The DOI matches its Crossref record; 376 of the 379 references it cites were found in a registry or an index.
Motivations and Methods for Analyzing Pulsatile Hormone Secretion
Open accessAbstract
Endocrine glands communicate with remote target cells via a mixture of continuous and intermittent signal exchange. Continuous signaling allows slowly varying control, whereas intermittency permits large rapid adjustments. The control systems that mediate such homeostatic corrections operate in a species-, gender-, age-, and context-selective fashion. Significant progress has been made in understanding mechanisms of adaptive interglandular signaling in vivo. Principal goals are to understand the physiological origins, significance, and mechanisms of pulsatile hormone secretion. Key analytical issues are: 1) to quantify the number, size, shape, and uniformity of pulses, nonpulsatile (basal) secretion, and elimination kinetics; 2) to evaluate regulation of the axis as a whole; and 3) to reconstruct dose-response interactions without disrupting hormone connections. This review will focus on the motivations driving and the methodologies used for such analyses.
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“To our knowledge, pulsatile ACTH secretion after caloric ingestion has never been quantified adequately by current standards (16).”
From Glucose ingestion selectively amplifies ACTH and cortisol secretory-burst mass and enhances their joint synchrony in healthy men. (2011) · cites this paper as [16]
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3 of the 379 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
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Wearable sensors offer opportunities for phenotyping perinatal mood disorders: a narrative review
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Synthesis, Secretion, and Transport of Peptide Hormones
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Metadata
- Authors
- Veldhuis, J. D., Keenan, D. M., & Pincus, S. M.
- Affiliations
- Mayo Clinic (US)
- University of Virginia (US)
- Independent Statistician (S.M.P.), Guilford, Connecticut 06437
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2008-12-01
- Volume
- 29
- Issue
- 7
- Pages
- 823-864
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- PMC
- PMC2647703
- OpenAlex
- W2098329444
- Cited by
- 223
- References
- 379
- Citations by year
- 2026: 11 · 2025: 5 · 2024: 1 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 8 · 2019: 12 · 2018: 15 · 2017: 16 · 2016: 14 · 2015: 14 · 2014: 16 · 2013: 14 · 2012: 16
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Endocrine Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R21AG023777, AG-23133, R21 AG 29215, AG-29362, R01AG029362, R01AG023133, R01 NIA AG019695, AG23777, R01AG019695, R21AG029215, R37AG019695)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK73148, R01DK073148)
- National Center for Research Resources (M01-RR00 585, M01RR000585)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- pulsatile hormone secretion, pulse analysis, basal secretion, elimination kinetics, dose-response interaction, homeostatic regulation
- MeSH terms
- Animals, Endocrine Glands, Hormones, Humans, Pulsatile Flow, Secretory Rate
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