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Cited by 98Pituitary Gland Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsBone health and osteoporosis research

Bone mineral density and parameters of bone metabolism in patients with acromegaly

Kotzmann, Harald, Bernecker, Peter, Hübsch, Peter, Pietschmann, Peter, Woloszczuk, Wolfgang, Svoboda, Thomas, Geyer, Georg, Luger, Anton·1993·Journal of Bone and Mineral Research
DOI 10.1002/jbmr.5650080410
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Abstract

To Assess The Effect Of Chronically Elevated Plasma Growth Hormone (Gh) Levels On Bone Metabolism And Bone Mineral Density (Bmd), 16 Patients (10 Females And 6 Males) With A Mean Age Of 49.1 ± 13.2 Years (Range 33–68) With Active Acromegaly Were Studied And Compared To A Control Group Of 16 Sex- And Age-Matched Subjects. Bmd Of The Lumbar Spine And Two Different Sites Of The Proximal Femur Were Measured By Dual-Energy X-Ray Absorptiometry (Norland Xr-26). In The Acromegalic Patients The Mean Plasma Gh Concentration Was 30.1 ± 11.1 μg/Liter, And The Mean Plasma Somatomedin C (Smc) Concentration Was 6.5 ± 1.5 U/Liter. Mean Serum Osteocalcin (Oc) Levels (14.3 ± 1.1 Versus 7.2 ± 0.4 Ng/Ml, P < 0.001) As Well As The Urinary Hydroxyproline Excretion (Ohp; 8.8 ± 1.4 Versus 2.7 ± 0.3 Mg, P < 0.0001) Were Significantly Higher In The Acromegalic Patients Than In The Control Subjects. In The Acromegalic Patients Bmd Was Significantly Elevated In The Two Examined Regions Of The Proximal Femur, That Is, The Femoral Neck (1.06 ± 0.05 Versus 0.86 ± 0.03 G/Cm2, p < 0.05) and Ward's triangle (0.92 ± 0.06 versus 0.76 ± 0.03 g/cm2, p < 0.02), whereas the BMD of the lumbar spine was not significantly different from that of control subjects. Among the patients with acromegaly a significant positive correlation between serum OC concentrations, on the one hand, and urinary OHP excretion (r = 0.7, p < 0.004) as well as BMD in the proximal femur (r = 0.64, p < 0.007), on the other hand, could be observed. We therefore conclude that in acromegaly bone turnover (formation and resorption) is increased and, moreover, that BMD is significantly enhanced in the proximal femur but not in the lumbar spine.

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Crossref · 10.1002/jbmr.5650080410

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  • Information about the influence of GH excess on BMD varies in the literature: in some studies BMD was increased or within reference ranges, while in other papers it was decreased.

    “Information about the influence of GH excess on BMD varies in the literature. In some studies BMD was reported to be increased or within the reference ranges, while in other papers it was decreased [17, 26, 34–37].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [35]

  • Patients with acromegaly generally demonstrate increased cortical bone mass, whereas trabecular BMD is more variable.

    “Patients with acromegaly generally demonstrate increased cortical bone mass, whereas trabecular BMD is more variable [23, 35, 41, 42].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [35]

  • Indicators of bone resorption such as urinary hydroxyproline/creatinine, urinary type I collagen cross-linked N-telopeptide, and serum C-terminal collagen type I cross-links are in higher concentrations in acromegaly than in controls.

    “Indicators of bone resorption such as urinary hydroxyproline/creatinine, urinary type I collagen cross-linked N-telopeptide, and serum C-terminal collagen type I cross-links are in higher concentrations than in controls [28, 29, 35, 40, 43].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [35]

  • In patients with acromegaly, bone turnover is increased.

    “It is well known that in patients with acromegaly bone turnover is increased [28, 29, 35].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [35]

  • Serum calcium and phosphate values and 24-hour urinary calcium are elevated in patients with active acromegaly.

    “Additionally, serum calcium and phosphate values and 24-hour urinary calcium are elevated in patients with active disease [27, 29, 34, 35, 41].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [35]

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Authors
Kotzmann, H., Bernecker, P., Hübsch, P., Pietschmann, P., Woloszczuk, W., Svoboda, T., Geyer, G., & Luger, A.
Affiliations
University of Vienna (AT)
Corresponding author
Kotzmann, Harald
ORCID
Venue
Journal of Bone and Mineral Research
Publisher
Oxford University Press (OUP)
Published
1993-04-01
Volume
8
Issue
4
Pages
459-465
ISSN
  • 0884-0431 (ISSN-L)
  • 1523-4681
DOI
10.1002/jbmr.5650080410
OpenAlex
W2052808852
Cited by
98
References
34
Citations by year
2024: 2 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 6 · 2014: 3 · 2013: 2
FWCI
1.80
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • Journal of Bone and Mineral Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
acromegaly, bone mineral density, bone metabolism, growth hormone, insulin-like growth factor I, osteocalcin, urinary hydroxyproline, proximal femur, lumbar spine, bone turnover markers
MeSH terms
Acromegaly, Adult, Aged, Female, Femur Neck, Humans, Hydroxyproline, Insulin-Like Growth Factor I, Lumbar Vertebrae, Male, Middle Aged, Growth Hormone, Absorptiometry, Photon, Bone Density, Osteocalcin

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