Cited by 223Hypothalamic control of reproductive hormonesGrowth Hormone and Insulin-like Growth FactorsCircadian rhythm and melatonin

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Motivations and Methods for Analyzing Pulsatile Hormone Secretion

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Veldhuis, Johannes D., Keenan, Daniel M., Pincus, Steven M.·2008·Endocrine Reviews

DOI 10.1210/er.2008-0005PMC PMC2647703

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Abstract

Endocrine glands communicate with remote target cells via a mixture of continuous and intermittent signal exchange. Continuous signaling allows slowly varying control, whereas intermittency permits large rapid adjustments. The control systems that mediate such homeostatic corrections operate in a species-, gender-, age-, and context-selective fashion. Significant progress has been made in understanding mechanisms of adaptive interglandular signaling in vivo. Principal goals are to understand the physiological origins, significance, and mechanisms of pulsatile hormone secretion. Key analytical issues are: 1) to quantify the number, size, shape, and uniformity of pulses, nonpulsatile (basal) secretion, and elimination kinetics; 2) to evaluate regulation of the axis as a whole; and 3) to reconstruct dose-response interactions without disrupting hormone connections. This review will focus on the motivations driving and the methodologies used for such analyses.

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Authors: Veldhuis, J. D., Keenan, D. M., & Pincus, S. M.
Affiliations: Mayo Clinic (US)
University of Virginia (US)
Independent Statistician (S.M.P.), Guilford, Connecticut 06437
ORCID: Veldhuis, Johannes D.
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 2008-12-01
Volume: 29
Issue: 7
Pages: 823-864
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/er.2008-0005
PMC: PMC2647703
OpenAlex: W2098329444
Cited by: 223
References: 379
Citations by year: 2026: 11 · 2025: 5 · 2024: 1 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 8 · 2019: 12 · 2018: 15 · 2017: 16 · 2016: 14 · 2015: 14 · 2014: 16 · 2013: 14 · 2012: 16
FWCI: 2.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Endocrine Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (R21AG023777, AG-23133, R21 AG 29215, AG-29362, R01AG029362, R01AG023133, R01 NIA AG019695, AG23777, R01AG019695, R21AG029215, R37AG019695)
National Institute of Diabetes and Digestive and Kidney Diseases (DK73148, R01DK073148)
National Center for Research Resources (M01-RR00 585, M01RR000585)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: pulsatile hormone secretion, pulse analysis, basal secretion, elimination kinetics, dose-response interaction, homeostatic regulation
MeSH terms: Animals, Endocrine Glands, Hormones, Humans, Pulsatile Flow, Secretory Rate

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Motivations and Methods for Analyzing Pulsatile Hormone Secretion

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