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Cited by 128Genetics, Aging, and Longevity in Model OrganismsDietary Effects on HealthRegulation of Appetite and Obesity

Energy Expenditure of Rhesus Monkeys Subjected to 11 Years of Dietary Restriction

Blanc, Stéphane, Schoeller, Dale, Kemnitz, Joseph, Weindruch, Richard, Colman, Ricki, Newton, Wendy, Wink, Kelly, Baum, Scott +1 more·2003·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2002-020405
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Abstract

Dietary restriction (DR) is currently the only paradigm that has consistently extended maximal life span and reduced the onset of age-related chronic diseases in all of the nonprimate species tested. Although it is controversial, some investigators have suggested that the underlying mechanisms may be mediated by adaptations in energy expenditure. We evaluated the extent to which DR alters energy metabolism in a unique cohort of rhesus monkeys submitted to DR for 11 yr. Total energy expenditure (doubly labeled water), resting energy expenditure (REE; indirect calorimetry), and nonbasal energy expenditure (calculated by difference) were measured in DR (n = 12) and control (n = 11) animals. Body composition was determined by dual energy x-ray absorptiometry. Both fat mass and fat-free mass were lower in the restricted animals (56 and 12%, respectively). DR induced a 17% lower total energy expenditure that was attributable to a 20% decrease in REE without changes in the nonbasal energy expenditure. Adjusted for fat-free mass, REE was 13% lower with DR (-250 kJ/d). Taken together with a reanalysis of previous DR experiments published in humans, rodents, and monkeys, these results suggest that DR may lower REE independent of the DR-induced changes in body composition. Whether this reduction in REE contributes to the life-extending properties of DR warrants further analysis, but it suggests that the long-standing debate regarding DR effects on metabolic rates may derive from the lack of consensus on how to adjust for body size and composition.

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  • DEE for adult orangutans was lower than macaques undergoing calorie restriction (z-score, -2.25).

    “this is lower than macaques undergoing calorie restriction (z-score, –2.25) (16).”

    From Metabolic adaptation for low energy throughput in orangutans. (2010) · cites this paper as [16]

  • The pattern of PAL and body composition seen in Great Ape Trust orangutans is unlike that of sedentary captive macaques involved in calorie restriction studies, including control subjects with normal diets, which have PAL of less than 1.3 and body fat percentages of 19.2% (calorie restricted) to 32.3% (normal diet).

    “The pattern of PAL and body composition seen in Great Ape Trust orangutans is unlike that of sedentary captive macaques involved in calorie restriction studies, including control subjects with normal diets, which have PAL of less than 1.3 and body fat percentages of 19.2% (calorie restricted) to 32.3% (normal diet) (16).”

    From Metabolic adaptation for low energy throughput in orangutans. (2010) · cites this paper as [16]

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Authors
Blanc, S., Schoeller, D., Kemnitz, J., Weindruch, R., Colman, R., Newton, W., Wink, K., Baum, S., & Ramsey, J.
Affiliations
  • Department of Nutritional Sciences (S.B., D.S.), Madison, Wisconsin 53706-1571;
  • University of Wisconsin–Madison (US)
  • Wisconsin Regional Primate Research Center (J.K., R.C., W.N., K.W., S.B.), Madison, Wisconsin 53706-1571;
  • University of California, Davis (US)
Corresponding author
Schoeller, Dale
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2003-01-01
Volume
88
Issue
1
Pages
16-23
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2002-020405
OpenAlex
W2155473438
Cited by
128
References
37
Citations by year
2024: 3 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 6 · 2016: 3 · 2015: 1 · 2014: 6 · 2013: 8 · 2012: 9
FWCI
3.13
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Centers for Disease Control and Prevention (PSI RR00167)
  • National Institute on Aging (P01-AG-11915, P01AG011915)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
dietary restriction, energy expenditure, resting energy expenditure, rhesus monkeys, body composition, fat mass, fat-free mass, lifespan extension, energy metabolism, body size adjustment
MeSH terms
Animals, Energy Intake, Calorimetry, Indirect, Diet, Energy Metabolism, Macaca mulatta, Rest

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