Physiological changes in dehydroepiandrosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: intracrinology.
Abstract
This study analyzes in detail the serum concentration of the active androgens and estrogens, as well as a series of free and conjugated forms of their precursors and metabolites, after daily application for 2 weeks of 10 mL 20% dehydroepiandrosterone (DHEA) solution on the skin to avoid first passage through the liver. In men, DHEA administration caused 175%, 90%, 200% and 120% increases in the circulating levels of DHEA and its sulfate (DHEA-S), DHEA-fatty acid esters, and androst-5-ene-3 beta,17 beta-diol, respectively, with a return to basal values 7 days after cessation of the 14-day treatment. Serum androstenedione increased by approximately 80%, whereas serum testosterone and dihydrotestosterone (DHT) remained unchanged. In parallel with the changes in serum DHEA, the concentrations of the conjugated metabolites of DHT, namely androsterone glucuronide, androstane-3 alpha,17 beta-diol-G, and androstane-3 beta,17 beta-diol-G increased by about 75%, 50%, and 75%, respectively, whereas androsterone-sulfate increased 115%. No consistent change was observed in serum estrone (E1) or estradiol (E2) in men receiving DHEA, whereas serum E1-sulfate and E2-sulfate were slightly and inconsistently increased by about 20%, and serum cortisol and aldosterone concentrations were unaffected by DHEA administration. Almost superimposable results were obtained in women for most steroids except testosterone, which was about 50% increased during DHEA treatment. This increase corresponded to about 0.8 nM testosterone, an effect undetectable in men because they already have much higher (approximately 15 nM) basal testosterone levels. In women, the serum levels of the conjugated metabolites of DHT, namely androsterone glucuronide, androstane-3 alpha,17 beta-diol-G, androstane-3 beta,17 beta-diol-G, and androsterone-sulfate were increased by 125%, 140%, 120% and 150%, respectively. The present study demonstrates that the serum concentrations of testosterone, DHT, E1, and E2 are poor indicators of total androgenic and estrogenic activity. However, the esterified metabolites of DHT appear as reliable markers of the total androgen pool, because they directly reflect the intracrine formation of androgens in the tissues possessing the steroidogenic enzymes required to transform the inactive precursors DHEA and DHEA-S into DHT. As well demonstrated in women, who synthesize almost all their androgens from DHEA and DHEA-S, supplementation with physiological amounts of exogeneous DHEA permits the biosynthesis of androgens limited to the appropriate target tissues without leakage of significant amounts of active androgens into the circulation. This local or intracrine biosynthesis and action of androgens eliminates the inappropriate exposure of other tissues to androgens and thus minimizes the risks of undesirable masculinizing or other androgen-related side effects of DHEA.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
DHEA serves as a precursor to many androgenic and estrogenic hormones.
“DHEA serves as a precursor to many androgenic and estrogenic hormones.32, 47, 48”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [32]
After percutaneous administration of DHEA in 60-to 70-yr-old men and women, changes in serum DHEA within the physiological range led only to small or nonsignificant changes in serum testosterone, DHT, or E2, whereas the concentration of conjugated metabolites of DHT were markedly increased.
“We then observed that changes in serum DHEA within the physiological range of young adult men and women led only to small or nonsignificant changes in serum testosterone, DHT, or E 2 , whereas, on the other hand, the concentration of the conjugated metabolites of DHT were markedly increased (27).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [27]
Total androgen production in women is more than two thirds, or 71%, of that observed in men, based on the sum of serum concentrations of ADT-G, 3α-diol-G, and 3β-diol-G.
“an estimate of the relative amount of total androgens in women and men calculated on the basis of the sum of the serum concentrations of these three metabolites suggests that total androgen production in women is more than two thirds, or 71%, of that observed in men (23,27).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [27]
Women at menopause are not only deprived from estrogens because of rapid loss of ovarian activity but also have been deprived from androgens for a longer period because of progressive decrease of serum DHEA levels starting years before menopause.
“women, at menopause, are not only deprived from estrogens because of a rapid loss of ovarian activity but also have been deprived from androgens for a longer period because of a progressive decrease of serum DHEA levels starting quite a few years before menopause.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [27]
Cites
Extension of Multiple Range Tests to Group Means with Unequal Numbers of Replications
Kramer, C. Y. (1956) · Biometrics · doi:10.2307/3001469 · Cited by 3,146 · see citing works
ORENTREICH, N., BRIND, J. L., RIZER, R. L., & VOGELMAN, J. H. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-3-551 · Cited by 1,349 · see citing works
Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.
Morales, A. J., Nolan, J. J., Nelson, J. C., & Yen, S. S. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.6.7515387 · Cited by 841 · see citing works
Important Advances in Oncology
DeVita, V. T., Hellman, S., & Rosenberg, S. A. (1991) · Anti-Cancer Drugs · doi:10.1097/00001813-199108000-00014 · Cited by 760 · see citing works
Deletion of steroid 5α-reductase 2 gene in male pseudohermaphroditism
Andersson, S., Berman, D. M., Jenkins, E. P., & Russell, D. W. (1991) · Nature · doi:10.1038/354159a0 · Cited by 643 · see citing works
Andersson, S., & Russell, D. W. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3640 · Cited by 501 · see citing works
The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology
Labrie, F., Luu-The, V., Lin, S.-X., Claude, L., Simard, J., Breton, R., & Bélanger, A. (1997) · Steroids · doi:10.1016/s0039-128x(96)00174-2 · Cited by 480 · see citing works
Self-citationChanges in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men
Bèlanger, A., Candas, B., Dupont, A., Cusan, L., Diamond, P., Gomez, J.-L., & Labrie, F. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.4.7962278 · Cited by 437 · see citing works
Self-citationNESTLER, J. E., BARLASCINI, C. O., CLORE, J. N., & BLACKARD, W. G. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-1-57 · Cited by 414 · see citing works
Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice.
Coleman, D. L., Leiter, E. H., & Schwizer, R. W. (1982) · Diabetes · doi:10.2337/diab.31.9.830 · Cited by 317 · see citing works
The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women
MORTOLA, J. F., & YEN, S. S. C. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-3-696 · Cited by 311 · see citing works
Complete androgen blockade for the treatment of prostate cancer.
Labrie, F., Dupont, A., & Bèlanger, A. (1985) · PubMed · Cited by 285 · see citing works
Self-citationDHEA and peripheral androgen and estrogen formation: intracrinology
LABRIE, F., BÉLANGER, A., SIMARD, J., LUU‐THE, V., & LABRIE, C. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17369.x · Cited by 280 · see citing works
Self-citationMIGEON, C. J., KELLER, A. R., LAWRENCE, B., & SHEPARD, T. H. (1957) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-17-9-1051 · Cited by 260 · see citing works
Luu-The, V., Zhang, Y., Poirier, D., & Labrie, F. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00209-x · Cited by 224 · see citing works
Self-citationBélanger, B., Bélanger, A., Labrie, F., Dupont, A., Cusan, L., & Monfette, G. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90514-1 · Cited by 212 · see citing works
Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women
Casson, P. R., Andersen, R. N., Herrod, H. G., Stentz, F. B., Straughn, A. B., Abraham, G. E., & Buster, J. E. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90431-h · Cited by 211 · see citing works
Structure of human type II 5 alpha-reductase gene
Labrie, F., Sugimoto, Y., Luu-The, V., Simard, J., Lachance, Y., Bachvarov, D. R., Leblanc, G., Durocher, F., & Paquet, N. (1992) · Endocrinology · doi:10.1210/endo.131.3.1505484 · Cited by 203 · see citing works
Self-citationSimultaneous radioimmunoassay of progestins, androgens and estrogens in rat testis
Bèlanger, A., Caron, S., & Picard, V. (1980) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(80)90190-9 · Cited by 177 · see citing works
Self-citationAndrogenic activity of dehydroepiandrosterone and androstenedione in the rat ventral prostate.
LABRIE, C., BELANGER, A., & LABRIE, F. (1988) · Endocrinology · doi:10.1210/endo-123-3-1412 · Cited by 167 · see citing works
Self-citationModulation of growth, differentiation and carcinogenesis by dehydroepiandrosterone.
Gordon, G. B., Shantz, L. M., & Talalay, P. (1987) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(87)90023-9 · Cited by 159 · see citing works
Adrenocortical function in old age: response to acute adrenocorticotropin stimulation.
VERMEULEN, A., DESLYPERE, J. P., SCHELFHOUT, W., VERDONCK, L., & RUBENS, R. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-1-187 · Cited by 135 · see citing works
Labrie, F., Simard, J., Luu-The, V., Bélanger, A., & Pelletier, G. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90308-6 · Cited by 132 · see citing works
Self-citationZumoff, B., Levin, J., Rosenfeld, R. S., Markham, M. J., Strain, G. W., & Fukushima, D. K. (1981) · PubMed · Cited by 123 · see citing works
Rodbard, D. (1974) · Endocrinology · doi:10.1210/endo-94-5-1427 · Cited by 116 · see citing works
Schriock, E. D., Buffington, C. K., Hubert, G. D., Kurtz, B. R., Kitabchi, A. E., Buster, J. E., & Givens, J. R. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-6-1329 · Cited by 115 · see citing works
Levels of plasma steroid glucuronides in intact and castrated men with prostatic cancer.
BÉLANGER, A., BROCHU, M., & CLICHE, J. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-62-5-812 · Cited by 108 · see citing works
Self-citationInhibition of tumor development by dehydroepiandrosterone and related steroids.
Schwartz, A. G., Pashko, L., & Whitcomb, J. M. (1986) · Toxicologic Pathology · doi:10.1177/019262338601400312 · Cited by 101 · see citing works
Science behind total androgen blockade: from gene to combination therapy.
Labrie, F., Bèlanger, A., Dupont, A., The, V. L., Simard, J., & Labrie, C. (1993) · PubMed · Cited by 91 · see citing works
Self-citationIDENTIFICATION AND ISOLATION OF DEHYDROISOANDROSTERONE FROM PERIPHERAL HUMAN PLASMA
Migeon, C. J., & Plager, J. E. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65504-8 · Cited by 71 · see citing works
Li, S., Yan, X., B�langer, A., & Labrie, F. (1994) · Breast Cancer Research and Treatment · doi:10.1007/bf00665681 · Cited by 70 · see citing works
Self-citationISOLATION OF DEHYDROISOANDROSTERONE SULFATE FROM NORMAL MALE URINE
Munson, P. L., Gallagher, T. F., & Koch, F. C. (1944) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)72091-7 · Cited by 68 · see citing works
LABRIE, Y., DUROCHER, F., LACHANCE, Y., TURGEON, C., SIMARD, J., LABRIE, C., & LABRIE, F. (1995) · DNA and Cell Biology · doi:10.1089/dna.1995.14.849 · Cited by 64 · see citing works
Self-citationCloning and expression of cDNA encoding human placental estrogen sulfotransferase
Bernier, F., López, I., Labrie, F., & Luu-The, V. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90159-7 · Cited by 58 · see citing works
Self-citationStructural Characterization and Expression of the Human Dehydroepiandrosterone Sulfotransferase Gene
LUU-THE, V., Dufort, I., Paquet, N., Reimnitz, G., & Labrie, F. (1995) · DNA and Cell Biology · doi:10.1089/dna.1995.14.511 · Cited by 52 · see citing works
Self-citationObesity in the dog: role of the adrenal steroid dehydroepiandrosterone (DHEA).
MacEwen, E. G., & Kurzman, I. D. (1991) · The Journal of Nutrition · doi:10.1093/jn/121.suppl_11.s51 · Cited by 49 · see citing works
Stahl, F., Schnorr, D., Pilz, C., & Dörner, G. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1211136 · Cited by 47 · see citing works
Bernier, F., Leblanc, G., Labrie, F., & Luu-The, V. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46914-1 · Cited by 43 · see citing works
Self-citationLabrie, F., Simard, J., Luu-The, V., Bèlanger, A., Pelletier, G., Morel, Y., Mébarki, F., Sánchez, R., Durocher, F., Turgeon, C., et al. (1996) · Springer eBooks · doi:10.1007/978-3-662-03230-5_10 · Cited by 34 · see citing works
Self-citationBèlanger, A., Labrie, F., Dupont, A., Brochu, M., & Cusan, L. (1988) · PubMed · Cited by 24 · see citing works
Self-citationUnconjugated and Glucuronide Steroid Levels in Human Breast Cyst Fluid
Bèlanger, A., Labrie, F., & Angeli, A. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb17795.x · Cited by 22 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications
Kaufman, J. M., & Vermeulen, A. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0013 · Cited by 1,079 · see citing works
Knop, E., Knop, N., Millar, T., Obata, H., & Sullivan, D. A. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6997c · Cited by 1,079 · see citing works
Sources of estrogen and their importance
Simpson, E. R. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00360-1 · Cited by 936 · see citing works
Dehydroepiandrosterone Replacement in Women with Adrenal Insufficiency
Arlt, W., Callies, F., van Vlijmen, J. C., Koehler, I., Reincke, M., Bidlingmaier, M., Huebler, D., Oettel, M., Ernst, M., Schulte, H. M., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909303411401 · Cited by 644 · see citing works
Molecular biology of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 –isomerase gene family
Simard, J., Ricketts, M.-L., Gingras, S., Soucy, P., Feltus, F. A., & Melner, M. H. (2005) · Endocrine Reviews · doi:10.1210/er.2002-0050 · Cited by 620 · see citing works
van den Beld, A. W., de Jong, F. H., Grobbee, D. E., Pols, H. A. P., & Lamberts, S. W. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6825 · Cited by 616 · see citing works
Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544 · see citing works
Self-citationKroboth, P. D., Salek, F. S., Pittenger, A. L., Fabian, T. J., & Frye, R. F. (1999) · The Journal of Clinical Pharmacology · doi:10.1177/00912709922007903 · Cited by 523 · see citing works
Circulating Androgen Levels and Self-reported Sexual Function in Women
Davis, S. R. (2005) · JAMA · doi:10.1001/jama.294.1.91 · Cited by 510 · see citing works
Minireview: Aromatase and the Regulation of Estrogen Biosynthesis--Some New Perspectives
Simpson, E. R., & Davis, S. R. (2001) · Endocrinology · doi:10.1210/endo.142.11.8547 · Cited by 501 · see citing works
Is dehydroepiandrosterone a hormone?
Labrie, F., Luu-The, V., Bèlanger, A., Lin, S.-X., Simard, J., Pelletier, G., & Labrie, C. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06264 · Cited by 454 · see citing works
Self-citationTFOS DEWS II Sex, Gender, and Hormones Report
Sullivan, D. A., Rocha, E. M., Aragona, P., Clayton, J. A., Ding, J., Golebiowski, B., Hampel, U., McDermott, A. M., Schaumberg, D. A., Srinivasan, S., et al. (2017) · The Ocular Surface · doi:10.1016/j.jtos.2017.04.001 · Cited by 451 · see citing works
Morales, A. J., Haubrich, R. H., Hwang, J. Y., Asakura, H., & Yen, S. S. C. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00507.x · Cited by 418 · see citing works
Estrogen: Consequences and Implications of Human Mutations in Synthesis and Action
Grumbach, M. M., & Auchus, R. J. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.12.6290 · Cited by 412 · see citing works
Labrie, F., Luu-The, V., Labrie, C., & Simard, J. (2001) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0216 · Cited by 366 · see citing works
Self-citationAndrogen therapy in women: a reappraisal: an Endocrine Society Clinical Practice Guideline
Wierman, M. E., Arlt, W., Basson, R., Davis, S. R., Miller, K. K., Murad, M. H., Rosner, W., & Santoro, N. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2260 · Cited by 363 · see citing works
Labrie, F., Bélanger, A., Luu-The, V., Labrie, C., Simard, J., Cusan, L., Gomez, J.-L., & Candas, B. (1998) · Steroids · doi:10.1016/s0039-128x(98)00007-5 · Cited by 347 · see citing works
Self-citationSteroid hormones and neurosteroids in normal and pathological aging of the nervous system
Schumacher, M., Weill‐Engerer, S., Lière, P., Robert, F., Franklin, R. J. M., García‐Segura, L. M., Lambert, J. J., Mayo, W., Melcangi, R. C., Párducz, Á., et al. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.004 · Cited by 296 · see citing works
Androgen glucuronides, instead of testosterone, as the new markers of androgenic activity in women
Labrie, F., Bélanger, A., Bélanger, P., Bérubé, R., Martel, C., Cusan, L., Gomez, J., Candas, B., Castiel, I., Chaussade, V., et al. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.02.004 · Cited by 296 · see citing works
Self-citationLabrie, F., Luu-The, V, Lin, S., Simard, J., Labrie, C., El-Alfy, M., Pelletier, G., & Belanger, A. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0250001 · Cited by 278 · see citing works
Self-citationLabrie, F., Diamond, P., Cusan, L., Gomez, J.-L., Bélanger, A., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4306 · Cited by 292 · see citing works
Self-citationDehydroepiandrosterone Monotherapy in Midlife-Onset Major and Minor Depression
Schmidt, P. J., Daly, R. C., Bloch, M., SMITH, M. J., Danaceau, M. A., Clair, L. S. S., Murphy, J. H., Haq, N., & Rubinow, D. R. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.2.154 · Cited by 252 · see citing works
The role of local estrogen Biosynthesis in males and females
Simpson, E., Rubin, G., Clyne, C., Robertson, K., O’Donnell, L., Jones, M., & Davis, S. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00254-x · Cited by 249 · see citing works
Identification of androgen receptor protein and 5alpha -reductase mRNA in human ocular tissues
Rocha, E. M. (2000) · British Journal of Ophthalmology · doi:10.1136/bjo.84.1.76 · Cited by 239 · see citing works
Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans
Bélanger, A., Pelletier, G., Labrie, F., Barbier, O., & Chouinard, S. (2003) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2003.10.005 · Cited by 235 · see citing works
Self-citationDehydroepiandrosterone (DHEA)—A Precursor Steroid or an Active Hormone in Human Physiology (CME)
Traish, A. M., Kang, H. P., Saad, F., & Guay, A. T. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02523.x · Cited by 237 · see citing works
Rosen, R. C., Giuliano, F., & Carson, C. C. (2005) · European Urology · doi:10.1016/j.eururo.2004.12.013 · Cited by 225 · see citing works
Intracrine androgen biosynthesis, metabolism and action revisited
Schiffer, L., Arlt, W., & Storbeck, K.-H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.08.016 · Cited by 217 · see citing works
Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne
Sawaya, M. E., & Shalita, A. R. (1998) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/120347549800300103 · Cited by 211 · see citing works
Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications
Pataky, M. W., Young, W. F., & Nair, K. S. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.07.033 · Cited by 207 · see citing works
Guillemette, C., Millikan, R. C., Newman, B. M., & Housman, D. E. (2000) · PubMed · Cited by 205 · see citing works
Arlt, W., Justl, H.-G., Callies, F., Reincke, M., Hübler, D., Oettel, M., Ernst, M., Schulte, H. M., & Allolio, B. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4850 · Cited by 199 · see citing works
Local estrogen biosynthesis in males and females.
Simpson, E. R., Rubin, G., Clyne, C. D., Robertson, K. M.-P., O’Donnell, L., Davis, S. R., & Jones, M. E. E. (1999) · Endocrine Related Cancer · doi:10.1677/erc.0.0060131 · Cited by 195 · see citing works
Hormones and Sexuality During Transition to Menopause
Gracia, C. R., Freeman, E. W., Sammel, M. D., Lin, H., & Mogul, M. (2007) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000258781.15142.0d · Cited by 197 · see citing works
Aromatase Activity and Bone Homeostasis in Men
Gennari, L., Nuti, R., & Bilezikian, J. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1717 · Cited by 190 · see citing works
Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies
Tchernof, A., & Labrie, F. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1510001 · Cited by 183 · see citing works
Self-citationDHEA, Important Source of Sex Steroids in Men and Even More in Women
Labrie, F. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)82004-7 · Cited by 183 · see citing works
Self-citationAlzheimer?s disease: the impact of age-related changes in reproductive hormones
Meethal, S. V., & Atwood, C. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4381-3 · Cited by 182 · see citing works
Mazat, L., Lafont, S., Berr, C., Debuire, B., Tessier, J.-F., Dartigues, J., & Baulieu, É.-É. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121177998 · Cited by 172 · see citing works
Effects of DHEA replacement on bone mineral density and body composition in elderly women and men
Villareal, D. T., Holloszy, J. O., & Kohrt, W. M. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01131.x · Cited by 169 · see citing works
The role of estrogen in cutaneous ageing and repair
Wilkinson, H. N., & Hardman, M. J. (2017) · Maturitas · doi:10.1016/j.maturitas.2017.06.026 · Cited by 162 · see citing works
Assessment of steroidogenesis and steroidogenic enzyme functions
Luu-The, V. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.05.017 · Cited by 161 · see citing works
Fassnacht, M., Schlenz, N., Schneider, S. B., Wudy, S. A., Allolio, B., & Arlt, W. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021875 · Cited by 158 · see citing works
Arlt, W., Haas, J., Callies, F., Reincke, M., Hübler, D., Oettel, M., Ernst, M. E., Schulte, H. M., & Allolio, B. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5789 · Cited by 158 · see citing works
Adrenarche and the evolution of human life history
Campbell, B. (2006) · American Journal of Human Biology · doi:10.1002/ajhb.20528 · Cited by 150 · see citing works
Løvås, K., Gebre-Medhin, G., Trovik, T. S., Fougner, K. J., Uhlving, S., Nedrebø, B. G., Myking, O. L., Kämpe, O., & Husebye, E. S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020769 · Cited by 144 · see citing works
Aromatization of androgens in women: current concepts and findings
Simpson, E. R. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02984-9 · Cited by 144 · see citing works
Arlt, W., Callies, F., Koehler, I., van Vlijmen, J. C., Faßnacht, M., Strasburger, C. J., Seibel, M. J., Huebler, D., Ernst, M. E., Oettel, M., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7974 · Cited by 139 · see citing works
Neuroactive steroids in affective disorders: target for novel antidepressant or anxiolytic drugs?
Schüle, C., Eser, D., Baghai, T. C., Nothdurfter, C., Kessler, J. S., & Rupprecht, R. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.025 · Cited by 141 · see citing works
Contribution of age and declining androgen levels to features of the metabolic syndrome in men
Blouin, K., Després, J., Couillard, C., Tremblay, A., Prud’homme, D., Bouchard, C., & Tchernof, A. (2005) · Metabolism · doi:10.1016/j.metabol.2005.03.006 · Cited by 134 · see citing works
Role of aromatase in sex steroid action
SIMPSON, E. R. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0250149 · Cited by 134 · see citing works
Tearful Relationships? Sex, Hormones, the Lacrimal Gland, and Aqueous-Deficient Dry Eye
Sullivan, D. A. (2004) · The Ocular Surface · doi:10.1016/s1542-0124(12)70147-7 · Cited by 132 · see citing works
Metabolism of DHEA in postmenopausal women following percutaneous administration
Labrie, F., Bélanger, A., Bélanger, P., Bérubé, R., Martel, C., Cusan, L., Gomez, J., Candas, B., Chaussade, V., Castiel, I., et al. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.09.034 · Cited by 129 · see citing works
Self-citationAre There Any Sensitive and Specific Sex Steroid Markers for Polycystic Ovary Syndrome?
Stener‐Victorin, E., Holm, G., Labrie, F., Nilsson, L., Janson, P. O., & Ohlsson, C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1908 · Cited by 126 · see citing works
Self-citationRosen, C. J. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.8.1384 · Cited by 121 · see citing works
Aromatase inhibitors in pediatrics
Wit, J. M., Hero, M. T., & Nuñez, S. B. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.161 · Cited by 118 · see citing works
McTernan, P. G., Anderson, L. A., Anwar, A. J., Eggo, M. C., Crocker, J., Barnett, A. H., Stewart, P. M., & Kumar, S. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8288 · Cited by 113 · see citing works
Effect of estrogen deficiency in the male: the ArKO mouse model
Murata, Y., Robertson, K. M., Jones, M. E. E., & Simpson, E. R. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00090-4 · Cited by 111 · see citing works
Nonsteroidal aromatase inhibitors: Recent advances
Recanatini, M., Cavalli, A., & Valenti, P. (2002) · Medicinal Research Reviews · doi:10.1002/med.10010 · Cited by 111 · see citing works
Basal plasma hormone levels in depressed perimenopausal women
Schmidt, P. J., Murphy, J. H., Haq, N., Danaceau, M. A., & Clair, L. S. S. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00004-5 · Cited by 109 · see citing works
Are women with Sjögren's syndrome androgen-deficient?
Sullivan, D. A., Bélanger, A., Cermak, J. M., Bérubé, R., Papas, A., Sullivan, R. M., Yamagami, H., Dana, M. R., & Labrie, F. (2003) · PubMed · Cited by 108 · see citing works
Self-citationJankowski, C. M., Gozansky, W. S., Schwartz, R. S., Dahl, D. J., Kittelson, J. M., Scott, S., Pelt, R. E. V., & Kohrt, W. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2484 · Cited by 109 · see citing works
Dehydroepiandrosterone and ageing.
Arlt, W. (2004) · Best practice & research. Clinical endocrinology & metabolism · doi:10.1016/j.beem.2004.02.006 · Cited by 121 · see citing works
Lunenfeld, B., Saad, F., & Hoesl, C. E. (2005) · The Aging Male · doi:10.1080/13685530500163416 · Cited by 108 · see citing works
Osteoporosis and male age-related hypogonadism: role of sex steroids on bone (patho)physiology
Rochira, V., Balestrieri, A., Madeo, B., Zirilli, L., Granata, A. R. M., & Carani, C. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02088 · Cited by 107 · see citing works
Hormonal Agents for the Treatment of Depression Associated with the Menopause
Herson, M., & Kulkarni, J. (2022) · Drugs & Aging · doi:10.1007/s40266-022-00962-x · Cited by 106 · see citing works
Labrie, F., Martel, C., Bélanger, A., & Pelletier, G. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.12.007 · Cited by 95 · see citing works
Self-citationEndogenous oestrogens are related to cognition in healthy elderly women
Lebrun, C. E. I., van der Schouw, Y. T., de Jong, F. H., Pols, H. A. P., Grobbee, D. E., & Lamberts, S. W. J. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02297.x · Cited by 95 · see citing works
Hormone replacement therapy: current controversies
Davison, S. L., & Davis, S. R. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01774.x · Cited by 94 · see citing works
DHEA therapy for women: effect on sexual function and wellbeing
Panjari, M., & Davis, S. R. (2007) · Human Reproduction Update · doi:10.1093/humupd/dml055 · Cited by 93 · see citing works
Portman, D. J., Labrie, F., Archer, D. F., Bouchard, C., Cusan, L., Girard, G., Ayotte, N. J., Koltun, W. D., Blouin, F., Young, D. G., et al. (2015) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000470 · Cited by 93 · see citing works
Self-citationBlouin, K., Nadeau, M., Mailloux, J. R., Daris, M., Lebel, S., Luu-The, V., & Tchernof, A. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00039.2008 · Cited by 92 · see citing works
DHEA for postmenopausal women: A review of the evidence
Panjari, M., & Davis, S. R. (2010) · Maturitas · doi:10.1016/j.maturitas.2009.12.017 · Cited by 91 · see citing works
GLUCURONIDATION OF ANABOLIC ANDROGENIC STEROIDS BY RECOMBINANT HUMAN UDP-GLUCURONOSYLTRANSFERASES
Kuuranne, T., Kurkela, M. J., Thevis, M., Schänzer, W., Finel, M., & Kostiainen, R. K. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.9.1117 · Cited by 90 · see citing works
Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men
Brown, G. A., Vukovich, M. D., Sharp, R. L., Reifenrath, T. A., Parsons, K. A., & King, D. S. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.6.2274 · Cited by 89 · see citing works
Misso, M. L., Jang, C., Adams, J., Tran, J., Murata, Y., Bell, R. J., Boon, W. C., Simpson, E. R., & Davis, S. R. (2005) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-200512020-00016 · Cited by 90 · see citing works
Atwood, C., Meethal, S. V., Liu, T., Wilson, A. C., Gallego, M. J., Smith, M. A., & Bowen, R. L. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.2.93 · Cited by 89 · see citing works
Bone Health and the Female Athlete Triad in Adolescent Athletes
Ackerman, K. E., & Misra, M. (2011) · The Physician and Sportsmedicine · doi:10.3810/psm.2011.02.1871 · Cited by 89 · see citing works
Human Growth: Assessment and Interpretation
Roche, A. F., & Sun, S. S. (2003) · Cited by 87 · see citing works
The importance of oestrogens in males
de Ronde, W., Pols, H. A. P., van Leeuwen, J. P. T. M., & de Jong, F. H. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01669.x · Cited by 85 · see citing works
DHEA treatment for HIV+ patients: effects on mood, androgenic and anabolic parameters
Rabkin, J. G., Ferrando, S. J., Wagner, G. J., & Rabkin, R. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00036-0 · Cited by 84 · see citing works
Science of intracrinology in postmenopausal women
Labrie, F., Bélanger, A., Pelletier, G., Martel, C., Archer, D. F., & Utian, W. H. (2017) · Menopause · doi:10.1097/gme.0000000000000808 · Cited by 82 · see citing works
Self-citationSex steroids in Sjögren’s syndrome
Konttinen, Y. T., Fuellen, G., Bing, Y., Porola, P., Stegaev, V., Trokovic, N., Falk, S. S. I., Liu, Y., Szodoray, P., & Takakubo, Y. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.01.004 · Cited by 78 · see citing works
The role of androgens and the androgen receptor in cycling endometrium
Cloke, B., & Christian, M. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.031 · Cited by 77 · see citing works
Development of a disease-specific quality of life questionnaire in Addison's disease.
Løvås, K., Curran, S., Oksnes, M., Husebye, E., Huppert, F., & Chatterjee, V. (2010) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2009-1711 · Cited by 78 · see citing works
van de Kerkhof, D., de Boer, D., Thijssen, J. H. H., & Maes, R. A. A. (2000) · Journal of Analytical Toxicology · doi:10.1093/jat/24.2.102 · Cited by 72 · see citing works
Vandenput, L., Labrie, F., Mellström, D., Swanson, C., Knutsson, T., Peeker, R., Ljunggren, Ö., Orwoll, E., Eriksson, A. L., Damber, J.-E., et al. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.061018 · Cited by 71 · see citing works
Self-citationAndrogen replacement therapy in women.
Cameron, D. R., & Braunstein, G. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.11.062 · Cited by 39 · see citing works
Blouin, K., Blanchette, S., Richard, C., Dupont, P., Luu-The, V., & Tchernof, A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00312.2004 · Cited by 67 · see citing works
PCOS, Sexuality, and Clitoral Vascularisation: A Pilot Study
Battaglia, C., Nappi, R. E., Mancini, F., Cianciosi, A., Persico, N., Busacchi, P., Facchinetti, F., & Sisti, G. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.01010.x · Cited by 67 · see citing works
Schirra, F., Suzuki, T., Dickinson, D. P., Townsend, D. J., Gipson, I. K., & Sullivan, D. A. (2006) · Cornea · doi:10.1097/01.ico.0000183664.80004.44 · Cited by 65 · see citing works
Tissue‐Specific Estrogen Biosynthesis and Metabolism
SIMPSON, E. R., Clyne, C. D., Speed, C. J., RUBIN, G., & Bulun, S. E. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb04002.x · Cited by 65 · see citing works
A Metabolome-Wide Study of Dry Eye Disease Reveals Serum Androgens as Biomarkers
Vehof, J., Hysi, P. G., & Hammond, C. J. (2017) · Ophthalmology · doi:10.1016/j.ophtha.2016.12.011 · Cited by 66 · see citing works
Pritchard, J., Després, J.-P., Gagnon, J., Tchernof, A., Nadeau, A., Tremblay, A., & Bouchard, C. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90125-7 · Cited by 62 · see citing works
Understanding sexual arousal and subjective–genital arousal desynchrony in women
Meston, C. M., & Stanton, A. M. (2019) · Nature Reviews Urology · doi:10.1038/s41585-018-0142-6 · Cited by 63 · see citing works
Therapeutic management of adrenal insufficiency
Hahner, S., & Allolio, B. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.09.009 · Cited by 61 · see citing works
Gingras, S., & Simard, J. (1999) · Endocrinology · doi:10.1210/endo.140.10.7038 · Cited by 62 · see citing works
Use of aromatase inhibitors to increase final height
Dunkel, L. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.04.031 · Cited by 60 · see citing works
Androgens and Glucuronidated Androgen Metabolites Are Associated with Metabolic Risk Factors in Men
Vandenput, L., Mellström, D., Lorentzon, M., Swanson, C., Karlsson, M. K., Brandberg, J., Lönn, L., ORWOLL, E. S., Smith, U., Labrie, F., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0252 · Cited by 59 · see citing works
Self-citationPanjari, M., Bell, R. J., Jane, F., Wolfe, R. S., Adams, J., Morrow, C., & Davis, S. R. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01381.x · Cited by 58 · see citing works
- Authors
- Labrie, F., Bélanger, A., Cusan, L., & Candas, B.
- Affiliations
- Centre hospitalier universitaire de Québec (CA)
- ORCID
- Candas, Bernard
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1997-08
- Volume
- 82
- Issue
- 8
- Pages
- 2403-2409
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2021443932
- Cited by
- 350
- References
- 41
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 12 · 2016: 4 · 2015: 10 · 2014: 8 · 2013: 8 · 2012: 3
- FWCI
- 13.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Keywords
- dehydroepiandrosterone, DHEA sulfate, androstenedione, androsterone glucuronide, androsterone sulfate, estrone sulfate, estradiol sulfate, intracrinology, steroid metabolism, sex differences, estradiol
- MeSH terms
- Administration, Cutaneous, Aged, Aldosterone, Androgens, Androstenedione, Dehydroepiandrosterone, Estradiol, Estrogens, Estrone, Fatty Acids, Female, Glucuronates, Humans, Hydrocortisone, Liver, Male, Middle Aged, Dihydrotestosterone, Testosterone, Dehydroepiandrosterone Sulfate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
