.7346 · Cited by 98 · see citing works
Analysis of the androgenic activity of synthetic “progestins” currently used for the treatment of prostate cancer
Labrie, C., Cusan, L., Plante, M., Lapointe, S., & Labrie, F. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)91054-5 · Cited by 91 · see citing works
Self-citation
MASCULINIZATION OF FEMALE FETUSES IN THE RAT BY PROGESTATIONAL COMPOUNDS
(1960) · Endocrinology · doi:10.1210/endo-66-1-140 · Cited by 82 · see citing works
A STUDY OF THE VIRILIZING EFFECT OF PROGESTOGENS ON THE FEMALE RAT FETUS
Suchowsky, G. K., & Junkmann, K. (1961) · Endocrinology · doi:10.1210/endo-68-2-341 · Cited by 79 · see citing works
A Biological Classification of Progestational Agents
Edgren, R. A., Jones, R. C., & Peterson, D. L. (1967) · Fertility and Sterility · doi:10.1016/s0015-0282(16)36250-1 · Cited by 76 · see citing works
Control of hormone receptor levels and growth of 7,12-dimethylbenz(a)anthracene-induced mammary tumors by estrogens, progesterone and prolactin.
ASSELIN, J., KELLY, P. A., CARON, M. G., & LABRIE, F. (1977) · Endocrinology · doi:10.1210/endo-101-3-666 · Cited by 73 · see citing works
Self-citation
Prevention by dehydroepiandrosterone of the development of mammary carcinoma induced by 7,12-dimethylbenz(a)anthracene (DMBA) in the rat.
Li, S., Yan, X., B�langer, A., & Labrie, F. (1994) · Breast Cancer Research and Treatment · doi:10.1007/bf00665681 · Cited by 70 · see citing works
Self-citation
Ontogeny of Mesenchymal Androgen Receptors in the Embryonic Mouse Mammary Gland
Wasner, G., HENNERMANN, I., & Kratochwil, K. (1983) · Endocrinology · doi:10.1210/endo-113-5-1771 · Cited by 65 · see citing works
Paracrine influence of human breast stromal fibroblasts on breast epithelial cells: Secretion of a polypeptide which stimulates reductive 17β‐oestradiol dehydrogenase activity
Adams, E. F., NEWTON, C. J., TAIT, G. H., Braunsberg, H., Reed, M. J., & James, V. H. T. (1988) · International Journal of Cancer · doi:10.1002/ijc.2910420122 · Cited by 63 · see citing works
Effects of estradiol and prolactin on steroid receptor levels in 7,12-dimethylbenz(a)anthracene-induced mammary tumors and uterus in the rat.
Asselin, J., & Labrie, F. (1978) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(78)90035-3 · Cited by 57 · see citing works
Self-citation
Fetal mammary gland differentiation in vitro in response to hormones
Ceriani, R. (1970) · Developmental Biology · doi:10.1016/0012-1606(70)90075-8 · Cited by 55 · see citing works
Androgen receptor-mediated stimulation of 17 beta-hydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in ZR-75-1 human breast cancer cells
Couture, P., Thériault, C., Simard, J., & Labrie, F. (1993) · Endocrinology · doi:10.1210/endo.132.1.8380373 · Cited by 54 · see citing works
Self-citation
Sexual Dimorphism of the Normal Rat Mammary Gland
Cardy, R. H. (1991) · Veterinary Pathology · doi:10.1177/030098589102800206 · Cited by 49 · see citing works
Endocrine Influences on the Mammary Gland
Russo, I. H., Medado, J., & Russo, J. (1989) · Monographs on pathology of laboratory animals · doi:10.1007/978-3-642-83749-4_39 · Cited by 49 · see citing works
Inhibitory effect of androgens on DMBA-induced mammary carcinoma in the rat.
Dauvois, S., Li, S., Martel, C., & Labrie, F. (1989) · Breast Cancer Research and Treatment · doi:10.1007/bf01806301 · Cited by 47 · see citing works
Self-citation
Organ culture in biomedical research.
Balls, M., & Monnickendam, M. A. (1976) · Cited by 47 · see citing works
Morphogenesis of the mammary gland
Heath, J. K. (1977) · Nature · doi:10.1038/265587a0 · Cited by 46 · see citing works
Combined Effects of Dehydroepiandrosterone and EM-800 on Bone Mass, Serum Lipids, and the Development of Dimethylbenz(A)Anthracene-Induced Mammary Carcinoma in the Rat
Luo, S., Sourla, A., Labrie, C., Bélanger, A., & Labrie, F. (1997) · Endocrinology · doi:10.1210/endo.138.10.5429 · Cited by 44 · see citing works
Self-citation
Relation of the neuroendocrine system to the development and growth of experimental mammary tumors
Meites, J. (1980) · Journal of Neural Transmission · doi:10.1007/bf01670031 · Cited by 42 · see citing works
Effect of Testosterone on the Mammary Gland
Selye, H., McEuen, C. S., & Collip, J. B. (1936) · Experimental Biology and Medicine · doi:10.3181/00379727-34-8558c · Cited by 42 · see citing works
Cell proliferation in fibrocystic disease and postmenopausal breast ducts measured by thymidine labeling
Meyer, J. S., & Connor, R. E. (1982) · Cancer · doi:10.1002/1097-0142(19820815)50:4 · Cited by 41 · see citing works
Studies of the components of an oral contraceptive agent in albino rats. I. Estrogenic component
Schardein, J. L. (1980) · Journal of Toxicology and Environmental Health · doi:10.1080/15287398009529907 · Cited by 35 · see citing works
Amplification of the mdm2 gene and p53 abnormalities in uterine sarcomas
Seki, A., Kodama, J., Miyagi, Y., Kamimura, S., Yoshinouchi, M., & Kudo, T. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970926)73:1 · Cited by 35 · see citing works
Self-citation
Calusterone (7β,17α-DimethyItestosterone) as Primary and Secondary Therapy of Advanced Breast Cancer
Gordan, G. S., Halden, A., Horn, Y., Fuery, J. J., Parsons, R. J., & Walter, R. M. (2009) · Oncology · doi:10.1159/000224811 · Cited by 32 · see citing works
Synthetic progestins stimulate prostatic binding protein messenger RNAs in the rat ventral prostate
Labrie, C., Simard, J., Zhao, H., Pelletier, G., & Labrie, F. (1990) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(90)90190-j · Cited by 30 · see citing works
Self-citation
Prolactin and lesions in breast, uterus, and prostate
長沢, 弘. (1989) · CRC Press eBooks · Cited by 29 · see citing works
Studies of the components of an oral contraceptive agent in albino rats. II. Progestogenic component and comparison of effects of the components and the combined agent
Schardein, J. L. (1980) · Journal of Toxicology and Environmental Health · doi:10.1080/15287398009529908 · Cited by 24 · see citing works
Androgenic 17 beta-hydroxysteroid dehydrogenase activity of expressed rat type I 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase
de Launoit, Y., Simard, J., Durocher, F., & Labrie, F. (1992) · Endocrinology · doi:10.1210/endo.130.1.1309351 · Cited by 23 · see citing works
Self-citation
From pathogenesis to hormone prevention of mammary carcinogenesis.
Russo, I. H., & Russo, J. (1986) · PubMed · Cited by 23 · see citing works
Treatment of the P815 murine mastocytoma with cisplatin or etoposide up-regulates cell-surface Fas (CD95) expression and increases sensitivity to anti-Fas antibody-mediated cytotoxicity and to lysis by anti-CD3-activated killer-T cells
Williams, B. A., Makrigiannis, A. P., Blay, J., & Hoskin, D. W. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19971104)73:3 · Cited by 22 · see citing works
Self-citation
THE EFFECT OF ANDROGENS ON THE MAMMARY GLAND OF THE FEMALE RHESUS MONKEY
WAGENEN, G. V., & Folley, S. J. (1939) · Journal of Endocrinology · doi:10.1677/joe.0.0010367 · Cited by 22 · see citing works
The Mammary Gland and Lactation
Davidson, A. P., & Stabenfeldt, G. H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-55227-1.00039-9 · Cited by 22 · see citing works
THE METABOLISM OF STEROIDS BY TISSUE FROM NORMAL AND NEOPLASTIC RAT BREAST
King, R. J. B., Panattoni, M., GORDON, J., & Baker, R. (1965) · Journal of Endocrinology · doi:10.1677/joe.0.0330127 · Cited by 21 · see citing works
Counteraction by Prolactin of Androgen-Induced Inhibition of Mammary Tumor Growth in Rats2
QUADRI, S. K., Kledzik, G. S., & Meites, J. (1974) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/52.3.875 · Cited by 21 · see citing works
The use of androgens in the treatment of neoplastic disease
Segaloff, A. (1977) · Pharmacology & Therapeutics Part C Clinical Pharmacology and Therapeutics · doi:10.1016/s0362-5486(77)80010-1 · Cited by 20 · see citing works
The Effects of Androgens on Induced Mammary Tumours in Rats
Young, S., BAKER, R. A., & HELFENSTEIN, J. E. (1965) · British Journal of Cancer · doi:10.1038/bjc.1965.18 · Cited by 20 · see citing works
THE METABOLISM OF TESTOSTERONE BY TISSUE FROM NORMAL AND NEOPLASTIC RAT BREAST
King, R. J. B., GORDON, J., & HELFENSTEIN, J. E. (1964) · Journal of Endocrinology · doi:10.1677/joe.0.0290103 · Cited by 18 · see citing works
Effects of Age and Long Term Ovariectomy on Prolactin Secretion, as Assessed by the Reverse Hemolytic Plaque Assay*
Sortino, M. A., & Wise, P. M. (1989) · Endocrinology · doi:10.1210/endo-124-1-90 · Cited by 16 · see citing works
Biochemical characterization of carcinogen-induced mammary hyperplastic aveolar nodule and tumor in the rat.
Dao, T. L., Chistakos, S. S., & Varela, R. M. (1975) · PubMed · Cited by 15 · see citing works
Androgen Control of Cytosol Progesterone Receptor Levels in the MT-W9B Transplantable Mammary Tumor in the Rat 2 3
Ip, M. M., Milholland, R. J., Kim, U., & Rosen, F. (1982) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/69.3.673 · Cited by 15 · see citing works
Growth inhibition of 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors by controlled-release low-dose medroxyprogesterone acetate.
Li, S., Lepage, M., Mérand, Y., Bélanger, A., & Labrie, F. (1992) · Breast Cancer Research and Treatment · doi:10.1007/bf01961245 · Cited by 14 · see citing works
Self-citation
Effect of Norethynodrel Alone or Combined with Mestranol on the Mammary Glands of the Adult Female Rat1
Kahn, R. H., & Baker, B. L. (1964) · Endocrinology · doi:10.1210/endo-75-5-818 · Cited by 13 · see citing works
Neoplastic transformation and DNA damage of mouse mammary epithelial cells by N-methyl-N′-nitrosourea in organ culture
Delp, C. R., Treves, J. S., & Banerjee, M. R. (1990) · Cancer Letters · doi:10.1016/0304-3835(90)90062-3 · Cited by 12 · see citing works
Prolactin and Lesions in Breast, Uterus, and Prostate
Nagasawa, H. (2020) · CRC Press eBooks · doi:10.1201/9780429279638 · Cited by 10 · see citing works
Serum prolactin concentrations in women treated with chlormadinone acetate
Beck, P. A., & Malarkey, W. B. (1976) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(76)90058-2 · Cited by 9 · see citing works
Thirteen-weeks subcutaneous treatment with high dose of natural sex hormones in rats with special reference to their effect on the pituitary-gonadal axis. II. Progesterone.
Attia, M. A., & Zayed, I. (1989) · PubMed · Cited by 8 · see citing works
Effects of Orally Administered Progesterone-Like Compounds on Mammary Gland Growth in Rats.
Griffith, D. R., Williams, R. L., & Turner, C. W. (1963) · Experimental Biology and Medicine · doi:10.3181/00379727-113-28377 · Cited by 8 · see citing works
Factors Modifying the Stimulatory Action of Norethynodrel on the Mammary Gland
Kahn, R. H., Baker, B. L., & ZANOTTI, D. B. (1965) · Endocrinology · doi:10.1210/endo-77-1-162 · Cited by 7 · see citing works

Flagged first, then by citations

Sorted by citations

Molecular biology of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 –isomerase gene family
Simard, J., Ricketts, M.-L., Gingras, S., Soucy, P., Feltus, F. A., & Melner, M. H. (2005) · Endocrine Reviews · doi:10.1210/er.2002-0050 · Cited by 620 · see citing works
Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone
Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544 · see citing works
Self-citation
Testosterone Effects on the Breast: Implications for Testosterone Therapy for Women
Somboonporn, W., & Davis, S. R. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0016 · Cited by 214 · see citing works
Low dose dehydroepiandrosterone affects behavior in hypopituitary androgen-deficient women: a placebo-controlled trial.
Johannsson, G., Burman, P., Wirén, L., Engström, B. E., Nilsson, A. G., Ottosson, M., Jonsson, B., Bengtsson, B.-Å., & Karlsson, F. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8494 · Cited by 175 · see citing works
Roles of androgens in the development, growth, and carcinogenesis of the mammary gland.
Liao, D., & Dickson, R. (2002) · Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(01)00185-6 · Cited by 160 · see citing works
Dehydroepiandrosterone Inhibits Human Vascular Smooth Muscle Cell Proliferation Independent of ARs and ERs
Williams, M. R. I., Ling, S., Dawood, T., Hashimura, K., Dai, A., Li, H., Liu, J., Funder, J. W., Sudhir, K., & Komesaroff, P. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.1.8161 · Cited by 148 · see citing works
Effect of Smoking on Breast Cancer in Carriers of Mutant BRCA1 or BRCA2 Genes
Brunet, J., Ghadirian, P., Rebbeck, T. R., Lerman, C., Garber, J. E., Tonin, P. N., Abrahamson, J., Foulkes, W. D., Daly, M., Costalas, J. W., et al. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.10.761 · Cited by 141 · see citing works
Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation
Lee, K., Shibutani, M., Takagi, H., Kato, N., Takigami, S., Uneyama, C., & Hirose, M. (2004) · Toxicology · doi:10.1016/j.tox.2004.06.013 · Cited by 138 · see citing works
Proliferative and Nonproliferative Lesions of the Rat and Mouse Mammary, Zymbal’s, Preputial, and Clitoral Glands
Rudmann, D. G., Cardiff, R. D., Chouinard, L., Goodman, D. G., Küttler, K., Marxfeld, H., Molinolo, A., Treumann, S., Yoshizawa, K., & For the INHAND Mammary, Z. (2012) · Toxicologic Pathology · doi:10.1177/0192623312454242 · Cited by 106 · see citing works
Dehydroepiandrosterone and its metabolites: Differential effects on androgen receptor trafficking and transcriptional activity
Mo, Q., Lu, S., & Simon, N. G. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.11.011 · Cited by 96 · see citing works
Induction of 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Type 1 Gene Transcription in Human Breast Cancer Cell Lines and in Normal Mammary Epithelial Cells by Interleukin-4 and Interleukin-13
Gingras, S., Moriggl, R., Groner, B., & Simard, J. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.1.0221 · Cited by 76 · see citing works
The Rat Mammary Gland: Morphologic Changes as an Indicator of Systemic Hormonal Perturbations Induced by Xenobiotics
Lucas, J. N., Rudmann, D. G., Credille, K. M., Irizarry, A. R., Peter, A. T., & Snyder, P. W. (2007) · Toxicologic Pathology · doi:10.1080/01926230601156260 · Cited by 72 · see citing works
Repeated dose (28 days) oral toxicity study of flutamide in rats, based on the draft protocol for the `Enhanced OECD Test Guideline 407' for screening for endocrine-disrupting chemicals
Toyoda, K., Shibutani, M., Tamura, T., Koujitani, T., Uneyama, C., & Hirose, M. (2000) · Archives of Toxicology · doi:10.1007/s002040050664 · Cited by 65 · see citing works
Differential Effects of Exogenous Androgen and an Androgen Receptor Antagonist in the Peri- and Postpubertal Murine Mammary Gland
Peters, A. A., Ingman, W. V., Tilley, W. D., & Butler, L. M. (2011) · Endocrinology · doi:10.1210/en.2011-1133 · Cited by 64 · see citing works
Tissue-specific and Androgen-repressible Regulation of the Rat Dehydroepiandrosterone Sulfotransferase Gene Promoter
Song, C. S., Jung, M. H., Kim, S. C., Hassan, T., Roy, A. K., & Chatterjee, B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.34.21856 · Cited by 62 · see citing works
Effects of dehydroepiandrosterone, Premarin and Acolbifene on histomorphology and sex steroid receptors in the rat vagina
Berger, L., Elalfy, M., Martel, C., & Labrie, F. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.02.018 · Cited by 62 · see citing works
Self-citation
Assessment of Circulating Hormones in Regulatory Toxicity Studies II. Male Reproductive Hormones
Chapin, R. E., & Creasy, D. M. (2012) · Toxicologic Pathology · doi:10.1177/0192623312443321 · Cited by 49 · see citing works
Mixtures of environmentally relevant endocrine disrupting chemicals affect mammary gland development in female and male rats
Mandrup, K. R., Johansson, H. K. L., Boberg, J., Pedersen, A. S., Mortensen, M. S., Jørgensen, J. S., Vinggaard, A. M., & Hass, U. (2014) · Reproductive Toxicology · doi:10.1016/j.reprotox.2014.09.016 · Cited by 42 · see citing works
Crucial role of cytokines in sex steroid formation in normal and tumoral tissues
Simard, J., & Gingras, S. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00387-7 · Cited by 40 · see citing works
Dehydroepiandrosterone, androgens and the mammary gland
Labrie, F. (2006) · Gynecological Endocrinology · doi:10.1080/09513590600624440 · Cited by 39 · see citing works
Self-citation
Effect of Dehydroepiandrosterone and the Antiestrogen EM-800 on Growth of Human ZR-75-1 Breast Cancer Xenografts
Couillard, S., Labrie, C., Bélanger, A., Candas, B., Pouliot, F., & Labrie, F. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.10.772 · Cited by 38 · see citing works
Self-citation
Effects of Ovariectomy and Dehydroepiandrosterone (DHEA) on Vaginal Wall Thickness and Innervation
Pelletier, G., Ouellet, J., Martel, C., & Labrie, F. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02895.x · Cited by 36 · see citing works
Self-citation
Is vulvovaginal atrophy due to a lack of both estrogens and androgens?
Labrie, F., Martel, C., & Pelletier, G. (2016) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000768 · Cited by 35 · see citing works
Self-citation
Endocrine disrupting effects in rats perinatally exposed to a dietary relevant mixture of phytoestrogens
Boberg, J., Mandrup, K. R., Jacobsen, P. R., Isling, L. K., Hadrup, N., Berthelsen, L. O., Engell-Kofoed, A. E., Kiersgaard, M. K., Vinggaard, A. M., Hass, U., et al. (2013) · Reproductive Toxicology · doi:10.1016/j.reprotox.2013.05.014 · Cited by 35 · see citing works
Androgen Resistance in Female Mice Increases Susceptibility to DMBA-Induced Mammary Tumors
Simanainen, U., Gao, Y., Walters, K. A., Watson, G., Desai, R., Jimenez, M., & Handelsman, D. J. (2012) · Hormones and Cancer · doi:10.1007/s12672-012-0107-9 · Cited by 27 · see citing works
How Stressful Is Maternity? Study about Cortisol and Dehydroepiandrosterone-Sulfate Coat and Claws Concentrations in Female Dogs from Mating to 60 Days Post-Partum
Fusi, J., Peric, T., Probo, M., Cotticelli, A., Faustini, M., & Veronesi, M. C. (2021) · Animals · doi:10.3390/ani11061632 · Cited by 26 · see citing works
Androgenic Action of Dehydroepiandrosterone (DHEA) on Nerve Density in the Ovariectomized Rat Vagina
Pelletier, G., Ouellet, J., Martel, C., & Labrie, F. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12219 · Cited by 26 · see citing works
Self-citation
Androgen Receptor Inactivation Resulted in Acceleration in Pubertal Mammary Gland Growth, Upregulation of ERα Expression, and Wnt/β-Catenin Signaling in Female Mice
Gao, Y., Walters, K. A., Desai, R., Zhou, H., Handelsman, D. J., & Simanainen, U. (2014) · Endocrinology · doi:10.1210/en.2014-1226 · Cited by 23 · see citing works
Androgen Dependent Mammary Gland Virilism in Rats Given the Selective Estrogen Receptor Modulator LY2066948 Hydrochloride
Rudmann, D. G., COHEN, I. R., Robbins, M. R., Coutant, D. E., & Henck, J. W. (2005) · Toxicologic Pathology · doi:10.1080/01926230500343902 · Cited by 22 · see citing works
Scientific and Regulatory Policy Committee (SRPC) Points to Consider
Keane, K. A., Parker, G. A., Regan, K. S., Picut, C. A., Dixon, D., Creasy, D. M., Giri, D. K., & Hukkanen, R. R. (2015) · Toxicologic Pathology · doi:10.1177/0192623315579943 · Cited by 21 · see citing works
Effects of intravaginal dehydroepiandrosterone on vaginal histomorphology, sex steroid receptor expression and cell proliferation in the rat
Berger, L., Elalfy, M., & Labrie, F. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.09.023 · Cited by 21 · see citing works
Self-citation
The increase in plasma C19Δ5 steroids in subcutaneous abdominal and jugular veins of dairy cattle during pregnancy is unrelated to estrogenic activity
Gabai, G., Marinelli, L., Simontacchi, C., & Bono, G. (2004) · Steroids · doi:10.1016/j.steroids.2003.12.001 · Cited by 20 · see citing works
Histologic and Cytologic Detection of Endocrine and Reproductive Tract Effects of Exemestane in Female Rats Treated for up to Twenty-eight Days
Mirsky, M. L., Sivaraman, L., Houle, C. D., Potter, D. M., Chapin, R. E., & Cappon, G. D. (2011) · Toxicologic Pathology · doi:10.1177/0192623311402220 · Cited by 18 · see citing works
Induction and Modulation of Hepatic Preneoplasia and Neoplasia in the Rat by Dehydroepiandrosterone
Mayer, D., Forstner, K., & Kopplow, K. (2003) · Toxicologic Pathology · doi:10.1080/01926230309742 · Cited by 17 · see citing works
Pharmacokinetics of oral dehydroepiandrosterone (DHEA) in the ovariectomised cynomolgus monkey
Leblanc, M., Labrie, C., Bélanger, A., Candas, B., & Labrie, F. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00059-6 · Cited by 16 · see citing works
Self-citation
Impact of dehydroepiandrosterone on hepatocarcinogenesis in the rat (Review).
Mayer, D., & Forstner, K. (2004) · International Journal of Oncology · doi:10.3892/ijo.25.4.1021 · Cited by 13 · see citing works
Plasma Lipoprotein Profile in the Male Cynomolgus Monkey under Normal, Hypogonadal, and Combined Androgen Blockade Conditions
Leblanc, M., Bélanger, M., Julien, P., Tchernof, A., Labrie, C., Bélanger, A., & Labrie, F. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031233 · Cited by 13 · see citing works
Self-citation
Distinct parameters are involved in controlling the number of rounds of cell division in each tissue during ascidian embryogenesis
Yamada, A., & Nishida, H. (1999) · Journal of Experimental Zoology · doi:10.1002/(sici)1097-010x(19990901)284:4 · Cited by 26 · see citing works
Future perspectives of selective estrogen receptor modulators used alone and in combination with DHEA
Labrie, F. (2006) · Endocrine Related Cancer · doi:10.1677/erc.1.00883 · Cited by 12 · see citing works
Self-citation
Effect of Castration on Some Physiological Aspect in Rats: Effect of Testosterone Hormone
Hassan, A. A. (2010) · Mağallaẗ al-tarbiyaẗ wa-al-ʻilm · doi:10.33899/edusj.2010.58390 · Cited by 7 · see citing works
Effects of dihydrotestosterone on gene expression in mammary gland
Aboghe, D. H., Bolduc, C., Yoshioka, M., & St‐Amand, J. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.06.006 · Cited by 7 · see citing works
Morphological changes induced by testosterone in the mammary glands of female Wistar rats
Chambô-Filho, A., Camargos, A. F., & Pereira, F. E. L. (2005) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2005000400008 · Cited by 7 · see citing works
Dehydroepiandrosterone treatment attenuates oestrogen-induced pituitary hyperplasia
Suárez, C. A., Tornadu, I. A. G., Khalil, W. K. B., & Becú‐Villalobos, D. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1740447 · Cited by 6 · see citing works
Relationship between morphological development and sex hormone receptor expression of mammary glands with age in male rats
Miyamoto, Y., Kawaguchi, H., & Tanimoto, A. (2018) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.17-0134 · Cited by 4 · see citing works
Characterization of adult male albino rat mammary gland: a histological and serological study
Gouda, Z. A., Ahmed, S. M., & Ghonaimy, N. M. E. (2015) · Journal of Histology and Histopathology · doi:10.7243/2055-091x-2-5 · Cited by 3 · see citing works
Pathology of the Male and Female Reproductive System and Mammary Gland
Vidal, J. D. (2019) · Springer eBooks · doi:10.1007/978-1-4939-9777-0_11 · Cited by 3 · see citing works
Chronic administration of dehydroepiandrosterone (DHEA) to female monkey and rat has no effect on mammary gland histology
Pelletier, G., Labrie, C., Martel, C., & Labrie, F. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.07.002 · Cited by 2 · see citing works
Self-citation
Porcine Placental Extract Improves the Lipid Profile and Body Weight in a Post-Menopausal Rat Model Without Affecting Reproductive Tissues
Purevdorj, T., Arata, M., Nii, M., Yamamoto, S., Noguchi, H., Takeda, A., Aoki, H., Inui, H., Kagawa, T., Kinouchi, R., et al. (2025) · Nutrients · doi:10.3390/nu17060984 · Cited by 1 · see citing works
Effets et mécanismes d'action d'un modulateur sélectif des récepteurs des oestrogènes sur le métabolisme des lipides
Lemieux, C. (2005) · Corpus Université Laval (Université Laval) · Cited by 1 · see citing works

Chronic administration of dehydroepiandrosterone (DHEA) to female monkey and rat has no effect on mammary gland histology
Pelletier, G., Labrie, C., Martel, C., & Labrie, F. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.07.002 · Cited by 2 · see citing works
Self-citation
Exclusive androgenic effect of dehydroepiandrosterone in sebaceous glands of rat skin
Sourla, A., Richard, V., Labrie, F., & Labrie, C. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1660455 · Cited by 11 · see citing works
Self-citation
Changes in ovarian morphology and serum hormones in the rat after treatment with dehydroepiandrosterone
Lee, M., Anderson, E., & Lee, G. Y. (1991) · The Anatomical Record · doi:10.1002/ar.1092310206 · Cited by 87 · see citing works
Effect of dehydroepiandrosterone on vaginal and uterine histomorphology in the rat.
Sourla, A., Flamand, M., Bélanger, A., & Labrie, F. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00052-1 · Cited by 40 · see citing works
Self-citation
THE ACTION OF DESOXYCORTICOSTERONE ACETATE ON THE MAMMARY GLAND OF THE IMMATURE OVARIECTOMIZED RAT
SMITH, T. C., & Braverman, L. E. (1953) · Endocrinology · doi:10.1210/endo-52-3-311 · Cited by 4 · see citing works

Authors: Sourla, A., Martel, C., Labrie, C., & Labrie, F.
Affiliations: Centre hospitalier de l'Université Laval (CA)
Corresponding author: Labrie, Fernand
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1998-02
Volume: 139
Issue: 2
Pages: 753-764
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo.139.2.5762
OpenAlex: W2129320642
Cited by: 49
References: 71
Citations by year: 2025: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 4
FWCI: 1.33
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: dehydroepiandrosterone, mammary gland development, estrogenic activity, flutamide, medroxyprogesterone acetate, dihydrotestosterone, estradiol, ovariectomy, lobuloalveolar development
MeSH terms: Androgen Antagonists, Androgens, Animals, Benzopyrans, Dehydroepiandrosterone, Estradiol, Estrogen Antagonists, Female, Flutamide, Mammary Glands, Animal, Medroxyprogesterone, Ovariectomy, Propionates, Dihydrotestosterone, Rats, Sprague-Dawley, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Almost exclusive androgenic action of dehydroepiandrosterone in the rat mammary gland.

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks