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Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence
Open accessAbstract
More than 2.1 million age-related fractures occur in the United States annually, resulting in an immense socioeconomic burden. Importantly, the age-related deterioration of bone structure is associated with impaired bone healing. Fracture healing is a dynamic process which can be divided into four stages. While the initial hematoma generates an inflammatory environment in which mesenchymal stem cells and macrophages orchestrate the framework for repair, angiogenesis and cartilage formation mark the second healing period. In the central region, endochondral ossification favors soft callus development while next to the fractured bony ends, intramembranous ossification directly forms woven bone. The third stage is characterized by removal and calcification of the endochondral cartilage. Finally, the chronic remodeling phase concludes the healing process. Impaired fracture healing due to aging is related to detrimental changes at the cellular level. Macrophages, osteocytes, and chondrocytes express markers of senescence, leading to reduced self-renewal and proliferative capacity. A prolonged phase of “inflammaging” results in an extended remodeling phase, characterized by a senescent microenvironment and deteriorating healing capacity. Although there is evidence that in the setting of injury, at least in some tissues, senescent cells may play a beneficial role in facilitating tissue repair, recent data demonstrate that clearing senescent cells enhances fracture repair. In this review, we summarize the physiological as well as pathological processes during fracture healing in endocrine disease and aging in order to establish a broad understanding of the biomechanical as well as molecular mechanisms involved in bone repair.
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“Dysregulated inflammation, as seen in cases of advanced age, diabetes, obesity, and autoimmune disease, is often associated with non-union, delayed healing, and other complications [1–3].”
From Osteoimmunology of Fracture Healing. (2024) · cites this paper as [3]
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“In general, this work in addition to that of others indicates pro-inflammatory cytokines such as IL-1β, IL-6, IFNγ, TNFα, and C-reactive protein (CRP) are more highly expressed in aged patients and associated with an increased risk for fracture [3, 51•, 82, 90, 91].”
From Osteoimmunology of Fracture Healing. (2024) · cites this paper as [3]
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“In studies using aged mice, lowering the level of M1 macrophages led to improved fracture healing [3, 87].”
From Osteoimmunology of Fracture Healing. (2024) · cites this paper as [3]
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“Platelets secrete PDGF, VEGF, TGFβ, and IGF-1 to promote mesenchymal progenitor cell proliferation and differentiation [3, 37].”
From Osteoimmunology of Fracture Healing. (2024) · cites this paper as [3]
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“B cells are prolific cytokine producers in the fracture callus; they express IL-10 to limit proinflammatory signaling and to reduce the early inflammatory response [3].”
From Osteoimmunology of Fracture Healing. (2024) · cites this paper as [3]
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Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042
Wang, G., Ma, R., Qiao, G., Wada, K., Aizawa, Y., & Satoh, T. (2015) · Integrative Medicine International · doi:10.1159/000368408 · Cited by 18,762
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670
Aging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,584
Self-citationNémeth, K., Leelahavanichkul, A., Yuen, P. S. T., Mayer, B., Parmelee, A., Doi, K., Robey, P. G., Leelahavanichkul, K., Koller, B. H., Brown, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1905 · Cited by 2,364
Senolytics improve physical function and increase lifespan in old age
Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Centers for Disease Control and Prevention., 2020, National Diabetes Statistics Report, 2020.
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Sorted by citations
Items 101–185 of 185
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The Evolution and Frontiers of Piezoelectric Materials for Bone and Cartilage Regeneration Research
Liu, J., Wang, Y. X., He, C., Wang, Y. X., & He, C. (2025) · Tissue Engineering Part C Methods · doi:10.1177/19373384251405475 · Cited by 2
RNA modifications: molecular orchestrators of wound healing
Guo, X., Liu, L., Yang, J., Dai, Y., Zhang, Q., Gu, R., Tan, M., Tang, M., & Nie, X. (2026) · Burns & Trauma · doi:10.1093/burnst/tkag010 · Cited by 2
Chen, Y., Huang, C., Zhou, Y., Liu, Z., Tang, X., Li, Y., Lu, C., & He, Q. (2026) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-026-01085-4 · Cited by 2
Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy
Su, Y., He, Z., Chen, Q., Chen, L., Wei, C., Zhou, Z., Lin, J., Li, H., & Xing, D. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.71155 · Cited by 2
Oxidative stress in bone healing: mechanisms, disease contexts, and therapeutic strategies
Fu, W., Pan, D., Liu, Y., He, Z., & Hu, X. (2026) · European journal of medical research · doi:10.1186/s40001-026-04478-7 · Cited by 2
Sun, X., Leder, B. Z., Bolster, M. B., Ly, T. V., Franco‐Garcia, E., Pu, C. T., & Fan, W. (2024) · Journal of the Endocrine Society · doi:10.1210/jendso/bvae050 · Cited by 2
Research on the Impact of Aging on Osteoclasts in Fracture Healing
王, 信. (2024) · Aging Research · doi:10.12677/ar.2024.114209 · Cited by 2
Larina, V. N., & Сергеевна, Щ. Е. (2024) · Cardiosomatics · doi:10.17816/cs632927 · Cited by 2
Osteogenic Effects of Bioactive Compounds Found in Fruits on Mesenchymal Stem Cells: A Review
Sodré, L. I., Gall, M. E. C., Elias, M. D. B., Oliveira, L. H. S., Lobo, F. A. T. F., Carias, R. B. V., & Teodoro, A. J. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuae209 · Cited by 3
Multiscale, interspecies evaluation of parameters affecting alveolar bone repair
Ticha, P., Joshi, A., Dworan, J. S., Armaro, M., Arioka, M., Xu, Q., Pilawski, I., Liu, Y., Chen, C., Pei, X., et al. (2025) · Journal of Periodontology · doi:10.1002/jper.24-0594 · Cited by 2
Murine Progeria Model Exhibits Delayed Fracture Healing with Dysregulated Local Immune ResponsePreprint
Duke, V. R., Philippon, M. J., Lind, D. R. G., Kasler, H. G., Yamaura, K., Huard, M., Czachor, M. E., Hollenbeck, J. F. M., Brown, J., Garcia, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.29.596277 · Cited by 2
Gomez-Gramajo, F., Rivoira, M. A., Rodríguez, V. A., Vargas, G. E., Mesones, R. V., Zago, M. P., Boccaccini, A. R., & Gorustovich, A. A. (2024) · Biomedical Materials · doi:10.1088/1748-605x/ad8c8b · Cited by 1
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Díaz-Pérez, J. A., & Rosenberg, A. E. (2025) · Surgical pathology clinics · doi:10.1016/j.path.2025.04.001 · Cited by 1
Sun, Q., Zhang, C., Chen, B., Liao, J., Bao, A., Zhao, C., Chen, H., He, D., Huang, W., & Dai, G. (2025) · Scientific Reports · doi:10.1038/s41598-025-11300-7 · Cited by 1
Chen, S., Li, Z., Bigdon, S. F., Häckel, S., Albers, C. E., & Gantenbein, B. (2025) · JOR Spine · doi:10.1002/jsp2.70136 · Cited by 1
Liu, B., Yang, X. H., Chang, H., Li, P., Chang, H., Wang, X., Zhang, J., & He, W. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.11.036 · Cited by 1
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Zhang, X., Kang, J., Wang, Q., Zhang, Y., Jiang, J., Jin, Z., Zhang, C., Sun, Z., Li, Z., Liu, R., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.157870 · Cited by 1
Wu, X., Yang, Y., Huang, H., Qiu, Y., Li, L., Bi, L., Song, K., Chen, X., Shao, L., Liao, Y., et al. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202504350 · Cited by 1
Joly, L.-M., Tertel, T., Sowislok, A., Bernd, G., & Jäger, M. (2026) · Biomolecules · doi:10.3390/biom16020289 · Cited by 1
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Dean, H. C., Saraswathy, V. M., Saini, A., Ou, T., McAdow, J. F., Tendolkar, A., Mokalled, M. H., & Johnson, A. N. (2026) · Development · doi:10.1242/dev.204993 · Cited by 1
Zhou, Q., Zhang, Y., Dai, Z., Li, Q., Xiu, W., Lv, H., Mou, Y., & Dong, H. (2026) · Regenerative Biomaterials · doi:10.1093/rb/rbag055 · Cited by 2
Xiao, L., Zhu, M., Li, X., Hu, J., Yu, K., Zhang, Q., Dai, J., Jia, Z., Li, J., Liu, H., et al. (2026) · Small Structures · doi:10.1002/sstr.202500832 · Cited by 1
Periosteal mitochondria DNA structures drive aging-associated poor skeletal repair
Wu, Y., Han, C., Yang, X., Wang, Y., Tian, W., Yuan, Q., Wang, H., Wang, H., Yin, B., Ye, L., et al. (2026) · Bone Research · doi:10.1038/s41413-026-00524-6 · Cited by 2
Li, R., Yang, J., Duan, W., Yang, K., Lo, K., Chen, Q., & Wang, B. (2026) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2400472 · Cited by 1
Zhang, W., Zhang, W., Guo, Y., Chen, D., Jiang, X., Zhang, J., Chen, E., Yuan, Y., Wu, W., Qian, Y., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-75340-x · Cited by 2
Ye, P., Bai, R., Ding, X., Chen, H., Bai, Z., & Wu, L. (2026) · Molecular Immunology · doi:10.1016/j.molimm.2026.07.010 · Cited by 1
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Zheng, X., Yuan, J., Peng, J., Wang, X., Xu, R., Feng, H., Wu, L., Xie, Y., Zhang, X., & Wu, W. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.27.661729 · Cited by 1
Qi, L., Pan, C., Yan, J., Ge, W., Liu, L., Zhao, H., Wang, J., Zhang, L., Lin, D., & Shen, S. G. (2023) · Research Square · doi:10.21203/rs.3.rs-3339133/v1
Tao, J., Lipe, B. C., Boyce, B. F., Xing, L., & Zhang, H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.04.565143
Qi, L., Pan, C., Yan, J., Ge, W., Wang, J., Liu, L., Zhang, L., Lin, D., & Shen, S. G. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4630998
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Xue, L., Hao, M., Liji, Y., Zhou, S., Yang, Y., Liu, T., Liang, B., Zhang, Y., & Xing, D. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4895329
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King, J. S., Wan, M., Kim, A., Novak, S., Prabhu, S., Kalajzić, I., Delany, A. M., & Sanjay, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.06.622348
Lee, S., Kim, J.-G., & Lee, D. (2025) · The Knee · doi:10.1016/j.knee.2025.01.013
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Hu, L., Yang, K., Chen, Y., Wang, H., Fu, Z., Jiang, L., Xu, J., Tian, H., Zhu, Y., Dai, Z., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101744
Tebeneva, P. A., & Makulova, A. A. (2025) · Journal of Clinical Practice · doi:10.17816/clinpract676866
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Xiang, G., Zhong, F., Yin, Y., Deng, L., Deng, A., Wang, Y., & Tan, Z. (2025) · Materials & Design · doi:10.1016/j.matdes.2025.113993
Audretsch, C. K., Histing, T., Schiltenwolf, A. L., Seidler, S., Höch, A., Küper, M. A., Herath, S. C., Menger, M. M., & Working Group on Pelvic Fractures of the German Trauma Society (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14103314
Giaze, T. R., Mohamed, N., Hashim, S. A. S., Shuid, A. N., Soelaiman, I. N., Muhammad, N., Sidik, F. Z. J., & Jamal, J. A. (2025) · Pharmaceuticals · doi:10.3390/ph18050736
Xiao, Q., Hou, G., Liu, S., Zhou, S., Chen, W., Zhang, Y., & Lv, H. (2025) · PLoS ONE · doi:10.1371/journal.pone.0323609
Otubain 2 stabilizes TNF‑receptor associated factor 3 to accelerate bone fracture healing
Zhang, L., Guo, J., Feng, S., Zheng, Y., Wang, H., Ma, H., Chen, W., Zhang, Y., & Hou, Z. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13588
Liao, R., Li, J., Xie, C., Yan, Q., Gan, D., Xiao, G., & Lin, L. (2025) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2025.06.003
Zhang, T., Hou, G., Xiao, Q., Hou, Z., Zhang, Y., Lv, H., & Chen, W. (2025) · Research Square · doi:10.21203/rs.3.rs-7080815/v1
Deshpande, A. D., Likhitha, B. N., Shukla, S., Emmanuel, R. S., Konda, P. K., Sharun, K., Kumar, R., Kumar, A. M., AMARPAL, A., Saikumar, G., et al. (2025) · Connective Tissue Research · doi:10.1080/03008207.2025.2540951
Zhang, W., Guo, Z., He, Z., Zhou, H., Liu, H., Peng, X., Yang, X., Zhong, R., Huang, W., Chu, L., et al. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1619084
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Yu, S. C., Liang, J., Li, Y., Ma, S. Y., Sun, J., Li, A., & Pei, D. (2025) · Journal of Dental Research · doi:10.1177/00220345251350658
Kitsukawa, Y., Shiraishi, R., Koike, A., Hyodo, T., Kunitomi, Y., Yagisawa, S., Hasegawa, T., Tsubura, Y., Komiyama, Y., Fukumoto, C., et al. (2025) · Journal of Oral and Maxillofacial Surgery Medicine and Pathology · doi:10.1016/j.ajoms.2025.09.010
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Bukhsh, A. T., Alhouty, M. A., Alosaimi, A. S., Baduwilan, A. M., Alraddadi, I. S., Fatani, O. H., AlSiaari, S. A., Alghamdi, Y. A., & Aljohani, A. (2025) · International Journal of Community Medicine and Public Health · doi:10.18203/2394-6040.ijcmph20253719
Milusheva, R. Y., Nurgaliev, I. N., Abilkasimov, A., & Rashidova, S. S. (2025) · Eurasian Journal of Chemistry · doi:10.31489/2959-0663/4-25-12
Wu, D.-Z., Zhu, G., Zhao, K., Gao, J., Cai, G.-X., Li, H.-Z., Huang, Y., Tu, C., Zhuang, J.-S., Huang, Z.-W., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24993646
Zheng, H., Cai, H., Chen, P.-B., Jiang, L., Zheng, X.-F., & Jiang, S. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02905-y
Rundle, C. H., Pourteymoor, S., Lai, E., Kesavan, C., & Mohan, S. (2026) · Biomedicines · doi:10.3390/biomedicines14010227
Khalil, S. S., Diab, T. M., Basha, S. A. Z., Elgohary, O. M., Al-Hawamdih, S. S., & Ahmed, S. I. (2026) · Nursing Forum · doi:10.1155/nuf/2952024
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Zhang, T., Wang, J., Jia, S., Ding, K., Du, X., Lyu, H., Hou, Z., Chai, R., & Chen, W. (2026) · Chinese Medical Journal · doi:10.1097/cm9.0000000000004089
Biomimetic mineralized chiral structural films guiding for enhanced cranial bone regeneration
Zhang, L. J., Wu, W., Qiu, J., Liu, Y., Muramatsu, A., Cheng, L., Si, M., Xiong, R., Feng, Y., & Jiang, B. (2026) · Materials Today Advances · doi:10.1016/j.mtadv.2026.100809
Jin, R., Zhang, G., Sun, Y., Xu, X., Wang, Y., Zhao, J., Yu, W., & Bai, Y. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202505439
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Yao, Q., He, L., Zou, H., Tan, X., Bao, C., Xiang, S., Tang, F., & Ao, J. (2026) · Materials Today Chemistry · doi:10.1016/j.mtchem.2026.103773
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Ouyang, Y., Zou, J., Huang, J., Liu, J., Zhang, Z., Zhang, Z., Wen, S., Pi, Y., Chen, D., Yang, L., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08456-9
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Zhang, Y., Chai, J., Ding, Q., Liu, L., Zhang, K., Lin, J., Zhang, J., & Huang, Y. (2026) · Open Research (University of Surrey) · doi:10.1002/viw2.70181
Tang, K., Chen, Y., Yu, Y., Huang, Z., Zhang, H., Tian, Y., Li, M., Yin, Y., Yang, B., & Liu, B. (2026) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2026.101173
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Pan, W., Qin, S., Zd, L., Wang, J., & Shan, Z. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156683
Wang, R., Wang, S., Ren, W., Cai, C., Zhang, H., He, T., Zhang, X., Zhang, H., & Shang, P. (2026) · Research Square · doi:10.21203/rs.3.rs-10415178/v1
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Fang, C., Li, Q., Zhao, Y., & Liu, C. (2026) · Folia Biologica · doi:10.14712/fb2026.0016
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Huang, T., Wu, S., Qian, W., Chen, R., Chen, E., Wang, M., Zhang, C., Zhou, C., Yu, L., Wu, M., et al. (2026) · Bone Research · doi:10.1038/s41413-026-00568-8
Yan, C., Pan, Y., Tian, Y., Sun, P., Jiang, X., & Zhang, Y. (2026) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2026.101188
Wu, Y., Lv, Y., & Xu, H. (2026) · Research Square · doi:10.21203/rs.3.rs-10564122/v1
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Li, Y., He, C., Fu, W., Cui, X., Huang, G., Moradi, L., Bi, J., MacLeod, R. S., & Liu, C.-J. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102408
Huang, C., Kuang, S., Chen, X., Fu, S., Wang, G., Li, Y., Tan, H., & Zhang, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1908275
Hariawan, B. S., Cahyani, D. M., Utomo, W. P., Farida, N., Rozafia, A. I., Purbowati, R., Miatmoko, A., & Hartanto, D. (2026) · Next Materials · doi:10.1016/j.nxmate.2026.103264
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Perini, M. M. D. L., & Li, J. (2026) · Current Osteoporosis Reports · doi:10.1007/s11914-026-00983-0
He, J., Liu, S., Li, M., Pan, Z., Liang, J., 邓敏华, Xiang, H., Cai, D., & Chen, X. (2026) · Injury · doi:10.1016/j.injury.2026.113704
Sun, Z., Wang, J., Wang, S., Ji, Z., 刁成鹏, Tang, T., Song, L., Liu, X., Wang, H., You, Y., et al. (2026) · Advanced Functional Materials · doi:10.1002/adfm.78383
Shen, H., Zhi, G., Li, Z., Yan, X., Du, Z., Zhang, S., Yang, R., Ma, X., Liu, H., 耿福能, et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1877955
Ramakrishnan, P., Thajuddin, N., Mohamed, S. B., Vinayagam, S., Gnanasekaran, L., Shanmugapriya, D., Rajamohan, R., Jalaludeen, A. M., & Sundaram, T. (2026) · Cell Biology International · doi:10.1002/cbin.70208
Ouyang, L., Zhang, Y., Liao, J., Zhang, Z., He, X., Lin, Z., Tao, R., Xie, X., Al-Smadi, F., Zhou, W., et al. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.09.028
Guo, T.-T., Hong-xin, Z., & Jiang, Q.-D. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1949165
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Cheers, G. M., Weimer, L. P., Finze, R., Wille, M., Savi, F. M., Mayer‐Wagner, S., Holzapfel, B. M., & Laubach, M. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124676
Lin, Q., Zhao, B., Liu, Z., Jin, X., Sun, W., Huang, H., Zhu, X., Zhang, H., Li, X., & Zhang, R. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158833
Xu, Y., Xu, H., Li, J., Zhang, X., He, P., Ding, C., Zhang, H., Qiu, Y., Chu, P. K.-H., Zhu, Z., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-11037042/v1
Hu, W., Zhu, J., Qi, X., Zeng, B., Li, Y., Wu, A., Zhang, Y., Shao, Y., Xue, J., Shen, X., et al. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.183026
冯, 朱. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.16103412
Zhuang, J., & Yu, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1979955
Wang, Z., Zhang, H., Liu, S., Wang, R., Wei, Y., 郑开禄, Guo, Y., Li, M., Yuan, D., Liu, Y., et al. (2026) · Advanced NanoBiomed Research · doi:10.1002/anbr.70169
Metadata
- Authors
- Saul, D., & Khosla, S.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Khosla, Sundeep
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2022-02-19
- Volume
- 43
- Issue
- 6
- Pages
- 984-1002
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- PMC
- PMC9695115
- OpenAlex
- W4213167559
- Cited by
- 185
- References
- 249
- Citations by year
- 2026: 55 · 2025: 65 · 2024: 47 · 2023: 16 · 2022: 2
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Endocrine Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (AG062413, AG065868)
- German Research Foundation (413501650)
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone fractures and treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- fracture healing, endocrine disorders, aging, cellular senescence, inflammaging, endochondral ossification, intramembranous ossification, mesenchymal stem cells, macrophages, osteocytes, chondrocytes, senolytics, bone remodeling, hematoma, angiogenesis, chondrogenesis
- MeSH terms
- Aging, Bony Callus, Endocrine System Diseases, Humans, Osteogenesis, Cellular Senescence, Fracture Healing, Fractures, Bone
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