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Cited by 505

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Minireview: Aromatase and the Regulation of Estrogen Biosynthesis—Some New Perspectives

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Simpson, Evan R., Davis, Susan R.·2001·Endocrinology
DOI 10.1210/endo.142.11.8547
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Abstract

There is a growing awareness that androgens and estrogens have general metabolic roles that are not directly involved in reproductive processes. These include actions on vascular function, lipid and carbohydrate metabolism, as well as bone mineralization and epiphyseal closure, in both sexes. In postmenopausal women, as in men, estrogen is no longer solely an endocrine factor, but instead is produced in a number of extragonadal sites and acts locally at these sites in a paracrine and intracrine fashion. These sites include breast, bone, vasculature, and brain. Within these sites, aromatase action can generate high levels of E2 locally without significantly affecting circulating levels. Circulating C(19) steroid precursors are essential substrates for extragonadal estrogen synthesis. The levels of these androgenic precursors decline markedly with advancing age in women, possibly from the mid to late reproductive years. This may be a fundamental reason why women are at increased risk for bone mineral loss and fracture and possibly decline of cognitive function, compared with men. Aromatase expression in these various sites is under the control of tissue-specific promoters regulated by different cohorts of transcription factors. Thus, in principle, it should be possible to develop selective aromatase modulators that block aromatase expression, for example, in breast, but allow unimpaired estrogen synthesis in other tissues such as bone.

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Metadata

Authors
Simpson, E. R., & Davis, S. R.
Venue
Endocrinology
Publisher
The Endocrine Society
Published
2001-11-01
Volume
142
Issue
11
Pages
4589-4594
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
DOI
10.1210/endo.142.11.8547
OpenAlex
W1984858425
Cited by
505
References
8
FWCI
10.18
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Minireview: Aromatase and the Regulation of Estrogen Biosynthesis—Some New Perspectives. https://app.cochat.ai/papers/10.1210/endo.142.11.8547
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Simpson, E. R., & Davis, S. R. (2001). Minireview: Aromatase and the Regulation of Estrogen Biosynthesis—Some New Perspectives. Endocrinology. https://doi.org/10.1210/endo.142.11.8547

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