The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Growth Hormone, Insulin-Like Growth Factor-1, and the Kidney: Pathophysiological and Clinical Implications
Abstract
Besides their growth-promoting properties, GH and IGF-1 regulate a broad spectrum of biological functions in several organs, including the kidney. This review focuses on the renal actions of GH and IGF-1, taking into account major advances in renal physiology and hormone biology made over the last 20 years, allowing us to move our understanding of GH/IGF-1 regulation of renal functions from a cellular to a molecular level. The main purpose of this review was to analyze how GH and IGF-1 regulate renal development, glomerular functions, and tubular handling of sodium, calcium, phosphate, and glucose. Whenever possible, the relative contributions, the nephronic topology, and the underlying molecular mechanisms of GH and IGF-1 actions were addressed. Beyond the physiological aspects of GH/IGF-1 action on the kidney, the review describes the impact of GH excess and deficiency on renal architecture and functions. It reports in particular new insights into the pathophysiological mechanism of body fluid retention and of changes in phospho-calcium metabolism in acromegaly as well as of the reciprocal changes in sodium, calcium, and phosphate homeostasis observed in GH deficiency. The second aim of this review was to analyze how the GH/IGF-1 axis contributes to major renal diseases such as diabetic nephropathy, renal failure, renal carcinoma, and polycystic renal disease. It summarizes the consequences of chronic renal failure and glucocorticoid therapy after renal transplantation on GH secretion and action and questions the interest of GH therapy in these conditions.
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Cites
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Self-citationVertebral Fractures in Patients With Acromegaly: A 3-Year Prospective Study
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Cited by
Systemic Complications of Acromegaly and the Impact of the Current Treatment Landscape: An Update
Gadelha, M. R., Kasuki, L., Lim, D. S. T., & Fleseriu, M. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00115 · Cited by 363
Günther, T., Tulipano, G., Dournaud, P., Bousquet, C., Csaba, Z., Kreienkamp, H.-J., Lupp, A., Korbonits, M., Castaño, J. P., Wester, H.-J., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.015388 · Cited by 253
Mazziotti, G., Frara, S., & Giustina, A. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00005 · Cited by 181
Self-citationSzczuko, M., Zapałowska-Chwyć, M., Drozd, A., Maciejewska, D., Starczewski, A., Wysokiński, P., & Stachowska, E. (2018) · Ginekologia Polska · doi:10.5603/gp.a2018.0051 · Cited by 23
Metadata
- Authors
- Kamenický, P., Mazziotti, G., Lombès, M., Giustina, A., & Chanson, P.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2013-12-20
- Volume
- 35
- Issue
- 2
- Pages
- 234-281
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2052875048
- Cited by
- 245
- References
- 13
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kamenický, P., Mazziotti, G., Lombès, M., Giustina, A., & Chanson, P. (2014). Growth Hormone, Insulin-Like Growth Factor-1, and the Kidney: Pathophysiological and Clinical Implications. Endocrine Reviews. https://doi.org/10.1210/er.2013-1071
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