The DOI matches its Crossref record; 257 of the 257 references it cites were found in a registry or an index.
Bile Acid Regulation of Gene Expression: Roles of Nuclear Hormone Receptors
Abstract
Bile acids derived from cholesterol and oxysterols derived from cholesterol and bile acid synthesis pathways are signaling molecules that regulate cholesterol homeostasis in mammals. Many nuclear receptors play pivotal roles in the regulation of bile acid and cholesterol metabolism. Bile acids activate the farnesoid X receptor (FXR) to inhibit transcription of the gene for cholesterol 7alpha-hydroxylase, and stimulate excretion and transport of bile acids. Therefore, FXR is a bile acid sensor that protects liver from accumulation of toxic bile acids and xenobiotics. Oxysterols activate the liver orphan receptors (LXR) to induce cholesterol 7alpha-hydroxylase and ATP-binding cassette family of transporters and thus promote reverse cholesterol transport from the peripheral tissues to the liver for degradation to bile acids. LXR also induces the sterol response element binding protein-1c that regulates lipogenesis. Therefore, FXR and LXR play critical roles in coordinate control of bile acid, cholesterol, and triglyceride metabolism to maintain lipid homeostasis. Nuclear receptors and bile acid/oxysterol-regulated genes are potential targets for developing drug therapies for lowering serum cholesterol and triglycerides and treating cardiovascular and liver diseases.
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Citations
Cites
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BackgroundIdentification of a nuclear receptor for bile acids
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Cited by
Bile acids: regulation of synthesis
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Self-citationKhovidhunkit, W., Kim, M.-S., Memon, R. A., Shigenaga, J. K., Moser, A. H., Feingold, K. R., & Grunfeld, C. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300019-jlr200 · Cited by 1,481
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Metadata
- Authors
- Chiang, J. Y. L.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2002-08-01
- Volume
- 23
- Issue
- 4
- Pages
- 443-463
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2005320735
- Cited by
- 484
- References
- 257
- FWCI
- 27.83
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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